Effectiveness of a bacteriophage YZU_PF006 in controlling dairy spoilage caused by Pseudomonas fluorescens by Lei Yuan, Lili Ma, Yang Liu, Xinhai Yuan, Shuo Wang, Wenyuan Zhou, Zhenbo Xu, Zhenquan Yang

“…Results demonstrated that phage YZU_PF006 effectively controlled P. fluorescens growth and production of protease at 7°C and 28°C in milk in a phage concentration-dependent way. …”
Get full text

ADAMTS13 Improves Endothelial Function and Reduces Inflammation in Diabetic Retinopathy by Ahmed M. Abu El-Asrar, Mohd I. Nawaz, Ajmal Ahmad, Mairaj Siddiquei, Eef Allegaert, Lowie Adyns, Lotte Vanbrabant, Priscilla W. Gikandi, Gert De Hertogh, Sofie Struyf, Ghislain Opdenakker

“…The protease, a disintegrin and metalloproteinase with thrombospondin type 1 motif member 13 (ADAMTS13), known to cleave only the von Willebrand factor (VWF), has powerful regulatory effects on microvascular platelet adhesion, thrombosis, inflammation, and endothelial dysfunction. …”
Get full text

Membrane-bound model of the ternary complex between factor VIIa/tissue factor and factor X by Melanie P. Muller, Alex Mortenson, Josepha C. Sedzro, Po-Chao Wen, James H. Morrissey, Emad Tajkhorshid

“…Strikingly, in our model, FX makes contact with TF:FVIIa chiefly via its γ-carboxyglutamate–rich (GLA) domain and protease domain, with the majority of the FX light chain (ie, its 2 epidermal growth factor–like domains) out in the solvent, making no direct contact with TF:FVIIa. …”
Get full text

Positively charged cytoplasmic residues in corin prevent signal peptidase cleavage and endoplasmic reticulum retention by Hui Li, Shijin Sun, Wenjun Guo, Lina Wang, Zihao Zhang, Yue Zhang, Ce Zhang, Meng Liu, Shengnan Zhang, Yayan Niu, Ningzheng Dong, Qingyu Wu

“…Herein, we studied the function of cytoplasmic residues in corin, a type II transmembrane serine protease in cardiovascular biology. We found that the positively charged residue at the cytoplasm-membrane interface of corin was not a primary determinant in membrane topology but probably served as a charge-repulsion mechanism in the endoplasmic reticulum (ER) to prevent interactions with proteins in the ER, including the signal peptidase. …”
Get full text

Effects of Dietary Pectin and Lactobacillus salivarius ATCC 11741 on Growth Performance, Immunocompetence, Gut Microbiota, Antioxidant Capacity, and Disease Resistance in Narrow-Cl... by Samyah Darwish Saddig Jastaniah, Hafsan Hafsan, Cheng-jui Tseng, Yasir Salam Karim, Mohammed Ubaid Hamza, Noora M. Hameed, Sura Hasan Al-Zubaidi, Saif Sabbar Kemil Almotlaq, Ghulam Yasin, A. Heri Iswanto, Mahnaz Dadras, Mohammad Mansouri Chorehi

“…Besides, diets incorporated with LS1PE1 and LS2PE2 significantly increased the activity of amylase and protease enzymes compared to LS1, LS2, and control groups (P<0.05). …”
Get full text

Study on the effect and mechanism of ultrasonic-assisted enzymolysis on antioxidant peptide activity in walnuts by Jiaying Huo, Zhaowei Cui, Ruru Zhang, Hui Ouyang, Xiaolong Liu, Ping Wang, Xiongwei Yu, Tingting Xie, Sihai Gao, Shugang Li

“…Results indicated that by optimizing the UAE process with neutral protease, an ultrasound power of 180 W, a 4.3 h duration and an enzyme dosage of 10 KU/g, the walnut peptides exhibited the most potent antioxidant activity. …”
Get full text

Effects of Artemisia argyi leaf water extract (AWE) on growth performance, muscle quality, intestinal microbial, and metabolomics of common carp (Cyprinus carpio) by Di Sun, Nanyang Zeng, Yingjia Pan, Qingsong Shu, Jixing Zou, Yingshi Huang, Guoxia Wang, Jun Shi

“…Additionally, A1 concentration elevated protease activity within the intestine, with Trypsin exhibiting markedly higher activity compared to other groups (p < 0.05). …”
Get full text

Identification of TMPRSS3 as a Significant Contributor to Autosomal Recessive Hearing Loss in the Chinese Population by Xue Gao, Sha-Sha Huang, Yong-Yi Yuan, Jin-Cao Xu, Ping Gu, Dan Bai, Dong-Yang Kang, Ming-Yu Han, Guo-Jian Wang, Mei-Guang Zhang, Jia Li, Pu Dai

“…Mutations in the TMPRSS3 (transmembrane protease, serine 3) gene cause prelingual (DFNB10) or postlingual (DFNB8) deafness. …”
Get full text

Effect of bacteriocin-producing Pediococcus acidilactici strains on the immune system and intestinal flora of normal mice by Yiteng Qiao, Zhichang Qiu, Fengwei Tian, Leilei Yu, Jianxin Zhao, Hao Zhang, Qixiao Zhai, Wei Chen

“…The produced components were identified as bacteriocins through protease treatment, pH adjustment and hydrogen peroxide treatment. …”
Get full text

Influence of Arbuscular Mycorrhizal Fungi on Nitrogen Dynamics During <i>Cinnamomum camphora</i> Litter Decomposition by Yuehong Gao, Xiaoyu Long, Yiqi Liao, Yonghui Lin, Zaihua He, Qin Kong, Xiangshi Kong, Xingbing He

“…Nitrification inhibition mainly promoted the utilization of plant-derived N by promoting the degradation of the amide I, amide II, and III bands by increasing protease activity, and it promoted ammonification by increasing urease activities, whereas it reduced the utilization of microbial-derived N by decreasing chitinase activity. …”
Get full text

Enzymatic Activity and Horizontal Gene Transfer of Heavy Metals and Antibiotic Resistant Proteus vulgaris from Hospital Wastewater: An Insight by Manzar Alam, Nilofer Bano, Tarun Kumar Upadhyay, Reem Binsuwaidan, Nawaf Alshammari, Amit Baran Sharangi, Radhey Shyam Kaushal, Mohd Saeed

“…From the total isolates, 98%, 84%, and 80% had urease, gelatinase, and amylase activity, whereas 68% and 56% displayed protease and beta-lactamase activity. Plasmids were present in all the selected resistant isolates and varied in size from 42.5 to 57.0 kb and molecular weight from 27.2 to 37.0 MD. …”
Get full text

The regulatory role of cystatin C in autophagy and neurodegeneration by T. A. Korolenko, A. B. Shintyapina, A. B. Pupyshev, A. A. Akopyan, G. S. Russkikh, M. A. Dikovskaya, V. A. Vavilin, E. L Zavjalov, M. A. Tikhonova, T. G. Amstislavskaya

“…In an experiment on C57Bl/6J mice, cystatin C concentration was significantly higher in brain tissue than in the liver and spleen: an indication of an important function of this cysteine protease inhibitor in the brain. Using a transgenic mouse model of Parkinson’s disease (5 months old), we demonstrated a significant increase in osmotic susceptibility of brain lysosomes, depending on autophagy, while in a murine model of Alzheimer’s disease, this parameter did not differ from that in the appropriate control.…”
Get full text

Comprehensive Assessment of Rapeseed Meal as a Fish Meal Substitute in Hybrid Sturgeon (Acipenser schrenckii ♀ × Acipenser baerii ♂) Diets: Impacts on Growth Performance, Body Comp... by Wenpeng Zhang, Siyuan Liu, Shidi Wang, Huamin Wang, Kaibo Ge, Yuhong Yang, Shaoxia Lu, Shicheng Han, Haibo Jiang, Chang’an Wang, Hongbai Liu

“…At 50% substitution, sturgeon valve intestinal protease activity reached its maximum, and the duodenal villus height (VH) was not significantly different from that of the control group (morphological and structural indices were lower in the treatment groups). …”
Get full text

Dietary β-Mannanase Affects the Growth, Antioxidant, and Immunes Responses of African Catfish, Clarias gariepinus, and Its Challenge Against Aeromonas hydrophila Infection by Ibrahim Adeshina, Bilal Ahamad Paray, Eijaz Ahmed Bhat, Shahid Sherzada, Olaolu O. Fawole, Dalhatu J. Bawa, Thais Pereira da Cruz, Lateef O. Tiamiyu

“…Results showed dietary β-mannanase levels considerably improved growth performance but did not affect fish survival. Also, amylase, protease, and lipase levels were significantly promoted in the fish fed with β-mannanase-fortified diets than the control group (p <0.05). …”
Get full text

Effective control of southern blight and root rot of Aconitum carmichaelii Debeaux by endophytic Bacillus velezensis YN-2-6S by Qian Wang, Yujie Qiu, Siyu Wang, Yumei Gou, Hongji Hou, Tianwei Su, Lan Zou, Jing Huang

“…In addition, YN-2-6S was able to produce glucanase, cellulase, protease, indole-3-acetic acid with growth-promoting ability. …”
Get full text

HIV-associated Lipodystrophy Syndrome: A Review of Clinical Aspects by Jean-Guy Baril, Patrice Junod, Roger LeBlanc, Harold Dion, Rachel Therrien, François Laplante, Julian Falutz, Pierre Côté, Marie-Nicole Hébert, Richard Lalonde, Normand Lapointe, Dominic Lévesque, Lyse Pinault, Danielle Rouleau, Cécile Tremblay, Benoît Trottier, Sylvie Trottier, Chris Tsoukas, Karl Weiss

“…Initially, these were ascribed to protease inhibitors, but it is now clear that nucleoside reverse transcriptase inhibitors also contribute to lipodystrophy syndrome. …”
Get full text

Dietary Thymol Improved Growth, Body Composition, Digestive Enzyme Activities, Hematology, Immunity, Antioxidant Defense, and Resistance to Streptococcus iniae in the Rainbow Trout... by Hafsan Hafsan, Marwan Mahmood Saleh, Rahman S. Zabibah, Rasha Fadhel Obaid, Hijran Sanaan Jabbar, Yasser Fakri Mustafa, Mohammed Q. Sultan, Gamal A. Gabr, Andrés Alexis Ramírez-Coronel, Mohammad Khodadadi, Mahnaz Dadras

“…TYM at dietary levels of 1.5-2.5 g significantly enhanced liver antioxidant enzyme activity [superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT)], immune components in blood [alternative complement activity (C3), total immunoglobulin (Ig), lysozyme activity, bactericidal activity, and total protein], and in mucus [alkaline phosphatase (ALP), protease activity, lysozyme activity, bactericidal activity, and total protein] compared to other diets (P<0.05). …”
Get full text

Genetic Markers Associated to Dyslipidemia in HIV-Infected Individuals on HAART by Rosmeri K. Lazzaretti, Aline S. Gasparotto, Marina G. de M. Sassi, Carísi A. Polanczyk, Regina Kuhmmer, Jussara M. Silveira, Rossana P. Basso, Cezar A. T. Pinheiro, Mariângela F. Silveira, Eduardo Sprinz, Vanessa S. Mattevi

“…The prevalence of dyslipidemia was particularly high among the protease inhibitors-treated patients (79%). APOE (rs429358 and rs7412) genotypes and APOA5 −1131T>C (rs662799) were associated with plasma triglycerides (TG) and low-density-lipoprotein cholesterol levels (LDL-C). …”
Get full text

Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult βENaC-Tg Mice by Ryan Brown, Donna M. Small, Declan F. Doherty, Leslie Holsinger, Robert Booth, Richard Williams, Rebecca J. Ingram, J. Stuart Elborn, Marcus A. Mall, Clifford C. Taggart, Sinéad Weldon

“…Elevated levels of the cysteine protease cathepsin S (CatS) are associated with chronic mucoobstructive lung diseases such as cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). …”
Get full text

Mast Cells Positive to Tryptase and c-Kit Receptor Expressing Cells Correlates with Angiogenesis in Gastric Cancer Patients Surgically Treated by Michele Ammendola, Rosario Sacco, Giuseppe Sammarco, Giuseppe Donato, Valeria Zuccalà, Roberto Romano, Maria Luposella, Rosa Patruno, Carlo Vallicelli, Giorgio Maria Verdecchia, Davide Cavaliere, Severino Montemurro, Girolamo Ranieri

“…Tryptase is a serin protease stored in mast cells granules, which plays a role in tumour angiogenesis. …”
Get full text