Genomic Characterization of <i>Laodelphax striatellus</i> Permutotetra-like Virus and Self-Cleavage Function of Viral Capsid Protein by Jun Piao, Jiarui Zhang, Lujie Zhang, Jingai Piao, Haitao Wang, Yilin Xie, Shuo Li

“…Detection of purified CP in vitro showed that the cleavage could occur independent of any protease, confirming that CP has self-cleavage characteristics.…”
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Preparation of Cod Gelatin Antifreeze Peptides and Its Application of Frozen-Thawed Surimi by Jin ZHANG, Tao YUAN, Xiaomei SHA, Yuelun XU, Yating KUANG, Zizi HU

“…The results showed that the optimal preparation process for DcAFPs involved using compound protease, with a substrate concentration of 3.5% (w/v), an enzyme-to-substrate ratio of 5% (w/w), a hydrolysis pH of 8, a hydrolysis temperature of 55 ℃, and a hydrolysis time of 2 hours. …”
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Lysosome and Cytoskeleton Pathways Are Robustly Enriched in the Blood of Septic Patients: A Meta-Analysis of Transcriptomic Data by Jie Ma, Chuanxi Chen, Andreas S. Barth, Chris Cheadle, Xiangdong Guan, Li Gao

“…The key regulatory genes in the “Lysosome” pathway include lysosomal acid hydrolases (e.g., protease cathepsin A, D) as well as the major (LAMP1, 2) and minor (SORT1, LAPTM4B) membrane proteins. …”
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Targeted therapy for cisplatin‐resistant lung cancer via aptamer‐guided nano‐zinc carriers containing USP14 siRNA by Xinmin Zhao, Xianghua Wu, Huijie Wang, Songtao Lai, Jialei Wang

“…Therefore, identifying novel biomarkers to improve the diagnosis and treatment of NSCLC is important. Ubiquitin‐specific protease (USP14) is involved in various pathological conditions including cancer; however, the role of USP14 in NSCLC remains elusive. …”
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The MMP-1/PAR-1 Axis Enhances Proliferation and Neuronal Differentiation of Adult Hippocampal Neural Progenitor Cells by Maria Maddalena Valente, Megan Allen, Valeria Bortolotto, Seung T. Lim, Katherine Conant, Mariagrazia Grilli

“…MMP substrates include protease-activated receptor-1 (PAR-1), a G-protein coupled receptor expressed in hippocampus. …”
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Incidence and Predictors of Antiretroviral Treatment Modification in HIV-Infected Adults: A Brazilian Historical Cohort from 2001 to 2010 by Letícia Penna Braga, Cássia Cristina Pinto Mendicino, Edna Afonso Reis, Ricardo Andrade Carmo, Cristiane Menezes de Pádua

“…Women (aHR = 1.62; p=0.022) and patients on protease inhibitor- (PI-) based regimens (aHR = 2.70; p<0.001) were at higher risk of ART modification.…”
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Early Delivery of Misfolded PrP from ER to Lysosomes by Autophagy by Constanza J. Cortes, Kefeng Qin, Eric M. Norstrom, William N. Green, Vytautas P. Bindokas, James A. Mastrianni

“…Additionally, 3-MA selectively impaired the degradation of insoluble Mut-PrP, resulting in an increase in protease-resistant PrP, whereas the induction of autophagy by rapamycin reduced it. …”
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Carbon Nanomaterials in the Treatment of Infectious Bone Defects and Wound Scars after Wushu Fractures by Shenghui Wei, Lei Zou, Xu Hu, Qiuming Li

“…In this paper, carbon nanofibers containing doxycycline, a small molecule protease inhibitor, were prepared by simple blending. …”
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Optimizing chitosan derived from Metapenaeus affinis: a novel anti-biofilm agent against Pseudomonas aeruginosa by Anali Riahi, Hadideh Mabudi, Elahe Tajbakhsh, Laleh Roomiani, Hasan Momtaz

“…In addition, sub-MIC (minimum inhibitory concentration) concentrations of extracted chitosan (10 and 100 µg/mL) successfully reduced the production of pyocyanin and rhamnolipid, as well as the swimming motility, protease activity and biofilm formation ability in comparison to the control group (P < 0.05). …”
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Inhibition of Cathepsin S Produces Neuroprotective Effects after Traumatic Brain Injury in Mice by Jianguo Xu, Handong Wang, Ke Ding, Xinyu Lu, Tao Li, Jiawei Wang, Chunxi Wang, Jian Wang

“…Cathepsin S (CatS) is a cysteine protease normally present in lysosomes. It has long been regarded as an enzyme that is primarily involved in general protein degradation. …”
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In Silico Analysis Revealed Five Novel High-Risk Single-Nucleotide Polymorphisms (rs200384291, rs201163886, rs193141883, rs201139487, and rs201723157) in ELANE Gene Causing Autosom... by Khyber Shinwari, Mikhail A. Bolkov, Muhammad Yasir Akbar, Liu Guojun, Svetlana S. Deryabina, Irina A. Tuzankina, Valery. A. Chereshnev

“…These mutations are shown to destabilize structure and disrupt ELANE protein activation, splicing, and folding and might diminish trypsin-like serine protease efficiency. Prediction of posttranslation modifications highlighted the significance of deleterious nsSNPs because some of nsSNPs affect potential phosphorylation sites. …”
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Bromhexine Hydrochloride Prophylaxis of COVID-19 for Medical Personnel: A Randomized Open-Label Study by Evgeny N. Mikhaylov, Tamara A. Lyubimtseva, Aleksandr D. Vakhrushev, Dmitry Stepanov, Dmitry S. Lebedev, Elena Yu. Vasilieva, Alexandra O. Konradi, Evgeny V. Shlyakhto

“…Bromhexine hydrochloride has been suggested as a TMPRSS2 protease blocker that precludes the penetration of SARS-CoV-2 into cells. …”
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Assessment of technogenic pollution by silver compounds on the biological properties of the soil (model experiment) by Tatiana Minnikova, Natalia Tsepina, Sergey Kolesnikov, Natalia Evstegneeva, Anna Kusina

“…Activity of catalase it was determined gasometrically, dehydrogenases, peroxidase, polyphenoloxidase, ferrireductase, ascorbatoxidase, phosphatase, invertase, urease, protease was determined photocolorimetrically, the total number of bacteria by luminescent method, Azotobacter sp. abundance by the method of fouling lumps on the Ashby medium, length of shoots and roots of wheat (Triticum aestivum L.) morphometrically. …”
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Changes in Digestive Enzyme Activities during Larval Development of Spotted Seatrout (Cynoscion nebulosus) by Martín Alberto Arenas-Pardo, Martha Gabriela Gaxiola-Cortés, Alvaro Fabricio Barreto-Altamirano, Adriana del Carmen Paredes-Medina, Iveth Gabriela Palomino-Albarrán, Patricia Margarita Balam-Uc, Juan Carlos Maldonado-Flores, Carlos Alfonso Álvarez-González

“…To optimize its feeding during larval rearing, this study aims to evaluate the primary gastric (pepsin), intestinal (leucine aminopeptidase and alkaline phosphatase), and pancreatic (alkaline protease, trypsin, chymotrypsin, amylase, and lipase) enzyme activities from hatching to day 30. …”
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Co-Localized in Amyloid Plaques Cathepsin B as a Source of Peptide Analogs Potential Drug Candidates for Alzheimer’s Disease by Marilena K. Theodoropoulou, Konstantina D. Vraila, Nikos C. Papandreou, Georgia I. Nasi, Vassiliki A. Iconomidou

“…The peptide analogs of co-localized protease, Cathepsin B, may act as such potent inhibitors. …”
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The Inhibitory Effects of Alpha 1 Antitrypsin on Endosomal TLR Signaling Pathways by Ahmed S. Elshikha, Georges Abboud, Rigena Avdiaj, Laurence Morel, Sihong Song

“…Human alpha 1 antitrypsin (hAAT) is a protease inhibitor with anti-inflammatory and immunoregulatory properties. …”
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Activation of PAR4 Upregulates p16 through Inhibition of DNMT1 and HDAC2 Expression via MAPK Signals in Esophageal Squamous Cell Carcinoma Cells by Ming Wang, Shuhong An, Diyi Wang, Haizhen Ji, Xingjing Guo, Zhaojin Wang

“…A previous study showed that a downexpression of protease-activated receptor 4 (PAR4) is associated with the development of esophageal squamous cell carcinoma (ESCC). …”
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The Effect of Glycerol Monolaurate on Intestinal Health and Disease Resistance in Cage-Farmed Juvenile Pompano Trachinotus ovatus by Huaxing Lin, Beiping Tan, Qihui Yang

“…Similar significant elevations in the protease activities were also found in the 0.10, 0.15, and 0.20% GML groups (P<0.05). …”
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The Potential of Defatted Yellow Mealworm (Tenebrio molitor) Meal as an Alternative Protein Source for Juvenile Chinese Mitten Crab (Eriocheir sinensis) by Wenxiang Yao, Chunyan Zhang, Sai Zhang, Guoan Hua, Sitong Zhao, Huiyang Shuang, Ningyang Sun, Yijun Sun, Lumpan Poolsawat, Jianguo Wang, Quan Wang

“…While when 100% fishmeal was replaced, significantly decreased the final body weight (FBW), weight gain (WG), serum alkaline phosphatase (AKP), acid phosphatase (ACP), lysozyme (LZM), glutathione peroxidase (GSH-Px), total antioxidant capacity (T-AOC), and total superoxide dismutase (T-SOD) activities, hepatopancreas protease activity, mid-intestine folds height and number (P<0.05), significantly increased the feed conversion ratio (FCR), serum malondialdehyde (MDA) content, and the abundance of intestinal harmful bacteria Shewanella (P<0.05). …”
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Validation Protocol of Vitamin D Supplementation in Patients with HIV-Infection by Elisabet Lerma-Chippirraz, Roberto Güerri-Fernández, Judit Villar García, Alicia González Mena, Ana Guelar Grinberg, María Milagro Montero, Luisa Sorli, Sonia Calzado, Juan Pablo Horcajada, Adolfo Díez-Pérez, Hernando Knobel Freud

“…Independent factors for not achieving PTH objective were tenofovir (TDF) and protease inhibitors use. In HIV-infected patients with hypovitaminosis, the protocol of cholecalciferol supplementation normalized vitamin D levels regardless of antiretroviral regimen in a high proportion of patients but it was less effective to correct hyperparathyroidism.…”
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