Enterokinase deficiency associated with novel TMPRSS15 gene mutations: a case report by Yunxi Li, Ruijuan Li, Yanyan Pan, Weiran Zhou, Xingcui Wang, Linlin Dong, Xuemei Liu, Hongxia Zhang

“…BackgroundEnterokinase deficiency (EKD,OMIM #226200) is a rare autosomal recessive genetic disorder caused by mutations in transmembrane protease serine 15 (TMPRSS15). Herein, we report a case of EKD in a patient with novel compound heterozygous TMPRSS15 mutations.Case presentationA 2-month-old female infant presented with chronic diarrhea, vomiting, pallor, general edema, skin lesions, and a failure to gain weight. …”
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Structural Analysis of Recombinant Human Preproinsulins by Structure Prediction, Molecular Dynamics, and Protein-Protein Docking by Sung Hun Jung, Chang-Kyu Kim, Gunhee Lee, Jonghwan Yoon, Minho Lee

“…Then, protein-protein docking between the models and trypsin was carried out to compare how efficiently the protease could access the cleavage sites of the proinsulin models. …”
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Differential Modulation of Annexin I Binding Sites on Monocytes and Neutrophils by H. S. Euzger, R. J. Flower, N. J. Goulding, M. Perretti

“…PMN incubation with sodium azide, but not protease inhibitors, partially blocked this process. …”
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Biological and Physicochemical Parameters Related to the Nitrogen Cycle in the Rhizospheric Soil of Native Potato (Solanum phureja) Crops of Colombia by Nathalia Flórez-Zapata, Daniel Uribe-Vélez

“…Finally the results showed that PR, protease activity and soil properties related with organic matter transformation has a positive relationship with productivity, which given the high organic matter content of the Andean soils being studied, we conclude that nitrogen mineralization process has an important role in the nitrogen cycle and its bioavailability in this ecosystem.…”
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Serious issues with cryo-EM structures of human prothrombinase by James A. Huntington, Alexandre Faille, Fatma Isik Ustok

“…Thrombin is generated from prothrombin through sequential cleavage at two sites by the enzyme complex prothrombinase, composed of a serine protease, factor (f) Xa and a cofactor, fVa, on phospholipid membranes. …”
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Therapeutic effects of epigallocatechin and epigallocatechin gallate on the allergic reaction of αs1-casein sensitized mice by Qianqian Zhang, Xiaofeng Yu, Linghan Tian, Yanjun Cong, Linfeng Li

“…The results showed that both EGC and EGCG significantly reduced levels of mast cell protease, histamine, specific IgE antibodies, and Th2 cytokines in allergic mice. …”
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Systemic Lupus Erythematosus with Concurrent Thrombotic Thrombocytopenic Purpura: A Case Report of Diagnostic Challenges and Management Approaches by Sonu Rahul Tej Gaddam, Manideep Katta, Sumana Simarla, Pruthvi Raj Kukunoor, Manichandana Katta

“…Thrombotic Thrombocytopenic Purpura (TTP) is a thrombotic microangiopathy in which decreased activity of the von Willebrand Factor (vWF) multimer-cleaving protease ADAMTS13 leads to microvascular thrombosis. …”
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Quinoline and Quinazoline Alkaloids against COVID-19: An In Silico Multitarget Approach by Esraa M. O. A. Ismail, Shaza W. Shantier, Mona S. Mohammed, Hassan H. Musa, Wadah Osman, Ramzi A. Mothana

“…Three of them, namely, norquinadoline A, deoxytryptoquivaline, and deoxynortryptoquivaline, showed strong binding to the three targets, SARS-CoV-2 main protease, spike glycoprotein, and human angiotensin-converting enzyme 2. …”
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Effect of amniotic fluid on hair follicle growth by Gamze Tumentemur, Elif Ganime Aygun, Bulut Yurtsever, Didem Cakirsoy, Ercument Ovali

“…Gamma irradiation likely improved the efficacy of FAFI by stabilizing active components and inhibiting protease activity.Conclusions: Irradiated hAF is a safe and effective therapeutic candidate for alopecia and HF growth disorders. …”
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Biomolecules of the Horseshoe Crab’s Hemolymph: Components of an Ancient Defensive Mechanism and Its Impact on the Pharmaceutical and Biomedical Industry by Md. Ashrafuzzaman, Mamudul Hasan Razu, Nazmir-Nur Showva, Tohmina Afroze Bondhon, Md. Moniruzzaman, Sad Al Rezwan Rahman, Md. Raisul Islam Rabby, Fatema Akter, Mala Khan

“…They also include tachylectins; protease inhibitors, such as cystatin and serpins; and anti-lipopolysaccharide (LPS) factors, which bind to LPS and agglutinate bacteria. …”
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Soil Application of Tannery Land Plaster: Effects on Nitrogen Mineralization and Soil Biochemical Properties by Caterina Giacometti, Luciano Cavani, Paola Gioacchini, Claudio Ciavatta, Claudio Marzadori

“…Extractable NH4 +-N and NO3 −-N, CO2-C evolution, microbial biomass-N, protease activity, and extractable Cr were monitored. …”
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Molecular Imaging of Cathepsin B Proteolytic Enzyme Activity Reflects the Inflammatory Component of Atherosclerotic Pathology and Can Quantitatively Demonstrate the Antiatheroscler... by Dong-Eog Kim, Jeong-Yeon Kim, Dawid Schellingerhout, Soo-Min Shon, Sang-Wuk Jeong, Eo-Jin Kim, Woo Kyung Kim

“…Inflammation in atherosclerotic plaques causes plaque vulnerability and rupture, leading to thromboembolic complications. Cathepsin B (CatB) proteases secreted by macrophages play a major role in plaque inflammation. …”
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Mechanisms of ubiquitin-independent proteasomal degradation and their roles in age-related neurodegenerative disease by Taylor R. Church, Seth S. Margolis, Seth S. Margolis

“…A major contributor to the deterioration of neuronal physiology is the disruption of protein catabolic pathways mediated by the proteasome, a large protease complex responsible for most cellular protein degradation. …”
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Morphological and Molecular Characteristics of Endophytic Fungi in Sugarcane as Antagonists of the Pathogen Fusarium sacchari by Asniah Asniah, Muhammad Taufik

“…Five of these isolates showed the highest inhibition against F. sacchari and produced cellulase, protease, and chitinase enzymes. Molecular identification results indicated that these five-sugarcane endophytic fungal isolates are Daldinia eschscholdzii, Hypoxylon pulicicidum, Trichoderma virens, Trichoderma harzianum, and Diaporthe phaseolorum. …”
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Porphyromonas gulae and canine periodontal disease: Current understanding and future directions by Kyu Hwan Kwack, Eun-Young Jang, Cheul Kim, Young-Suk Choi, Jae-Hyung Lee, Ji-Hoi Moon

“…This review examines the initial isolation, phylogenetic analysis, habitat, host range, relationships with host health status and age, and key pathogenic determinants, including fimbriae, proteases, citrullinating enzyme, and lipopolysaccharide. …”
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Structural basis for c-di-GMP-mediated inside-out signaling controlling periplasmic proteolysis. by Marcos V A S Navarro, Peter D Newell, Petya V Krasteva, Debashree Chatterjee, Dean R Madden, George A O'Toole, Holger Sondermann

“…Our structural and functional analyses identified a conserved system for the regulation of periplasmic proteases in a wide variety of bacteria, including many free-living and pathogenic species.…”
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Enhancement of postharvest performance in Lilium tigrinum Ker Gawl flowers with Salicylic acid: a signalling molecule and a growth regulator by Moonisah Aftab, Haris Yousuf Lone, Wajahat Waseem Tantray, Aijaz A. Wani, Mohmad Arief Zargar, Inayatullah Tahir

“…Furthermore, SA treatment enhances total soluble protein content, increased proline accumulation, decreased specific protease activity and maintained lower amino acid levels. …”
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Iatrogenic Cushing Syndrome Secondary to Ritonavir-Epidural Triamcinolone Interaction: An Illustrative Case and Review by Sapna Sadarangani, Melody L. Berg, William Mauck, Stacey Rizza

“…The patient’s ART was changed to a non-HIV protease inhibitor- (PI-) containing program, her symptoms improved, and she did not require hydrocortisone replacement. …”
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Selection of probiotic bacteria from the coral reef and tiger grouper fish (Epinephelus foscoguttatus) farming environment by . Ilmiah, . Sukenda, . Widanarni, Enang Harris

“…The results of hydrolyzing the highest protease amylase and lipase enzyme, respectively isolates K15 and T36; isolates T41 and K8; isolates K55 and K68. …”
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Egg yolk hydrolysate shows osteogenic activity in MC3T3-E1 osteoblastic cells by Ilekuttige Priyan Shanura Fernando, Pauline Duffuler, Jianping Wu

“…Effects of fractions were evaluated on osteoblastogenesis. FC, obtained via Protease M and Lipase AY digestion, stood out compared to FA and FB, demonstrating improved MC3T3-El proliferation, RUNX2 production, Akt phosphorylation, and osteoid mineralization. …”
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