Chondroitin 6-Sulfation Regulates Perineuronal Net Formation by Controlling the Stability of Aggrecan by Shinji Miyata, Hiroshi Kitagawa

“…Finally, we found that increased 6-sulfation accelerated proteolysis of aggrecan by a disintegrin and metalloproteinase domain with thrombospondin motif (ADAMTS) protease. Taken together, our results indicate that sulfation patterns of CS chains on aggrecan influenced the stability of the CSPG, thereby regulating formation of PNNs and neural plasticity.…”
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Mice with Catalytically Inactive Cathepsin A Display Neurobehavioral Alterations by O. Y. Calhan, V. Seyrantepe

“…The lysosomal carboxypeptidase A, Cathepsin A (CathA), is a serine protease with two distinct functions. CathA protects β-galactosidase and sialidase Neu1 against proteolytic degradation by forming a multienzyme complex and activates sialidase Neu1. …”
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An Update on the Management of Chronic Hepatitis C: Consensus Guidelines from the Canadian Association for the Study of the Liver by Robert P Myers, Alnoor Ramji, Marc Bilodeau, Stephen Wong, Jordan J Feld

“…It reviews the epidemiology of hepatitis C in Canada, preferred diagnostic testing approaches and recommendations for the treatment of chronically infected patients with the newly approved protease inhibitors (boceprevir and telaprevir), including those who have previously failed pegylated interferon and ribavirin therapy. …”
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An Unusual Case of Rapidly Progressive Hyperbilirubinemia by Kimberly M. Thornton, Michael F. Nyp, Lejla Music Aplenc, Gary L. Jones, Shannon L. Carpenter, Erin M. Guest, Steven M. Shapiro, Winston M. Manimtim

“…Further testing revealed a deficiency of ADAMTS13 protein, or von Willebrand factor-cleaving protease, a finding diagnostic of congenital thrombotic thrombocytopenic purpura, or Upshaw-Schulman syndrome. …”
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Towards the discovery of molecules with anti-COVID-19 activity: Relationships between screening and docking results by Dmytro Anokhin, Sergiy Kovalenko, Pavlo Trostianko, Alexander Kyrychenko, Anton Zakharov, Tetiana Zubatiuk, Volodymyr Ivanov, Oleg Kalugin

“…We use the logistic regression to construct the predictive model for the main protease Mpro inhibitors.…”
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Zn(II) and Fe(II) complexes of  2,4-dinitro-N-[(Z)-[(E)-3-(2-nitrophenyl)prop-2-enylidene] amino] aniline: synthesis, characterization and In Silico SARS-CoV-2 inhibition studies by K. O. Eberendu, J. I. Iheanyichukwu, O. M. Mac-kalunta, C. I. Nwankwo, I. E. Otuokere, J. C. Nnaji

“…These results recommend biological, preclinical, and clinical trials take place, with the target being SARS-CoV-2 protease …”
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Motion-Genetic Testing is Useful in the Diagnosis of Nonhereditary Pancreatic Conditions: Arguments for the Motion by David C Whitcomb

“…Mutations of three major genes are associated with an increased risk of acute and chronic pancreatitis: the cationic trypsinogen (PRSS1) gene, the cystic fibrosis transmembrane conductance regulator (CFTR) gene, and the pancreatic secretory trypsin inhibitor (PSTI) or serine protease inhibitor, Kazal type 1 (SPINK1) gene. Some autosomal dominant forms of hereditary pancreatitis are associated with mutations of the PRSS1 gene, which can be readily identified by genetic testing. …”
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Role of Extracellular Hemoglobin in Thrombosis and Vascular Occlusion in Patients with Sickle Cell Anemia by Zhou Zhou, Molly Behymer, Prasenjit Guchhait

“…Thus, the data suggest that Hb-bound VWF multimers are ultralarge and hyperactive because they are resistant to the protease. The Hb-bound VWF multimers are elevated parallely with the level of ECHb in patients' plasma, and is associated with the pathogenesis of thrombosis and vascular occlusion in SCA.…”
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Unveiling Cathepsin B inhibition with repurposed drugs for anticancer and anti-Alzheimer's drug discovery. by Mohammed Alrouji, Sabina Yasmin, Mohammed S Alshammari, Fahad A Alhumaydhi, Sharaf E Sharaf, Moyad Shahwan, Anas Shamsi

“…Cathepsin B (CatB) is a cysteine protease that plays a pivotal role in this process, making it a potential target for the development of anti-Alzheimer's therapies. …”
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Pathologic complete response following low-dose radiation for advanced oral cavity cancer in a patient with human immunodeficiency virus by Amy B. Leming, Andrea L. Johnston, Greg A. Krempl, Evan J. Fowle, Daniel J. Morton, Christina E. Henson

“…Conclusions To our knowledge, this is the first case of pathologic complete response for a patient on HAART following a single cycle of the Quad-Shot regimen for advanced oral cavity SCCa. Protease inhibitors in HAART can induce spontaneous tumor regression via inhibition of proteasome function and activation of apoptosis, and thus act as a cancer therapeutic. …”
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Hypercoagulation syndrome at liver cirrhosis by I. A. Kurkina, M. V. Mayevskaya, B. V. Silayev, V. T. Ivashkin

“…As the possible reasons causing clotting, decrease of plasma anticoagulants level, elevation of von Willebrand factor level, decrease of ADAMTS13 protease level, changes of vascular wall and decrease of profibrinolytic factors level are taken into account. …”
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Increased matrix metalloproteinase-1 expression by coexposure to UVA and cigarette sidestream smoke and contribution of histone acetylation by Ryoma Ito, Yukako Komaki, Yuko Ibuki

“…In this study, combined effect of UVA and cigarette sidestream smoke (CSS) on matrix metalloproteinase-1 (MMP-1) induction was investigated. MMP-1 is the main protease that initiates collagen type I fiber fragmentation in human skin and is associated with aging. …”
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The Possible Potential Therapeutic Targets for Drug Induced Gingival Overgrowth by Tamilselvan Subramani, Vidhya Rathnavelu, Noorjahan Banu Alitheen

“…Since inflammation is the prerequisite for gingival overgrowth, mast cells and its protease enzymes also play a vital role in the pathogenesis of gingival fibrosis. …”
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N-Acetylcysteine and Other Sulfur-Donors as a Preventative and Adjunct Therapy for COVID-19 by Heidi N du Preez, Colleen Aldous, Hendrik G Kruger, Lin Johnson

“…In the severe to critically ill, it is advised that IV NAC should be administered immediately upon hospital admission, and in the late stage of the disease, IV sodium thiosulfate should be considered. Doxycycline as a protease inhibitor will prevent shedding and further degradation of the glycocalyx.…”
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Nattokinase as a functional food ingredient: therapeutic applications and mechanisms in age-related diseases by Hao Wu, Qian Zhang, Hao Suo, Feng Xu, Wanxu Huang, Dan Ohtan Wang

“…As the key thrombolytic ingredient of natto, the serine protease nattokinase (NK) has been developed into a widely-used dietary supplement. …”
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Permeation Peptide Conjugates for In Vivo Molecular Imaging Applications by Kristin E. Bullok, Seth T. Gammon, Stefania Violini, Andrew M. Prantner, Victor M. Villalobos, Vijay Sharma, David Piwnica-Worms

“…Strategies to develop permeation peptides into molecular imaging probes have included incorporation of targeting motifs such as molecular beacons or protease cleavable domains that enable selective retention, activatable fluorescence, or targeted transduction. …”
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Placental Maspin Gene Expression Pattern May Be Used to Distinguish Between Preeclampsia and Intrauterine Growth Restriction by Gogsen Onalan, Yunus Kasim Terzi, Yusuf Aytac Tohma, Erkan Yurtcu, Esra Kuscu, Feride Iffet Sahin, Hulusi Bulent Zeyneloglu

“… Objective: Maspin is one of the members of serin protease inhibitor superfamily, and acts as a tumor suppressor protein. …”
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Evaluation of corn steep liquor on the digestibility and growth performance of juvenile common carp strain Sinyonya by Dodi Hermawan, Lukman Anugrah Agung, Indah Juwita Sari, Haeru Wahyudin, Immanuel Tarigan

“…In addition, CSL elevated the activity of protease, amylase, and lipase enzymes in the digestive tract of common carp. …”
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Exploring the effect of feeding broiler chickens a diet incorporating unfermented or fermented palm kernel cake: growth performance, digestibility, biochemical indices, digestive e... by Sindaye Daniel, Shehata Zeid, Liao Jinghong, Suqin Hang

“…The experiment period was 42 days, and the PKC fermentation process took 48 h in an incubator set at pH 4.8 and 37 °C with a mix of Lactobacillus plantarum LY19, Bacillus natto NDI, acid protease (250 U/g), cellulase (160 U/g), and mannanylanase (45 U/g). …”
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Effects of Lysozyme, Proteinase K, and Cephalosporins on Biofilm Formation by Clinical Isolates of Pseudomonas aeruginosa by Mohamed Eladawy, Mohammed El-Mowafy, Mohamed Mohamed Adel El-Sokkary, Rasha Barwa

“…The effects of lysozyme (hydrolytic enzyme) and proteinase K (protease) on biofilm formation were evaluated at different concentrations. …”
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