Bidirectional approach of Punica granatum natural compounds: reduction in lung cancer and SARS-CoV-2 propagation by Md. Abul Barkat, Afreen Fatima, Bushra Riaz, Mohd. Zaheen Hassan, Tanveer Ahamad, Abdulkareem A. Alanezi, Harshita Barkat, Afaf F. Almuqati, Yahya I. Asiri, Sahabjada Siddiqui

“…The glide module of Maestro software was used to investigate the molecular-docking interaction of the constituents against main protease (Mpro) and papain-like protease (PLpro) of SARS-CoV-2. …”
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Prevalence of HIV Drug Resistance Mutations in HIV Type 1 Isolates in Antiretroviral Therapy Naïve Population from Northern India by S. Sinha, H. Ahmad, R. C. Shekhar, N. Kumar, L. Dar, J. C. Samantaray, S. K. Sharma, A. Bhargava, R. M. Pandey, R. L. Mitsuyasu, J. L. Fahey

“…Analysis was performed using Viroseq genotyping system based on sequencing of entire protease and two-thirds of the Reverse Transcriptase (RT) region of pol gene. …”
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Distal protein-protein interactions contribute to nirmatrelvir resistance by Eric M. Lewandowski, Xiujun Zhang, Haozhou Tan, Aiden Jaskolka-Brown, Navita Kohaal, Aliaksandra Frazier, Jesper J. Madsen, Lian M. C. Jacobs, Jun Wang, Yu Chen

“…Abstract SARS-CoV-2 main protease, Mpro, is responsible for processing the viral polyproteins into individual proteins, including the protease itself. …”
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Produção, Pré-Purificação e Encapsulamento de Enzima Proteolítica Secretada por Fungo Filamentoso by Jad Lorena Feitosa Simplicio, Bianca Muniz de Sousa, Humberto Oliveira da Silva Pereira, Yasmim Menezes do Nascimento, Adriana Crispim de Freitas

“…Dessa forma, o objetivo deste trabalho foi produzir, purificar parcialmente e encapsular a enzima microbiana protease obtida por fermentação semissólida. O extrato enzimático foi produzido a partir da fermentação de substrato com diferentes composições físico-químicas através do agente de fermentação o fungo filamentoso Aspergillus oryzae. …”
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Inherited Causes of Exocrine Pancreatic Dysfunction by Peter R Durie

“…The exocrine pancreas is functionally immature at birth. Protease function is probably adequate, but lipase activity approximates 5% to 10% of adult values in the newborn and remains low in infancy. …”
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Endometriosis, Angiogenesis and Tissue Factor by Graciela Krikun

“…In addition to its role as the initiator of the hemostatic cascade, TF is known to be involved in angiogenesis via intracellular signaling that utilizes the protease activated receptor-2 (PAR-2). We now review the physiologic expression of TF in the endometrium and its altered expression in multiple cell types derived from eutopic and ectopic endometrium from women with endometriosis compared with normal endometrium. …”
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Sympathetic Prions by Markus Glatzel

“…The infectious agent is termed prion and is thought to be composed of a modified protein (PrPSc or PrPRES), a protease-resistant conformer of the normal host-encoded membrane glycoprotein, PrPC[1]. …”
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Influence of caffeic acid and Bacillus coagulans supplementation on growth, digestive enzymes, immune response, and antioxidant gene expression in common carp (Cyprinus carpio) and... by Seyedeh Shiva Alavinejad, Mehdi Soltani, Seyed saeed Mirzargar, Poulin Shohreh, Ali Taherimirghaed

“…In addition, amylase, lipase, protease, and trypsin in CA group exhibited a higher activity than CD (P < 0.05). …”
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The Ability of Combined Flavonol and Trihydroxyorganic Acid to Suppress SARS-CoV-2 Reproduction by Andrey Bogoyavlenskiy, Pavel Alexyuk, Madina Alexyuk, Vladimir Berezin, Irina Zaitseva, Elmira Omirtaeva, Adolat Manakbayeva, Yergali Moldakhanov, Elmira Anarkulova, Anar Imangazy, Kuralay Akanova, Zhumagali Koshemetov, Nurkul Orazymbetova, Bakyt Umuraliyev

“…These proteins include ACE2 protein, HRV 3C Protease, and Mpro (Main Protease). It was shown that the plant-based complex effectively inhibited the activity of these viral proteins. …”
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Literature study of Zn supplementation in feed for optimizing Nile tilapia Oreochromis niloticus growth by Muhammad Agus Suprayudi, Hendri Inarto, Julie Ekasari

“…The results of this literature review indicate that zinc supplementation in feed can have a positive impact on overall fish growth by increasing digestive enzyme activity, particularly protease enzymes. The level of zinc supplementation in fish is influenced by several factors including, fish size, feed consumption quantity, and duration of maintenance. …”
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A Versatile Method to Create Antibody/Split‐Enzyme Complexes and Its Application to a Rapid, Homogeneous, and Universal Electrochemical Immunosensing System by Yuka Tobita, Kensuke Hirano, Daimei Miura, Yuma Hatano, Wakako Tsugawa, Kazunori Ikebukuro, Koji Sode, Ryutaro Asano

“…SpyCatchers are genetically fused at each terminus of flavin adenine dinucleotide‐dependent glucose dehydrogenase (FAD‐GDH) and a protease recognition sequence is inserted into a loop region to prepare a soluble protein and the split GDH. …”
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Triple Active Antiretroviral Regimen Including Enfuvirtide Via the Biojector is Effective and Safe by Mona Loutfy, Colin Kovacs

“…The addition of enfuvirtide and efavirenz to the present patient’s new antiretroviral regimen ensured that two fully active agents were in use in the setting of a moderate degree of nucleoside resistance and a high level of protease resistance, and where non-nucleoside reverse transcriptase inhibitors were still fully active. …”
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Global stability of an HIV-1 model with distributed intracellular delays and a combination therapy by Shengqiang Liu, Lin Wang

“…The general model include two distributed intracellular delays and a combination therapy with a reverse transcriptase inhibitor and a protease inhibitor. It is shown that the model exhibits a threshold dynamics: if the basic reproduction number is less than or equal to one, then the HIV-1 infection is cleared from the T-cell population; whereas if the basic reproduction number is larger than one, then the HIV-1 infection persists and the viral concentration maintains at a constant level.…”
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Murine Leukemia Viruses: Objects and Organisms by Alan Rein

“…These are the Gag polyprotein, which is the structural protein of a retrovirus particle, the Pol protein, comprising the three retroviral enzymes—protease, which catalyzes the maturation of the particle, reverse transcriptase, which copies the viral RNA into DNA upon infection of a new host cell, and integrase, which inserts the DNA into the chromosomal DNA of the host cell, and the Env polyprotein, which induces the fusion of the viral membrane with that of the new host cell, initiating infection. …”
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Miniaturized Multichannel Near Infrared Endoscope for Mouse Imaging by Martin A. Funovics, Herlen Alencar, Henry S. Su, Khashayarsha Khazaie, Ralph Weissleder, Umar Mahmood

“…Using a mouse model of colonic adenomatosis, we show that both perfusion and protease activity can be detected simultaneously, independently, and repeatedly in live mice. …”
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Evolocumab-induced delayed skin hypersensitivity reaction in a patient with familial hypercholesterolaemia by Grzegorz Porebski, Alicja Dziadowiec

“…In this report, we describe a patient with a delayed cutaneous hypersensitivity reaction to evolocumab, a human monoclonal antibody directed against the serine protease proprotein convertase subtilisin/kexin type 9 used to reduce low-density lipoprotein concentrations in the treatment of familial hypercholesterolaemia. …”
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Creation of a recombinant Komagataella phaffii strain, a producer of proteinase K from Tritirachium album by A. B. Beklemishev, M. B. Pykhtina, Ya. M. Kulikov, T. N. Goryachkovskaya, D. V. Bochkov, S. V. Sergeeva, A. R. Vasileva, V. P. Romanov, D. S. Novikova, S. E. Peltek

“…The resulting recombinant protease has a high specific proteolytic activity: ~5000 U/mg.…”
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Halophilic bacteria of salt lakes and saline soils of the Peri-Caspian lowland (Republic of Daghestan) and their biotechnological potential by E. A. Khalilova, S. T. Kotenko, E. A. Islammagomedova, A. A. Abakarova, N. A. Chernyh, D. A. Aliverdiyeva

“…Strain G2 chemolithotroph; reduces nitrate or nitrite as electron donors; catalase-, amylase-, protease- and β-galactosidase-positive; lipase-, oxidase- and urease-negative. …”
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A mathematical model for treatment-resistant mutations of HIV by Helen Moore, Weiqing Gu

“…Our modelincorporates two types of resistant mutations: strains that are notresponsive to protease inhibitors, and strains that are not responsiveto reverse transcriptase inhibitors. …”
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The Biology and Function of Tissue Inhibitor of Metalloproteinase 2 in the Lungs by Louis Costanzo, Brian Soto, Richard Meier, Patrick Geraghty

“…Tissue inhibitors of matrix metalloproteinases (TIMP) are a family of four endogenous proteins that primarily function to inhibit the activities of proteases such as the matrix metalloproteinases (MMP). …”
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