Engineering a promiscuous prenyltransferase for selective biosynthesis of an undescribed bioactive cannabinoid analog by Qin Yan, Yue-Gui Chen, Xiao-Wen Yang, An Wang, Xiao-Ping He, Xue Tang, Hong Hu, Kai Guo, Zong-Hua Xiao, Yan Liu, Sheng-Hong Li

Get full text

Promiscuous Chemokine Antagonist (BKT130) Suppresses Laser-Induced Choroidal Neovascularization by Inhibition of Monocyte Recruitment by Shira Hagbi-Levi, Michal Abraham, Liran Tiosano, Batya Rinsky, Michelle Grunin, Orly Eizenberg, Amnon Peled, Itay Chowers

“…This study is aimed at assessing if perturbation of chemokine signaling and mononuclear cell recruitment may serve as novel complementary therapeutic targets for nvAMD. Methods. A promiscuous chemokine antagonist (BKT130), aflibercept treatment, or combined BKT130+aflibercept treatment was tested in an in vivo laser-induced model of choroidal neovascularization (LI-CNV) and in an ex vivo choroidal sprouting assay (CSA). …”
Get full text

Promiscuous, diseased and unfit: Discourses and embodiments of Indian indentured women across the British Empire, c. 1840–1920 by Morag Flora Wright

“…I chart three imperial discourses which attempted to embody indentured women in markedly different ways: as promiscuous wives, as diseased and as possessors of unfit wombs. …”
Get full text

The Importance of Olfaction for Mixed Paternity in Birds by Charlotta Kvarnemo, Alice Anderstedt, Maria Strandh, Donald Blomqvist

Subjects: Get full text

Confining the margins, marginalizing the confined: The Distress of Neglected Lockdown Victims in Indian Cities by Rémi de Bercegol, Anthony Goreau-Ponceaud, Shankare Gowda, Antony Raj

“…In addition to the fact that the protective measures against the virus are impossible to respect there, due to promiscuity and insufficient access to water, the brutal disappearance of everyday livelihood strongly aggravates the low standard of living of the inhabitants. …”
Get full text

Confiner les marges, marginaliser les confins : la souffrance des oubliés du lockdown dans les villes indiennes by Rémi de Bercegol, Anthony Goreau-Ponceaud, Shankare Gowda, Antony Raj

“…In addition to the fact that the protective measures against the virus are impossible to respect there, due to promiscuity and insufficient access to water, the brutal disappearance of everyday livelihood strongly aggravates the low standard of living of the inhabitants. …”
Get full text

'Saving' the child in Victorian Dundee by Chrissie Urquhart

“…Contemporary observers argued that it was the drunkenness, ignorance, promiscuity, and irresponsibility of parents which were responsible for the 'gangs' of disorderly and offending children 'swarming' the streets of Victorian towns (Pearson, 1983; Platt, 1969; Shore, 1999). …”

Plasma Membrane Transporters in Modern Liver Pharmacology by Jose J. G. Marin

“…An additional interesting aspect of the role of plasma membrane transporters in liver pharmacology regards the promiscuity of many of these carriers, which accounts for a variety of drug-drug, endogenous substances-drug and food components-drug interactions with clinical relevance.…”
Get full text

Diversion in the settlement of the criminal act of disposal of infants by Sanusi Sanusi

“…The rise of child promiscuity has resulted in children becoming pregnant out of wedlock and then giving birth. …”
Get full text

The role of the Indonesian child protection commission in the Papua province conflict by Yuspani Asemki, Titin Purwaningsih

“…The findings starkly expose a pervasive lack of attention and security afforded to Papuan children by pertinent institutions, consequently exposing them to elevated social risks, such as alcoholism, promiscuity, and substance abuse. Notably, despite its designated mandate, the current role of KPAI appears inadequate, particularly in times of conflict, exacerbating the vulnerability of Papuan children and magnifying their potential as social liabilities. …”
Get full text

Religious beliefs and practices toward HPV vaccine acceptance in Islamic countries: A scoping review. by Sezer Kisa, Adnan Kisa

“…Some of them believe vaccines lead to infertility and sexual promiscuity, defy religious norms, are a sneaky way to inject good Muslims with haram ingredients, and are an abandonment of righteous principles in general.…”
Get full text

Interrogating the Contestations in Zimbabwe’s New Marriage Law and Arbitration in Family Disputes by Bernard Pindukai Humbe, Fortune Sibanda

“…The problem identified by this study was that the new Act has been received with mixed emotions especially by religious communities with the majority complaining that it promotes promiscuity and marriage breakups. Using Alternative Dispute Resolution as a conceptual framework and in-depth interviews, observation and documentary analysis of print and electronic media to gather data, the study established that the new Act promotes paradoxes over marriage dispute resolution because the customary law and decisions have been submerged. …”
Get full text

Educators' perceptions on the benefits and barriers of oral PrEP uptake among adolescent girls and young women in Vulindlela, KwaZulu-Natal by Simamkele Bokolo, Eliza Govender

“…However, these benefits were clouded by barriers and concerns around minimal, or poor condom use as a result of oral PrEP use which could promote promiscuity and minimalise efficacy. These findings highlight the need for more contextual community-driven communication strategies around PrEP, and emphasise the value of a community-centred approach that promotes dialogue among key role players, like educators, to further enhance PrEP communication. …”
Get full text

Evaluation of Yeast Alcohol Acetyltransferases for Ethyl Acetate Production in Clostridium ljungdahlii by Santiago T. Boto, Kareem Gerges, Bettina Bardl, Miriam A. Rosenbaum

“…Hence, ethyl acetate production was enabled in C. ljungdahlii at low titers, which could be explained by the high energetic cost of operation of AATs, and their shown promiscuity. However, we also show that this opens the door to more complex esterification reactions of higher added value biomolecules.…”
Get full text

Mining versatile feruloyl esterases: phylogenetic classification, structural features, and deep learning model by Liang Guo, Yuxin Dong, Deyong Zhang, Xinrong Pan, Xinjie Jin, Xinyu Yan, Yin Lu

“…Further, molecular dynamics simulations and dynamical cross-correlation matrix analysis were employed to explore structural dynamics differences between promiscuous and substrate-specific FEs. Finally, to expand the repertoire of versatile FEs, we employed deep learning models to predict potentially promiscuous enzymes and identified 38 and 75 potential versatile FEs from cluster 1 and cluster 3 with a probability score exceeding 90%. …”
Get full text

Contribution of the P3AP2KB Service in Handling the Impact of Child Marriage in Sleman Regency by Fakih Abdul Rozak, Putri Ayu Nurmalinda, Syarif Hidayatullah

“…The results of this research show several factors behind the application for marriage dispensation at the Sleman Regency Religious Court, such as: pregnancy out of wedlock, customs/ culture, avoiding adultery, promiscuity and economics. The impacts resulting from the marriage dispensation include: protection of children’s rights, negative stigma from society, health problems both physically and psychologically, and economic difficulties. …”
Get full text

Different MHC class I cell surface expression levels in diverse chicken lines, associations with B blood group, and proposed relationship to antigen-binding repertoire by Michael Kaiser, Jim Kaufman, Susan J. Lamont

“…The chicken MHC class I protein binds its cognate antigen(s) over a repertoire spectrum ranging from promiscuous (generalist) to fastidious (specialist). …”
Get full text

Broad substrate scope C-C oxidation in cyclodipeptides catalysed by a flavin-dependent filament by Emmajay Sutherland, Christopher J. Harding, Tancrède du Monceau de Bergendal, Gordon J. Florence, Katrin Ackermann, Bela E. Bode, Silvia Synowsky, Ramasubramanian Sundaramoorthy, Clarissa Melo Czekster

“…The enzyme exhibits promiscuity, processing various cyclic dipeptides as substrates in a distributive manner. …”
Get full text

Flavonoids and anthocyanins in seagrasses: implications for climate change adaptation and resilience by Jana Botes, Jana Botes, Xiao Ma, Xiao Ma, Jiyang Chang, Jiyang Chang, Yves Van de Peer, Yves Van de Peer, Yves Van de Peer, Yves Van de Peer, Dave Kenneth Berger, Dave Kenneth Berger

“…Certain features, such as catalytic promiscuity and metabolon interactions, allow flavonoid metabolism to expand to produce novel compounds and respond to a variety of stimuli. …”
Get full text

Impact of predictive selection of LbCas12a CRISPR RNAs upon on‐ and off‐target editing rates in soybean by Linda Rymarquis, Chenxi Wu, Diane Hohorst, Miguel Vega‐Sanchez, Thomas E. Mullen, Vijetha Vemulapalli, Douglas R. Smith

“…Plants with a desired on‐target edit and no off‐target edits could be identified in the T1 generation for 100% of the T0 plants edited with the Unique crRNA compared with the 65% of T0 plants edited with the Promiscuous crRNA. This confirms that proper crRNA selection can reduce or eliminate off‐target editing. …”
Get full text