Vaginal Primary Malignant Melanoma: A Rare and Aggressive Tumor by Georgios Androutsopoulos, Emmanouil Terzakis, Georgia Ioannidou, Athanasios Tsamandas, Georgios Decavalas

“…Follow up 5 months after initial diagnosis revealed no evidence of local recurrence or distant metastasis. The prognosis of vaginal primary malignant melanoma is very poor despite treatment modality, because most of the cases are diagnosed at advanced stage. …”
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Bilateral Anterior and Intermediate Uveitis with Occlusive Vasculitis as Sole Manifestation of Relapse in Multiple Sclerosis by Angelica Pedraza-Concha, Karin Brandauer, Alejandro Tello, Carlos Mario Rangel, Christian Scheib

“…This case shows how multiple sclerosis may only manifest with ocular involvement and exemplifies the broad spectrum of manifestations and complications, taking into account that ischemic areas from vasculitis and other comorbidities led to macular edema and unfortunately, prognosis became poorer. The complex course of the case enables emphasizing the responsibility role of the ophthalmologists in such systemic entities that may compromise the eye, in which suspicion of the disease and an adequate timing management approach is essential.…”
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Multifocal Retroperitoneal Sarcoma by Theodosios Theodosopoulos, Dionysios Dellaportas, Vasiliki Psychogiou, Anneza Yiallourou, George Polymeneas, Georgios Gkiokas, Dionysios Voros

“…Multifocality is another prognostic factor, which compromises therapy and finally makes prognosis worse due to multiple adverse implications. …”
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A rare manifestation of adrenocortical carcinoma as a mimic of pheochromocytoma: a case report and literature review by Joanna Sobolewska, Wioleta Respondek, Przemyslaw Witek

“…Similarly, in the case of pheochromocytoma, the lack of early diagnosis worsens the patient’s prognosis. Even though both ACC and pheochromocytoma are among the less frequent adrenal lesions, neither should be excluded during differential diagnostics, especially in patients with an equivocal clinical presentation and non-typical adenoma radiological features. …”
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Psychosocial Distress and the Quality of Life of Cancer Patients in Rural Hospitals in Limpopo Province: A Qualitative Study by Dorah Ursula Ramathuba, Neo Jacqueline Ramutumbu

“…Findings: The participants revealed experiences of symptomatic distress resulting in biopsychosocial distress such as pain, fatigue, emotional distress related to prognosis and uncertainty about the future, psychosocial distress related to a lack or absence of support, financial instability, and poor self-esteem. …”
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Metastatic Granulosa Cell Tumor of the Testis: Clinical Presentation and Management by Anand Mohapatra, Aaron M. Potretzke, Brent A. Knight, Min Han, Robert S. Figenshau

“…While most adult GCTs are benign, those that present with distant metastases manifest a grave prognosis. Treatments for aggressive GCTs are not well established. …”
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Limbal Stem Cell Transplantation: Clinical Results, Limits, and Perspectives by Marta Sacchetti, Paolo Rama, Alice Bruscolini, Alessandro Lambiase

“…In these patients, the conjunctivalization of the cornea is associated with visual impairment and cornea transplantation has poor prognosis for recurrence of the conjunctivalization. …”
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The Natural History and Outcomes of the Patients with Carcinosarcoma Involving Kidney and Renal Pelvis by Jue Wang, Fen Wei Wang, Anne Kessinger

“…CSKP commonly presented as high-grade, advanced stage disease, and was associated with a poor prognosis regardless of location.…”
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Polymyositis-Dermatomyositis and Interstitial Lung Disease in Pregnant Woman Successfully Treated with Cyclosporine and Tapered Steroid Therapy by Saito Mayu, Sakiko Isojima, Yoko Miura, Shinichiro Nishimi, Mika Hatano, Takahiro Tokunaga, Ryo Takahashi, Keiko Koide, Yusuke Miwa

“…Several reports have associated the disease activity with fetal prognosis, higher rates of eclampsia, preterm births, and fetal deaths. …”
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Radiation-Induced Peripheral Malignant Nerve Sheath Tumor Arising from Vestibular Schwannoma after Linac-Based Stereotactic Radiation Therapy: A Case Report and Review of Literatur... by Putipun Puataweepong, Taweesak Janwityanujit, Noppadol Larbcharoensub, Mantana Dhanachai

“…However, with the poor prognosis of MPNST, this possibility should be explained to the patient before radiation treatment option.…”
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Congenital Lumbar Hernia: A 15-Year Experience at a Single Tertiary Centre by K. N. Rattan, Arushi Agarwal, Ankur Dhiman, Ananta Rattan

“…For a defect of >5 cm, meshplasty should be considered. Prognosis is excellent.…”
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Case Report: Ductal Carcinoma In Situ in the Male Breast by Joshua Chern, Lydia Liao, Raymond Baraldi, Elizabeth Tinney, Karen Hendershott, Pauline Germaine

“…High-grade ductal carcinoma in situ is incredibly rare in male patients. The prognosis for ductal carcinoma in situ (DCIS) in a male patient is the same as it would be for a female with the same stage disease; therefore, early recognition and diagnosis are of the utmost importance. …”
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Comparison of frontal QRS-T angle in mitral valve prolapse without arrhythmic phenotype with healthy individuals by Celal Kilit

“…Mitral valve prolapse (MVP) is generally known as a benign disease with a good prognosis. Patients with the arrhythmic MVP (AMVP) phenotype have an increased risk of ventricular arrhythmia and sudden cardiac death. …”
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Autopsy Findings in Conjoined Twin with Single Heart and Single Liver by Kar Asaranti, Mohanty Pranati, Kar Tushar, Behera Jagadish, Behera Susmita, Nayak Amarendra

“…The autopsy done can help counsil the parents for further pregnancies and determine the prognosis depending upon the type of cardiac anomaly by Seo classification when detected antenatally. …”
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Transformation of Follicular Lymphoma to Double Hit B-Cell Lymphoma Causing Hypercalcemia in a 69-Year-Old Female: A Case Report and Review of the Literature by Sakshi Kapur, Miles B. Levin

“…These tumors mostly occur in adults and carry a very poor prognosis. Double hit lymphomas can occur de novo, or arise from transformation of follicular lymphoma. …”
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Sudden Cardiac Death: The Most Feared but Potentially Preventable Presentation of Wolff-Parkinson-White Syndrome by Ana Rita Pereira, Alexandra Briosa, Rita Miranda, Sofia Sequeira Almeida, Luís Brandão, Hélder Pereira

“…Wolff-Parkinson-White syndrome is an uncommon cardiac disorder characterized by the presence of one or more accessory pathways that predispose patients to frequent episodes of arrhythmias. The prognosis is usually good, but there is a lifetime risk of malignant arrhythmias and sudden cardiac death. …”
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An Osteolytic Metastasis of Humerus from an Asymptomatic Squamous Cell Carcinoma of Lung: A Rare Clinical Entity by Anirban Das, Sudipta Pandit, Sibes k. Das, Sumitra Basuthakur, Somnath Das

“…Systemic cytotoxic chemotherapy, local palliative radiotherapy, adequate analgesia, and internal fixation of the affected long bone are different modalities of treatment in this advanced stage of disease. But the prognosis is definitely poor in this stage IV disease.…”
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Platelet-white cell ratio is more strongly associated with mortality than other common risk ratios derived from complete blood counts by Brody H. Foy, Jonathan C. T. Carlson, Aaron D. Aguirre, John M. Higgins

“…The platelet-to-white-cell ratio’s association with prognosis is consistent with recently identified inflammatory dynamics and may provide a convenient and interpretable summary of patient inflammatory state.…”
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Application of adoptive cell therapy in malignant melanoma by Qianrong Hu, Jiangying Xuan, Lu Wang, Kangjie Shen, Zixu Gao, Yuhong Zhou, Chuanyuan Wei, Jianying Gu

“…Patients with advanced melanoma suffer a poor prognosis and generally cannot benefit well from surgical resection and chemo/target therapy due to metastasis and drug resistance. …”
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Fluctuating Roles of Matrix Metalloproteinase-9 in Oral Squamous Cell Carcinoma by Suvi-Tuuli Vilen, Tuula Salo, Timo Sorsa, Pia Nyberg

“…The development of early metastases is typical for oral cancer, and increased MMP-9 expression is associated with a poor disease prognosis. However, many studies fail to relate MMP-9 expression with metastasis formation. …”
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