Iron deficiency anaemia: pathophysiology, assessment, practical management by Matthew James Brookes, Mark A Samaan, Esha Sharma, Aditi Kumar, Alexandra Marley

“…This has shown to improve quality of life, morbidity, prognosis in chronic disease and outcomes in pregnancy. …”
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ACSL4 promotes the formation of the proliferative subtype in hepatoblastoma by Wei Dang, Qin Li, Xiaoying Wang

“…Among them, the proliferative subtype, characterized by enhanced proliferative capacity, poor prognosis, and an immunosuppressive tumor microenvironment, was particularly notable. …”
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The Enormity of Chronic Kidney Disease in Nigeria: The Situation in a Teaching Hospital in South-East Nigeria by Ifeoma I. Ulasi, Chinwuba K. Ijoma

“…Death from renal causes constituted 22.03% of medical deaths. Conclusion. The prognosis for CKD patients in Nigeria is abysmal. Only few patients had renal-replacement-therapy (RRT). …”
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Cladophialophora bantiana Cerebral Phaeohyphomycosis Complicated by Pulmonary Nocardiosis: A Tale of Two Infections by Muhammad Farhan Khaliq, Rayan E. Ihle, Christopher P. Schirtzinger

“…After several weeks in the hospital and deteriorating status with poor prognosis, medical care was withdrawn. Cladophialophora bantiana infection is rare and requires multidisciplinary approach for accurate diagnostic confirmation. …”
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A Rare Case of Uterine Leiomyosarcoma with Metastasis to the Thyroid Gland by Gabriel Irizarry-Villafañe, Nadyeschka Rivera-Santana, Michelle Mangual-García, Alex González-Bóssolo, Rafael Trinidad-Hernández, Miosotis García-Maldonado, Víctor Carlo-Chévere

“…Uterine leiomyosarcomas are aggressive tumors associated with a poor prognosis. These neoplasms have high metastatic potential, more frequently affecting the lungs, liver, and peritoneum. …”
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The role of radiotherapy in small cell lung cancer: a new paradigm for the radiation oncologist by Paolo Borghetti, Sara Ramella, Sara Ramella, Umberto Ricardi

“…Small cell lung cancer (SCLC) is an aggressive tumor that presents in most cases as a metastatic disease. The prognosis is poor, but the advent of immunotherapy has rekindled hopes for outcomes. …”
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Support of the Laboratory in the Diagnosis of Fungal Ocular Infections by Virginia Vanzzini Zago, Marino Alcantara Castro, Ramon Naranjo Tackman

“…Correct diagnosis is important because an early medical treatment gives a better prognosis for visual acuity. In some cases, fungal infections are misdiagnosed and the antifungal treatment is delayed.…”
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The Identification of Immune-Related Biomarkers for Osteoarthritis Immunotherapy Based on Single-Cell RNA Sequencing Analysis by Zhe Tan, Rong Chen, Hanyu Lin, Hong Wang

“…In recent years, many researchers focused on bioinformatics analysis to explore new biomarkers for the diagnosis, treatment, and prognosis of human diseases. In this work, we obtain the traditional RNA sequencing data of OA patients from the GEO database. …”
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A review of the pathogenesis of mitochondria in breast cancer and progress of targeting mitochondria for breast cancer treatment by Aoling Huang, Haochen Xue, Ting Xie, Lingyan Xiang, Zhengzhuo Chen, Aolong Ma, Honglin Yan, Jingping Yuan

“…However, the heterogeneity, drug resistance, and poor prognosis of breast cancer highlight an urgent need for further exploration of its underlying mechanisms. …”
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Prognostic Parameters for the Primary Care of Melanoma Patients: What Is Really Risky in Melanoma? by Daniela Göppner, Martin Leverkus

“…The identification of morphological surrogates and prognostic parameters in tumors with such genetic alteration seems therefore crucial when differentiating and classifying this heterogeneous tumor entity in more detail and thus facilitates the stratification of prognosis as well as therapy. This review summarizes the current understanding of carcinogenesis and gives a detailed overview of known morphologic and potentially future genetic prognostic parameters in malignant melanoma.…”
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A Nonpediatric Extraosseous Ewing Sarcoma of the Pancreas: Differential Diagnosis and Therapeutic Strategies by Binoy Yohannan, Mark Feldman

“…Extraosseous Ewing’s sarcoma is a rare and aggressive malignant tumor with a poor prognosis. The pancreas is an extremely uncommon primary site, with only 27 cases that have been published worldwide. …”
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A Case of Legg-Calvé-Perthes Disease due to Transient Synovitis of the Hip by Tadahiko Ohtsuru, Yasuaki Murata, Yuji Morita, Yutaro Munakata, Yoshiharu Kato

“…Transient synovitis (TS) of the hip develops spontaneously in childhood; it usually has a good prognosis and is a self-limiting disease. However, its pathology is not well known. …”
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Complete Recovery from COVID-19 Bilateral Pneumonia in an Immunosuppressed Man with Immune-Mediated Necrotizing Myopathy by Thomas C. Bolig, Nada Abdulaziz, Elena Schiopu

“…More data are needed regarding management and prognosis of patients with connective tissue diseases who become infected with SARS-CoV-2.…”
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Oral submucous fibrosis: a contemporary narrative review with a proposed inter-professional approach for an early diagnosis and clinical management by Naman R. Rao, Alessandro Villa, Chandramani B. More, Ruwan D. Jayasinghe, Alexander Ross Kerr, Newell W. Johnson

“…Despite this, there have been no significant improvements in prognosis for decades. This expert opinion paper updates the literature and provides a critique of diagnostic and therapeutic pitfalls common in developing countries and of deficiencies in management. …”
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Physiopathological Mechanisms of Association between Metabolic Syndrome and Arterial Hypertension: an Update by Luis Enrique Jiménez Franco, Dianelys María Gutiérrez Pérez, Milagros Lisset León Regal, Claudia González Martínez, Lucía Baños Leyva, Arionnis Matos Olivero

“…The metabolic disorders associated with arterial hypertension play a key role in its appearance and maintenance, and modify the long-term prognosis in hypertensive patients and alter the therapeutic strategy.…”
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Myocardial Viability: What We Knew and What Is New by Adel Shabana, Ayman El-Menyar

“…Some patients with chronic ischemic left ventricular dysfunction have shown significant improvements of contractility with favorable long-term prognosis after revascularization. Several imaging techniques are available for the assessment of viable myocardium, based on the detection of preserved perfusion, preserved glucose metabolism, intact cell membrane and mitochondria, and presence of contractile reserve. …”
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Radioresistance in rectal cancer: can nanoparticles turn the tide? by Diogo Coelho, Diogo Estêvão, Maria José Oliveira, Bruno Sarmento

“…However, radioresistance remains a major obstacle often correlated with poor prognosis. Multifunctional nanomedicines offer a promising approach to improve radiotherapy response rates, as well as to increase the intratumoral concentration of chemotherapeutic agents, such as 5-Fluorouracil. …”
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Anaplastic Large Cell Lymphoma Occurring in an HIV-Positive Patient by Philippe Genet, Driss Chaoui, Virginie Masse, Ahmad Al Jijakli, Nina Arakelyan, Laurent Sutton

“…The literature review was performed focusing on incidence, clinical characteristics, prognosis, and physiopathology of ALCL in HIV patients. …”
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Elastography in Hepatology by Ludovico Abenavoli, Christophe Corpechot, Raoul Poupon

“…Besides its importance for prognosis, determining the level of fibrosis reveals the natural history of the disease and the risk factors associated with its progression, to guide the antifibrotic action of different treatments. …”
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Up-to-Date Tailored Systemic Treatment in Pancreatic Ductal Adenocarcinoma by Caroline Y. K. Fong, Emma Burke, David Cunningham, Naureen Starling

“…Research has since focussed on understanding the role and interplay between various components of the desmoplastic stroma and tumour microenvironment, in addition to developing targeted therapies based on molecular features to improve the prognosis associated with this malignancy. This review will summarise the available systemic treatment options and discuss potential methods to refine the resolution of patient selection to enhance responses to currently available therapies. …”
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