Management of a Previously Failed Root Perforation Repair with Geristore and Deepithelialized Gingival Graft: A 5-Year Follow-Up Case Report by Talal M. Zahid

“…More specifically, perforations occurring relative to the crestal bone have a poor prognosis even after repair due to their proximity to the gingival tissues. …”
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1H MR Spectroscopy in Gliomatosis: Is there a Sensitivity Issue? by M. Szewczyk-Bieda, A. K. Kanodia, G. Main, M. S. Eljamel

“…Normal MRS in a patient with suspicion of gliomatosis on MRI should not reassure clinicians into assuming a benign aetiology or a good prognosis in short term.…”
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Rare Intracardiac Tumor: Primary Cardiac Lymphoma Presenting as Atypical Angina by Karthigesu Aimanan, K. Saravana Kumar, M. N. Mohd Arif, Md Noor Zuraini, Md Jamil Ramdzan, L. Hamdan

“…Preoperative confirmation of the pathology is fundamental in guiding an early treatment plan, which allows for improved prognosis. Unfortunately, in most cases, primary cardiac lymphoma is only identified on postoperative histopathological analyses, which affect the treatment plan and outcome. …”
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ADVANCEMENTS IN MODERN SURGICAL MANAGEMENT OF TIBIAL PLATEAU FRACTURES: A COMPREHENSIVE REVIEW by Norin Forna, Paul-Dan Sîrbu, Savin Liliana, Lucian Eva, Wilhelm Friedl, Eugen Carata, Tudor Pinteală, Răzvan Tudor, Mihnea Theodor Sîrbu

“…Effective surgical management minimizes the risk of joint instability, enhances long-term prognosis, and maintains the patient’s quality of life. …”
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Biomarkers to Improve Diagnosis and Monitoring of Obstructive Sleep Apnea Syndrome: Current Status and Future Perspectives by Konstantinos Archontogeorgis, Evangelia Nena, Nikolaos Papanas, Paschalis Steiropoulos

“…There is accumulating data on the utility of serum biomarkers for the evaluation of disease severity, prognosis, and response to treatment. However, current knowledge is limited by data collection techniques, disease complexity, and potential confounding factors. …”
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Mechanisms of Resistance to Trastuzumab and Novel Therapeutic Strategies in HER2-Positive Breast Cancer by Andrea L. A. Wong, Soo-Chin Lee

“…HER2-positive breast cancers have poorer prognosis and are prime candidates for molecular-targeted therapy because they are driven by the unique mechanism of HER2 oncogene addiction. …”
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Simultaneous surgery for gastrostomy and laryngotracheal separation in a patient with Tay‒Sachs disease by Masaharu Moroto, Uda Daisuke, Tomoya Yodoi, Yoshihiro Nitta, Yohei Sugimoto, Tomohiro Chiyonobu, Hiroyuki Yamada, Kayo Ozaki, Taichi Nakatani, Norio Sakai

“…Despite an initially good prognosis, she died at 3 years of age.…”
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Laryngeal Synovial Sarcoma: A Rare Clinical Entity by Clair Saxby, Ron Bova, Melanie Edwards

“…The patient received adjuvant chemotherapy followed by a course of radiotherapy and remains alive and disease free at 18 months after treatment. Discussion. Prognosis for patients with SS is related to primary tumour extent, grade, and size. …”
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LARP3 inhibits the apoptosis of hepatocellular carcinoma via the ROS/PI3K/c-Fos axis. by Lin Zhu, Qianqian Meng, Weiyi Qian, Weiting Shao, Yuyue Lu, Shuai Jin, Afei Zhang, Shuang G Yan, Jingtao Lu

“…In this study, through bioinformatics analysis, we concluded that LARP3 expression is associated with a poor prognosis for patients with HCC. Through cellular experiments such as gene editing and phenotypic functions, we found that LARP3 promotes the occurrence and development of HCC and inhibits apoptosis. …”
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Sister Mary Joseph's Nodule as a First Manifestation of Primary Peritoneal Cancer by C. Iavazzo, K. Madhuri, S. Essapen, N. Akrivos, A. Tailor, S. Butler-Manuel

“…Through a literature search, we also discuss the pathophysiology, diagnostic approach, management, and prognosis of such a condition.…”
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Recurrent Pleural Effusions Occurring in Association with Primary Pulmonary Amyloidosis by Lauren Tada, Humayun Anjum, W. Kenneth Linville, Salim Surani

“…These portend an overall poor prognosis with mean survival time of approximately 1.8 months. …”
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MASH as an emerging cause of hepatocellular carcinoma: current knowledge and future perspectives by Michael Karin, Ju Youn Kim

“…However, it is difficult to understand how metabolic complications lead to the poor prognosis of liver diseases and which molecular mechanisms are underpinning MAFLD‐driven HCC development. …”
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Desmoplastic reaction in the microenvironment of head and neck and other solid tumors: the therapeutic barrier by Kohei Okuyama, Maiko Tsuchiya, Kala Chand Debnath, Shajedul Islam, Souichi Yanamoto

“…Notably, human papillomavirus-driven HNSCC exhibits distinct DR characteristics that further influence the prognosis. DR promotes epithelial-mesenchymal transition and cancer cell invasion through CAF-mediated extracellular matrix remodeling and signaling pathways such as transforming growth factor-beta. …”
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Concurrent Cemento-Osseous Dysplasia and Osteogenic Sarcoma: Report of Two Cases by A. A. Olusanya, B. F. Adeyemi, A. O. Adisa

“…Cemento-osseous dysplasia (COD) represents a rare group of benign fibroosseous disorders, while osteogenic sarcoma (OS) on the hand, is a malignant tumour of ominous prognosis. A combination of COD and OS is rare and sparsely reported in literature. …”
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Anterior Segment Findings in Vitamin A Deficiency: A Case Series by Pierangela Rubino, Paolo Mora, Nicola Ungaro, Stefano A. Gandolfi, Jelka G. Orsoni

“…The diagnostic workup, therapy, and prognosis are discussed.…”
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Tracheobronchial Manifestations of Aspergillus Infections by Rafal Krenke, Elzbieta M. Grabczak

“…To be consistent with clinical practice, an approach basing on specific conditions predisposing to invasive Aspergillus tracheobronchial infections is used to present the differences in the clinical course and prognosis of these infections. Thus, invasive or potentially invasive Aspergillus airway diseases are discussed separately in three groups of patients: (1) lung transplant recipients, (2) highly immunocompromised patients with hematologic malignancies and/or patients undergoing hematopoietic stem cell transplantation, and (3) the remaining, less severely immunocompromised patients or even immunocompetent subjects.…”
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Chronic Heart Failure: We Are Fighting the Battle, but Are We Winning the War? by John J. Atherton

“…Heart failure represents an end-stage phenotype of a number of cardiovascular diseases and is generally associated with a poor prognosis. A number of organized battles fought over the last two to three decades have resulted in considerable advances in treatment including the use of drugs that interfere with neurohormonal activation and device-based therapies such as implantable cardioverter defibrillators and cardiac resynchronization therapy. …”
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Application of Spatial Transcriptomics in Digestive System Tumors by Bowen Huang, Yingjia Chen, Shuqiang Yuan

“…These technologies are also instrumental in the diagnosis, prognosis, and treatment of digestive system tumors. …”
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Melanoma Disparities among US Hispanics: Use of the Social Ecological Model to Contextualize Reasons for Inequitable Outcomes and Frame a Research Agenda by Valerie M. Harvey, Charlene W. Oldfield, Jarvis T. Chen, Karl Eschbach

“…Early detection and diagnosis are critical given the poor prognosis and limited treatment options of advanced-stage disease. …”
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Fibrolamellar Carcinoma: 2012 Update by Michael Torbenson

“…Fibrolamellar carcinomas are not indolent tumors, but have an overall better prognosis than typical hepatocellular carcinomas, in part because of the younger age at presentation and the lack of cirrhosis. …”
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