Nanoparticle-Based Therapies for Management of Subarachnoid Hemorrhage, Neurotrauma, and Stroke by Grace Hey, Ilyas Mehkri, Yusuf Mehkri, Hasan Maqbool, Mubariz Tahirkheli, Samuel Woodford, Brandon Lucke-Wold

“…Despite numerous therapeutic modalities that are available to minimize neurologic damage and secondary injury, the prognosis can still be dismal and unpredictable. Nanoparticle (NP) technology allows for deliberate, modular, and minimally invasive drug delivery. …”
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Evolution of Treatment Outcomes and Prognostic Factors in Esophageal Cancer Surgery: A Retrospective Analysis of 1500 Consecutive Esophagostomies by Yasue Kimura, MD, PhD, Eiji Oki, MD, PhD, Tomonori Nakanoko, MD, PhD, Qingjiang Hu, MD, PhD, Keita Natsugoe, MD, Sho Nanbara, MD, PhD, Ryota Nakanishi, MD, PhD, Yuichiro Nakashima, MD, PhD, Mitsuhiko Ota, MD, PhD, Tomoharu Yoshizumi, MD, PhD

“…We evaluated the treatment outcomes, complications, and prognosis of 1500 consecutive patients who underwent esophagectomy during 5 periods: group A (n = 284), 1964–1984; group B (n = 345), 1985–1993; group C (n = 253), 1994–2002; group D (n = 297), 2003–2012; and group E (n = 321), 2013–March 2020. …”
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The Usefulness of Soluble ST2 Concentration in Heart Failure with Reduced Ejection Fraction to Predict Severe Impairment in Exercise Capacity Assessed in Cardiopulmonary Exercise T... by Magdalena Dudek, Marta Kałużna-Oleksy, Filip Sawczak, Agata Kukfisz, Aleksandra Soloch, Jacek Migaj, Maciej Lesiak, Ewa Straburzyńska-Migaj

“…<b>Background/Objectives</b>: Heart failure (HF) constitutes a complex clinical syndrome that is highly prevalent worldwide, comprises a serious prognosis, and results in a reduced quality of life. …”
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Upregulated SAE1 Drives Tumorigenesis and Is Associated with Poor Clinical Outcomes in Breast Cancer by Hong Liu, Jing Wang, Yunhai Li, Feng Luo, Lei Xing

“…Its overexpression was associated with poor BC prognosis. Additionally, it was an independent prognostic factor for BC patients. …”
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Prediction of major adverse cardiovascular events following ST-segment elevation myocardial infarction using cardiac obesity marker—epicardial adipose tissue mass index: a prospect... by Zeyan Liu, Jinbo Wang, Yanfang Yang, Jinglin Cheng, Min Yang, Ye Zhang

“…The accumulation of epicardial adipose tissue (EAT) may be associated with poorer STEMI prognosis and could serve as a potential prognostic marker. …”
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Aquaporins in oral health and disease: A narrative review by Shailja Chatterjee

“…Its expression has been shown to have a significant correlation with the aggressiveness of tumors as well as prognosis. Aim: The current narrative review aimed to highlight the role of AQPs in maintaining homeostasis in cellular functioning and their expressions in diseased states and other conditions. …”
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A Rare Case of Metastatic Choriocarcinoma of Lung Origin by Parth Rali, Jianwu Xie, Grishma Rali, Mayur Rali, Jan Silverman, Khalid Malik

“…Due to the paucity of data, there are no guidelines for treatment. Prognosis of this malignancy is extremely poor. We report a rare case of metastatic primary lung choriocarcinoma in a 69-year-old postmenopausal woman who was treated with combination of surgery, chemotherapy, and radiation. …”
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Neutrophils Promote Larynx Squamous Cell Carcinoma Progression via Activating the IL-17/JAK/STAT3 Pathway by Tianyi Liu, Shimin Zong, Yang Jiang, Rui Zhao, Jie Wang, Qingquan Hua

“…Laryngeal squamous cell carcinoma (LSCC) is the main type of laryngeal cancer with poor prognosis. Incidence of LSCC increases every year, posing a great threat to human health. …”
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Diagnostic Possibilities of Determining the Level of Faecal Calprotectin in Clinical Practice by A. A. Sheptulin, S. S. Kardasheva, A. A. Kurbatova

“…In patients with already established diagnosis of inflammatory bowel diseases (IBD), dynamic monitoring of the level of FCP allows to assess the course and prognosis of the disease, as well as the effectiveness of treatment. …”
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Circulating Tumor Cells Measurements in Hepatocellular Carcinoma by Franck Chiappini

“…CTC detection and identification can be used to estimate prognosis and may serve as an early marker to assess antitumor activity of treatment. …”
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Primary Meningococcal Polyarthritis in an Adult Woman by José Celso Giordan Cavalcanti Sarinho, Marília Soares e Silva Arcadipane, Graziela Tavares Miola Menezes, Danilo Fernando Costa Duarte, Waldenise Cossermelli, Ivan Aprahamian

“…Early diagnosis of polyarthritis caused by meningococcal bacteria usually present a good prognosis when properly treated.…”
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Gastrointestinal Motility Disorders and Their Clinical Implications in Cirrhosis by Eleni Theocharidou, Ameet Dhar, David Patch

“…Pharmacological interventions aiming to alter gastrointestinal motility in cirrhosis could potentially have a beneficial effect reducing the risk of hepatic decompensation and improving prognosis.…”
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An Unusual Erupted Complex Composite Odontoma: A Rare Case by Dawasaz Ali Azhar, Mohammad Zahir Kota, Sherif El-Nagdy

“…The early diagnosis, followed by a proper treatment at the right time, will result in a favorable prognosis.…”
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Infectious encephalitis diagnosis and treatment in immunosupressed patients: a case report and review of literature by M. Jokubaitis, J. Valaikienė

“…Early diagnosis and initiation of appropriate treatment of bacterial meningoencephalitis correlates with better prognosis for the patient. This article describes an atypical clinical case of a bacterial meningoencephalitis with stroke-like symptoms in a patient with multiple myeloma. …”
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Müllerianosis of the urinary bladder in pre- and postmenopausal women: a literature review by Dimitrios Diamantidis, Georgios Tsakaldimis, Stavros Lailisidis, Evangelia Deligeorgiou, Nikolaos Panagiotopoulos, Nektraria Kritsotaki, Charalampos Kafalis, Chousein Chousein, Stilianos Giannakopoulos, Christos Kalaitzis

“…In some cases, hormonal therapy is also explored. While the prognosis is generally favorable, recurrence is possible, emphasizing the need for long-term follow-up. …”
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Diagnosis and Management of Lentigo Maligna: Clinical Presentation and Comprehensive Review by Piyu Parth Naik

“…If left untreated, LM will progress to lentigo maligna melanoma (LMM), a form of invasive melanoma with the same prognosis as other forms of invasive melanoma. LM is more common in the elderly, with a peak occurrence between the ages of 65 and 80 years. …”
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Iatrogenic T-Cell Lymphoma with Associated Hemophagocytic Lymphohistiocyotsis in a Patient with Long-Standing Rheumatoid Arthritis by X. A. Andrade, H. E. Fuentes, D. M. Oramas, H. Mann, P. Kovarik

“…Clinical presentation with associated hemophagocytic lymphohistiocyotsis is rare and confers a poor prognosis. This case report illustrates a case of a patient with long-standing rheumatoid arthritis and an iatrogenic peripheral T-cell lymphoma with secondary hemophagocytic lymphohistiocytosis who achieved a complete response after intensive chemotherapy.…”
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Breast Angiosarcoma Metastatic to the Ovary by Frederico F. Souza, Amol Katkar, Annick D. Van den Abbeele, Pamela J. Dipiro

“…Although unusual, breast angiosarcomas tend to metastasize hematogenously rather than lymphogenously, have high rates of local recurrence, that often develop metastases soon after treatment, and have a dismal prognosis. We present a case of a solitary ovarian metastasis from angiosarcoma of the breast.…”
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Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome (MMIHS): Series of 4 Cases Caused by Mutation of ACTG2 (Actin Gamma 2, Smooth Muscle) Gene by Katarzyna Ignasiak-Budzyńska, Mikołaj Danko, Janusz Książyk

“…Two of them also manifested disorders from other systems. The prognosis for these patients is poor, but a constant betterment of management in MMIHS, in which the leading role plays TPN (total parental nutrition), causes improvement of patients’ survival.…”
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Pelvic Discontinuity Caused by Acetabular Overreaming during Primary Total Hip Arthroplasty by Iori Takigami, Yoshiki Ito, Takashi Mizoguchi, Katsuji Shimizu

“…Previous reports of acetabular fracture during THA have indicated that it has a relatively good prognosis without extensive treatment. However, to our knowledge, there has been no report of pelvic discontinuity necessitating acetabular reconstruction surgery as an intraoperative complication of primary THA.…”
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