Hypocomplementemic urticarial vasculitis syndrome: A disease with many faces by Ankit Agrawal, Sangeetha Pabolu, Shirisha Ale, Yesenia Galan

“…Although rare, it raises the awareness among the physicians about its clinical presentation and diagnostic approach and also predicts the prognosis of the same.…”
Get full text

Infiltrating Cardiac Synovial Sarcoma Presenting as Acute Cerebrovascular Accident by Kelechukwu U. Okoro, Matthew D. Roby, David C. Sane, Robert E. Budin

“…When present, these tumors portend a poor prognosis with high morbidity and mortality that is attributable to their inherent infiltrative capacity, especially in the absence of treatment. …”
Get full text

Combined Therapy for Distant Metastasis of Sacral Chordoma by Birol Özkal, Can Yaldız, Peyker Temiz, Cüneyt Temiz

“…Chordomas are locally invasive and have low tendency to metastasis and have a poor prognosis in long-term follow-up. Metastasis may be seen in a rate of 5–40% of the chordomas. …”
Get full text

Breast cancer and pregnancy. Literature review and case report by Lidia Torres Aja, Julio Sarmiento Sánchez, José Duarte Pérez

“…Diagnosis is performed, in most cases, in advanced stages of the disease, which leads to a worse prognosis and survival than in non-pregnant and puerperal women. …”
Get full text

Aggressive Behaviour of Metastatic Melanoma in a Patient with Neurofibromatosis Type 1 by Robert W. Foley, Robert M. Maweni, Aurelie Fabre, David G. Healy

“…Malignant melanoma is a common skin neoplasm bearing poor prognosis when presenting with metastases. Rarely melanoma metastases present without an identifiable primary cutaneous lesion despite exhaustive workup. …”
Get full text

Hypertrophic Cardiomyopathy and Wolff-Parkinson-White Syndrome in a Young African Soldier with Recurrent Syncope by Mohammed Abdullahi Talle, Faruk Buba, Aimé Bonny, Musa Mohammed Baba

“…Concurrence of HCM and WPW has been reported in many cases, but whether the prognosis or severity of arrhythmia is different compared to the individual disorders remains unsettled. …”
Get full text

Scrotal Verrucous Carcinoma: An Exceptional Localization of a Rare Tumor by K. Imrani, A. Lahfidi, L. Belkouchi, H. Jerguigue, R. Latib, Y. Omor

“…The treatment is based on surgical excision. The prognosis is relatively good, but local recurrences are frequent. …”
Get full text

Progress of Clinical Research on Trop2 in Solid Tumors by Ying ZHANG, Yueping LIU

“…Trophoblast cell surface antigen 2 (Trop2) is a glycoprotein that is barely expressed in normal tissues but highly expressed in malignant tumors; it is remarkably associated with poor prognosis. Various targeted therapeutics against Trop2, such as anti-Trop2 antibodies and antibody-drug conjugate drugs targeting Trop2, have been developed, and some therapeutics have been approved or are in clinical trials for cancer treatment. …”
Get full text

Sebaceous vs. lipid-rich carcinoma of the breast. Clinicopathological characteristics and correlations – a report of two cases and a literature review by Nikola Živković, Ana Cvetanović, Miloš Kostić, Maja Jovičić Milentijević, Miodrag Djordjević, Tijana Denčić, Julija Cvetković, Mirjana Ćuk

“…On one side there is a tumour with a relatively excellent prognosis, and on the other, a highly aggressive carcinoma with a tendency for early metastases.…”
Get full text

Understanding glioblastoma at the single-cell level: Recent advances and future challenges. by Yahaya A Yabo, Dieter Henrik Heiland

“…As single-cell technologies are developed further, more insights into the cellular and molecular heterogeneity of glioblastomas are expected, which will help guide the development of personalized and effective therapies, thereby improving prognosis and quality of life for patients.…”
Get full text

Successful Nonsurgical Treatment of Pneumomediastinum, Pneumothorax, Pneumoperitoneum, Pneumoretroperitoneum, and Subcutaneous Emphysema following ERCP by L. Fujii, A. Lau, D. E. Fleischer, M. E. Harrison

“…Diagnosis requires a high clinical suspicion for early detection to allow optimal management of the perforation and a better prognosis. Treatment depends on the location and mechanism and increasingly involves nonoperative management. …”
Get full text

Ventricular Septal Defect from Takotsubo Syndrome by Daniel Y. Lu, Julie Caplow, Neha Quatromoni, Rhondalyn Forde-McLean, Anjali Tiku Owens

“…Takotsubo Syndrome is a transient condition characterized by left ventricular systolic dysfunction with apical akinesis/dyskinesis and ballooning. Although the prognosis with medical management is excellent in most cases, rare cases of serious complications can occur. …”
Get full text

Circulating Cytokine Levels as Markers of Inflammation in Philadelphia Negative Myeloproliferative Neoplasms: Diagnostic and Prognostic Interest by Julie Mondet, Kais Hussein, Pascal Mossuz

“…In particular, there is evidence that cytokines are implicated in the functional symptoms of Philadelphia negative myeloproliferative neoplasms (Ph− MPNs), suggesting that evaluation of circulating levels of cytokines could be of clinical interest for the characterization of patients at the time of diagnosis and for disease prognosis. In this review, we present the current knowledge on alteration of circulating cytokine profiles in MPNs and their role in myelofibrosis pathogenesis. …”
Get full text

Growing Teratoma Syndrome: A Rare Case Report and Review of the Literature by Nirmala Kampan, Trika Irianta, Arifuddin Djuana, Lim Pei Shan, Mohd Hashim Omar, Ahmad Zailani Hatta Mohd Dali

“…Complete resection is usually curative and renders better prognosis.…”
Get full text

Severe Pulmonary Hypertension as Initial Presentation of SLE: A Case Report and Literature Review by Rabia Kiani, Muhammad Danial Siddiqui, Hamza Tantoush

“…SLE associated with PAH carries worse prognosis that isolated SLE. However, there has been improvement in mortality of the patients in the recent years owing to newer treatment options available. …”
Get full text

Diffuse Melanosis and Ascites due to Metastatic Malignant Melanoma by Elena Sendagorta, Angel Pizarro, Marta Feito, Matias Mayor, Paloma Ramírez, Uxua Floristán, Rosa Feltes

“…Diffuse cutaneus melanosis is a rare entity that complicates a small percentage of metastatic melanomas, confering a fatal prognosis. We discuss briefly the current evidence on pathogenesis of melanosis arising from metastatic melanoma.…”
Get full text

Solitary Extramedullary Plasmacytoma of the Thyroid Gland by M. Ridal, N. Ouattassi, T. Harmouch, A. Amarti, M. N. Alami

“…Although localized forms management is still controversial, authors require combined approach for regional metastatic forms. The prognosis is favorable compared to solitary bone plasmacytomas or multiple myeloma.…”
Get full text

The Role of the Microbiome and Intestinal Mucosal Barrier in the Development and Progression of Non-Alcoholic Fatty Liver Disease by T. S. Krolevets, M. A. Livzan, S. I. Mozgovoy

“…Liver fibrosis constitutes the leading factor determining the prognosis of patients in NAFLD, including cases associated with cardiovascular complications. …”
Get full text

Current Diagnosis and Therapeutic Approach of Functional Mitral Regurgitation by Prima Almazini

“…This condition can contribute to heart failure progression and lead to a poor prognosis. Functional mitral regurgitation is found in approximately one-third of patients with heart failure with a decreased ejection fraction. …”
Get full text

The Evolution of Prognostic Factors in Multiple Myeloma by Amr Hanbali, Mona Hassanein, Walid Rasheed, Mahmoud Aljurf, Fahad Alsharif

“…Multiple myeloma (MM) is a heterogeneous hematologic malignancy involving the proliferation of plasma cells derived by different genetic events contributing to the development, progression, and prognosis of this disease. Despite improvement in treatment strategies of MM over the last decade, the disease remains incurable. …”
Get full text