Multi-omics analysis reveals that neutrophil extracellular traps related gene TIMP1 promotes CRC progression and influences ferroptosis by Yuzhao Jin, Luyu Liao, Qianping Chen, Bufu Tang, Jin Jiang, Ji Zhu, Minghua Bai

“…Transcriptome and single-cell data reveal that TIMP1 is highly expressed in neutrophils and is associated with poor prognosis in colorectal cancer patients and the occurrence of ferroptosis. …”
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Prognostic signature based on mitochondria- and angiogenesis-related genes associated with immune microenvironment of multiple myeloma by Dai Zhang, Yu Xing, Lu Liu, Xiaoqing Zhang, Cong Ma, MengYao Xu, Ruiqi Li, HanJing Wei, Yan Zhao, Bingxin Xu, Shuhao Mei

“…Introduction: Mitochondria and angiogenesis play key roles in multiple myeloma (MM) development, but their interrelated genes affecting MM prognosis are under-studied.Methods: We analyzed TCGA_MMRF and GSE4581 datasets to identify four genes – CCNB1, CDC25C, HSP90AA1, and PARP1 – that significantly correlate with MM prognosis, with high expression indicating poor outcomes.Results: A prognostic signature based on these genes stratified patients into high- and low-risk groups, with the latter showing better survival. …”
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Prognostic Factor Analysis of Intraocular Pressure with Neovascular Glaucoma by Satoko Nakano, Takako Nakamuro, Katsuhiko Yokoyama, Kunihiro Kiyosaki, Toshiaki Kubota

“…Stand-alone and combination anti-VEGF therapies were not associated with improved long-term prognosis of IOP. Conclusions. Angle closure was found to have the greatest effect on NVG-IOP prognosis. …”
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Therapeutic implications and comprehensive insights into cellular senescence and aging in the tumor microenvironment of sarcoma by Pengfei Zan, Yi Zhang, Yidong Zhu, Qingjing Chen, Zhengwei Duan, Yonghao Guan, Kaiyuan Liu, Anquan Shang, Zihua Li

“…Abstract Sarcoma (SARC), a diverse group of stromal tumors arising from mesenchymal tissues, is often associated with a poor prognosis. Emerging evidence indicates that senescent cells within the tumor microenvironment (TME) significantly contribute to cancer progression and metastasis. …”
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Head and Neck Squamous Cell Carcinoma: NT5E Could Be a Prognostic Biomarker by Yaoting Zhang, Sultan Kadasah, Jiaheng Xie, Dongsheng Gu

“…Head and neck squamous cell carcinoma (HNSCC) is a type of tumour with a relatively poor prognosis. In recent years, immune checkpoint inhibitors, such as CTLA-4 and PD-1/PDL-1 inhibitors, have improved the treatment status of advanced tumours. …”
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Coexisting Malignant Melanoma and Blue Nevus of the Uterine Cervix: An Unusual Combination by David Parada, Karla B. Peña, Frances Riu

“…MM displays aggressive behavior with a poor prognosis. We report the case of a 76-year-old postmenopausal woman abnormal vaginal bleeding. …”
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De Novo Heterozygous Mutation in FGFR2 Causing Type II Pfeiffer Syndrome by Rafat Mosalli, Alfia Fatma, Mohammed A. Almatrafi, Mayada Mazroua, Bosco Paes

“…The subtypes overlap with heterogeneous clinical manifestations and variable prognosis dependent on neurological and respiratory compromise that impact short- and long-term outcomes and survival. …”
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Subpial hemorrhage: A rare and underrecognized site of intracranial hemorrhage in neonates by Anass El M Aary

“…Despite its rarity, SPH generally carries a good prognosis with timely intervention, although larger hemorrhages or cases in preterm infants may have a more uncertain prognosis.…”
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Aberrant MicroRNAs in Pancreatic Cancer: Researches and Clinical Implications by Tao Sun, Xiangyu Kong, Yiqi Du, Zhaoshen Li

“…Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a high rate of mortality and poor prognosis. Numerous studies have proved that microRNA (miRNA) may play a vital role in a wide range of malignancies, including PDAC, and dysregulated miRNAs, including circulating miRNAs, are associated with PDAC proliferation, invasion, chemosensitivity, and radiosensitivity, as well as prognosis. …”
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Plasmacytoid urothelial carcinoma with duodenal metastasis—A rare tumor with unusual site of metastasis with grim outcome by Aparna Chenniappan, Norton S. Stephen, Bheemanathi H. Srinivas, Sreerag K. Sreenivasan, Ramkumar Govindarajalou

“…Plasmacytoid urothelial carcinoma (PUC) is a newly recognized rare variant of urothelial carcinoma, which is now being increasingly diagnosed prospectively as well as by retrospective analysis of cases with a poor prognosis. Morphologically, these tumors simulate plasma cell neoplasms and pose a diagnostic challenge. …”
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The Clinical Outcomes of Ventricular Septal Rupture Secondary to Acute Myocardial Infarction: A Retrospective, Observational Trial by Xin-Ying Zhang, Li-Zhao Bian, Nai-Liang Tian

“…Coronary revascularization combined with the closure of rupture might be helpful in improving their prognosis.…”
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Plasmablastic Lymphoma: A Systematic Review by Jorge J. Castillo, John L. Reagan

“…PBL represents a diagnostic challenge given its characteristic morphology and lack of CD20 expression, and also a therapeutic challenge, with early responses to therapy, but with high relapse rates and poor prognosis. In recent years, our understanding and clinical experience with PBL has increased in both HIV-positive and -negative settings. …”
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Perils and Pitfalls Regarding Differential Diagnosis and Treatment of Primary Cutaneous Anaplastic Large-Cell Lymphoma by Michael D. Diamantidis, Athena D. Myrou

“…Nevertheless, PC-ALCL must be distinguished from secondary skin lesions in systemic ALCL, which confer a poor prognosis, and other CD30+ PCLPDs, reactive conditions, or borderline cases. …”
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PROGNOSTIC FACTORS FOR RESECTABLE COMMON BILE DUCT CANCER by A. Yu. Syskova, I. S. Stilidi, A. N. Polyakov

“…Common bile duct cancer is a rare malignant disease with a poor prognosis. Five-year overall survival is 18-48%, and more than half of the patients relapse within five years.Metastases in the regional lymph nodes and the presence of tumor cells in the margin of the resection are independent factors of a negative prognosis and are associated with a high risk of recurrence.The clinical significance of other prognostic factors, such as renal invasion, low degree of differentiation, tumor size, pancreatic invasion and the need for resection of adjacent organs, require further study.…”
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The theses for MD degree by article Editorial

“…T.N.Sergeyeva – Polyps of cardioesophageal junction at children: causes, development, treatment approach and prognosis.…”
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Droplets Cas13a‐RPA measurement delineates potential role for plasma circWDR37 in colorectal cancer by Jingsong Xu, Li Cao, Shuang Yang, Ying Jian, Yu Liu, Zhen Shen, Qian Liu, Xiang Chen, Min Li, Shun Li, Xiaolei Zuo, Min Li, Hua Wang

“…The clinical sample findings demonstrated that circWDR37 detection can be utilized to effectively screen for CRC at an early stage and enable accurate assessment of prognosis. CircWDR37 is confirmed as a groundbreaking biomarker for both diagnosis and prognosis evaluation in CRC patients. …”
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Resection and Reconstruction of Maxillary Class IIIc Defect in a Case of Adenoid Cystic Carcinoma: Cost-Sensitive Technique without Microvascular Grafts by Dwarkadas Adwani, Anirudh Bhattacharya, Rajender Singh Arora, Ramawatar Soni, Nitin Adwani

“…The expressions of tumor markers too have a significant role in determining the prognosis. The treatment of choice consists of wide radical resection of the tumor followed by radiotherapy. …”
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The Renin-Angiotensin-Aldosterone System as a Therapeutic Target in Late Injury Caused by Ischemia-Reperfusion by Simón Quetzalcóatl Rodríguez-Lara, Leonel García-Benavides, Alejandra Guillermina Miranda-Díaz

“…The search for the understanding of the diverse therapeutic alternatives in molecular coupling could favor the prognosis and evolution of patients who are subject to the I/R process.…”
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Pulmonary Blastoma: A Rare Primary Lung Malignancy by Mahmoud S. Alahwal, Iqbal H. Maniyar, Faiza Saleem, Mariam Alshiekh

“…Surgery is the mainstay of treatment. The prognosis of this rare malignancy is poor and the overall 5-year survival is around 15%. …”
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Ominous Occurrence of Spinal Intradural Primary Malignant Peripheral Nerve Sheath Tumor Four Decades following Radiation Therapy for Testicular Seminoma by Osmond C. Wu, Berje H. Shammassian, Arunit J. S. Chugh, Aparna Harbhajanka, Manish K. Kasliwal

“…Primary intradural malignant peripheral nerve sheath tumor (MPNST) is an extremely rare diagnosis and is associated with an extremely poor prognosis. A 77-year-old man diagnosed with an intradural MPNST, more than 40 years after radiation for a testicular seminoma, is reported. …”
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