Pulmonary hypertension in Finland 2008-2020: A descriptive real-world cohort study (FINPAH) by Markku Pentikäinen, Piia Simonen, Helena Tuunanen, Pauliina Leskelä, Terttu Harju, Pertti Jääskeläinen, Christian Asseburg, Minna Oksanen, Erkki Soini, Christina Wennerström, Airi Puhakka, Terttu Harju, Elina Heliövaara, Pertti Jääskeläinen, Katriina Kahlos, Pentti Korhonen, Tiina Kyllönen, Pauliina Leskelä, Kirsi Majamaa-Voltti, Piia Simonen, Anu Turpeinen, Helena Tuunanen, Ville Vepsäläinen, Tapani Vihinen

“…Background: To assess characteristics, risk group distribution, and prognosis of patients with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH) in Finland. …”
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Corticosteroid use beyond 1-year post heart transplantation is associated with worse outcomes: A contemporary analysis of the ISHLT registry by Abhishek Jaiswal, MD, William L. Baker, Pharm.D, Ashwin Pillai, MD, Michelle Kittleson, MD, PhD, Balaphanidhar Mogga, MD, Zeina Jedeon, MD, Caroline Chen, David A. Baran, MD

“…Whether this observation indicates steroid use is a marker of higher risk or worsens prognosis warrants prospective investigation.…”
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Efficacy and Safety of Low-Dose Lenvatinib and Toripalimab in Patients With Recurrent Platinum-Resistant Ovarian Cancer: Study Protocol of a Multicenter, Open-Label, Single-Arm, Ph... by Su H, Shang X, Liu H, Wang Y, Yu Y, Xu Y, Jiang K, Feng F

“…Exploratory objectives aim to identify biomarkers and molecular signatures for predicting response or prognosis.Keywords: ovarian cancer, platinum-resistant, immune checkpoint inhibitor, lenvatinib, dose adjustment…”
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Classification of distinct tendinopathy subtypes for precision therapeutics by Chenqi Tang, Zetao Wang, Yuanhao Xie, Yang Fei, Junchao Luo, Canlong Wang, Yue Ying, Peiwen He, Ruojing Yan, Yangwu Chen, Jiayun Huang, Yiwen Xu, Zicheng Wang, Boon Chin Heng, Hengzhi Liu, Jianyou Li, Zi Yin, Haobo Wu, Weishan Chen, Hongwei Ouyang, Xiao Chen, Weiliang Shen

“…Abstract Rotator cuff tendinopathy is the most common tendinopathy type with the worst prognosis. Conventional treatments often elicit heterogeneous drug responses due to the diversity of tendinopathy. …”
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Early prediction of in-hospital mortality in patients with congestive heart failure in intensive care unit: a retrospective observational cohort study by Tao Huang, Rui Yang, Jun Lyu, Didi Han, Fengshuo Xu, Shuai Zheng, Luming Zhang, Haiyan Yin

“…Early diagnosis and risk assessment of death of patients with CHF are critical to prognosis and treatment. The purpose of this study was to establish a nomogram that predicts the in-hospital death of patients with CHF in the intensive care unit (ICU).Design A retrospective observational cohort study.Setting and participants Data for the study were from 30 411 patients with CHF in the Medical Information Mart for Intensive Care database and the eICU Collaborative Research Database (eICU-CRD).Primary outcome In-hospital mortality.Methods Univariate logistic regression analysis was used to select risk factors associated with in-hospital mortality of patients with CHF, and multivariate logistic regression was used to build the prediction model. …”
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Development a glycosylated extracellular vesicle-derived miRNA Signature for early detection of esophageal squamous cell carcinoma by Jianlin Chen, Yue Zheng, Zhen Wang, Qi Gao, Kun Hao, Xiongfeng Chen, Nantian Ke, Xiang Lv, Jiamiao Weng, Yuhong Zhong, Zhixin Huang, Miao Fu, Lilan Zhao, Fan Lin, Hui Mi, Haijun Tang, Chundong Yu, Yi Huang

“…Abstract Background Esophageal squamous cell carcinoma (ESCC) is often diagnosed at an advanced stage due to the lack of non-invasive early detection tools, which significantly impacts patient prognosis. Given that glycosylation alterations especially high sialylation and fucosylation, frequently occur during cellular malignant transformation, but their roles are not elucidated. …”
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Multiple patterns of EEG parameters and their role in the prediction of patients with prolonged disorders of consciousness by Hui Li, Hui Li, Hui Li, Linghui Dong, Linghui Dong, Linghui Dong, Wenlong Su, Wenlong Su, Ying Liu, Ying Liu, Zhiqing Tang, Zhiqing Tang, Xingxing Liao, Xingxing Liao, Junzi Long, Junzi Long, Xiaonian Zhang, Xinting Sun, Hao Zhang, Hao Zhang, Hao Zhang, Hao Zhang

“…Predictive models constructed for each component using support vector machine revealed that microstates had the highest AUC (0.95), followed by MMN and P3a (0.65), and finally spectral power (0.05).DiscussionThis study provides preliminary evidence for the application of microstate-based multiple EEG features for prognosis prediction in pDoC.Clinical trial registrationchictr.org.cn, identifier ChiCTR2200064099.…”
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Immunomodulatory Functions of Mesenchymal Stem Cells in Tissue Engineering by Haojiang Li, Shi Shen, Haitao Fu, Zhenyong Wang, Xu Li, Xiang Sui, Mei Yuan, Shuyun Liu, Guiqin Wang, Quanyi Guo

“…The inflammatory response to chronic injury affects tissue regeneration and has become an important factor influencing the prognosis of patients. In previous stem cell treatments, it was revealed that stem cells not only have the ability for direct differentiation or regeneration in chronic tissue damage but also have a regulatory effect on the immune microenvironment. …”
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Mechanistic insights into 125I seed implantation therapy for Cholangiocarcinoma: focus on ROS-Mediated apoptosis and the role of GPX2 by Jun Luo, Zheng Yao, Weiren Liang, Danjun Song, Hui Zeng, Yi Jiang, Zhehan Bao, Jiaping Zheng, Yinan Ding

“…Abstract Objectives Cholangiocarcinoma (CCA) is a rare tumor with a poor prognosis and poses significant therapeutic challenges. …”
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Association between monocyte-lymphocyte ratio and all-cause and cardiovascular mortality in patients with chronic kidney diseases: A data analysis from national health and nutritio... by Wenwu Liu, Shuwei Weng, Chenghui Cao, Yuting Yi, Yue Wu, Daoquan Peng

“…Background The relationship between monocyte-to-lymphocyte ratio (MLR) and prognosis in patients with chronic kidney disease (CKD) remains unclear. …”
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Global, regional and national burden of neuroblastoma and other peripheral nervous system tumors, 1990 to 2021 and predictions to 2035: visualizing epidemiological characteristics... by Chaoyan Yue, Qi Zhang, Fenyong Sun, Qiuhui Pan

“…Future research should focus on improving early diagnosis, risk stratification and target therapy in order to reduce the global burden of disease and improve patients’ prognosis. Funding: This study was supported by National Natural Science Foundation of China (No. 82293662, No 82172357 and No 81930066), Key project of Shanghai ''Science and Technology Innovation Action Plan (22JC1402304) and Research fund of Shanghai Municipal Health Bureau (No. 2019cxjq03).…”
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Mortality and immunological indicators of men who have sex with men living with HIV on antiretroviral therapy: a 10-year retrospective cohort study in Southern China by Huaxiang Lu, Huanhuan Chen, Shujia Liang, Yuhua Ruan, He Jiang, Jinghua Huang, Guangjie Tan, Xiuling Wu, Jianjun Li, Chen Gong, Qiuying Zhu, Guanghua Lan

“…Conclusions Mortality among MSM PLHIV on ART in Guangxi is relatively low, and both high viral loads and low CD4+/CD8+ T cell ratios during treatment and at recent follow-up are strongly predictive of a serious prognosis and should be closely monitored.…”
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Development of a nomogram for predicting pancreatic portal hypertension in patients with acute pancreatitis: a retrospective study by Yong Lv, Hui Luo, Yingjie Zhang, Xiangping Wang, Yanglin Pan, Yunling Li, Qiaoyu Su, Xianchen Zhan, Linhui Zhang, Xiaoyu Kang, Shuhui Liang, Gui Ren

“…The risk factors associated with PPH, as well as the overall prognosis, warrant further investigation. This study aims to develop and validate a nomogram to predict PPH in patients with AP.Methods Consecutive patients with AP from 2015 to 2023 were retrospectively included in the study. …”
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Plasma Levels of Propionylcarnitine Improved Prediction of Heart Failure and All-Cause Mortality in Patients with Stable Coronary Artery Disease by Jairo Lumpuy-Castillo, Francisco J. Rupérez, Brenda Lee Simas Porto, Carmen Cristóbal, Nieves Tarín, Ana Isabel Huelmos, Joaquín Alonso, Jesús Egido, Ignacio Mahíllo-Fernández, Lorenzo López-Bescós, José Tuñón, Óscar Lorenzo

“…The release of acylcarnitines may be altered after coronary artery disease (CAD) in subjects with recurrent clinical outcomes, and this could be used as a prognosis tool. Methods: Patients with stable coronary artery disease (SCAD) who had suffered an acute coronary syndrome 6–9 months before were followed for up to 4.3 years for adverse events. …”
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Frequency of remission achievement in the pre-treat-to-target decade in juvenile idiopathic arthritis by Ana Isabel Rebollo-Giménez, Angela Pistorio, Silvia Maria Orsi, Francesca Ridella, Elena Aldera, Luca Carlini, Valentina Natoli, Marco Burrone, Silvia Rosina, Roberta Naddei, Alessandro Consolaro, Esperanza Naredo, Angelo Ravelli

“…Abstract Background Over the past two decades there has been a remarkable advance in the management of juvenile idiopathic arthritis (JIA), which has led to considerable improvement in prognosis. In 2018, the introduction of the treat-to-target (T2T) strategy in JIA has been advocated to further ameliorate disease outcome. …”
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Exploring biomarkers and molecular mechanisms of Type 2 diabetes mellitus promotes colorectal cancer progression based on transcriptomics by Simin Luo, Yuhong Zhu, Zhanli Guo, Chuan Zheng, Xi Fu, Fengming You, Xueke Li

“…External datasets confirmed from both mRNA and protein expression levels that low COX11 expression was significantly associated with poor CRC prognosis. Immune infiltration analysis suggested that its expression related to the proportion of M2 macrophages. …”
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Research progress of auricular point therapy to relieve preoperative period anxiety before elective surgery in adults (耳穴压豆缓解成年人择期手术术前焦虑的研究进展)... by GAO Yuan (高原), XU Lingzhi (徐凌志), LI Suxia (李素霞)

“…Not only can preoperative anxiety lead to delays or cancellations of surgical procedures, but it can also negatively impact the prognosis of the condition being treated. To alleviate this issue, non-pharmacological interventions such as prayer, massage, music, imagery, and acupuncture have been widely employed. …”
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Effect of comorbidity classes on survival of patients with gastrointestinal tract cancer by Linna Gao, Tian Yao, Shaohua Ge, Jiuwei Cui, Wei Li, Zengqing Guo, Hongxia Xu, Min Weng, Suyi Li, Qinghua Yao, Wen Hu, Lan Zhou, Junqiang Chen, Xianghua Wu, Qingchuan Zhao, Hongli Li, Hanping Shi, Yi Ba, He Huang, The Investigation on Nutrition Status and its Clinical Outcome of Common Cancers (INSCOC) Group

“…The combination of different comorbidities class plays a vital role in the prognosis of GTC.…”
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Clinical characteristics and outcomes of surgical resection for brain metastases from lung adenocarcinoma by Ming Li, Zhiying Li, Hang Zhang, Hiroaki Wakimoto, Linlin Sun, Tiantian Wang, Shengli Zhou, Liyun Zhou

“…Multivariate analysis revealed that smoking history, Ki67 percentage, KPS after craniotomy, and molecular targeted therapy after craniotomy were independent factors affecting the survival time of patients.ConclusionsAlthough survival remains poor, patients who had no-smoking history, Ki67 percentage ≤30%, KPS≥80 after craniotomy, and molecular targeted therapy after craniotomy can improve the prognosis and prolong the survival time.…”
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The Genetic Landscape of Human Glioblastoma and Matched Primary Cancer Stem Cells Reveals Intratumour Similarity and Intertumour Heterogeneity by Chiara Pesenti, Stefania Elena Navone, Laura Guarnaccia, Andrea Terrasi, Jole Costanza, Rosamaria Silipigni, Silvana Guarneri, Nicola Fusco, Laura Fontana, Marco Locatelli, Paolo Rampini, Rolando Campanella, Silvia Tabano, Monica Miozzo, Giovanni Marfia

“…Despite countless experimental researches for new therapeutic strategies and promising clinical trials, the prognosis remains extremely poor, with a mean survival of less than 14 months. …”
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