Impact of re-operation on progression-free survival in patients with recurrent GBM: Experience in a tertiary referral center. by Houssein Darwish, Tasnim Diab, Sarah Kawtharani, Mounir Barake, Bader Ali, Nagham Ramadan, Hiba Fadlallah, Jeannot Kekedjian, Marwan Najjar, Hazem I Assi

“…GBM is known for its aggressive nature and poor prognosis, with most patients experiencing tumor recurrence despite initial treatments. …”
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The Association between Type-2 Diabetes Duration and Major Adverse Cardiac Events after Percutaneous Coronary Intervention by Botey Katamu Benjamin, Chunguang Qiu, Zhanying Han, Wenjie Lu, Guoju Sun, Xiaofei Qin, Xule Wang, Xi Wang, Ran Li, Liang Pan

“…Diabetes is an independent risk factor for coronary artery disease and portends adverse prognosis in diabetic patients undergoing percutaneous coronary intervention (PCI) compared to nondiabetic patients. …”
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Lower Urinary Tract and Gastrointestinal Dysfunction Are Common in Early Parkinson’s Disease by Daniel Martinez-Ramirez, Edna Sophia Velazquez-Avila, Alejandro Almaraz-Espinoza, Arnulfo Gonzalez-Cantú, Genaro Vazquez-Elizondo, Daniel Overa-Posada, Amin Cervantes-Arriaga, Mayela Rodriguez-Violante, Mirna Gonzalez-Gonzalez

“…Autonomic dysfunction in PD is associated with a worse prognosis. We sought to characterize autonomic dysfunction and identify associated factors in patients with early PD. …”
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Pleural metastases from differentiated thyroid cancer: clinical features and long-term outcomes by Mengyue Liu, Juan Tang, Nan Sun, Chuang Xi, Chentian Shen, Song Hongjun, Quanyong Luo, Xianzhao Deng, Zhongling Qiu

“…This study investigated the clinicopathological characteristics of patients with PM from DTC that were treated surgically and with 131I therapy and evaluated their long-term prognosis and prognostic factors. Methods: A review of the Shanghai Sixth People’s Hospital medical records from 2010 to 2023 identified PM in 27 of 14,473 patients with DTC. …”
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Butyrylcholinesterase Levels on Admission Predict Severity and 12-Month Mortality in Hospitalized AIDS Patients by Lijun Xu, Biao Zhu, Ying Huang, Zongxing Yang, Jia Sun, Yan Xu, Jinlei Zheng, Sabine Kinloch, Michael T. Yin, Honglei Weng, Nanping Wu

“…We wished to ascertain if BChE level is associated with the progression/prognosis of AIDS patients. Methods. BChE levels (in U/L) were measured in 505 patients; <4500 was defined as “low” and ≥4500 as “normal.” …”
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ITGA4 as a potential prognostic and immunotherapeutic biomarker in human cancer and its clinical significance in gastric cancer: an integrated analysis and validation by Jiaxing Zhang, Jiaxing Zhang, Gang Wang, Jie Liu, Futian Tang, Song Wang, Yumin Li, Yumin Li

“…In GC, high ITGA4 expression was related to poor prognosis, promoted tumor proliferation and migration, and enhanced immune cell infiltration. …”
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The Association between ER, PR, HER2, and ER−/PR+ Expression and Lung Cancer Subsequent in Breast Cancer Patients: A Retrospective Cohort Study Based on SEER Database by Hong Yu Shao, Bao Tan Hao, Feng Xiao Gao

“…Furthermore, it appears that the prognosis of BC-LuC may be influenced by the presence of ER+ and PR+. …”
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Hypoxia Induced Lnc191 Upregulation Dictates the Progression of Esophageal Squamous Cell Carcinoma by Activating GRP78/ERK Pathway by Sisi Wei, Xinyi Fan, Xiaoya Li, Wei Zhou, Zhihua Zhang, Suli Dai, Huilai Lv, Yueping Liu, Baoen Shan, Lianmei Zhao, Qimin Zhan, Yongmei Song

“…In the present study, a novel hypoxia‐induced long noncoding RNA (lncRNA) is identified first, lnc191, which is highly expressed in clinical ESCC tissues and is positively correlated with poor prognosis of ESCC patients. These findings provide evidence that the hypoxia‐inducible factor‐1α (HIF‐1α)‐mediated transcriptional activation of lnc191 enhances the growth and metastasis of ESCC cells both in vitro and in vivo. …”
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Longitudinal MRI evaluation of the efficacy of non-enhanced lung cancer brain metastases by Xian Zhang, Jun Yang, Hong Hu, Yong Wang, Zhenfeng Zhang, Jinhao lv, Junping Li

“…Approximately 30–40% of cancer patients develop BM at some stage of their illness, presenting with a high incidence and poor prognosis. Our clinical findings indicate a significant disparity in the efficacy between non-enhanced and enhanced lung cancer BM. …”
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Real-world treatment patterns of patients with acute coronary syndrome based on 15-year data by Inga S. Egorova, Natalia N. Vezikova

“…CONCLUSION: Fifteen-year register data showed a high percentage of reperfusion interventions for ACS and prescription of drugs that improve the prognosis. A high percentage of life-threatening complications was noted, especially in STEACS; however, hospital mortality is low if proper treatment is provided.…”
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Emerging nanomedicine strategies for hepatocellular carcinoma therapy by Chen Guo, Jiayu Zhang, Xiaomeng Cai, Rui Dou, Jiaruo Tang, Zhengyuan Huang, Xueting Wang, Yan Guo, Hanqing Chen, Jun Chen

“…Patients in advanced stages have a poor prognosis, and the survival rate after cancer metastasis is notably low. …”
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Rare and syndromic tumours in South African children: A novel report from Sub-Saharan Africa by Alessia Pisapia, Guy Shemesh, Derek Harrison

“…Overall, although lower than that reported in higher income countries, the prognosis of these tumours remains good. Level of evidence: IV…”
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Low albumin-to-creatinine ratios (ACR) are associated with poor outcomes in cancer patients by Hong Zhao, Xiangrui Li, Xiaoyue Liu, Chenan Liu, Xin Zheng, Yue Chen, Jinyu Shi, Qiteng Liu, Zhaoting Bu, Hanping Shi

“…Abstract Background The albumin-to-creatinine ratio (ACR) is known to predict prognosis in liposarcoma patients, but its role in other tumors remains unclear. …”
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MetALD: Clinical aspects, pathophysiology and treatmentKeypoints by Jordi Gratacós-Ginès, Silvia Ariño, Pau Sancho-Bru, Ramon Bataller, Elisa Pose

“…A few cohort studies have also assessed the prognosis of this patient population, with preliminary data suggesting that MetALD is associated with an intermediate risk of liver fibrosis, decompensation and mortality among steatotic liver disease subtypes. …”
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Triglyceride-glucose index predicts adverse cardiovascular events in patients with H-type hypertension combined with coronary heart disease: a retrospective cohort study by Changjiang Li, Shun Zhao, Yingkai Li, Songyuan He, Wen Jian, Yanci Liu, Zichao Cheng, Hongyu Peng

“…However, the relationship between the TyG index and prognosis in patients with H-type hypertension combined with CHD has not yet been reported. …”
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HSF1 Alleviates Brain Injury by Inhibiting NLRP3-Induced Pyroptosis in a Sepsis Model by Yi-fu He, Xi-min Hu, Md. Asaduzzaman Khan, Bo-yao Yu, Yi-cun Sheng, Xian-zhong Xiao, Xin-xing Wan, Si-pin Tan, Kun Xiong

“…The brain injury caused by sepsis could increase the risk of mortality in septic patients, which seriously affects the septic patient’s prognosis of survival. Although there remains a focus on sepsis research, clinical measures to prevent and treat brain injury in sepsis are not yet available, and the high mortality rate is still a big health burden. …”
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Blood Genome-Wide Transcriptional Profiles of HER2 Negative Breast Cancers Patients by Ovidiu Balacescu, Loredana Balacescu, Oana Virtic, Simona Visan, Claudia Gherman, Flaviu Drigla, Laura Pop, Gabriela Bolba-Morar, Carmen Lisencu, Bogdan Fetica, Oana Tudoran, Ioana Berindan-Neagoe

“…In this study, we explored blood transcriptional patterns of patients with two subtypes of HER2 negative breast cancers, with different prognosis and therapeutic outcome. Peripheral blood samples from seven healthy female donors and 29 women with breast cancer including 14 triple-negative breast cancers and 15 hormone-dependent breast cancers were evaluated by microarray. …”
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A Case Study Identified a New Mutation in the TTN Gene for Inherited Hypertrophic Cardiomyopathy by Dong J, Liu M, Chen Q, Zha L

“…Jiangtao Dong,1– 4,&ast; Meilin Liu,1– 3,&ast; Qianwen Chen,1– 3,5 Lingfeng Zha1– 3 1Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 2Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 3Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 4Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 5Department of Pediatric Cardiology, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430070, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Lingfeng Zha, Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, People’s Republic of China, Tel +86-15827177185, Email zhalf@hust.edu.cnBackground: Hypertrophic cardiomyopathy (HCM) is the most common hereditary cardiomyopathy, with variable pathogenesis, clinical presentation, and prognosis. Although mutations in genes encoding sarcomere proteins have been reported to explain the genetic etiology of 40%-60% of HCM patients, the etiology of approximately 1/3 of HCM patients remains unknown. …”
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Non‐Invasive Photoacoustic Cerebrovascular Monitoring of Early‐Stage Ischemic Strokes In Vivo by Jiwoong Kim, Joo Young Kweon, Seongwook Choi, Hyunseo Jeon, Minsik Sung, Rongkang Gao, Chengbo Liu, Chulhong Kim, Yong Joo Ahn

“…By monitoring collateral circulation and neovascularization after ischemic stroke, the natural recovery process can be better understood, optimize further treatment strategies, and improve the prognosis. Photoacoustic computed tomography (PACT), a non‐invasive imaging modality that captures multiparametric high‐resolution images of vessel structures, is well suited for evaluating cerebrovascular structures and their function. …”
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Efficacy and Safety of Recombinant Human Thrombopoietin (rhTPO) on Coagulation Function and Inflammatory Factors in the Treatment of Patients with Sepsis-Related Thrombocytopenia by Huijuan Wang MD, Dong Chen MD, Ming He MD

“…Background this study aimed to investigate the efficacy of recombinant human thrombopoietin (rhTPO) in the treatment of sepsis-associated thrombocytopenia, and to evaluate its impact on coagulation function, inflammatory markers, platelet (Plt) count, and patient prognosis. Methods a total of 144 patients with sepsis-associated thrombocytopenia, admitted to our hospital between 2022 and 2023, were selected for the study. …”
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