Glioblastoma drives protease-independent extracellular matrix invasion of microglia by Chia-Wen Chang, Ashwin Bale, Rohit Bhargava, Brendan A.C. Harley

“…Microglia infiltration into the tumor microenvironment is associated with immunosuppression and poor prognosis. Improved physicochemical understanding of microglia activation and invasion may provide novel GBM therapeutic strategies essential for improving long-term treatment efficacy. …”
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Hepatic arterial infusion chemotherapy combined with systemic therapy sequentially or simultaneously for advanced hepatocellular carcinoma by Yu-zhe Cao, Jia-yu Pan, Guang-lei Zheng, Chao An, Meng-Xuan Zuo

“…The patients who received hepatic arterial infusion chemotherapy combined with targeted therapy and PD-(L)1 blockade simultaneously have a better prognosis than those who received it sequentially.…”
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A case of de novo neuroendocrine prostate cancer presented with elevated level of serum CEA carrying BRCA2 mutation: case report and literature review by Weizhe Han, Nihati Rexiati, Fang Yu, Yongzhi Wang, Yueli Tian, Jianyuan Wu, Gang Wang, Tao Liu, Zhonghua Yang

“…Potential circulating or fluid markers might facilitate early diagnosis thus improving prognosis of NEPC, especially for de novo NEPC.Case presentationA man of 71-year was presented with elevated level of serum carcinoembryonic antigen (CEA) (1296.5 ng/ml) and normal PSA (0.47ng/ml). …”
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Association between colorectal cancer and arthritis among Americans in 2005–2016 by Zhongbo Hou, Niping Qin, Yanlin He, Jiang Chen, Yibo Cao, Wei Xie, Tianbao Xiao

“…Stratified analysis showed that arthritis was positively associated with CRC, and the area under the curve (AUC) was 0.818, indicating that arthritis was more effective in the prognosis of CRC. Finally, the decision curve and calibration curve indicated that the nomogram could effectively predict CRC. …”
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Potential Target Antigens for a Universal Vaccine in Epithelial Ovarian Cancer by Renee Vermeij, Toos Daemen, Geertruida H. de Bock, Pauline de Graeff, Ninke Leffers, Annechien Lambeck, Klaske A. ten Hoor, Harry Hollema, Ate G. J. van der Zee, Hans W. Nijman

“…The prognosis of epithelial ovarian cancer (EOC), the primary cause of death from gynaecological malignancies, has only modestly improved over the last decades. …”
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Bibliometric analysis of glycolysis and prostate cancer research from 2004 to 2024 by Congxu Zhu, Jingjing Yang, Lumei Liu, Bonan Li, Tiansong Sun, Wen Sheng, Qinghu He

“…Glycolysis has also demonstrated significant clinical value in the diagnosis and prognosis of PCa. Moreover, drugs targeting glycolytic inhibitors and natural products have exhibited therapeutic potential against this disease. …”
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Efficacy and Safety Evaluation of Immune Checkpoint Inhibitors in Combination With Chemotherapy for Extensive Small Cell Lung Cancer: Real‐World Evidence by Yuta Yamanaka, Yukiko Okuno, Keisuke Kamisako, Yuta Okazaki, Kentaro Nakanishi, Yume Sanada, Kiyori Yoshida, Tatsuki Ikoma, Yuki Takeyasu, Utae Katsushima, Hiroshige Yoshioka, Takayasu Kurata

“…Despite the retrospective nature of this study and the potential for various biases, we recommend the preferential use of Atezo + CE in patients with brain metastasis to potentially enhance prognosis.…”
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Prognostic significance of neutrophil extracellular trap-related genes in childhood acute lymphoblastic leukemia: insights from multi-omics and in vitro experiment by Cheng Chen, Yu Ma, Yadai Gao, Huiqing Ge, Xiaochun Zhang

“…Independent prognostic analysis identified risk scores and primary diagnosis as independent predictors of prognosis. Immune cell profiling showed significant differences in cell populations such as aDCs, eosinophils and Th2 cells between risk groups. …”
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Association of neutrophil-to-lymphocyte ratio with severe abdominal aortic calcification: new evidence from the United States by Hao Deng, Mengmeng Sun, Zhentong Zhao, Kun Fan, Zizhang Zhao, Yifan Chi, Wei Sheng

“…The NLR is associated with the prognosis of a range of diseases, including circulatory, infectious, psychiatric, and neoplastic conditions. …”
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Risk Stratification and Adjuvant Chemotherapy for High‐Risk Stage IA Lung Adenocarcinoma: The Unmet Needs by Chen Shen, Haoran Liu, Bofei Li, Jiaming Wang, Yiyang Wang, Feichao Bao, Zhitao Gu, Wentao Fang

“…ABSTRACT Introduction To identify high‐risk patients for recurrence in resected stage IA lung adenocarcinoma and evaluate the impact of adjuvant chemotherapy (ACT) on their prognosis, as well as explore potential novel adjuvant therapies. …”
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Diagnosis of Malignant Endometrial Lesions from Ultrasound Radiomics Features and Clinical Variables Using Machine Learning Methods by Shanshan Li, Jiali Wang, Li Zhou, Hui Wang, Xiangyu Wang, Jian Hu, Qingxiu Ai

“…Background: The prognosis of patients with early diagnosis of malignant endometrial lesions is good. …”
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Advantages of using T1-mapping in cardiac magnetic resonance imaging in patients with acromegaly by Alina A. Almaskhanova, Konstantin V. Melkozerov, Elena G. Przhiyalkovskaya, Natalia V. Tarbaeva, Anastasya Y. Korneluk, Raisa S. Kosharnaia, Victor Y. Kalashnikov, Zhanna E. Belaya, Galina A. Mel'nichenko, Natalia G. Mokrysheva

“…The T1-mapping method, which is actively developing, can serve as a marker for early diffuse myocardial fibrosis and help determine the prognosis for patients with acromegalic cardiomyopathy.…”
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Biomarkers for Diagnosis and Prediction of Outcomes in Contrast-Induced Nephropathy by Justor Banda, Raquel Duarte, Therese Dix-Peek, Caroline Dickens, Pravin Manga, Saraladevi Naicker

“…Serum cystatin C at 24 h was the best biomarker for CIN diagnosis, while baseline levels of serum IL18, β2M, and TNFα were best for predicting prognosis.…”
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Preoperative assessment of liver regeneration using T1 mapping and the functional liver imaging score derived from Gd-EOB-DTPA-enhanced magnetic resonance for patient with hepatoce... by Qian Li, Tong Zhang, Shan Yao, Feifei Gao, Lisha Nie, Hehan Tang, Bin Song, Bin Song, Yi Wei

“…Nevertheless, in the patients undergoing major hepatectomy (n=25), no T1 mapping parameter and FLIS was the independent predictor of RI.ConclusionsT1 mapping parameters and FLIS were the potential noninvasive indicators of liver regeneration, except for HCC patients undergoing major hepatectomy.Clinical relevance statementThe value of T1 mapping and FLIS with Gd-EOB-DTPA MRI for accurate preoperative evaluation of liver regeneration is critical to prevent liver failure and improve prognosis of HCC patients.…”
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How Does Indonesian Chronic Disease Patient Adhere to Their Treatment? A Cross-Sectional Analysis of 11,408 Subjects by Pradipta IS, Aprilio K, Ningsih YF, Pratama MAA, Gatera VA, Alfian SD, Iskandarsyah A, Abdulah R

“…Soekarno KM 21, Jatinangor, Sumedang, West Java, 45363, Indonesia, Email ivanpradipta@unpad.ac.idBackground: Chronic disease has become an increasing burden in Indonesia, increasing the importance of treatment adherence to control the disease prognosis. Therefore, we aim to determine the prevalence and characteristics of nonadherence in Indonesian chronic disease population.Methods: We identified 11,408 adult subjects with chronic diseases from the fifth Indonesian Family Life Survey. …”
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RETRACTED ARTICLE: NR3C2 affects the proliferation and invasiveness of colon cancer cells through the Wnt/β-Catenin signaling pathway by Ke Nie, Zhong-Jiang He, Ling-Jun Kong

“…In addition, we also studied the relationship between NR3C2 expression and prognosis, pathological parameters. The relative role of NR3C2 were further predicted through bioinformatics methods and receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of NR3C2 in colon cancer. …”
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Effect of the Floor Level on the Probability of a Neurologically Favorable Discharge after Cardiac Arrest according to the Event Location by Han Joo Choi, Hyung Jun Moon, Won Jung Jeong, Gi Woon Kim, Jae Hyug Woo, Kyoung Mi Lee, Hyuk Joong Choi, Yong Jin Park, Choung Ah Lee

“…The results suggest that the prognosis of an OHCA patient is more likely to be affected by the building structure and use rather than the floor height.…”
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Alpha-1 Antitrypsin as a Regulatory Protease Inhibitor Modulating Inflammation and Shaping the Tumor Microenvironment in Cancer by Siyu Xiang, Liu Yang, Yun He, Feng Ding, Shuangying Qiao, Zonghua Su, Zheng Chen, Aiping Lu, Fangfei Li

“…Therefore, in this review, we have elucidated the pivotal roles of AAT in inflammation and the tumor microenvironment, including the structure and molecular properties of AAT, its molecular functions in the regulation of the inflammatory response and tumor microenvironment, and its clinical implications in cancer including its diagnosis, prognosis, and therapeutic intervention. This review seeks to bridge the gap in the understanding of AAT between inflammatory diseases and cancer, and to foster deeper investigations into its translational potential in cancer immunotherapy in the future.…”
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Blood biomarkers for vascular cognitive impairment based on neuronal function: a systematic review and meta-analysis by Weiquan Huang, Libin Liao, Qian Liu, Rongchao Ma, Xuan He, Xuan He, Xiaoqiong Du, Dujuan Sha, Dujuan Sha, Dujuan Sha, Dujuan Sha

“…Numerous studies suggest that blood biomarkers may play a crucial role in the detection and prognosis of VCI. This study conducted a meta-analysis to evaluate the potential of various blood biomarkers associated with neuronal function as indicators of VCI. …”
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Clinical characteristics and risk factors of Clostridioides difficile infection in children with diarrhoea by Ning Wang, Kun Jiang, Jinyue Huang, Mengzhu Hou, Lu Wang, Wei Wang, Yulian Fang

“…Multi-factor logistic regression analysis was used to show that a history of hospitalisation within the last three months, a history of antibiotic treatment for ≥7 days, non-breastfeeding, and a history of antibiotic combined with probiotic treatment were risk factors for CDI in children with diarrhoea (P < 0.05).ConclusionsA history of hospitalisation within the last three months, previous antibiotic treatment for ≥7 days or combined with probiotic treatment, and non-breastfeeding are risk factors for CDI in children with diarrhoea, so children with diarrhoea who present as described above need to be alerted to CDI and are advised to have active investigations to facilitate rapid and effective control of the disease and improve prognosis.…”
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