RNA-seq and In Vitro Experiments Reveal the Protective Effect of Curcumin against 5-Fluorouracil-Induced Intestinal Mucositis via IL-6/STAT3 Signaling Pathway by Xuan-ying Wang, Bo Zhang, Yi Lu, Lu Xu, Yi-jie Wang, Bi-yu Cai, Qing-hua Yao

“…IM-induced gastrointestinal adverse reactions become frequent reason to postpone chemotherapy and have negative impacts on therapeutic outcomes and prognosis. Various studies have evidenced the anticancer role of curcumin in many cancers; except for this effect, studies also indicated a protective role of curcumin in intestinal diseases. …”
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Comprehensive Analysis of the Mechanism of Anoikis in Hepatocellular Carcinoma by Dongqian Li, Qian Bao, Shiqi Ren, Haoxiang Ding, Chengfeng Guo, Kai Gao, Jian Wan, Yao Wang, MingYan Zhu, Yicheng Xiong

“…The external validation data (GSE76427) were procured from Gene Expression Omnibus (GEO) to verify the performance of the clinical prognosis gene signature. Western blotting and immunohistochemistry (IHC) analysis confirmed the expression of risk genes. …”
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Glioblastoma-derived migrasomes promote migration and invasion by releasing PAK4 and LAMA4 by Zhe Huang, Ming Wang, Yitian Chen, Hua Tang, Kuo Tang, Mingkuan Zhao, Wei Yang, Zhengjun Zhou, Junjie Tian, Wei Xiang, Shenjie Li, Qinglian Luo, Luotong Liu, Yanru Zhao, Tao Li, Jie Zhou, Ligang Chen

“…We found that expression levels of key migrasome formation factor, tetraspanin 4 (TSPAN4), correlated positively with pathological grade and poor prognosis of GBM based on the databases and clinical samples analysis. …”
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Neuropathology of AIDS: An Autopsy Review of 284 Cases from Brazil Comparing the Findings Pre- and Post-HAART (Highly Active Antiretroviral Therapy) and Pre- and Postmortem Correla... by Ana Cristina Araújo Lemos Silva, Blenda Sousa Carli Rodrigues, Adilha Misson Rua Micheletti, Sebastião Tostes, Antonio Carlos Oliveira Meneses, Mário Leon Silva-Vergara, Sheila Jorge Adad

“…In 91 (55.1%) of 165 cases with relevant brain lesions (or 32% of the total 284 cases), there was discordance between pre- and postmortem diagnosis; disagreement type 1 (important disease that if diagnosed in life could change the patient prognosis) occurred in 49 (53.8%) of 91 discordant cases (17.6% of the total 284) indicating the autopsy importance, even with HAART and advanced diagnostics technologies.…”
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Hepatic function markers as prognostic factors in patients with acute kidney injury undergoing continuous renal replacement therapy by Takuya Nishino, Yoshiaki Kubota, Tetsuya Kashiwagi, Akio Hirama, Kuniya Asai, Masahiro Yasutake, Shinichiro Kumita

“…In Phase 1, the T-Bil, aspartate transaminase (AST), alanine transaminase (ALT), and AST/ALT (De Ritis ratio) levels at CRRT initiation were not associated with the prognosis, while T-Bil, AST, and the De Ritis ratio 3 days after CRRT initiation were independent factors. …”
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The prognostic importance of the pan-immune-inflammation value in patients with septic shock by Yasemin Bozkurt Turan

“…Abstract Introduction The purpose of this study was to determine whether the pan-immune-inflammation value (PIV), a novel biomarker combining neutrophil platelet, monocyte, and lymphocyte counts, some of the most widespread indicators of systemic inflammation, can predict mortality and prognosis in patients admitted to the intensive care unit (ICU) with septic shock. …”
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The preoperative neutrophil‐to‐lymphocyte ratio is not a marker of prostate cancer characteristics but is an independent predictor of biochemical recurrence in patients receiving r... by Zhi Cao, Jin Ji, Chao Zhang, Fubo Wang, Huan Xu, Yongwei Yu, Yinghao Sun

“…In this study, we assessed the association between preoperative NLR and the clinicopathological characteristics, biomolecular features and prognosis of patients with localized prostate cancer treated with radical prostatectomy. …”
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Sympathetic innervation induced by nerve growth factor promotes malignant transformation in gastric cancer by Takefumi Itami, Yukinori Kurokawa, Takaomi Hagi, Shinnosuke Nagano, Rennosuke Nakamoto, Yu Kamakura, Tsuyoshi Takahashi, Takuro Saito, Kazuyoshi Yamamoto, Kota Momose, Kotaro Yamashita, Koji Tanaka, Tomoki Makino, Kiyokazu Nakajima, Hidetoshi Eguchi, Yuichiro Doki

“…High NGF expression in tumor tissue was significantly associated with increased SND and poorer prognosis. In vitro studies demonstrated that nerve elongation of PC12 cells, a model for sympathetic neuron-like cells, was promoted by co-culture with gastric cancer cells expressing high NGF levels whereas nerve elongation was suppressed by NGF knockdown. …”
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The Neutrophil-to-Monocyte Ratio and Platelet-to-White Blood Cell Ratio Represent Novel Prognostic Markers in Patients with Pancreatic Cancer by Feng Tang, Penghui Dai, Qiongqiong Wei, Ke Gan, Zijie Wang, Huan Chen, Ting Li, Muhan Lv, Mingming Deng, Gang Luo

“…Elevated NMR (>48) and depressed PWR (<6) were independently associated with poor prognosis in patients with pancreatic cancer.…”
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Golgi scaffold protein PAQR11 in pan-cancer landscape: A comprehensive bioinformatics exploration of expression patterns, prognostic significance, and potential immunological funct... by Zhu Liu, Zhi-Qiang Ling

“…Conclusions: The comprehensive analysis of PAQR11 underscores its significance as a biomarker for cancer prognosis and its role in regulating immunological and epigenetic processes. …”
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A glimpse into the future: Integrating artificial intelligence for precision HER2‐positive breast cancer management by Xinpei Deng, Yixuan Yan, Zekai Zhan, Jindong Xie, Hailin Tang, Yutian Zou, Jian Tu, Peng Liu

“…Abstract Breast cancer (BC), specifically HER2‐positives subtype, has a poor prognosis. Nevertheless, the development of anti‐HER2 therapy yielded satisfactory outcomes. …”
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GTPase GPN3 facilitates cell proliferation and migration in non-small cell lung cancer by impeding clathrin-mediated endocytosis of EGFR by Linlin Xu, Jiankun Guo, Xinsheng Xie, Hailong Wang, Alan Jiang, Changhua Huang, Hua Yang, Shiwen Luo, Limin Chen

“…Furthermore, our findings indicate that aberrant overexpression of GPN3 is observed in non-small cell lung cancer (NSCLC) tissues compared to adjacent normal tissues, and high expression levels of GPN3 are associated with poor prognosis for NSCLC patients. Collectively, these findings reveal that GPN3 acts as an oncogene promoting cell proliferation and migration in NSCLC through regulation of clathrin-dependent EGFR endocytosis. …”
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Successful Neurological Recovery with Multimodality Therapy without Surgery for Spinal Metastases from Advanced Gastric Cancer by Hideyuki Kinoshita, Hiroto Kamoda, Takeshi Ishii, Yoko Hagiwara, Toshinori Tsukanishi, Yusuke Amanuma, Rino Nankinzan, Sumihisa Orita, Kazuhide Inage, Naoya Hirosawa, Seiji Ohtori, Tsukasa Yonemoto

“…Advanced gastric cancer with bone metastasis has a very poor prognosis with short median survival. To the best of our knowledge, no reports in literature have described extensive recovery of paralysis with multimodality treatment without surgery in these cases. …”
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A nomogram prediction model for mild cognitive impairment in non-dialysis outpatient patients with chronic kidney disease by Qin Yang, Yuhe Xiang, Guoting Ma, Min Cao, Yixi Fang, Wenbin Xu, Lin Li, Qin Li, Yu Feng, Qian Yang

“…Background The high prevalence of mild cognitive impairment (MCI) in non-dialysis individuals with chronic kidney disease (CKD) impacts their prognosis and quality of life.Objective This study aims to investigate the variables associated with MCI in non-dialysis outpatient patients with CKD and to construct and verify a nomogram prediction model.Methods 416 participants selected from two hospitals in Chengdu, between January 2023 and June 2023. …”
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Symptomatic neurosyphilis in HIV-negative patients: a retrospective cohort study by Qiaoer Chen, Qiaoer Chen, Weiqi Wu, Lu Wang, Honghong Huang, Lingxing Wang

“…CSF protein level and parenchymal type may be risk factors for poor prognosis.…”
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Practices and preferences in the use of magnification among endodontists and restorative dentists: A multicentre study. by Azhar Iqbal, Mohmed Isaqali Karobari, Deepti Shrivastava, Kumar Chandan Srivastava, Bilal Arjumand, Hmoud Ali Algarni, Meshal Aber Alonazi, Muhsen Alnasser, Osama Khattak, Jamaluddin Syed, Reham Mohmad Attia, Asma Abubakar Rashed, Sherif El Sayed Sultan

“…<h4>Conclusions</h4>Most of the participants believe that dental magnification devices enhance the prognosis and quality of treatment of possibly all operative and endodontics procedures. …”
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Stemness-related gene signatures as a predictive tool for breast cancer radiosensitivity by Jinzhi Lai, Rongfu Huang, Jingshan Huang

“…Radiotherapy within the RS group significantly improved prognosis compared to non-radiotherapy patients. This signature was further validated in the METABRIC dataset. …”
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The amplitude of low frequency fluctuation and spontaneous brain activity alterations in age-related macular degeneration by Yan Yan Zhang, Jin Yu Hu, Qian Ling, San Hua Xu, Min Kang, Hong Wei, Jie Zou, Quanyong Yi, Gang Tan, Yi Shao, Yi Shao

“…The under the curve of the ROC (AUC) of the three regions shows high accuracy of the diagnosis.ConclusionThe abnormal spontaneous brain activity of patients with AMD suggests scope for the use of ALFF in the diagnosis or prognosis in AMD.…”
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New Onset of Diabetes Mellitus and Associated Factors among COVID-19 Patients in COVID-19 Care Centers, Addis Ababa, Ethiopia 2022 by Asaminew Habtamu Sane, Migbar Sibhat Mekonnen, Melsew Getnet Tsegaw, Wuletaw Chane Zewde, Edmialem Getahun Mesfin, Hailu Asmare Beyene, Taye Mezgebu Ashine, Kasie Gebeyehu Tiruneh, Melkie Ambaw Mengistie

“…New onset of diabetes mellitus was noted as the commonest comorbidity in the COVID-19 pandemic, which contributed to a worse prognosis. Existing evidence showed that new-onset diabetes is associated with increased mortality compared to nondiabetic and known diabetic patients in the COVID-19 era. …”
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The Relevance of the Virchow Node and Virchow Triad in Renal Cancer Diagnosis by Luiza-Roxana Dorobantu-Lungu, Viviana Dinca, Andrei Gegiu, Dan Spataru, Andreea Toma, Luminita Welt, Mihaela Florentina Badea, Constantin Caruntu, Cristian Scheau, Ilinca Savulescu-Fiedler

“…Renal cell carcinoma (RCC) associated with Xp11.2 translocation/gene fusion TFE3 is a rare subtype of kidney cancer that was classified in 2016 as belonging to the family of renal carcinomas with MiT gene translocation (microphthalmia-associated transcription factor). The prognosis for these kidney cancers is poorer compared to other types. …”
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