YTHDF1 Regulates RELA m6A Modification and Activates the NF‐Kappa B Signaling Pathway to Promote the Mechanism of Gastric Cancer by Yangyuan Huang, Shihao Liang, Liping Li, Qingyu Zeng, Bin Li

“…Methods Online databases and immunohistochemistry (IHC) of clinical samples were used to analyze the differential expression of YTHDF1 in the GC and nearby tissues, and its effect on survival prognosis. In vitro experimental study of GC, other mechanisms and functional analyses were specifically designed and performed too. …”
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Pediatric pancreatic acinar cell carcinoma with a non-canonical BRAF-KMT2C fusion and a classic SND1-BRAF fusion: a case report and literature review by Yaqin Wang, Jiasi Zhang, Dimin Nie, Ai Zhang, Qun Hu, Aiguo Liu

“…Abstract Background Pediatric pancreatic acinar cell carcinoma (PACC) is an exceptionally rare and poorly understood malignancy with a challenging prognosis. Its clinical presentation is often atypical, and standardized treatment guidelines are currently unavailable. …”
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Establishment and characterization of ovarian clear cell carcinoma patient-derived xenografts by Joseph J. Caumanns, Shang Li, Gert J. Meersma, Evelien W. Duiker, Ate G. J. van der Zee, G. Bea A. Wisman, Steven de Jong

“…Abstract Interest in understanding the high chemoresistance and poor prognosis of advanced ovarian clear cell carcinoma (OCCC) is rising. …”
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NON-FUNCTIONING SPORADIC PANCREATIC NEUROENDOCRINE TUMOR IS AN INDEPENDENT RISK FACTOR FOR RECURRENCE AFTER SURGICAL TREATMENT by Estela Regina Ramos Figueira, André Luis Montagnini, Jessica Okubo, Ana Gabriela Vivarelli Fernandes, Marina Alessandra Pereira, Ulysses Ribeiro Junior, Paulo Herman, José Jukemura

“…While surgical resection remains the only curative option, the impact of factors such as tumor grade, size, and type on prognosis and recurrence is still unclear. AIMS: To investigate prognostic risk factors and outcomes in patients with sporadic PNETs treated surgically. …”
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Evaluation of the efficiency of smear layer removal during endodontic treatment using scanning electron microscopy: an in vitro study by Svetlana Razumova, Anzhela Brago, Anzhelika Kryuchkova, Vasiliy Troitskiy, Ruzanna Bragunova, Haydar Barakat

“…Abstract Background The smear layer formed during root canal instrumentation negatively affects root canal irrigation activity, which in turn can affect the treatment prognosis of endodontic treatment. Aim The aim of this study is to compare the efficiency of smear layer and debris removal in root canals using different irrigation protocols using scanning electron microscopy (SEM). …”
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Outcomes for Dostarlimab and Real-World Treatments in Post-platinum Patients With Advanced/Recurrent Endometrial Cancer: The GARNET Trial Versus a US Electronic Health Record-Based... by Scott Goulden, Qin Shen, Robert L. Coleman, Cara Mathews, Matthias Hunger, Ankit Pahwa, Rene Schade

“…**Background:** Patients with advanced or recurrent endometrial cancer (EC) have limited treatment options following platinum-based chemotherapy and poor prognosis. The single-arm, Phase I GARNET trial (NCT02715284) previously reported dostarlimab efficacy in mismatch repair–deficient/microsatellite instability–high advanced or recurrent EC. …”
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The diagnostic accuracy of circulating free DNA for the detection of KRAS mutation status in colorectal cancer: A meta‐analysis by Wenli Xie, Li Xie, Xianrang Song

“…Abstract KRAS mutations have been reported as a reliable biomarker for epidermal growth factor receptor (EGFR) targeted therapy and are also associated with poor prognosis in colorectal cancer (CRC) patients. However, limitations of detecting KRAS mutations in tissues are obvious. …”
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Influence of Life Style Factors on Barrett’s Oesophagus by A. Horna Strand, T. Franzén

“…Since the incidence of adenocarcinoma of the oesophagus is rising, the prognosis is poor, and surveillance programs are expensive and mostly cost ineffective, there is a need to increase the knowledge of risk factors in Barrett’s oesophagus and oesophageal cancer in order to be able to give attention to medical prevention and/or surveillance programs. …”
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MYH9 promotes malignant progression of glioma cells through regulating β-catenin stability via epithelial-mesenchymal transition signaling pathway by Zigui Chen, Chao Liu, Wei Zheng, Zhilong Li, Yuanhui Tang, Jun Peng, Changfeng Miao, Dandan Zheng, Ying Xia

“…In summary, we suggest that MYH9 is a potential molecular marker for predicting tumour progression and prognosis and highlight its role in a new molecular mechanism of tumour metastasis.…”
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Resonance frequency analysis – indicator of post-implantation morphology of mandibular bone tissue by A. P. Oshurko, I. Yu. Oliinyk, N. B. Kuzniak, L. M. Herasym

“…The RFA study indicates not only the primary stability of implants but also a full-fledged stage-bystage clinical prognosis of the further functionality of a prosthetic structure based on short implants with proper preservation of the morphological functionality of bone tissue.…”
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Development of metastasis and survival prediction model of luminal and non-luminal breast cancer with weakly supervised learning based on pathomics by Hui Liu, Linlin Ying, Xing Song, Xueping Xiang, Shumei Wei

“…Conclusion Our study demonstrates the significant potential of deep learning models in predicting breast cancer metastasis and prognosis, with the pathomic model showing high accuracy in identifying tumor areas and ER status. …”
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Pre-existing atrial fibrillation and risk of arterial thromboembolism and death following pneumonia: a population-based cohort study by Reimar Wernich Thomsen, Christian Fynbo Christiansen, Bodil Steen Rasmussen, Lars Hvilsted Rasmussen, Jacob Gamst

“…Increased mortality was found in digoxin users (aHR 1.16 (95% CI 1.06 to 1.28)).Conclusions Pre-existing AF is frequent in patients hospitalised with pneumonia and a marker of increased risk of ATE and death, explained by higher patient age and comorbidity. Prognosis is closely related to preadmission medical treatment for AF.…”
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The prevalence, clinical features, and long-term outcome of patients with primary Sjögren’s syndrome with renal involvement by Howook Jeon, Youngjae Park, Jennifer Jooha Lee, Yoo-Seok Suh, Seung-Ki Kwok, Sung-Hwan Park, Wan-Uk Kim, Jung Hee Koh

“…To investigate clinical features and long-term prognosis of renal involvement, we compared the clinical outcomes for the entire cohort based on the presence or absence of renal involvement. …”
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Combination chemotherapy with sintilimab for treatment of a male patient with primary pulmonary choriocarcinoma: a case report and literature review by Xiaojing Liang, Guoqing Xu, Jisong Zhang, Li Xu, Liangliang Dong, Xiaoyue Wang, Weidong Han, Enguo Chen

“…Cytotoxic chemotherapy has a limited effect on the prognosis of PPC. Recently, immune checkpoint inhibitors (ICIs) have shown promising treatment effectiveness. …”
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Paratesticular Serous Borderline Tumor in a Pediatric Patient by Itzel Araceli Ortiz Meza, Marco Antonio Ponce Camacho, Rodolfo Franco Márquez, Mauricio Delgado Morquecho, Raquel Garza Guajardo, Oralia Barboza Quintana

“…In the few cases reported, the prognosis is usually favorable after surgical resection, with disease-free follow-up for up to 18 years.…”
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FPR1 affects acute rejection in kidney transplantation by regulating iron metabolism in neutrophils by Peiyuan Li, Wenbin Ji, Baotong Zhang, Haowen Jia, Jinmiao Wang, Zhaonan Sun, Yifan Wang, Weiwei Wang, Feng Qi

“…Abstract Background Acute rejection (AR) is one of the significant factors contributing to poor prognosis in patients following kidney transplantation. …”
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Long-Term Outcomes of Coronary and Carotid Artery Disease Revascularization in the FRIENDS Study by Fabrizio Tomai, Anna Piccoli, Fausto Castriota, Luca Weltert, Bernhard Reimers, Gabriele Pesarini, Raoul Borioni, Giovanni De Persio, Roberto Nerla, Andrea Pacchioni, Alberto Cremonesi, Flavio Ribichini

“…Multisite artery disease is common and patients with combined disease have poor prognosis. The best therapeutic strategy for patients with concomitant carotid obstructive disease (COD) and coronary artery disease (CAD) remains controversial. …”
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CircWDR78 inhibits the development of colorectal cancer by regulating the miR-653-3p/RGS4 axis by Chu Hao, Yunju Pu, Jiunian Li, Zhi Zhong, Zhaohui Huang, Xue Wang

“…Low diagnostic accuracy, poor prognosis, and high recurrence rates attributed to the high mortality rate of CRC. …”
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Immunohistochemical Expression of Dual-Specificity Protein Phosphatase 4 in Patients with Colorectal Adenocarcinoma by Jongmin Sim, Kijong Yi, Hyunsung Kim, Hyein Ahn, Yumin Chung, Abdul Rehman, Se Min Jang, Kang Hong Lee, Kiseok Jang, Seung Sam Paik

“…DUSP4 protein is frequently upregulated in colorectal adenocarcinoma and may play an important role in carcinogenesis and cancer progression and may be a marker of adverse prognosis.…”
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The clinical journey of belantamab mafodotin in relapsed or refractory multiple myeloma: lessons in drug development by Pralay Mukhopadhyay, Hesham A. Abdullah, Joanna B. Opalinska, Prani Paka, Eric Richards, Katja Weisel, Suzanne Trudel, Maria-Victoria Mateos, Meletios Athanasios Dimopoulos, Sagar Lonial

“…Abstract Patients with relapsed/refractory multiple myeloma (RRMM) have a poor prognosis and a need remains for novel effective therapies. …”
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