The Clinical Importance of Optic Nerve Sheath Diameter in Patients with Traumatic Brain Injury: Preliminary Report by Burcu AVCI OZBALIK, Tugba BINGOL TANRIVERDI, Hafize Gulsah OZCAN, Melek GURA CELIK

“…In cases of severe TBI, the prediction of prognosis is essential. The enlargement of the optic nerve sheath diameter (ONSD) shows an increased intracranial pressure and is associated with poor outcomes. …”
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Location or size? A finite element analysis study of necrotic lesion impact on femoral head collapse by Shun Lu, Tianye Lin, Longfei Han, Ziqi Li, Mingcong He, Qiushi Wei

“…We used them to evaluate the effect of the location and size of necrotic lesions on collapse by finite element analysis, to offer a framework for evaluating the prognosis of osteonecrosis of the femoral head (ONFH) in clinical settings. …”
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Muribaculum intestinale-derived 3-hydroxybutyric acid from Heterophyllin B attenuated pulmonary fibrosis through IDO1-mediated ferroptosis by Ce Chen, Jialin Wang, Mengqin Cheng, Haifeng Xie, Wei Li, Chaofeng Zhang

“…Pulmonary fibrosis (PF) is a fatal disease with increasing incidence, poor prognosis, and unclear pathogenesis. Our previous research demonstrated the beneficial effects of the natural cyclopeptide Heterophyllin B (HB) in PF. …”
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Examining the etiology and pregnancy outcomes of 152 critically ill pregnant patients in the Intensive Care Unit by Weiman Liu, Junyou Su, Sumei Wang

“…There was a statistically significant difference in mortality among the three groups of patients with different SOFA scores (p = 0.000), suggesting that the mortality of critically ill pregnant women with higher SOFA scores increased, making it a valuable tool for evaluating prognosis. Conclusion Non-obstetric factors were the primary contributors for ICU admission of expecting mothers. …”
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Cytosolic DNA composition is determined by genomic instability mechanism and regulates dendritic cell-mediated anti-tumor immunity by Shayla R. Mosley, Angie Chen, David N.W. Doell, Siwon Choi, Courtney Mowat, Felix Meier-Stephenson, Vanessa Meier-Stephenson, Kristi Baker

“…Summary: Patients with colorectal cancers (CRCs) that have microsatellite instability (MSI) (MSI CRCs) face a better prognosis than those with the more common chromosomal instability (CIN) subtype (CIN CRCs) due to improved T cell-mediated anti-tumor immune responses. …”
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Matching-Adjusted Indirect Comparison of the Efficacy and Safety of Erdafitinib vs Enfortumab Vedotin in Patients with Locally Advanced Metastatic Urothelial Carcinoma by Suzy Van Sanden, Ayman Youssef, Simona Baculea, Keith Stubbs, Spyros Triantos, Zijiao Yuan, Caitlin Daly

“…**Background:** For patients with locally advanced or metastatic urothelial carcinoma (la/mUC), prognosis is poor and effective treatment options are limited. …”
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The Development and Applications of a Dual Optical Imaging System for Studying Glioma Stem Cells by Po-An Tai MD, PhD, Yen-Lin Liu MD, PhD, Ya-Ting Wen MD, Chien-Min Lin MD, PhD, Thanh-Tuan Huynh MD, PhD, Michael Hsiao DVM, PhD, Alexander T. H. Wu PhD, Li Wei MD, PhD

“…Glioblastoma multiforme represents one of the deadliest brain tumor types, manifested by a high rate of recurrence and poor prognosis. The presence of glioma stem cells (GSCs) can repopulate the tumor posttreatment and resist therapeutics. …”
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PIVKA-II as a surrogate biomarker for therapeutic response in Non-AFP-secreting hepatocellular carcinoma by San-Chi Chen, Hsiang-Ling Ho, Chien-An Liu, Yi‑Ping Hung, Nai-Jung Chiang, Ming‑Huang Chen, Yee Chao, Muh-Hwa Yang

“…Conclusions This study is the first to establish the “50–50 rule” for PIVKA-II response in non-AFP-secreting HCC treated with systemic therapy, highlighting its value as a surrogate marker for radiological outcomes and prognosis.…”
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Cluster analysis of post-COVID-19 physical and mental health outcomes 3–6 months after SARS-CoV-2 infection: results of the French Prospective ALCOVID Cohort Study by Philippe Halfon, Laurent Chiche, Hervé Pegliasco, Stanislas Rebaudet, Thomas Escoda, Hervé Faralli, Frédéric Cohen

“…In addition to their PCC symptoms, the patients in these clusters differed in terms of their demographic characteristics (sex), comorbidities and severity of COVID-19.Conclusions The four identified PCC clusters corresponded to distinct and coherent clinical and paraclinical entities, making it possible to consider adapted and personalised prognosis and therapeutic interventions.…”
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Study on Clinicopathological Features and Risk Factors of Patients with Multiple Primary Breast Cancers and Thyroid Disease by Jie Li, Yonghong Liu, Jian Jin, Qingfeng Shi, Yanting Ji, Bo Zhang, Pengfei Hu

“…Therefore, clinical attention should be paid to the above factors in the process of clinical treatment, and early-risk screening should be performed to achieve the purpose of improving the prognosis to the greatest extent.…”
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The importance of Naples prognostic score in predicting long-term mortality in heart failure patients by Sidar Şiyar Aydın, Selim Aydemir, Murat Özmen, Emrah Aksakal, İbrahim Saraç, Faruk Aydınyılmaz, Onur Altınkaya, Oğuzhan Birdal, İbrahim Halil Tanboğa

“…Malnutrition and increased inflammation predict poor disease prognosis. The parameters of the Naples prognostic score (NPS) include albumin, total cholesterol, neutrophil-lymphocyte ratio (NLR), and lymphocyte-monocyte ratio (LMR). …”
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Visual and somatosensory evoked potentials abnormalities among Behçet’s disease patients and their relation to disease activity, severity and antiphospholipid antibodies: a cross-s... by Ghada S. Nageeb, Enass A. Eliwa, Ibrahim Tharwat, Lamiaa A. Mohammad, Nada Alaa Attia

“…Conclusion Abnormal VEP and SSEP studies can be considered as indicators for BD severity and hence poorer prognosis. VEP study is a valuable tool in BD and may indicate ocular involvement or ocular activity. …”
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Penalized landmark supermodels (penLM) for dynamic prediction for time-to-event outcomes in high-dimensional data by Anya H. Fries, Eunji Choi, Summer S. Han

“…Abstract Background To effectively monitor long-term outcomes among cancer patients, it is critical to accurately assess patients’ dynamic prognosis, which often involves utilizing multiple data sources (e.g., tumor registries, treatment histories, and patient-reported outcomes). …”
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IL-18 Blockage Reduces Neuroinflammation and Promotes Functional Recovery in a Mouse Model of Spinal Cord Injury by Easmin Begum, Md Rashel Mahmod, Md Mahbobur Rahman, Fumiko Fukuma, Takeshi Urano, Yuki Fujita

“…The prognosis of spinal cord injury (SCI) is closely linked to secondary injury processes, predominantly driven by neuroinflammation. …”
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Myocardial Perfusion Scintigraphy in Ischemic Heart Disease by Sonia María Sánchez Valcarcel, Katia Ravelo Llanes, Iván Rodríguez Cortina, Geovedy Martínez García, Cesia Rivera Garmendia

“…<br /><strong>Objective:</strong> to demonstrate the value of myocardial perfusion scintigraphy in the ischemic heart disease prognosis. <br /><strong>Method:</strong> a descriptive, prospective longitudinal section study was carried out in 180 patients, in which myocardial perfusion studies were performed to detect ischemia, from January 2018 to December 2019 at the Center for Surgical Medical Research. …”
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CSF shunts as conduits for metastasis: is there a discrepancy between retrograde and antegrade spread? by Andrea Cuschieri, Robert Pisani, Shawn Agius

“…All primary tumours were in the abdomen or pelvic cavity with treatment from metastasis depending on patient characteristics. Generally, the prognosis was poor, with one patient succumbing to peritonitis, four cases showing residual disease, and one patient receiving palliative care. …”
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Clinical Evaluation of the Diagnostic Role of MicroRNA-155 in Breast Cancer by Fatemeh Hosseini Mojahed, Amir Hossein Aalami, Vahid Pouresmaeil, Amir Amirabadi, Mahdi Qasemi Rad, Amirhossein Sahebkar

“…Biochemical markers, including microRNAs (miRs), may facilitate the diagnosis and prognosis of breast cancer. This study was aimed at assessing serum miR-155 expression in patients with breast cancer and receptors. …”
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Associates of an Elevated Natriuretic Peptide Level in Stable Heart Failure Patients: Implications for Targeted Management by Aftab Jan, Ian Dawkins, Niamh Murphy, Patrick Collier, John Baugh, Mark Ledwidge, Kenneth McDonald, Chris J. Watson

“…Persistently elevated natriuretic peptide (NP) levels in heart failure (HF) patients are associated with impaired prognosis. Recent work suggests that NP-guided therapy can improve outcome, but the mechanisms behind an elevated BNP remain unclear. …”
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Uncarboxylated osteocalcin induced miR-143-3p targets SP7 and activates PI3K/Akt signaling in TNBC cells to promote invasion and migration by Qian Du, Jiaojiao Xu, Miao Zhang, Jianhong Yang

“…Triple-negative breast cancer (TNBC) is an exceptionally aggressive malignancy with poor prognosis. Patients often have elevated mortality and recurrence rates, along with a pronounced risk of distant metastasis. …”
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GB18-06, a nanobody targeting GDF15, effectively alleviates weight loss and restores physical function in cachexia models by Yu Huang, Jinyong Wang, Xiling Wei, Hui Zhang, Wei Shang, Xiangling Zhang, Lanjiao Zhai, Xi Chen, Huiming Li, Suofu Qin

“…It is a debilitating condition that negatively affects prognosis and survival. However, there is currently no effective pharmacological intervention that can reverse body weight loss and improve physical performance in patients with cachexia. …”
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