Isovitexin targets SIRT3 to prevent steroid-induced osteonecrosis of the femoral head by modulating mitophagy-mediated ferroptosis by Yinuo Fan, Zhiwen Chen, Haixing Wang, Mengyu Jiang, Hongduo Lu, Yangwenxiang Wei, Yunhao Hu, Liang Mo, Yuhao Liu, Chi Zhou, Wei He, Zhenqiu Chen

“…Improving bone formation driven by osteoblasts has shown promising outcomes in the prognosis of SIONFH. Isovitexin has demonstrated antioxidant properties, but its therapeutic effects on GC-induced oxidative stress and SIONFH remain unexplored. …”
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Targeting SLC4A4: A Novel Approach in Colorectal Cancer Drug Repurposing by Krunal Pawar, Pramodkumar P. Gupta, Pooran Singh Solanki, Ravi Ranjan Kumar Niraj, Shanker L. Kothari

“…Background: Colorectal cancer (CRC) is a complex and increasingly prevalent malignancy with significant challenges in its treatment and prognosis. This study aims to explore the role of the SLC4A4 transporter as a biomarker in CRC progression and its potential as a therapeutic target, particularly in relation to tumor acidity and immune response. …”
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Ischaemia-reperfusion time differences in ST-elevation myocardial infarction in very young patients: a cohort study by Pablo Juan-Salvadores, Luis Mariano De La Torre Fonseca, Beatriz Calderon-Cruz, Cesar Veiga, Samuel Pintos-Rodríguez, Saleta Fernandez Barbeira, Victor Alfonso Jimenez Diaz, Andres Iñiguez Romo

“…It is essential to emphasise that each minute of delay in providing medical care is negatively correlated to the patient’s prognosis. The present study was carried out to evaluate the ischaemia-reperfusion times in patients ≤40 years of age versus individuals >40 years of age and their association with mortality and major adverse cardiac event (MACE) over the long term.Methods A retrospective, multicentre cohort study was carried out in 6799 patients diagnosed with STEMI. …”
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Application of Stem Cell Therapy for ACL Graft Regeneration by Canlong Wang, Yejun Hu, Shichen Zhang, Dengfeng Ruan, Zizhan Huang, Peiwen He, Honglu Cai, Boon Chin Heng, Xiao Chen, Weiliang Shen

“…Graft regeneration after anterior cruciate ligament (ACL) reconstruction surgery is a complex three-stage process, which usually takes a long duration and often results in fibrous scar tissue formation that exerts a detrimental impact on the patients’ prognosis. Hence, as a regeneration technique, stem cell transplantation has attracted increasing attention. …”
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Advances in chromosomal microarray analysis: Transforming neurology and neurosurgery by Wireko Andrew Awuah, Muhammad Hamza Shah, Vivek Sanker, Krishitha Meenu Mannan, Sruthi Ranganathan, Princess Afia Nkrumah-Boateng, Mabel Frimpong, Kwadwo Darko, Joecelyn Kirani Tan, Toufik Abdul-Rahman, Oday Atallah

“…CMA also aids in stratifying risk for cerebrovascular diseases, enabling preventive interventions that improve patient prognosis. Despite its potential, challenges remain, such as interpreting variants of uncertain significance (VOUS), the lack of standardised testing guidelines, and issues of cost and accessibility. …”
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Selective inhibition of TGF-β-induced epithelial-mesenchymal transition overcomes chemotherapy resistance in high-risk lung squamous cell carcinoma by Liangdong Sun, Jue Wang, Huansha Yu, Xinsheng Zhu, Jing Zhang, Junjie Hu, Yilv Yan, Xun Zhang, Yuming Zhu, Gening Jiang, Ming Ding, Peng Zhang, Lele Zhang

“…Our study provides valuable insights into prognosis stratification and the development of therapeutic strategies for LUSC.…”
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Clinicopathologic Significance of CXCL12 and CXCR4 Expressions in Patients with Colorectal Cancer by Naomi Yoshuantari, Didik Setyo Heriyanto, Susanna Hilda Hutajulu, Johan Kurnianda, Ahmad Ghozali

“…Colorectal cancer (CRC) is both a global and national burden, being the third most common malignancy in men and the second in women, worldwide. The prognosis of CRC is affected by various factors like the histological grade, angiolymphatic invasion, and distant metastases. …”
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The Role of PPAR Gamma in Systemic Sclerosis by Andréa Tavares Dantas, Michelly Cristiny Pereira, Moacyr Jesus Barreto de Melo Rego, Laurindo Ferreira da Rocha, Ivan da Rocha Pitta, Cláudia Diniz Lopes Marques, Angela Luzia Branco Pinto Duarte, Maira Galdino da Rocha Pitta

“…Fibrosis is recognized as an important feature of many chronic diseases, such as systemic sclerosis (SSc), an autoimmune disease of unknown etiology, characterized by immune dysregulation and vascular injury, followed by progressive fibrosis affecting the skin and multiple internal organs. SSc has a poor prognosis because no therapy has been shown to reverse or arrest the progression of fibrosis, representing a major unmet medical need. …”
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Assessment of retinal pigment epithelium tears in eyes with submacular hemorrhage secondary to age-related macular degeneration by Tomoko Ueda-Consolvo, Syogo Takahashi, Toshihiko Oiwake, Tomoko Nakamura, Masaaki Ishida, Shuichiro Yanagisawa, Atsushi Hayashi

“…An RPE tear which was smaller than 1DD and treatment-naïve condition were associated with better prognosis.…”
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Recurrence of a t(8;21)-Positive Acute Myeloid Leukemia in the Form of a Granulocytic Sarcoma Involving Cranial Bones: A Diagnostic and Therapeutic Challenge by Ambra Di Veroli, Alessandro Micarelli, Mariagiovanna Cefalo, Eleonora Ceresoli, Daniela Nasso, Laura Cicconi, Simone Mauramati, Fabrizio Ottaviani, Adriano Venditti, Sergio Amadori

“…FLT3 ITD is generally strongly associated with poor prognosis in AML, and is rarely reported in patients with t(8;21). …”
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Expression of Angiogenesis Regulatory Proteins and Epithelial-Mesenchymal Transition Factors in Platelets of the Breast Cancer Patients by Hui Han, Fang-Li Cao, Bao-Zhong Wang, Xue-Ru Mu, Guang-Yao Li, Xiu-Wen Wang

“…VEGF, PDGF, and TGF-β1 concentrations in platelets may be associated with prognosis.…”
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Predictors of Length of Hospitalization for Neonatal Sepsis at Kenyatta Nation Hospital, Kenya: A Prospective Cross‐Sectional Study by Athman Khaltuma Tisho, Patrick Mwirigi Mbugua, Rose Bosire, Simon Muturi Karanja

“…Conclusion The findings provide insights into the factors that can be monitored to predict the prognosis of neonatal sepsis. Besides, remedies can target these variables to mitigate prolonged hospitalization and severity of neonatal sepsis.…”
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Identification of hub genes, non-coding RNAs and pathways in Renal cell carcinoma (RCC): A comprehensive in silico study by Ahmad Golestanifar, Hengameh Khedri, Parisa Noorabadi, Mohammadreza Saberiyan

“…Further analysis indicated that these genes could be potential biomarkers for prognosis and therapeutic targets. We constructed a competitive endogenous RNA (ceRNA) network involving lncRNAs, circRNAs, and miRNAs, suggesting complex regulatory interactions that drive KIRC pathogenesis.Additionally, the study examined drug sensitivity associated with the expression of hub genes, revealing the potential for personalized treatments. …”
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Intratumoral <i>Fusobacterium nucleatum</i> in Pancreatic Cancer: Current and Future Perspectives by Domenica Lucia D’Antonio, Anna Zenoniani, Samia Umme, Adriano Piattelli, Maria Cristina Curia

“…<i>Fusobacterium nucleatum (Fn)</i>, an anaerobic Gram-negative bacterium primarily residing in the oral cavity, has garnered significant attention for its emerging role in several extra-oral human diseases and, lately, in pancreatic cancer progression and prognosis. It is now recognized as oncobacterium. <i>Fn</i> engages in pancreatic tumorigenesis and metastasis through multifaceted mechanisms, including immune response modulation, virulence factors, control of cell proliferation, intestinal metabolite interactions, DNA damage, and epithelial–mesenchymal transition. …”
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Implantable Ultrasound‐Powered MXene/PVA Hydrogel‐Based Generator for Treatment of Glioblastoma by Xiaoping Hu, Ziyi Qiu, Yilin Yang, Ting Xu, Kai Sheng, Weicheng Lu, Jingdun Xie, Bingzhe Xu

“…Abstract Glioblastoma (GBM) is a lethal disease with a poor prognosis due to its strong infiltration, which makes it difficult to remove completely. …”
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Glutamine and cancer: metabolism, immune microenvironment, and therapeutic targets by Ding Nan, Weiping Yao, Luanluan Huang, Ruiqi Liu, Xiaoyan Chen, Wenjie Xia, Hailong Sheng, Haibo Zhang, Xiaodong Liang, Yanwei Lu

“…Oral supplementation with glutamine also enhances the immune capabilities of cancer patients, improves the sensitivity to chemotherapy and radiotherapy, and improves prognosis. The unique metabolism of glutamine in cancer cells, its function in various immune cells, the impact of inhibitors of glutamine metabolism, and the therapeutic use of glutamine supplements are all covered in detail in this article.…”
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Relationship Between Corpus Callusom Index and Clinical Subtypes, Severity of Cognitive Disorders, and Disability in Multiple Sclerosis by Hussein Soleimantabar, Mehran Ghaffari, Shno Hosseini, Moosa Seifzade

“…Background: Brain magnetic resonance imaging (MRI) is crucial to determine the prognosis of multiple sclerosis (MS). The use of simple and accessible techniques that can be used for examining and managing the cognitive status and disability of patients with MS is one of the important concerns. …”
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Rib suppression-based radiomics for diagnosis of neonatal respiratory distress syndrome in chest X-rays by Yudong Wang, Zongjin Qu, Zhengjun Dai, Yuhong Li, Yanyan Liu, Wei Wang, Lianxiang Xiao, Yi Zhang

“…This study provides a promising new method for the imaging diagnosis and prognosis evaluation of neonatal respiratory distress syndrome, showcasing the potential of radiomics in pediatric imaging.…”
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A graph neural network approach for hierarchical mapping of breast cancer protein communities by Xiao Zhang, Qian Liu

“…Conclusion The proposed graph neural network approach to analyzing breast cancer protein communities in a hierarchical structure provides a novel perspective on breast cancer prognosis and treatment. By targeting entire gene sets, we were able to evaluate the prognostic and therapeutic value of genes (or gene sets) at different levels, from gene-level to system-level biology. …”
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COVID-19 and Obesity: An Epidemiologic Analysis of the Brazilian Data by Diego Assis Gonçalves, Victória Ribeiro, Ana Gualberto, Fernanda Peres, Michaela Luconi, Jacy Gameiro

“…Obesity has been associated with an important role in disease development and a worse prognosis. We aimed to explore epidemiological data from Brazil, discussing the potential relationships between obesity and COVID-19 severity in this country. …”
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