miR-301a-mediated crosstalk between the Hedgehog and HIPPO/YAP signaling pathways promotes pancreatic cancer by Bing Qi, Yuqiong Wang, Xian Zhu, Yanfang Gong, Jing Jin, Hongyu Wu, Xiaohua Man, Feng Liu, Wenzhu Yao, Jun Gao

“…Pancreatic ductal adenocarcinoma (PDAC) poses a significant challenge in oncology due to its dismal prognosis and limited therapeutic options. In this study, we investigated the role of miR-301a in facilitating crosstalk between the Hedgehog (Hh) and HIPPO/YAP signaling pathways during the progression of PDAC. …”
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Ultrasound investigation in estimation of vascular invasion and morphological verification of pancreatic tumors by S. O. Stepanov, N. A. Rubtsova, D. V. Sidorov, L. O. Petrov, L. A. Mitina, V. I. Kazakevich, Ye. N. Slavnova, E. V. Prozorova

“…Though morphological verification is the leading factor in assessment of prognosis and treatment approach at oncologic diseases, its necessity and ways of tissue sampling at PT is discussed up to now.Conclusion. …”
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Pain Sensitization and Neuropathic Pain-like Symptoms Associated with Effectiveness of Exercise Therapy in Patients with Hip and Knee Osteoarthritis by Takafumi Hattori, Kazuhiro Shimo, Yuto Niwa, Yuichi Katsura, Yuji Tokiwa, Satoshi Ohga, Takako Matsubara

“…These findings could be useful for prognosis prediction and for planning exercise therapy and combining with other treatment.…”
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Hubungan Ekspresi Survivin dengan Subtipe Molekuler Karsinoma Mammae Invasif by Shinta Ayu Intan, Yenita Yenita, Tofrizal Tofrizal, RZ Nizar

“…Karsinoma ini memiliki prognosis, respon pengobatan serta perilaku klinis yang berbeda yang disebabkan oleh karakteristik molekuler yang berbeda. …”
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Aberrant c-AMP signalling in richter syndrome revealed by single-cell transcriptome and 3D chromatin analysis by Heng Li, Cheng Xing, Ji Li, Yihao Zhan, Ming Luo, Peilong Wang, Yue Sheng, Hongling Peng

“…Abstract Richter syndrome (RS), characterized by aggressive lymphoma arising from chronic lymphocytic leukaemia (CLL), presents a poor response to treatment and grim prognosis. To elucidate RS mechanisms, paired samples from a patient with DLBCL-RS were subjected to single-cell RNA sequencing (scRNA-seq) and high-throughput chromosome conformation capture (Hi-C) sequencing. …”
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Evaluation of the Influence of Sensor Geometry and Physical Parameters on Impedance-Based Structural Health Monitoring by L.V. Palomino, K.M. Tsuruta, J.R.V. Mour Jr, D.A. Radea, V. Steffen Jr., D.J. Inman

“…Structural Health Monitoring (SHM) is the process of damage identification in mechanical structures that encompasses four main phases: damage detection, damage localization, damage extent evaluation and prognosis of residual life. Among various existing SHM techniques, the one based on electromechanical impedance measurements has been considered as one of the most effective, especially in the identification of incipient damage. …”
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Hypocalcaemic cardiomyopathy: a description of two cases and a literature review by Martin Válek, Lenka Roblová, Ivan Raška Jr., Dita Schaffelhoferová, Tomáš Paleček

“…Once calcium supplementation is administered, the disease has a good prognosis and, in most individuals, a significant improvement (21%) or even normalization (74%) of the left ventricular systolic function occurs.…”
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Integrative analysis of single-cell and transcriptome sequencing with experimental validation reveals PKHD1L1 as a novel biomarker in lung adenocarcinoma by Xiangqian Zhang, Jie Wang, Hanyang Su, Xiaojin Liu

“…Furthermore, we found that low PKHD1L1 expression was a strong predictor of poor prognosis in patients with LUAD. Pathway enrichment analyses revealed that PKHD1L1 is associated primarily with asthma and multiple immune processes. …”
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Blunt Isolated Small Bowel Perforation Intervention: Does a Delay in Management Matter? by Sung Yong Hong, Se Hun Kim, Ki Hoon Kim

“…The effects of a delayed intervention on prognosis are unclear. We aimed to determine whether the time to surgical intervention affects outcomes in patients with blunt small bowel perforation. …”
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Identification and Functional Analysis of EPOR+ Tumor-Associated Macrophages in Human Osteosarcoma Lung Metastasis by Yanxing Li, Ming Li, Rong Wei, Junlong Wu

“…Moreover, the clinicopathologic factors and prognosis of patients with CD163+EPOR+ macrophages were compared. …”
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Comparative Analysis of Acral Melanoma in Chinese and Caucasian Patients by Kai Huang, Yu Xu, Emmanuel M. Gabriel, Subhasis Misra, Yong Chen, Sanjay P. Bagaria

“…Acral melanoma (AM) is a rare subtype of melanoma, which is one of the least common in Caucasian patients but is a common subtype of melanoma in Chinese patients. It is unclear if prognosis differs between Chinese and Caucasian patients diagnosed with AM. …”
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Evaluation of Mast Cells in Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma by Ashish Shrestha, Shashi Keshwar, Toniya Raut

“…Proper quantification of mast cells using specific stains can guide to define prognosis in oral potentially malignant disorders and oral cancer.…”
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Effect of Narrow Band Ultraviolet B Therapy versus Methotrexate on Serum Levels of Interleukin-17 and Interleukin-23 in Egyptian Patients with Severe Psoriasis by Tarek Mahmoud Elghandour, Sahar El Sayed Youssef, Dalia Gamal Aly, Mohamed Said Abd Elhameed, Mehrevan Mostafa Abdel Moneim

“…Interleukin-17 and IL-23 serum level may serve as a potential biomarker for predicting the prognosis and therapeutic response of NB-UVB or MTX in treating psoriasis.…”
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The prognostic value of the platelet-to-lymphocyte ratio in multiple myeloma patients treated with a bortezomib-based regimen by Quane Zhang, Yifan Wang, Wenting Shi, Yue Chen, Zhengmei He, Liang Yu, Chunling Wang

“…However, the relationship between the PLR and prognosis in myeloma patients has not been clearly demonstrated. …”
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GPX3-Mediated Oxidative Stress Affects Pyrimidine Metabolism Levels in Stomach Adenocarcinoma via the AMPK/mTOR Pathway by Yaowen Zhang, Yixin Yang, Shanshan Kuang, Yang Zhang, Hancheng Qin, Jisheng Xie

“…Our findings demonstrate GPX3 is a reliable biomarker for the prognosis of amino acid metabolism and a probable target for STAD therapy.…”
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Real-World Treatment Patterns, Survival, and Costs for Ovarian Cancer in Canada: A Retrospective Cohort Study Using Provincial Administrative Data by Manjusha Hurry, Shazia Hassan, Soo Jin Seung, Ryan N. Walton, Ashlie Elnoursi, Jacob D. McGee

“…**Background:** In 2020, approximately 3100 Canadian women were diagnosed with ovarian cancer (OC), with 1950 women dying of this disease. Prognosis for OC remains poor, with 70% to 75% of cases diagnosed at an advanced stage and an overall 5-year survival of 46%. …”
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A Nomogram for Predicting Overall Survival in Primary Central Nervous System Lymphoma: A Retrospective Study by Ling Y, Miao X, Zhou X, Ma J, Lin Z, Li Q, Zhang M, Ma Y, Chen B

“…The model accurately and effectively stratifies the prognosis of patients with PCNSL and offers valuable clinical guidance for decision making.Keywords: PCNSL, prognostic model, risk stratification, NLR, albumin, D-Dimer…”
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Effect of Adalimumab on Refractory Arthritis in Juvenile Idiopathic Inflammatory Myopathy with Anti-MDA5 Autoantibody by Takako Miyamae, Takuma Hara, Aki Hanaya, Yumi Tani, Takayuki Kishi, Hisashi Yamanaka

“…Further experience is needed to determine the pathology, severity, and prognosis of this type of arthritis.…”
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Impact of clinical pharmacist integration on diabetes management: a prospective cohort by Nur Burcu Kutluay, Muhammed Yunus Bektay, Betul Sumbul-Sekerci, Abdusselam Sekerci, Fikret Vehbi Izzettin

“…Conclusion Pharmaceutical care services provided to diabetes patients had positive effects on disease prognosis, knowledge levels and disease perceptions. …”
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Blocking TNF-α Reduces <i>Leishmania major</i>-Induced Hyperalgesia and Changes the Cytokine Profile in the Paw Skin of BALB/c Mice with a Potential Positive Effect on Parasite Cle... by Muriel Tahtouh Zaatar, Sara Salman, Reem Hoblos, Rabih Roufayel, Ziad Fajloun, Jean-Marc Sabatier, Marc Karam

“…Infliximab may also have beneficial effects on the prognosis of cutaneous leishmaniasis by reducing the parasite burden.…”
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