Clinicopathological and molecular analyses of uterine carcinosarcomas using next-generation sequencing: A single-center experience by Ezgi Genç Erdoğan, Tülin D. Yalta, Nuray Can, Necdet Süt, Ebru Taştekin, Ufuk Usta, Fulya Öz Puyan, Fatma E. Usturalı Keskin, Busem B. Kurt

“…Aim: In this study, we aimed to perform DNA-based mutation analysis in 12 genes (KRAS, NRAS, EGFR, C-KIT, BRAF, PDGFRA, ALK, ERBB2, ERBB3, ESR1, RAF1, PIK3CA) to determine the molecular subtypes of UCS using next-generation sequencing (NGS) in patients with aggressive UCS and poor prognosis. We aimed to compare the results of our analysis with clinicopathological data to contribute to the development of targeted therapy approaches related to the molecular changes of UCS. …”
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The diagnosis and treatment of 56 cases of breast hamartoma: a single-center analysis and a review of the literature by Hao Su, Caiyun Bai, Zhimin Fan, Di Wu, Fengjiang Qu

“…Pathological analysis identified ducts and fibrous tissue, with intra-tumoral fat content ranging from 10 to 90%.ConclusionBreast hamartoma is prevalent among perimenopausal women and is characterized by ultrasound and radiography; surgical intervention remains the primary treatment with a good prognosis.…”
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Metastatic Status and Dissection Effect of Regional/Extraregional Lymph Nodes in Japanese Patients with Squamous Cell Carcinoma of the Anal Canal: A Multicenter Retrospective Cohor... by Takayuki Torigoe, Keiji Hirata, Kazutaka Yamada, Yoichi Ajioka, Kenichi Sugihara

“…Although the UICC TNM Classification considered the inferior mesenteric trunk/root nodes as extraregional lymph nodes, actively targeting them with the treatment can improve the prognosis.…”
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Exploring Unique Extracellular Vesicles Associated Signatures: Prognostic Insights, Immune Microenvironment Dynamics, and Therapeutic Responses in Pancreatic Adenocarcinoma by Kai Nan, Ming Zhang, Zilong Geng, Yuankai Zhang, Lin Liu, Zhi Yang, Peng Xu

“…Our study establishes a compelling link between two extracellular vesicles-related gene signatures, prognosis, and immune infiltration in PAAD. Notably, these signatures serve as robust prognostic indicators for PAAD patients, offering valuable insights for the strategic selection of immunotherapeutic interventions.…”
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Prognostic Value of Microvascular Density in Dukes A and B (T1–T4, N0, M0) Colorectal Carcinomas by Rafael Uribarrena A, Javier Ortego, Javier Fuentes, Nuria Raventós, Pilar Parra, Rafael Uribarrena E

“…Aproximatelly 30% of patients operated on for colorectal cancer (CRC), with an expectedly favourable prognosis (Dukes A-B/T1–T4, N0, M0) suffer recurrence and/or die. …”
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Analysis of selected factors influencing mortality of patients with COVID-19 treated in a community hospital in a rural region of Poland by Marek Kos, Renata Hatalska-Żerebiec, Małgorzata Jurczyk-Stachyra, Karol Paciura, Justyna Janeczko, Robert Podsiadły, Piotr Sobolewski

“…Conclusion: Fever and high laboratory values of inflammation, in particular coexisting sepsis, worsened the prognosis in patients with COVID-19. Most traditional methods of treating the infection did not affect the course of the disease. …”
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Intestinal Schwannoma: A Clinicopathological, Immunohistochemical, and Prognostic Study of 9 Cases by Zhenbo Shu, Chunsheng Li, Mingze Sun, Zhongmin Li

“…The patients’ clinicopathological features and prognosis were analyzed. Results. This study enrolled 9 patients with intestinal schwannoma, including 3 males and 6 females. …”
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Prognostic Value of Adrenomedullin and Natriuretic Peptides in Uroseptic Patients Induced by Ureteroscopy by Wei Hu, Pang-hu Zhou, Wei Wang, Lijun Zhang, Xiao-bin Zhang

“…In conclusion, ADM, along with ANP and BNP, is valuable for prognosis in urosepsis secondary to URS which is associated with irrigation pressure.…”
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A new NCL-targeting aptamer-drug conjugate as a promising therapy against esophageal cancer by Xue Zheng, Ying Wang, Huaiyu Duan, Junqi Hou, Shiming He

“…Abstract Esophageal cancer (EC) is one of the most common highly malignant tumors of the digestive system, with a poor prognosis under current treatment regimens. Nucleolin (NCL) is overexpressed in many tumors, and drugs specifically targeting NCL may offer a promising strategy for treating esophageal cancer. …”
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IDMPF: intelligent diabetes mellitus prediction framework using machine learning by Leila Ismail, Huned Materwala

“…Design/methodology/approach – Health professionals and stakeholders are striving for classification models to support prognosis of diabetes and formulate strategies for prevention. …”
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Challenging a Misnomer? The Role of Inflammatory Pathways in Inflammatory Breast Cancer by Riley J. Morrow, Nima Etemadi, Belinda Yeo, Matthias Ernst

“…The more aggressive triple-negative and HER2-positive breast cancer subtypes are overrepresented in inflammatory breast cancer compared with noninflammatory breast cancer, with a poorer prognosis in response to conventional therapies. Despite its name, there remains some controversy regarding the role of inflammation in inflammatory breast cancer. …”
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Hip Osteonecrosis Is Associated with Increased Plasma IL-33 Level by Jinhui Ma, Wanshou Guo, Zirong Li, Bailiang Wang, Shirui Li, Peng Wang

“…Our findings seem to indicate that IL-33 effects may be detrimental during ONFH, which appeared to be associated with the prognosis of ONFH. The IL-33 deserves particular attention in the pathogenesis of ONFH.…”
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Widespread mutagenesis and chromosomal instability shape somatic genomes in systemic sclerosis by Sriram Vijayraghavan, Thomas Blouin, James McCollum, Latarsha Porcher, François Virard, Jiri Zavadil, Carol Feghali-Bostwick, Natalie Saini

“…Roughly 4-22% of patients with systemic sclerosis develop cancer, which drastically worsens prognosis. However, the mechanisms underlying systemic sclerosis initiation, propagation, and cancer development are poorly understood. …”
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The Emerging Role of miRNAs and Their Clinical Implication in Biliary Tract Cancer by Nina Nayara Ferreira Martins, Kelly Cristina da Silva Oliveira, Amanda Braga Bona, Marília de Arruda Cardoso Smith, Geraldo Ishak, Paulo Pimentel Assumpção, Rommel Rodríguez Burbano, Danielle Queiroz Calcagno

“…Biliary tract cancers are aggressive malignancies that include gallbladder cancer and tumors of intra- and extrahepatic ducts and have a poor prognosis. Surgical resection remains the main curative therapy. …”
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Shared decision-making between patients and healthcare providers at rural health facilities in Eastern Uganda: an exploratory qualitative study by Ranga Solomon Owino, Olivia Kituuka, Paul Kutyabami, Nelson K. Sewankambo

“…Many healthcare providers noted that shared decision-making could improve patient prognosis but are faced with challenges related to low male involvement and the influence of cultural and religious practices, including myths and patriarchal attitudes which impact effective patient engagement. …”
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FBXL16 Promotes Endometrial Progesterone Resistance via PP2AB55α/Cyclin D1 Axis in Ishikawa by Haoen Liu, Li Han, Liyan Zhong, Xiaodan Zhuang, Yan Peng

“…The high expression of FBXL16 was positively correlated with MPA resistance and poor prognosis of endometrial cancer. MPA tolerance of endometrial cancer cells was inhibited by knockdown of FBXL16 in DNA content assessment, CCK-8, and colony formation. …”
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Identifying Key Biomarkers and Immune Infiltration in Female Patients with Ischemic Stroke Based on Weighted Gene Co-Expression Network Analysis by Haipeng Xu, Kelin He, Rong Hu, YanZhi Ge, Xinyun Li, Fengjia Ni, Bei Que, Yi Chen, Ruijie Ma

“…Evidence shows that ischemic stroke (IS) accounts for nearly 80 percent of all strokes and that the etiology, risk factors, and prognosis of this disease differ by gender. Female patients may bear a greater burden than male patients. …”
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STK3 Suppresses Ovarian Cancer Progression by Activating NF-κB Signaling to Recruit CD8+ T-Cells by Xiangyu Wang, Fengmian Wang, Zhi-Gang Zhang, Xiao-Mei Yang, Rong Zhang

“…STK3 was significantly downregulated in OC patients, and the low STK3 expression was correlated with a poor prognosis. In vitro cell proliferation, apoptosis, and migration assays, and in vivo subcutaneous xenograft tumor models were used to determine the roles of STK3. …”
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Malignant Lymphoma in the Psoas Major Muscle by Nobuhiro Akuzawa, Takashi Hatori, Aya Takase, Jun Aoki, Shinji Sakurai, Masahiko Kurabayashi

“…In addition, determination of the lymphoma subtype has important implications for the treatment of skeletal muscle lymphoma because DLCBL may have an especially poor prognosis.…”
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The Addition of the Geriatric Nutritional Risk Index to the Prognostic Scoring Systems Did Not Improve Mortality Prediction in Trauma Patients in the Intensive Care Unit by Cheng-Shyuan Rau, Ching-Hua Tsai, Sheng-En Chou, Wei-Ti Su, Shiun-Yuan Hsu, Ching-Hua Hsieh

“…Malnutrition is prevalent among critically ill patients and has been associated with a poor prognosis. This study sought to determine whether the addition of a nutritional indicator to the various variables of prognostic scoring models can improve the prediction of mortality among trauma patients in the intensive care unit (ICU). …”
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