Aggressive Differentiated Thyroid Cancer due to EML4e13-ALKe20 Fusion: A Case Presentation and Review of the Literature by Rodhan Khthir, Zainab Shaheen, Prasanna Santhanam, Saroj Sigdel

“…The rapid progression of clinical signs and symptoms and the local extension beyond the thyroid and lymph nodes with the persistence of high-volume local disease after thyroidectomy highlight the aggressive nature of this mutation and the importance of performing genetic analysis to guide future treatments and determine prognosis. Conclusion. This case highlights the importance of using molecular diagnostics in patient care, especially if the presentation is unusual for DTC. …”
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Synergistic Effect of Geranylgeranyltransferase Inhibitor, GGTI, and Docetaxel on the Growth of Prostate Cancer Cells by Bin Han, Naohiro Fujimoto, Mizuki Kobayashi, Tetsuro Matsumoto

“…Most advanced prostate cancers progress to castration resistant prostate cancer (CRPC) after a few years of androgen deprivation therapy and the prognosis of patients with CRPC is poor. Although docetaxel and cabazitaxel can prolong the survival of patients with CRPC, inevitable progression appears following those treatments. …”
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Difficulties the Conservative Treatment of Crohn’s Disease Complicated by Autoimmune Hemophilia A by E. L. Belyaeva, O. I. Filippova, A. V. Koloskov, A. A. Naydenov, F. D. Albegova

“…When acquired coagulopathy develops in a patient with bleeding against the background of an inflammatory bowel disease, it aggravates the course of the disease and worsens the prognosis.…”
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Overexpression of PLCG2 and TMEM38A inhibit tumor progression in clear cell renal cell carcinoma by Yiqiao Zhao, Liang Yang, Xiaojie Bai, Lu Du, Huan Lai, Yiyang Liu, Ping Chen, Michael E. DiSanto, Xinhua Zhang

“…In our study, we used bioinformatics methods to select four putative target genes associated with EMT and prognosis and developed a nomogram model which could accurately predicting 5-year patient survival rates. …”
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Loss of YTHDC1 m6A reading function promotes invasiveness in urothelial carcinoma of the bladder by Jinyun Xu, Jonas Koch, Claudia Schmidt, Malin Nientiedt, Manuel Neuberger, Philipp Erben, Maurice Stephan Michel, Manuel Rodríguez-Paredes, Frank Lyko

“…Abstract Bladder cancer poses significant clinical challenges due to its high metastatic potential and poor prognosis, especially when it progresses to muscle-invasive stages. …”
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15q23 Gain in a Neonate with a Giant Omphalocele and Multiple Co-Occurring Anomalies by Hui-Fang Zhou, Christopher J. O’Conor, Chiraag Gangahar, Louis P. Dehner

“…Data have shown that omphalocele with co-occurring genetic abnormality has worse prognosis than isolated omphalocele. Chromosomal analysis by a conventional technique such as karyotyping can only detect aneuploidy and large segmental duplication or deletion. …”
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The Metabolic Syndrome and Biochemical Recurrence following Radical Prostatectomy by Jennifer M. Post, Jennifer L. Beebe-Dimmer, Hal Morgenstern, Christine Neslund-Dudas, Cathryn H. Bock, Nora Nock, Andrew Rundle, Michelle Jankowski, Benjamin A. Rybicki

“…We conclude that hypertension may contribute to a poorer prognosis in surgically treated prostate cancer patients. …”
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Feature Fusion Model Using Transfer Learning and Bidirectional Attention Mechanism for Plant Pipeline Leak Detection by Yujin Han, Yourak Choi, Jonghyuk Lee, Ji-Hoon Bae

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An Eleven-Year Retrospective Study of Endogenous Bacterial Endophthalmitis by Takashi Nishida, Kyoko Ishida, Yoshiaki Niwa, Hideaki Kawakami, Kiyofumi Mochizuki, Kiyofumi Ohkusu

“…EBE is generally associated with poor visual outcome; however the prognosis may depend on initial VA, extent of ocular involvement, and an interval between onset of ocular symptoms and intravitreal antibiotic injection. …”
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The Role of Gut Microbiota in Tumor Immunotherapy by Miao Wu, Jiawei Bai, Chengtai Ma, Jie Wei, Xianjin Du

“…These characteristics may be used as biomarkers to predict the prognosis of immunotherapy and may also be developed as “immune potentiators” to assist immunotherapy. …”
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Early intervention in eating disorders: introducing the chronopathogram by Antonio Preti, Francesco Bevione, Maria Carla Lacidogna, Andrea Raballo, Michele Poletti, Giovanni Abbate-Daga

“…Early intervention in EDs, inspired by the model developed for psychosis, emphasizes the importance of timely identification and treatment initiation to improve prognosis. Challenges in identifying prodromal phases and measuring the duration of untreated illness highlight the complexity of early intervention efforts in EDs. …”
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TRANSMETACARPAL REPLANTATION. ELEVEN YEARS LATER by Binka Popova, Elena Mateva, Kevork Kaykchian, Deyan Sokolov

“…In transmetacarpal replantations with level through the proximal part of the palm some interosseous muscles are preserved, and repair of the motor branch of the ulnar nerve is with favorable prognosis regarding functional recovery.                     …”
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High Fasting Plasma Glucose during Early Pregnancy: A Review about Early Gestational Diabetes Mellitus by E. Cosson, L. Carbillon, P. Valensi

“…Finally, observational data suggest that early management of intermediate hyperglycemia may improve prognosis, through reduced gestational weight gain and potential early introduction of hypoglycemic agents. …”
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Response Gene to Complement 32 is associated with poor patient survival and an inflamed tumor-immune microenvironment in clear cell renal cell carcinoma by Lingling Li, Xiaocui Bu, Shuhui Wang, Yan Liu, Chongdao Chen, Wei Zhang, Peng Zhao

“…The level of RGC-32 expression was positively correlated with ISUP grade and Ki67 expression and was an independent poor prognosis factor of patients with ccRCC. RGC-32 expression was negatively correlated with the infiltration of TIL and CD3+T cells, but positively correlated with infiltration of PD-1+cells. …”
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Autoimmunity promotes chronic lymphocytic leukemia progression in an indolent disease model by Lisa Pfeuffer, Viola Siegert, Riccardo Trozzo, Katja Steiger, Roland Rad, Jürgen Ruland, Maike Buchner

“…Autoimmune complications frequently arise in CLL patients and are associated with poor clinical prognosis. This study investigates the connection between plasma cell-mediated autoimmunity and CLL progression using a mouse model that expresses an active Receptor Activator of NF-κB (RANK) in B cells (RK mice), where autoimmune manifestations coexist with CLL. …”
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Phosphorylation of p53 Serine 15 Is a Predictor of Survival for Patients with Hepatocellular Carcinoma by Taewoo Yang, Yegyun Choi, Jae Won Joh, Steve K. Cho, Dae-Shick Kim, Sung-Gyoo Park

“…Hepatocellular carcinoma (HCC) is one of the most common malignant cancers with a poor prognosis. Several commonly investigated immunohistochemical markers in resected HCC have potential prognostic value, but the prognostic utility of p53 expression in HCC has remained elusive. …”
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Unmet needs in atopic dermatitis management: an expert consensus by Annalisa Patrizi, Antonio Costanzo, Cataldo Patruno, Valentina Maria Busà, Andrea Chiricozzi, Giampiero Girolomoni

“…Aiming to identify unmet needs in clinical management of patients with AD, we used a Delphi consensus process.Methods A set of statements regarding diagnosis, management, prognosis, and treatment was identified by five experts (Steering Committee). …”
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Bell’s Palsy: A Prospective Study by Ahmed Hassan Kamil Mustafa, Ahmed Mohammed Suleiman

“…We failed to demonstrate any relation between postauricular pain and prognosis of Bell’s palsy. The percentage of taste changes in our study is low in comparison with those obtained in the literature. …”
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Translocation (6;15)(q12;q15): A Novel Mutation in a Patient with Therapy-Related Myelodysplastic Syndrome by Saba F. Ali, Rebecca J. Sonu, Denis M. Dwyre, Brian A. Jonas, Hooman H. Rashidi

“…Patients with t-MDS, a group of heterogeneous stem cell related disorders resulting as a latent complication of cytotoxic and/or radiation therapy, generally tend to have a poorer prognosis than de novo MDS. We present a unique case of a patient who initially presented with acute myeloid leukemia (AML) with a normal karyotype and FLT3-ITD and NPM1 mutations. …”
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Extra-Anatomic Jump Graft from the Right Colic Vein: A Novel Technique to Manage Portal Vein Thrombosis in Liver Transplantation by Paolo Magistri, Giuseppe Tarantino, Tiziana Olivieri, Annarita Pecchi, Roberto Ballarin, Fabrizio Di Benedetto

“…Complete PVT is associated with higher morbidity rates and poor prognosis, while comparable long-term outcomes can be achieved as long as physiological portal inflow is restored. …”
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