Generational Expression of Muir-Torre Syndrome in a Canadian Family by Kaitlin Alexandra Vanderbeck, R. Gary Sibbald, Nirosha Murugan

“…The case demonstrates that the management of MTS, a potentially underreported syndrome, requires a multiprofessional approach incorporating vigilance, screening, and expert knowledge for successful diagnosis and potentially improved prognosis for patients and their families. The case also demonstrates the varied heritability of MTS and prompts the question of how MTS is expressed in succeeding generations.…”
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Primary Pericardial Mesothelioma: A Rare Entity by Mohit Godar, Jianhua Liu, Pengguo Zhang, Yang Xia, Qinghai Yuan

“…The neoplasm is highly aggressive and carries a dismal prognosis with an overall survival of less than six months. …”
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Characterization of a pleomorphic rhabdomyosarcoma cell line by Sandra Stickler, Clemens Lang, Maximilian Rieche, Marie-Therese Eggerstorfer, Martin Hohenegger, Maximilian Hochmair, Gerhard Hamilton

“…Abstract Pleomorphic rhabdomyosarcoma (PRMS) is an extremely rare soft tissue tumor with dismal prognosis that has a higher incidence in adults compared to the other RMS subtypes. …”
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Calcific Uremic Arteriolopathy in Peritoneal Dialysis Populations by Nicholas New, Janaki Mohandas, George T. John, Sharad Ratanjee, Helen Healy, Leo Francis, Dwarakanathan Ranganathan

“…This combination therapy may be changing the historically poor prognosis of calcific uremic arteriolopathy reported in the literature. …”
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Papillary Thyroid Carcinoma in a Branchial Cleft Cyst without a Thyroid Primary: Navigating a Diagnostic Dilemma by Douglas S. Ruhl, Mark F. Sheridan, Joseph C. Sniezek

“…A thorough discussion of the etiologies of these lateral neck masses is reviewed including the embryogenesis of thyroid tissue in a branchial cleft cyst. The prognosis of patients with papillary thyroid carcinoma in lateral neck cysts without a primary site identified appears to be good following excision of the cyst and total thyroidectomy. …”
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Giant Isolated Omphalocele: Role of Prenatal Diagnosis in Prognostic Asessment and Perinatal Management by A. M. Cubo, M. V. Lapresa Alcalde, I. Gastaca, M. O. Rodríguez-Martín, M. C. Martín Seisdedos, M. V. R. Velasco Ayuso, R. C. Cebrián Muiños, J. M. Sayagués

“…It has a high association with genetic and structural defects; however, if the latter is ruled out, its prognosis improves significantly. Prenatal diagnosis has a key role in this condition as omphalocele can be diagnosed by ultrasound in the first trimester scan, enabling a coordinated approach strategy to achieve the best perinatal results. …”
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Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH): A Case of Indolent Pulmonary Nodules Diagnosed with Robotic-Assisted Navigational Bronchoscopy by Adam Purdy, Firas Ido, Deborah Stahlnecker

“…DIPNECH presents with characteristic radiographic and histologic findings, but its diagnosis, management, and prognosis are often underrecognized and poorly understood. …”
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The Proviral Reservoirs of Human Immunodeficiency Virus (HIV) Infection by Andrey I. Murzin, Kirill A. Elfimov, Natalia M. Gashnikova

“…Early initiation of ART improves the prognosis of the course of HIV infection, which is explained by the reduction in the proviral reservoir pool observed in the early stages of the disease. …”
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Demanding Diagnosis of Splenic Angiosarcoma as Cause of Delayed Treatment of Spontaneous Splenic Rupture: A Case Report and Literature Review by Sara Coppola, Andrea Leva, Fabio Pagni, Simone Famularo, Luca Gianotti

“…Primary splenic angiosarcoma is a very rare mesenchymal malignant tumor associated with a poor prognosis due to its high metastatic potential. This disease can be easily neglected and spontaneous splenic rupture is a frequent manifestation at the time of diagnosis leading to a poor outcome because of peritoneal dissemination. …”
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Efficacy of Venetoclax and Dexamethasone in Refractory IgM Primary Plasma Cell Leukemia with t(11;14) and TP53 Mutation: A Case Report and Literature Review by Salimah Valliani, Mir Ali, Omar Mahmoo, Sanjay Hinduja, Calvin K. Chen, Lloyd Damon, Haifaa Abdulhaq

“…He progressed on proteasome inhibitors, immunomodulating agents, and other chemotherapy medications but later achieved very good partial response (VGPR) to venetoclax and dexamethasone. Given the poor prognosis of pPCL, further studies using venetoclax alone or in combination with other novel agents as first-line treatment options are warranted particularly in patients with t(11;14).…”
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Neratinib and the Role of Anti‐HER2 Therapy in Salivary Duct Carcinoma by Martina Napolitano, Lucia Trudu, Enrica Martinelli, Chiara Santini, Massimo Dominici, Federica Bertolini

“…ABSTRACT Backgroud Salivary duct carcinoma (SDC) is a rare and aggressive malignancy with a generally dismal prognosis and no standard of care established, despite a known association with epidermal growth factor receptor 2 (HER2) and androgen receptor (AR) over‐expression. …”
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Concurrent Central Diabetes Insipidus and Acute Myeloid Leukemia by Stephanie L. Pritzl, Daniel R. Matson, Mark B. Juckett, David J. Ciske

“…We emphasize that new onset CDI can occur as a rare complication of AML where it portends a poor prognosis and may be related to AML subtypes displaying MECOM gene dysregulation.…”
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TNPO1-Mediated Nuclear Import of FUBP1 Contributes to Tumor Immune Evasion by Increasing NRP1 Expression in Cervical Cancer by BiKang Yang, Jing Chen, YinCheng Teng

“…In the present study, we found that FUBP1 mRNA and protein expressions were markedly upregulated and closely linked with poor prognosis in cervical cancer. In vitro, functional experiments showed that knockdown of FUBP1 inhibited CC cell proliferation and migration. …”
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Nuclear DNA Content of Fine Needle Aspirates of Invasive Ductal Carcinomas of the Breast by Sudip Sarker, Allan Spigelman, Marjorie Walker, Dulcie Coleman

“…This suggests that ploidy might contribute to the pre‐operative assessment of prognosis. We conclude that nuclear DNA of breast cancer FNAs may be of value in the pre‐operative biological assessment of breast cancer patients.…”
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Sequential Kinase Inhibition (Idelalisib/Ibrutinib) Induces Clinical Remission in B-Cell Prolymphocytic Leukemia Harboring a 17p Deletion by H. Coelho, M. Badior, T. Melo

“…In conclusion, given the poor prognosis of B-PLL and the lack of effective treatment modalities, the findings here suggest that both ibrutinib and idelalisib should be considered as upfront therapy of B-PLL and as a bridge to allo-HSCT.…”
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Downregulation of TET1 Promotes Glioma Cell Proliferation and Invasion by Targeting Wnt/β-Catenin Pathway by Jianwen Ji, Qiuxiang You, Jidong Zhang, Yutao Wang, Jing Cheng, Xiangyun Huang, Yundong Zhang

“…Glioma is the most common malignant tumor in adult brain characteristic with poor prognosis and low survival rate. Despite the application of advanced surgery, chemotherapy, and radiotherapy, the patients with glioma suffer poor treatment effects due to the complex molecular mechanisms of pathological process. …”
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Squamous Cell Carcinoma Arising in a Mature Cystic Teratoma by Suna Avcı, Fatih Selcukbiricik, Ahmet Bilici, Gülkan Özkan, Ayse Ayşim Özağarı, Fatih Borlu

“…According to histopathological diagnosis, squamous cell carcinoma arising in a mature cystic teratoma is diagnosed as a reason for the mass in the right adnexa of the patient. Conclusion. The prognosis of the malign transformation of MCT depends on surgery stage; however it is extremely poor. …”
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DNA repair in cancer stem cells as a factor for glioma resistance to radiotherapy by Yu. S. Makusheva, G. L. Dianov

“…The main reason for dismal prognosis is the high level of tumor recurrence because of resistance to different ways of treatment. …”
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Pain catastrophising in Chinese patients with breast cancer during postoperative chemotherapy: a qualitative study by Jing Ma, Jingyi Wang, Hongying Wang, Chen Tang, Yanting Zhang, Wenjia Long, Jun Zhong

“…The interview data were sorted out and analysed by content analysis method.Results A total of 11 patients were interviewed and five categories were summarised: (1) Physical memory of pain; (2) the special meaning of time; (3) disease treatment and prognosis; (4) interpersonal communication and coping; (5) personal behaviour and growth.Conclusion Patients with breast cancer have adverse pain experience during postoperative chemotherapy. …”
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The Partial Duplication of the 5′ Segment of KMT2A Revealed KMT2A-MLLT10 Rearrangement in a Boy with Acute Myeloid Leukemia by Hiroko Fukushima, Toru Nanmoku, Sho Hosaka, Yuni Yamaki, Nobutaka Kiyokawa, Takashi Fukushima, Ryo Sumazaki

“…The duplication of 5′ segment of KMT2A is a rare molecular event in childhood leukemia, and the influence on prognosis is unknown. Here, we report on a boy who developed acute monocytic leukemia. …”
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