Particularities and management of late-onset rheumatoid arthritis by Enrique Martínez González, Liena Perdomo Roselló, Reiny Lorena Rosquete Ávila

“…The clinical characteristics are heterogeneous, with greater involvement of large joints, more constitutional symptoms, stiffness and extra-articular manifestations mostly of a cardiorespiratory nature, as well as less seropositivity. The prognosis depends mainly on age, comorbidities, seropositivity and the type of treatment; which is worse than in younger patients. …”
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Zygomycosis in Two Hematologic Cases by M. T. García-Romero, J. García-Méndez, R. Arenas, T. Ferrari-Carballo, J. Chanona-Vilchis, E. Cervera-Ceballos

“…These infections have poor prognosis due to the involvement of vital anatomic structures and late diagnosis. …”
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SLC1A4 Promotes Malignant Transformation of Hepatocellular Carcinoma by Activating the AKT Signaling by Jiaoyun Zheng, Jian Gong

“…Worse more, a high level of SLC1A4 may lead to a poor prognosis of HCC. Mechanically, silencing SLC1A4 inhibited the phosphorylation activation of AKT by suppressing the ubiquitin modification of AKT at lysine 63 and amino acid influx represented by D-serine, decreasing the protein level of β-catenin in the cell nucleus and suppressing the transcriptional activity of c-Myc and EpCAM promoters. …”
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A large giant cell tumor of the larynx: case report and review of the literature by Andrew Arndt, Rachelle LeBlanc, Peter Spafford

“…Conclusion GCTs of the larynx have a good prognosis and can be treated successfully through complete resection of the tumor, negating the need for adjunctive therapy such as radiation, chemo or denosumab therapy.…”
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Primary Synovial Sarcoma of Kidney: A Rare Differential Diagnosis of Renomegaly by Gaurang Modi, Irappa Madabhavi, Harsha Panchal, Asha Anand, Apurva Patel, Sonia Parikh, Swaroop Revannasiddaiah

“…Primary SS of kidney are very rare tumours with poor prognosis. Though they have characteristic histology and immunohistochemistry (IHC) due to rarity of incidence it is difficult to diagnose them. …”
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The Diagnosis Is in the Smear: A Case and Review of Spur Cell Anemia in Cirrhosis by Gabriella A. Raffa, Diana M. Byrnes, John J. Byrnes

“…The presence of spur cells is an indicator of poor prognosis and high risk of mortality. Currently, the only definitive cure is liver transplantation. …”
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A Strangulated Congenital Diaphragmatic Bochdalek Hernia Diagnosed in an Adult by Warsinggih Warsinggih, Julianus Aboyaman Uwuratuw, Arham Arsyad, Muhammad Faruk

“…Late-diagnosed CDHs are extremely rare and always show small defects that justify a better prognosis than CDHs with large defects. In most cases, such CDHs go undiagnosed due to their mild, delayed symptoms. …”
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Monitoring of perioperative tissue perfusion and impact on patient outcomes by Bin Li, Yuchen Dai, Wenlan Cai, Menghan Sun, Jie Sun

“…Combining these measures provides a more accurate assessment of tissue perfusion and patient prognosis.…”
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The Role of Device Diagnostic Algorithms in the Assessment and Management of Patients with Systolic Heart Failure: A Review by Andrew C. T. Ha, Richard A. Leather, Paul G. Novak, Laurence D. Sterns, Anthony S. L. Tang

“…Hospitalization due to heart failure (HF) exacerbation represents a major burden in health care and portends a poor long-term prognosis for patients. As a result, there is considerable interest to develop novel tools and strategies to better detect onset of volume overload, as HF hospitalizations may be reduced if appropriate interventions can be promptly delivered. …”
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Heart rhythm disorders and features of their management at COVID-19 pandemic by Yu.M. Mostovoy, T.D. Danilevych

“…In addition, there are controversial questions about the features of their management, drug interactions, routing and prognosis of the patients. The review displays the latest data from both foreign and domestic scientists about the prevalence of rhythm disorders against the background of coronavirus infection and highlights the main problematic issues of the management of the patients…”
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Cognitive Behavioral Therapy of a Generalized Anxiety Disorder Case Comorbid with Health Anxiety by Nalan Kara

“…It is often seen with other psychiatric disorders and this complicates the diagnosis, tretment and prognosis. In this case report Cognitive Behavioral Therapy (CBT) of a GAD patient comorbid with health anxiety was introduced and the place of CBT in these conditions was discussed. …”
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Clear Cell Myoepithelial Carcinoma Arising from the Hard Palate with Metastasis to the Lungs by Jiayun Fang, Amanda Kornfield, Alex Clavijo, Shikhar Vyas, Alison Ulbrandt, Carsten Schroeder, J. Kenneth Byrd, Daniel Kleven

“…Due to the low number of reported cases, prognosis and treatment of this neoplasm is not well defined.…”
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Increased aPKC Expression Correlates with Prostatic Adenocarcinoma Gleason Score and Tumor Stage in the Japanese Population by Anthony S. Perry, Bungo Furusato, Raymond B. Nagle, Sourav Ghosh

“…Levels of the protein kinase aPKC have been previously correlated with prostate cancer prognosis in a British cohort. However, prostate cancer incidence and progression rates, as well as genetic changes in this disease, show strong ethnic variance, particularly in Asian populations. …”
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Application of Metabolomics in Thyroid Cancer Research by Anna Wojakowska, Mykola Chekan, Piotr Widlak, Monika Pietrowska

“…Classification of thyroid cancer is the primary step in the assessment of prognosis and selection of the treatment. However, in some cases, cytological and histological patterns are inconclusive; hence, classification based on histopathology could be supported by molecular biomarkers, including markers identified with the use of high-throughput “omics” techniques. …”
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PKM2 Promotes Breast Cancer Progression by Regulating Epithelial Mesenchymal Transition by Hui Xiao, Longxiao Zhang, Yuan Chen, Chengjun Zhou, Xiao Wang, Dehai Wang, Zhenzhong Liu

“…In this study, we showed that PKM2 is upregulated in breast cancer tissues and the upregulating of PKM2 in breast cancer correlates with poor prognosis. PKM2 can regulate tumor progression by promoting tumor cell viability and mobility. …”
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Paraquat poisoning from accidental ingestion leading to fatal outcome: A case report by Chao Liu, Mengya Yao, Jiangrong Ma, Shinan Nie

“…Subsequently, aggressive interventions such as hemoperfusion and continuous renal replacement therapy were initiated, yet there was a further decline in respiratory function, necessitating mechanical ventilation. The prognosis was poor, and ultimately, the family chose to withdraw care. …”
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Genome Stability Pathways in Head and Neck Cancers by Glenn Jenkins, Kenneth J. O'Byrne, Benedict Panizza, Derek J. Richard

“…Targeted inhibition of signalling receptors has proven to be a clinically-validated therapy, and protein expression of other DNA repair and signalling molecules associated with cancer behaviour could potentially provide a more refined clinical model for prognosis and treatment prediction. Development and expansion of current genomic stability models is furthering our understanding of HNSCC pathophysiology and uncovering new, promising treatment strategies.…”
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Primary Pure Squamous Cell Carcinoma of the Gallbladder Locally Invading the Liver, Duodenum, and Stomach: A Case Report and Literature Review by Aldrin C. Alpuerto, Maximo E. Mora, R. Jonathan Robitsek, Sebastian D. Schubl

“…SCC of the gallbladder portends a worse prognosis than the more common adenocarcinoma variant because of its aggressive invasion to local structures and because it is often diagnosed at an advanced stage. …”
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Intratumoral microbiota, fatty acid metabolism, and tumor microenvironment constitute an unresolved trinity in colon adenocarcinoma by Guangyi Liu, Kun Liu, Lei Ji, Yang Li

“…More importantly, the crosstalk between the three can have a significant impact on prognosis, response to immunotherapy, and drug sensitivity of patients. …”
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Clinical Significance and Pathogenic Mechanisms of Long Non-Coding RNA TRPM2-AS in Cancers by Shichen Huang MS, Bowen Li MS, Huanyu Chen MD, Cheng Rong, Zheng Yang MD, Xianqin Zhang PhD

“…The elevated levels of TRPM2-AS are associated with important clinicopathological parameters such as tumor size, tumor stage, and lymph node metastasis, revealing that TRPM2-AS could be a potential target for cancer diagnosis, prognosis and treatment. Moreover, TRPM2-AS is involved in regulating the cell proliferation, migration, invasion, apoptosis, drug or radio resistance by serving as a competing endogenous RNA, directly bounding to proteins and regulating multiple signaling pathways. …”
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