Expression of Sclerostin in Osteoporotic Fracture Patients Is Associated with DNA Methylation in the CpG Island of the SOST Gene by Yanming Cao, Bin Wang, Ding Wang, Dongxiang Zhan, Caiyuan Mai, Peng Wang, Qiushi Wei, Yamei Liu, Haibin Wang, Wei He, Liangliang Xu

“…Our study demonstrated that DNA methylation influenced the transcriptional expression of SOST gene, which probably may play an important role in the pathogenesis of primary osteoporosis.…”
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DNA barcoding: how many earthworm species are there in the south of West Siberia? by S. V. Shekhovtsov, N. E. Bazarova, D. I. Berman, N. A. Bulakhova, E. V. Golovanova, S. V. Konyaev, T. M. Krugova, I. I. Lyubechanskii, S. E. Peltek

“…The rest of the novel clusters probably represent new earthworm species. Therefore, we can conclude that a large portion of earthworm biodiversity in the south of West Siberia is still unexplored.…”
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Pig nasal and rectal microbiotas are involved in the antibody response to Glaesserella parasuis by Pau Obregon-Gutierrez, Yasser Mahmmod, Emili Barba-Vidal, Marina Sibila, Florencia Correa-Fiz, Virginia Aragón

“…Altogether, these results suggest that the microbiota is associated with the antibody response to G. parasuis (and probably to other pathogens) and serves as starting point to understand the factors that contribute to immunization in pigs.…”
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Activation of the Nrf2/HO-1 pathway restores N-acetylcysteine-induced impairment of the hypothalamus-pituitary-adrenal axis negative feedback by up-regulating GRα expression and do... by Amanda Silva Chaves, Raíssa Duarte Ventura, Maria Florencia Pacini, Nathalia Santos Magalhães, Patrícia Machado Rodrigues e Silva, Marco Aurélio Martins, Ana Rosa Pérez, Vinicius Frias Carvalho, Vinicius Frias Carvalho, Vinicius Frias Carvalho, Vinicius Frias Carvalho

“…In conclusion, these findings showed that NAC reduced the Nrf2-HO-1 pathway activation in the pituitary gland, in a mechanism probably related to a local downregulation of GRα and an up-regulation of GRβ, leading to a failure of negative feedback of the HPA axis and consequently to the hyperactivity of this neuroendocrine axis.…”
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Evaluation of the Tyrosine and Dopamine Serum Levels in Experimental Infected BALB/c Mice with Chronic Toxoplasmosis by Mehdi Mirzaeipour, Fattaneh Mikaeili, Qasem Asgari, Mohammad Nohtani, Sajad Rashidi, Mohammad Saleh Bahreini

“…No detection of tyrosine level in most of the sample groups is probably related to the very low concentration of tyrosine in sera. …”
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3D Localization of FRB 20190425A for Its Potential Host Galaxy and Implications by Da-Chun Qiang, Zhi-Qiang You, Sheng Yang, Zong-Hong Zhu, Ting-Wan Chen

“…We employed various methodologies to determine the most probable host galaxy of GW190424 and FRB 20190425A, including a comparison of galaxy properties and constraints on their reported observation limits using various kilonova models. …”
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Parathyroid Carcinoma in the Setting of Tertiary Hyperparathyroidism: Case Report and Review of the Literature by Federico Cappellacci, Fabio Medas, Gian Luigi Canu, Maria Letizia Lai, Giovanni Conzo, Enrico Erdas, Pietro Giorgio Calò

“…Neck ultrasound (US) showed a solid hypodense mass, probably the right inferior parathyroid gland, with an estimated size of 25 × 15 × 13 mm; the 99mTc-sestamibi SPECT/CT scan revealed a large radiotracer activity area in the right cervical region, compatible with a hyperfunctioning right inferior parathyroid gland. …”
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Parasitic contamination of lettuce: comparison between establishments located in areas with high and low economic values by Gustavo Trentini Barancelli, Larissa Kochenborger, Fernanda Gracieli Machado Brum, Fabiana Tonial, Cassiano Mateus Forcelini

“…Results: Parasitic forms were found in 80% of the samples, namely: ciliated cysts (probable Balantioides coli), larvae of nematode, Ascaris lumbricoides, cestode eggs, Giardia lamblia, Hymenolepis nana, Entamoeba coli, and Fasciola hepatica. …”
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Evaluation of the longitudinal deformation of left ventricle and its changes in myocardial infarction and coronary heart disease with obstructive coronary artery lesions by N.V. Tytarenko, M.P. Kopytsya, I.V. Rodionova, A.V. Kobets

“…The analysis of the strain curves is carried out, the characteristics of the strain curve in normal conditions and in ischemia are presented. The probable signs of ischemia are the phenomena of early systolic lengthening and postsystolic shortening on the curves of longitudinal deformation. …”
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Curcumin Prevents Free Fatty Acid-Induced Lipid Accumulation via Targeting the miR-22-3p/ CRLS1 Pathway in HepG2 Cells by Yuanyuan Mei, Xiaoting Sun, Shi-Ying Huang, Xiaowen Wu, Kuo-Ting Ho, Liming Lu, Chaoxiang Chen, Jian Li, Jingwen Liu, Guiling Li

“…Thus, miR-22-3p and CRLS1 showed opposite effects in modulating lipid metabolism, which probably involved mitochondrial control. In summary, this study demonstrated that curcumin improved hepatic lipid metabolism via targeting the miR-22-3p/ CRLS1 pathway. …”
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Liquid smoke-infused edible coatings: Antimicrobial agents for preserving cherry tomatoes by Muhammad Faisal, Dieni Mansur, Hera Desvita, M. Bagas Heriansyah

“…The quality of cherry tomato was also analyzed through the Most Probable Number (MPN) test for E. coli and the measurement of the L∗ value. …”
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Distribution Characteristics of the Plasma Irregularities Inside the Mid‐Latitude Ionospheric Trough Based on Swarm In Situ Measurements by Yiwen Liu, Wenhao Xie, Chao Xiong, Ting Ye, Yuhao Wang, Xin Wan, Yueyan Cao

“…The relatively low nightside MTI occurrence rate in high solar activity years probably results from the relatively small electron temperature gradient. …”
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The first cases of collagenous sprue successfully treated with thioguanine by Chris J J Mulder, Gerd Bouma, Tom van Gils, Tine van de Donk, Foke van Delft, E Andra Neefjes-Borst

“…The thickened membrane persisted in the last patient, probably because of the short time of follow-up.Conclusions CS should be separated from coeliac disease. …”
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Parasitic contamination of lettuce: comparison between establishments located in areas with high and low economic values by Gustavo Trentini Barancelli, Larissa Kochenborger, Fernanda Gracieli Machado Brum, Fabiana Tonial, Cassiano Mateus Forcelini

“…Results: Parasitic forms were found in 80% of the samples, namely: ciliated cysts (probable Balantioides coli), larvae of nematode, Ascaris lumbricoides, cestode eggs, Giardia lamblia, Hymenolepis nana, Entamoeba coli, and Fasciola hepatica. …”
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Evaluating Mechanical Properties of Few Layers MoS2 Nanosheets-Polymer Composites by Muhammad Bilal Khan, Rahim Jan, Amir Habib, Ahmad Nawaz Khan

“…The high aspect ratio of MoS2 nanosheets, homogeneous dispersion inside polymer, and their probable planar orientation are the possible reasons for the effective stress transfer, resulting in enhanced mechanical characteristics. …”
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Climatic Trends in Hail Precipitation in France: Spatial, Altitudinal, and Temporal Variability by Lucía Hermida, José Luis Sánchez, Laura López, Claude Berthet, Jean Dessens, Eduardo García-Ortega, Andrés Merino

“…There was a high concentration of hailpads with positive trend near the Pyrenees, probably owing to orographic effects, and if we apply cluster analysis with the Mann-Kendall values, the spatial variability is accentuated for stations at higher altitude.…”
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The therapeutic potential of vitamins A, C, and D in pancreatic cancer by Alban Piotrowsky, Markus Burkard, Hendrik Schmieder, Sascha Venturelli, Olga Renner, Luigi Marongiu

“…While the antitumor effect of vitamin C is probably mainly due to its pro-oxidative effect in supraphysiological concentrations, vitamin A and vitamin D exert their effect by activating nuclear receptors and influencing gene transcription. …”
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Targeting the activated allosteric conformation of the endothelin receptor B in melanoma with an antibody-drug conjugate: mechanisms and therapeutic efficacy by Amaury Herbet, Marie Hautière, Frédéric Jean-Alphonse, Delphine Vivier, Christophe Leboeuf, Narciso Costa, Aloïse Mabondzo, Guilhem Bousquet, Franck Denat, Eric Reiter, Didier Boquet

“…Inhibition of their signaling pathways with antagonist drugs has been the subject of numerous clinical trials, but the results have not met expectations probably due to the high endothelin concentrations in the tumor microenvironment and their unusually high affinity for their receptors. …”
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The History of the Brazilian Sardine (<i>Sardinella brasiliensis</i>) Between Two Fishery Collapses: An Ecosystem Modeling Approach to Study Its Life Cycle by Rafael Schroeder, Angélica Petermann, Alberto Teodorico Correia

“…This pattern was coincidental with the increasing mean temperature of the catches, which was probably acting as a limiting factor for the primary production, resulting in a higher natural mortality and flow to detritus. …”
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Features of the biomorphological and geographic structure of segetal floras in a number of regions in Russia by O. G. Baranova, A. S. Tretyakova, N. N. Luneva, A. A. Zverev, P. V. Kondratkov, T. A. Terekhina, G. R. Khasanova, S. M. Yamalov, M. V. Lebedeva, N. A. Bagrikova

“…The ratio of life forms (an increased share of therophytes, and a decreased share of phanerophytes) is probably a characteristic feature of the segetal flora, associated with the living environments of plants in agricultural phytocenoses. …”
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