Effect of Tumor Necrosis Factor Family Member LIGHT (TNFSF14) on the Activation of Basophils and Eosinophils Interacting with Bronchial Epithelial Cells by Huai Na Qiu, Chun Kwok Wong, Jie Dong, Christopher Wai-Kei Lam, Zhe Cai

“…Results showed that LIGHT could significantly promote intercellular adhesion, cell surface expression of intercellular adhesion molecule-1, release of airway remodeling-related IL-6, CXCL8, and MMP-9 from BEAS-2B cells upon interaction with basophils/eosinophils, probably via the intercellular interaction, cell surface receptors HVEM and LTβR on BEAS-2B cells, and extracellular signal-regulated kinase, p38 mitogen activated protein kinase, and NF-κB signaling pathways. …”
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Technical, social, psychological and ethical aspects of human-robot collaboration: a case study of the 'Robin Heart' medical robot by Małgorzata Suchacka, Mariusz Wojewoda, Zbigniew Nawrat, Artur Domurat, Angelika Magdalena Pabian

“…Improving the human-machine relationship will probably dominate many years of activity of multi-disciplinary teams combining humanistic, biological and technical approaches. …”
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SGLT2i and GLP-1RA in Cardiometabolic and Renal Diseases: From Glycemic Control to Adipose Tissue Inflammation and Senescence by Luis D'Marco, Valery Morillo, José Luis Gorriz, María K. Suarez, Manuel Nava, Ángel Ortega, Heliana Parra, Nelson Villasmil, Joselyn Rojas-Quintero, Valmore Bermúdez

“…This review intends to expose the probable molecular mechanisms and compile evidence of the synergistic or additive anti-inflammatory effects of SGLT2i and GLP-1RA and their potential impact on the management of patients with obesity and cardiorenal compromise.…”
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Targeted Therapies Compared to Dacarbazine for Treatment of BRAFV600E Metastatic Melanoma: A Cost-Effectiveness Analysis by Vanessa Shih, Renske M. ten Ham, Christine T. Bui, Dan N. Tran, Jie Ting, Leslie Wilson

“…A Markov model was developed using a societal perspective. Transition probabilities were derived from two Phase III registration trials comparing each BRAF inhibitor against dacarbazine. …”
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Functional state of the nigrostriatal system of Krushinsky – Molodkina rats during audiogenic seizure expression by N. A. Dorofeeva, L. S. Nikitina, D. V. Zosen, M. V. Glazova, E. V. Chernigovskaya

“…We demonstrated activation of GABA in the substantia nigra pars reticulate, which probably results in the inhibition of glutamate neurons of the thalamus and could be one of the mechanisms inhibiting seizure activity during ataxia.…”
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Efficient and accurate methodologies for MCS-based probabilistic analysis of tunnel face stability by Bin Li, Yong-Kai Shen, Yuan-Sheng Lan

“…Results show that the failure probabilities predicted by the ensemble of metamodels compare well with those determined according to direct MCS-based 3D numerical simulations, implying that the ensemble of metamodels is also accurate.…”
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Double disaggregation of the decline of terrestrial water storage for a highly cultivated dryland partially covered by glaciers by Zongxia Wang, Suxia Liu

“…Besides the Tianshan Mountains, TWS also declined significantly downstream where it should have increased given the substantive glacier meltwater supply from upstream, implying that the evolution of TWS in NSTM has probably deviated from natural manners. Pixel-wise internal disaggregation indicated that groundwater storage was the predominant hydrological component leading to TWS depletion in most of the NSTM except for glacier-covered areas. …”
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Short-Term Bixin Supplementation of Healthy Subjects Decreases the Susceptibility of LDL to Cu2+-Induced Oxidation Ex Vivo by Lisiane Conte, Sabrina Somacal, Sabrina Marafiga Nichelle, Cristine Rampelotto, Silvino Sasso Robalo, Miguel Roehrs, Tatiana Emanuelli

“…Moreover, we observed that the changes in these parameters were positively associated, supporting the hypothesis that bixin decreases the susceptibility of LDL to Cu2+-induced oxidation by decreasing NOx levels, probably by downregulating the inducible nitric oxide synthase.…”
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Legacy and emerging organic pollutants in indoor and outdoor environments in Africa: Contamination levels, health risks, and analytical techniques by Godfrey Muhwezi, Christine Kyarimpa, Ivan Gumula, Christine Betty Nagawa, Solomon Omwoma, Henry Matovu, Julius Matsiko, Silver Odongo, Douglas Sifuna, Ivan Špánik, Charles Drago Kato, Patrick Ssebugere

“…Gas Chromatography and mass spectrometry were the most frequently used analytical techniques for both air and dust probably due to their sensitivity and selectivity in detecting chemical traces at the pg m−3 and ng g−1 levels. …”
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TRAF1 Gene Polymorphism Correlates with the Titre of Gp210 Antibody in Patients with Primary Biliary Cirrhosis by Agnieszka Kempinska-Podhorodecka, Zakera Shums, Michał Wasilewicz, Ewa Wunsch, Malgorzata Milkiewicz, Dimitrios P. Bogdanos, Gary L. Norman, Piotr Milkiewicz

“…TRAF1 polymorphisms occur with the similar frequency in PBC patients and in the general population, but their presence is probably involved in the regulation of specific PBC-related autoantibodies.…”
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Automatic Grape Cluster Detection Combining YOLO Model and Remote Sensing Imagery by Ana María Codes-Alcaraz, Nicola Furnitto, Giuseppe Sottosanti, Sabina Failla, Herminia Puerto, Carmen Rocamora-Osorio, Pedro Freire-García, Juan Miguel Ramírez-Cuesta

“…On the contrary, vegetation indexes derived from Sentinel-2 and PlanetScope satellites were found not able to predict grape cluster numbers (R² lower than 0.23), probably due to the fact that these indexes are more related to vegetation vigor, which is not always related to yield parameters (e.g., cluster number). …”
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Novel thiazolyl-pyrimidine derivatives as potential anticancer agents: Synthesis, biological evaluation, and molecular docking studies by Tariq Z. Abolibda, Abdel-Aziz A.A. El-Sayed, Basant Farag, Magdi E.A. Zaki, Abdulwahed Alrehaily, Hossein M. Elbadawy, Ahmad A. Al-Shahri, Saleh R. Alsenani, Sobhi M. Gomha

“…Molecular docking analyses were conducted to investigate the probable binding conformations of the most potent anticancer agents. …”
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Host cell responses to Candida albicans biofilm-derived extracellular vesicles by Kamila Kulig, Ewelina Wronowska, Magdalena Juszczak, Magdalena Juszczak, Marcin Zawrotniak, Justyna Karkowska-Kuleta, Maria Rapala-Kozik

“…Internalization of EVs by THP-1 macrophage-like cells was confirmed, identifying macropinocytosis and phagocytosis as the most probable mechanisms, as demonstrated using various inhibitors that target potential vesicle uptake pathways in human cells. …”
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HPV16 <em>E6</em> Oncogene Contributes to Cancer Immune Evasion by Regulating PD-L1 Expression through a miR-143/HIF-1a Pathway by Georgios Konstantopoulos, Danai Leventakou, Despoina-Rozi Saltiel, Efthalia Zervoudi, Eirini Logotheti, Spyros Pettas, Korina Karagianni, Angeliki Daiou, Konstantinos E. Hatzistergos, Dimitra Dafou, Minas Arsenakis, Amanda Psyrri, Christine Kottaridi

“…These findings indicate that E6 protein probably plays a significant role in enabling cervical cancer cells to evade the immune system, while we propose a molecular pathway in cervical cancer, where PD-L1’s expression is regulated by E6 protein through a miR-143/HIF-1a axis.…”
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Detection of fusion events by RNA sequencing in FFPE versus freshly frozen colorectal cancer tissue samples by Maxim Sorokin, Maxim Sorokin, Maxim Sorokin, Maxim Sorokin, Vladimir Lyadov, Vladimir Lyadov, Vladimir Lyadov, Maria Suntsova, Marat Garipov, Anna Semenova, Natalia Popova, Egor Guguchkin, Rustam Heydarov, Marianna Zolotovskaia, Xiaowen Zhao, Qing Yan, Ye Wang, Evgeny Karpulevich, Anton Buzdin, Anton Buzdin, Anton Buzdin, Anton Buzdin

“…Most of the fusions detected most probably represented read-through, microdeletion or local duplication events. …”
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Disability, comorbidities and risk determinants at end of TB treatment in Kenya, Uganda, Zambia and Zimbabwe by The Kenya, Uganda, Zambia, and Zimbabwe TB Disability Study Group (members listed here in alphabetical order):, S.A. Adakun, F.M. Banda, A. Bloom, M. Bochnowicz, J. Chakaya, A. Chansa, H. Chiguvare, R. Chimzizi, C. Colvin, J.P. Dongo, A. Durena, C. Duri, R. Edmund, A.D. Harries, I. Kathure, F.N. Kavenga, Y. Lin, H. Luzze, I. Mbithi, M. Mputu, A. Mubanga, D. Nair, M. Ngwenya, B. Okotu, P. Owiti, A. Owuor, P. Thekkur, C. Timire, S. Turyahabwe, E. Tweyongyere, M. YaDiul, R. Zachariah, K. Zimba

“…The most common risk determinants were ‘probable alcohol dependence’ (15%) and malnutrition (14%). …”
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Masking Ability of Various Metal Complexing Ligands at 1.0 mM Concentrations on the Potentiometric Determination of Fluoride in Aqueous Samples by Sakuni M. De Silva, Samitha Deraniyagala, Janitha K. Walpita, Indira Jayaweera, Saranga Diyabalanage, Asitha T. Cooray

“…All the other masking agents produced significantly low concentrations compared to the reference buffer. The most probable reasons for the underestimation of fluoride concentrations could be shorter decomplexing time and lower masking agent concentrations.…”
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Goat’s Milk Powder Enriched with Red (<i>Lycium barbarum</i> L.) and Black (<i>Lycium ruthenicum</i> Murray) Goji Berry Extracts: Chemical Characterization, Antioxidant Properties,... by Danijel D. Milinčić, Aleksandar Ž. Kostić, Steva Lević, Uroš M. Gašić, Dragana D. Božić, Relja Suručić, Tijana D. Ilić, Viktor A. Nedović, Bojana B. Vidović, Mirjana B. Pešić

“…The GMLR showed the highest TPC and displayed a ferric ion-reducing power, probably contributed by anthocyanins and some phenylamides. …”
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Bacterial Composition of Dairy Base during Fermentation by Mariya V. Gryaznova, Inna Yu. Burakova, Yuliya D. Smirnova, Ekaterina Yu. Nesterova, Natalia S. Rodionova, Evgeniy S. Popov, Mikhail Yu. Syromyatnikov, Vasily N. Popov

“…Eventually, Lactobacillus replaced all other genera, including Bifidobacterium, probably, as a result of pH going down during fermentation. …”
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Does Cisapride, as a 5HT4 Receptor Agonist, Aggravate the Severity of TNBS-Induced Colitis in Rat? by Azadeh Motavallian, Mohsen Minaiyan, Mohammad Rabbani, Parvin Mahzouni, Sasan Andalib, Alireza Abed, Mohammad Reza Babavalian

“…There is a pressing need for research that will lead to the reveal of targets designed to analyse the possible pathways for the treatment of IBD. Because of the probable involvement of serotonin in inflammatory conditions of intestine and the important role of 5HT4 receptors in GI function, the investigation of the role of 5HT4 receptors in the pathogenesis of IBD will be interesting. …”
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