Ionizing radiation and photodynamic therapy lead to multimodal tumor cell death, synergistic cytotoxicity and immune cell invasion in human bladder cancer organoids by Annabell Reinhold, Annegret Glasow, Sandra Nürnberger, Annett Weimann, Lucie Telemann, Jens-Uwe Stolzenburg, Jochen Neuhaus, Mandy Berndt-Paetz

“…While apoptosis, necroptosis and ferroptosis were clearly involved in cell death of T-24 cells, cytotoxicity in RT-112 cells was probably provoked by apoptosis, ferroptosis and pyroptosis. …”
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Hemodynamic Evaluation of Nonselective β-Blockers in Patients with Cirrhosis and Refractory Ascites by Alberto Ferrarese, Valerie Tikhonoff, Edoardo Casiglia, Paolo Angeli, Silvano Fasolato, Diego Faggian, Alberto Zanetto, Giacomo Germani, Francesco Paolo Russo, Patrizia Burra, Marco Senzolo

“…The negative inotropic effect of NSBB was counterbalanced by a smaller decrease of vascular resistances after LVP, probably due to splanchnic β2-blockade. This pilot study showed that NSBB introduction may be void of detrimental hemodynamic effects after LVP in cirrhotics with refractory ascites.…”
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Metabolic Phenotyping of Adipose-Derived Stem Cells Reveals a Unique Signature and Intrinsic Differences between Fat Pads by Camille Lefevre, Baptiste Panthu, Danielle Naville, Sylvie Guibert, Claudie Pinteur, Bénédicte Elena-Herrmann, Hubert Vidal, Gilles J. P. Rautureau, Anne Mey

“…Altogether, our results suggest a difference between depots in the capacity of ASC mitochondria to assimilate pyruvate, with probable consequences on their differentiation potential in pathways requiring an increased mitochondrial activity. …”
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Association of Serum Alpha-Tocopherol and Retinol with the Extent of Coronary Lesions in Coronary Artery Disease by Carolinne Thaísa de Oliveira Fernandes Miranda, Victor Hugo Rezende Duarte, Marina Sampaio de Menezes Cruz, Mychelle Kytchia Rodrigues Nunes Duarte, Jéssica Nayara Góes de Araújo, Ayda Maria Quirino Silva dos Santos, Juliana Marinho de Oliveira, Maria Sanali Moura Oliveira Paiva, Adriana Augusto Rezende, Mario Hiroyuki Hirata, Rosario Dominguez Crespo Hirata, Karla Danielly da Silva Ribeiro, André Ducati Luchessi, Vivian Nogueira Silbiger

“…The low level of alpha-tocopherol together with the presence of dyslipidemia is probably associated with the initial events in atherosclerosis. …”
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Retinal Nerve Fiber Layer Thickness Progression after Robotic-Assisted Laparoscopic Radical Prostatectomy in Glaucoma Patients by Kazuyuki Hirooka, Kaori Ukegawa, Eri Nitta, Nobufumi Ueda, Yushi Hayashida, Hiromi Hirama, Rikiya Taoka, Yuma Sakura, Mari Yamasaki, Hiroyuki Tsunemori, Mikio Sugimoto, Yoshiaki Kiuchi

“…Since an increased IOP during the surgery was the probable cause of the changes, ophthalmologic examinations should be performed before and after RALP, especially in glaucoma patients.…”
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Groundwater vulnerability and, risk assessment of seawater intrusion for the development of a strategy plan towards sustainability: Case of the Souss-Massa coastal area, Morocco by Yassine Ez-zaouy, Lhoussaine Bouchaou, Mohammed Hssaisoune, Abdelhaq Aangri, Gianluigi Busico, Saadou Oumarou Danni, Oumaima Attar, Mohamed Nehmadou, Aicha Saad, Yassine Ait Brahim

“…An improved GALDIT (composed by nine parameters: groundwater occurrence (G), hydraulic conductivity (A), groundwater above sea level (L), distance from the shore (D), impact of existing status of sea water intrusion (I), thickness of the aquifer (T), river contribution (R), hydraulic gradient (HG), detected and probable seawater intrusion (DPSWI) was applied in the study area using Analytical Hierarchy Process (AHP) and Sensitivity Analysis (SA) to map groundwater vulnerability to seawater intrusion (GWVSI). …”
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Safety and recommendation of voriconazole for invasive pulmonary aspergillosis in severe liver disease patients: a retrospective cohort study by Xin Zhang, Caopei Zheng, Ling Zhang, Yuqing Sun, Ying Liang, Xue Chen, Lijun Pang, Yulin Zhang

“…Methods This was a retrospective cohort study of SLD patients diagnosed with proven or probable IPA at Beijing Youan Hospital, Capital Medical University between January 1, 2012 to January 31, 2023. …”
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Easy, fast and reproducible Stochastic Cellular Automata with chouca by Génin, Alexandre, Dupont, Guillaume, Valencia, Daniel, Zucconi, Mauro, Ávila-Thieme, M. Isidora, Navarrete, Sergio A., Wieters, Evie A.

“…To provide a unifying, well-tested technical basis to this class of models and facilitate their implementation, we built chouca, an R package that translates definitions of SCA models into compiled code, and runs simulations in an efficient way. chouca supports SCA based on rectangular grids where transition probabilities are defined for each cell, with performance typically two to three orders of magnitude above typical implementations in interpreted languages (e.g. …”
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Amphiphilic Ruthenium(II) Terpyridine Sensitizers with Long Alkyl Chain Substituted β-Diketonato Ligands: An Efficient Coadsorbent-Free Dye-Sensitized Solar Cells by Ashraful Islam, Surya Prakash Singh, Masatoshi Yanagida, Mohammad Rezaul Karim, Liyuan Han

“…However, the photovoltaic performance of A3 was not dependent on DCA at all, probably due to the inherent structural nature of the A3 molecule.…”
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Lower Urinary Tract and Gastrointestinal Dysfunction Are Common in Early Parkinson’s Disease by Daniel Martinez-Ramirez, Edna Sophia Velazquez-Avila, Alejandro Almaraz-Espinoza, Arnulfo Gonzalez-Cantú, Genaro Vazquez-Elizondo, Daniel Overa-Posada, Amin Cervantes-Arriaga, Mayela Rodriguez-Violante, Mirna Gonzalez-Gonzalez

“…Patients with fatigue (beta = 4.28, p<0.001), probable rapid eye movement sleep behavior disorder (beta = 2.71, p<0.001), excessive daytime sleepiness (beta = 1.88,p=0.039), impulsivity and compulsivity (beta = 2.42, p<0.001), and increasing age (beta = 1.05, p<0.001) were more likely to have high dysautonomic scores. …”
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Polymorphism in the TRP8 gene in Kyrgyz population: putative association with highland adaptation by V. N. Babenko, Ж. Т. Isakova, E. T. Talaibekova, D. A. Asambaeva, V. F. Kobzev, T. A. Potapova, M. I. Voevoda, A. A. Aldashev

“…Comparison of haplotype frequencies in Kyrgyz people with Europeans, East Asians, and Africans shows a clear narrowing of genotype variation in Europeans in comparison to all others. Probably, this phenomenon is related to a population size decline (bottleneck effect) during the evolution. …”
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Emulsifying Properties of Dried Soy-Whey, Dried Tofu-Whey, and Their Isolated Proteins by Sobral Pablo A., Ossa J. Sebastian Henao, Palazolo Gonzalo G., Wagner Jorge R.

“…Again, this improvement was more pronounced for samples obtained from soy-whey, probably due to partial protein denaturation associated to treatment with the organic solvent. …”
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The impact of weather conditions in different years on the biochemical composition of linseed oil by G. A. Popova, N. B. Rogalskaya, N. V. Knyazeva, V. M. Trofimova, T. V. Shelenga, E. A. Porokhovinova, N. B. Brutch

“…The assessed genotypes probably possess different regulatory mechanisms for fatty acid biosynthesis. …”
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Identification of candidate genes involved in Zika virus-induced reversible paralysis of mice by John D. Morrey, Venkatraman Siddharthan, Hong Wang, Alexandre L. R. Oliveira, Keiichiro Susuki, Rakesh Kaundal, Sara M. Freeman, Aaron J. Thomas, Naveen Duhan, Nathan G. Corry

“…Consequently, paralysis was probably caused by by-stander effects. To address this, we performed bioinformatics analysis on spinal cord RNA to identify 2058 differentially expressed genes (DEGs) that were altered during paralysis and then normalized after paralysis. …”
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Economic and clinical burden associated with respiratory syncytial virus and impact of universal immunization with nirsevimab in Italy by Andrea Marcellusi, Chiara Bini, Barbara Muzii, Samira Soudani, Alexia Kieffer, Matthieu Beuvelet, Elena Bozzola, Fabio Midulla, Eugenio Baraldi, Paolo Bonanni, Sara Boccalini, Luigi Orfeo

“…Methods: A static decision analytic model previously used in the US was adapted to evaluate the RSV-related health and cost outcomes associated with nirsevimab versus standard of care (SoC) for the prevention of RSV medically attended lower respiratory tract infections (RSV-MA-LRTIs). Monthly probabilities of RSV infections, health events, mortality, and complications associated with RSV infections were obtained from the literature. …”
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Decreased expression of miR-200a and miR-223-3p in endometriosis during the secretory phase of menstrual cycle: Insights from a case-control study on molecular biomarkers and disea... by Yasaman Nazari Hagh, Mohamadreza Ahmadifard, Sedigheh Esmaelzadeh, Soheila Abbaszadeh, Naser Shokrzadeh

“…Conclusion: Our results suggest that miR-200a and miR-223-3p are involved in the EM pathogenesis, while other genes and signaling pathways are probably involved in the implantation failure. …”
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Genomic changes during the evolution of the Coxiella genus along the parasitism-mutualism continuum by Santos-Garcia, Diego, Morel, Olivier, Henri, Hélène, El Filali, Adil, Buysse, Marie, Noël, Valérie, McCoy, Karen D., Gottlieb, Yuval, Klasson, Lisa, Zenner, Lionel, Duron, Olivier, Vavre, Fabrice

“…Results highlight the probably parasitic nature of the common ancestor of the Coxiellaceae. …”
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Evaluation of a PCR-based lateral flow device for detecting Aspergillus and Candida species from clinical specimens by Ariff Khalid, Jacinta Santhanam, Mohd Nizam Tzar, Ang-Lim Chua, Sharifah Fadilah Abdul Wahid, Wan Rahiza Wan Mat, Raha Abd Rahman, Petrick Periyasamy

“…Against the clinical diagnosis of proven or probable IFDs, the findings show that the LFA system produced a high specificity of 99.4 % while the sensitivity was only moderate at 47.8 % due to the difficulty of extracting fungal DNA from blood samples. …”
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Special Staining of the Liquid-Based Cytopathology Test in Bronchoalveolar Lavage Fluid for Diagnosis of Invasive Pulmonary Aspergillosis with Nonneutropenic Patients by Yue Hu, Lin Zheng, Deng Pan, Lei Shao, Xianfa Xu, Yiming Yu, Qidong Zhuang, Zaichun Deng, Zhongbo Chen

“…Among 47 possible IPA patients, 25 patients had proven/probable IPA, and 11 patients had other invasive fungal diseases. …”
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Clinical Differences between Eosinophilic and Noneosinophilic Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Multicenter Cross-Sectional Study by Guangming Dai, Yajuan Ran, Jiajia Wang, Xingru Chen, Junnan Peng, Xinglong Li, Huojin Deng, Min Xiao, Tao Zhu

“…Our results indicate that viral-dominant infections are the probable major etiologies of eosinophilic AECOPD. Noneosinophilic AECOPD is more likely associated with bacterial-dominant infections. …”
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