Improving drug repositioning with negative data labeling using large language models by Milan Picard, Mickael Leclercq, Antoine Bodein, Marie Pier Scott-Boyer, Olivier Perin, Arnaud Droit

“…Positive-Unlabeled (PU) learning has been used to overcome this issue by either randomly sampling unlabeled drugs or identifying probable negatives but still suffers from misclassification or oversimplified decision boundaries. …”
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Ajouts, omissions, substitutions : la main fautive des copistes dans le texte de L’Éducation sentimentale by Pierre-Marc de Biasi, Déborah Boltz

“…The copyists’ copy – we have noted four different handwritings – has until today never been studied. Why? Probably because the act itself of “copying” has always been considered negligible, quite insignificant. …”
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Changes in Hemodynamics and Tissue Oxygenation Saturation in the Brain and Skeletal Muscle Induced by Speech Therapy – A Near-Infrared Spectroscopy Study by U. Wolf, F. Scholkmann, R. Rosenberger, M. Wolf, M. Nelle

“…Possible physiological explanations for these changes are discussed. A probable reason is a different effect of recitations on the sympathetic nervous system. …”
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The impact of the ursodeoxycholic acid as monotherapy and in the combination with the lactulose on the biochemical blood tests values of the nonalcoholic steatohepatitis patients by I. V. Mayev, Yu. A. Kucheryavyy, S. V. Morozov, M. G. Saidullayeva, M. L. Akhtayeva, N. Yu. Stukova, E. A. Krasnyakova

“…However, the statistical credibility was not reached, which, probably, can be explained by the peculiarities of the sampling.Conclusions. …”
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Deníky Marie Jany hraběnky Harbuval von Chamaré (1722-1792) by Pavla Janáčková

“…However, Maria Johanna probably prefered a quiet way of living, but it is also possible that the lack of other archive material disallows us to reveal all her life. …”
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FTIR: A novel method for identifying fish gut contents by Abolfazl Aminimehr, Mohammad Amini Chermahini, Laleh Moosavi Dehmoordi

“…However, the formulated feed, which is a mixture of various plant and animal-derived materials, and its resulting feces were not as distinguishable.Conclusion: According to the results, it seems that the FTIR will be practical and reliable method to identify foods used by fish in aquaculture or nature using fish feces. Probably, in the latter case, it will be easier to identify, because in nature, more uniform food items (plant or animal sources) are usually consumed.…”
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Devonian–Mississippian magmatism related to extensional collapse in Svalbard: implications for radiating dyke swarms [version 1; peer review: 2 approved] by Gillian R. Foulger, Sebastian Tappe, Jean-Baptiste P. Koehl, Ingrid M. Anell

“…The sills are unconformably overlain by relatively undeformed Pennsylvanian–Mesozoic sedimentary rocks and crosscut by Cretaceous dykes of the High Arctic Large Igneous Province. The sills probably intruded along extensional fractures during post-Caledonian reactivation–overprinting of the late Neoproterozoic thrust system. …”
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The Suitability of Recycled Domestic Wastewater in Plain Concrete Production. by Orishaba, James

“…The compressive strength for concrete mixed with freshwater and secondary treated wastewater exceeded the characteristic strength but did not reach the target mean strength at 28 days probably because of environmental conditions such as temperature where the cubes were casted from which were not controlled, but it was ok since it was greater than the characteristic strength.…”
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Management Style and Employee Performance in Selected Primary Schools in Kajara County, Ntungamo District by Denis, Kamusiime Banshobeize

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Bothrops asper snake venom and its metalloproteinase BaP–1 activate the complement system. Role in leucocyte recruitment by Sandra H. P. Farsky, Luís Roberto C. Gonçalves, José M. Gutiérrez, Adriana P. Correa, Alexandra Rucavado, Philippe Gasque, Denise V. Tambourgi

“…Data obtained demonstrated that serum incubated with crude venom and its purified metalloproteinase BaP–1 are able to induce rat neutrophil chemotaxis, probably mediated by agent(s) derived from the complement system. …”
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Fluvial terrace formation in a mountainous area (2): influence of eustatism, tectonics and altitudinal distribution of watersheds based on an allostratigraphic study (Albania) by Mugnier, Jean-Louis, Guzmán, Oswaldo, Vassallo, Riccardo,  Matraku, Kristina, Jouanne, François

“…The thick Holocene valley fill, locally affected by fill-cut terraces, extends several tens kilometer within the mountain valleys and is probably linked to the mid-Holocene sea-level highstand.…”
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Dark Matter Halos of Luminous Active Galactic Nuclei from Galaxy–Galaxy Lensing with the HSC Subaru Strategic Program by Wentao Luo, John D. Silverman, Surhud More, Andy Goulding, Hironao Miyatake, Takahiro Nishimichi, Chiaki Hikage, Lalitwadee Kawinwanichakij, Junyao Li, Qinxun Li, Xiangchong Li, Elinor Medezinski, Masamune Oguri, Taira Oogi, Cristobal Sifon

“…These results indicate that massive halos with a higher clustering bias tend to suppress AGN activity, probably due to the lack of available gas.…”
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Safety and Efficacy of Second-Generation Drug-Eluting Stents in Real-World Practice: Insights from the Multicenter Grand-DES Registry by You-Jeong Ki, Kyung Woo Park, Jeehoon Kang, Chee-Hoon Kim, Jung-Kyu Han, Han-Mo Yang, Hyun-Jae Kang, Bon-Kwon Koo, Hyo-Soo Kim

“…The rate of definite or probable stent thrombosis (0.6% vs. 0.8% vs. 0.5%, P=0.549) was similar. …”
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Cost-Effectiveness of Bariatric Surgery versus Medication Therapy for Obese Patients with Type 2 Diabetes in China: A Markov Analysis by Bin Wan, Nan Fang, Wei Guan, Haixia Ding, Ying Wang, Xin Ge, Hui Liang, Xin Li, Yiyang Zhan

“…The health-care costs in the bariatric surgery group, proportion of patients in each group with remission of diabetes, and state transition probabilities were calculated based on observed resource utilization from the hospital information system (HIS). …”
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Inhaling arsenic aggravates airway hyperreactivity by upregulating PNEC-sourced 5-HT in OVA-induced allergic asthma by Xue Lu, Zhu-Xia Tan, Ya-Xin Yao, Ze-Yan Li, Yan-Yan Zhu, Qian-Qun Yang, Zhao Li, Kun Peng, Yan Wang, De-Xiang Xu

“…Mechanistically, OVA-induced elevation of 5-hydroxytryptamine (5-HT), probably secreted by pulmonary neuroendocrine cells (PNECs), was exacerbated in As-exposed mice. …”
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Allium cepa L. as a natural antioxidant: Its efficacy in combating heat stress-induced physiological alterations by Ayobami O. Sobanke, Afusat Aiyeola, Frances I. Okwuonu, Wuraola S. Nnaemeka, Jeremiah C. Ndubuisi, Franklin I. Udeoji, Jane N. Adiele

“…However, the positive benefits of AC were partially diminished in the HS + AC group, perhaps due to the severe oxidative stress caused by heat stress (HS).This study highlights the probable potential of AC as a natural antioxidant in modifying heat stress-induced oxidative damage, hematological changes, and lipid metabolism disruptions; however, its protective effects are insufficient to mitigate heat stress. …”
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Effects of the Proactive Interdisciplinary Self-Management (PRISMA) Program on Online Care Platform Usage in Patients with Type 2 Diabetes in Primary Care: A Randomized Controlled... by Esther du Pon, Nanne Kleefstra, Frits Cleveringa, Ad van Dooren, Eibert R. Heerdink, Sandra van Dulmen

“…In addition, only a small proportion of the patients logged on twice or more. Patients probably need other encouragements to manage their condition using an online platform.…”
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Late-onset first epileptic seizure and cerebral small vessel disease: role of juxtacortical white matter lesions by Adrian Nasca, Adrian Nasca, Leo Sokolovič, Leo Sokolovič, Oliver Koprda, Patrick Haage, Patrick Haage, Thorsten Schmidt, Juraj Kukolja, Juraj Kukolja

“…ObjectiveThe cause of late-onset first epileptic seizures (LOFES) in older age is often not readily evident. In absence of probable causes, it has been suggested that cerebral small vessel disease (CSVD), which is common with increasing age, may be crucial. …”
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Congenital muscular dystrophies and myopathies: the leading cause of genetic muscular disorders in eleven Chinese families by Bin Mao, Xiaoling Cai, Na Lin, Yulin Jiang, Na Hao, Yifang Dai, Danhua Guo, Deqin He, Huili Xue, Lingji Chen, Qianqian He, Min Zhang, Meihuan Chen, Hailong Huang, Liangpu Xu

“…Conclusions CMDs and CMYOs were probably responsible for most of the cases (9/11) of genetic muscular defects in this study. …”
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Fitness costs of Mycobacterium tuberculosis resistant to rifampicin is compensated by rapid Th2 polarization mediated by early and high IL-4 production during mice infection by Ma. Fernanda Arce-Aceves, Roberto Espinosa-Neira, Dulce A. Mata-Espinosa, Jorge A. Barrios-Payan, Hugo G. Castelán-Sánchez, Sofía L. Alcaraz-Estrada, Mauricio Castañón-Arreola, Rogelio Hernández-Pando

“…Thus, high and rapid bias to Th2 response is a mechanism of Mtb virulence, which could be mediated by rifampicin-resistant Mtb isolates, probably by high production and secretion of specific antigens.…”
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