A Corticobasal Syndrome Variant of Familial Creutzfeldt-Jakob Disease with Stroke-Like Onset by Ján Necpál, Martin Stelzer, Silvia Koščová, Michal Patarák

“…Creutzfeldt-Jakob disease (CJD) is an untreatable rare human prion disease characterized by rapidly progressive dementia along with various neurological features, including myoclonus and sometimes other movement disorders. …”
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RNA-Binding Proteins in Amyotrophic Lateral Sclerosis and Neurodegeneration by Scott E. Ugras, James Shorter

“…While the causes of this devastating disease are poorly understood, recent advances have implicated RNA-binding proteins (RBPs) that contain predicted prion domains as a major culprit. Specifically, mutations in the RBPs TDP-43 and FUS can cause ALS. …”
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Preface by Peter Hinow, Pierre Magal, Shigui Ruan

“…Webb.The topics of the 12 articles appearing in this special issue includeevolutionary dynamics of population growth, spatio-temporal dynamicsin reaction-diffusion biological models, transmission dynamics ofinfectious diseases, modeling of antibiotic-resistant bacteria in hospitals,analysis of Prion models, age-structured models in ecology and epidemiology,modeling of immune response to infections, modeling of cancer growth, etc.These topics partially represent the broad areas of Glenn's research interest.For more information please click the “Full Text” above.…”
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Synaptic Paths to Neurodegeneration: The Emerging Role of TDP-43 and FUS in Synaptic Functions by Shuo-Chien Ling

“…Furthermore, the ability of the low-complexity prion-like domains of TDP-43 and FUS to form liquid droplets suggests a potential mechanism for mRNP assembly and conversion. …”
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Toll-Like Receptors Expression and Signaling in Glia Cells in Neuro-Amyloidogenic Diseases: Towards Future Therapeutic Application by Dorit Trudler, Dorit Farfara, Dan Frenkel

“…This paper will focus on TLR signaling in glial cells in neurodegenerative diseases such as Alzheimer's disease, prion diseases, amyotrophic lateral sclerosis, and Parkinson's disease. …”
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Down but Not Out: The Consequences of Pretangle Tau in the Locus Coeruleus by Termpanit Chalermpalanupap, David Weinshenker, Jacki M. Rorabaugh

“…In this review, we combine the literature on how pathogenic tau affects forebrain neurons with the known properties and degeneration patterns of LC neurons to synthesize hypotheses on hyperphosphorylated tau-induced dysfunction of LC neurons and the prion-like spread of pretangle tau from the LC to the forebrain. …”
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The Contribution of α-Synuclein Spreading to Parkinson’s Disease Synaptopathy by Francesca Longhena, Gaia Faustini, Cristina Missale, Marina Pizzi, PierFranco Spano, Arianna Bellucci

“…Indeed, monomeric, oligomeric, and fibrillary α-synuclein can move from cell to cell and can trigger the aggregation of the endogenous protein in recipient neurons. This novel “prion-like” behavior could further contribute to synaptic failure in PD and other synucleinopathies. …”
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Creutzfeldt-Jakob Disease and Infection Control by Lynn Johnston, John Conly

“…However, a recent American publication made recommendations on what procedures should be used for reprocessing items that have been in contact with the prion protein (PrP) (4). These recommendations differ substantially from the draft Canadian guidelines. …”
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Recursive seed amplification detects distinct α-synuclein strains in cerebrospinal fluid of patients with Parkinson’s disease by Stefan Bräuer, Iñaki Schniewind, Elisabeth Dinter, Björn H. Falkenburger

“…Pathologically, it is characterized by neuronal inclusions containing misfolded, fibrillar alpha-synuclein (aSyn). Prion-like properties of aSyn contribute to the spread of aSyn pathology throughout the nervous system as the disease progresses. …”
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The doppel (Dpl) Protein Influences In Vitro Migration Capability in Astrocytoma-Derived Cells by Alberto Azzalin, Elena Sbalchiero, Giulia Barbieri, Silvia Palumbo, Cristina Muzzini, Sergio Comincini

“…Doppel (Dpl) protein is the paralogue of the cellular prion (PrPC) protein. In humans, Dpl is expressed almost exclusively in testis where it is involved in spermatogenesis. …”
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Bioinformatics Analysis of Exercise-Related Biomarkers in Diabetes by Xiaoju Bao, Jingyue Qiu, Qin Xuan, Xinming Ye

“…Then, the GSEA analysis showed that 6 KEGG pathways were associated with postexercise prediabetic samples, namely, ABC transporters, focal adhesion, MAPK signaling pathway, prion diseases, melanogenesis, and gap junction. …”
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Human Islet Amyloid Polypeptide Fibril Binding to Catalase: A Transmission Electron Microscopy and Microplate Study by Nathaniel G. N. Milton, J. Robin Harris

“…Human IAPP fibrils are toxic in a similar manner to Alzheimer's amyloid-β (Aβ) and prion protein (PrP) fibrils. Previous studies have shown that catalase binds to Aβ fibrils and appears to recognize a region containing the Gly-Ala-Ile-Ile sequence that is similar to the Gly-Ala-Ile-Leu sequence found in human IAPP residues 24-27. …”
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Pengembangan dan Efektivitas Buku Panduan Konseling Karir Ginzberg dengan Teknik Modeling untuk Memilih Studi Lanjut Siswa by I Komang Agus Ugrasena, I Ketut Dharsana, Kadek Suranata

“…The results of the study concluded that the results obtained from the validity test using Lawshe, Gilbert, G. E., & Prion, S. (2016) CVR and CVI showed a per-item value greater than 0 (CVR>0). …”
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Brain-derived tau oligomer polymorphs: distinct aggregations, stability profiles, and biological activities by Filippa Lo Cascio, Suhyeorn Park, Urmi Sengupta, Nicha Puangmalai, Nemil Bhatt, Nikita Shchankin, Cynthia Jerez, Naomi Moreno, Alice Bittar, Rhea Xavier, Yingxin Zhao, Cankun Wang, Hongjun Fu, Qin Ma, Mauro Montalbano, Rakez Kayed

“…Tau oligomers are suggested to be the primary neurotoxic species that initiate aggregation and propagate prion-like structures. Furthermore, different diseases are shown to have distinct structural characteristics of aggregated tau, denoted as polymorphs. …”
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Early Delivery of Misfolded PrP from ER to Lysosomes by Autophagy by Constanza J. Cortes, Kefeng Qin, Eric M. Norstrom, William N. Green, Vytautas P. Bindokas, James A. Mastrianni

“…Prion diseases are linked to the accumulation of a misfolded isoform (PrPSc) of prion protein (PrP). …”
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Pharmacological Modulation of Three Modalities of CA1 Hippocampal Long-Term Potentiation in the Ts65Dn Mouse Model of Down Syndrome by Jonah J. Scott-McKean, Adriano L. Roque, Krystyna Surewicz, Mark W. Johnson, Witold K. Surewicz, Alberto C. S. Costa

“…Because 4xHFS-induced LTP had not yet been characterized in Ts65Dn mice, we also investigated the effects of picrotoxin, amyloid beta oligomers, and soluble recombinant human prion protein (rPrP) on this form of LTP. Whereas ≥10 μM picrotoxin increased LTP to control levels, it also caused seizure-like oscillations. …”
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Iatrogenic cerebral amyloid angiopathy and Alzheimer's disease co‐pathology by Francisco Hernández‐Fernández, Isabel Martínez‐Fernández, Rosa Barbella‐Aponte, Inmaculada Feria Vilar, Oscar Ayo‐Martín, Jorge García‐García, Rosa Collado, Alberto Andrés, Mar Hernández‐Guillamón, Francisco José Pena Pardo, Cristina Barrena, Miguel de laFuente, Gemma Serrano‐Heras, María Melero, Elena Lozano Setién, Luis López, Tomás Segura

“…Abstract Iatrogenic cerebral amyloid angiopathy, a disease caused by contact with neurosurgical material or human growth hormone contaminated by beta‐amyloid peptide (Aβ), has a prion‐like transmission mechanism. We present a series of three patients under 55 years of age who underwent cranial surgery. …”
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Halloysite clay nanotubes as platforms for loading of aptamers and antisense oligonucleotides by Maria Rita Caruso, Martina Maria Calvino, Giuseppe Cavallaro, Jussara Amato, Simona Marzano, Federica D'Aria, Concetta Giancola, Giuseppe Lazzara, Stefana Milioto, Bruno Pagano

“…In this study, halloysite clay nanotubes have been investigated as a platform for the encapsulation of an antisense oligonucleotide (ASO1) and a DNA aptamer (D12) with potential in the treatment of prion diseases. The loading of both molecules within halloysite cavity has been conducted by using the cyclic vacuum assisted protocol in aqueous medium. …”
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Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neurons by Amir T. Marvian, Tabea Strauss, Qilin Tang, Benjamin J. Tuck, Sophie Keeling, Daniel Rüdiger, Negar Mirzazadeh Dizaji, Hossein Mohammad-Beigi, Brigitte Nuscher, Pijush Chakraborty, Duncan S. Sutherland, William A. McEwan, Thomas Köglsperger, Stefan Zahler, Markus Zweckstetter, Stefan F. Lichtenthaler, Wolfgang Wurst, Sigrid Schwarz, Günter Höglinger

“…Abstract Background The prion-like spreading of Tau pathology is the leading cause of disease progression in various tauopathies. …”
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