Clinical Characteristics of Concomitant Systemic Lupus Erythematosus and Primary Biliary Cirrhosis: A Literature Review by Toru Shizuma

“…Although autoimmune diseases often coexist, concomitant cases of systemic lupus erythematosus (SLE) and primary biliary cirrhosis (PBC) are uncommon. In this review paper, 34 cases of SLE with concomitant PBC found in English and Japanese scientific literature and Japanese proceedings were reviewed and summarized, including cases with liver dysfunction complicated by SLE. …”
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Novel Approach to Bile Duct Damage in Primary Biliary Cirrhosis: Participation of Cellular Senescence and Autophagy by Motoko Sasaki, Yasuni Nakanuma

“…Primary biliary cirrhosis (PBC) is characterized by antimitochondrial autoantibodies (AMAs) in patients' sera and histologically by chronic nonsuppurative destructive cholangitis in small bile ducts, eventually followed by extensive bile duct loss and biliary cirrhosis. …”
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Vitamin D Receptor Polymorphisms Predispose to Primary Biliary Cirrhosis and Severity of the Disease in Polish Population by Agnieszka Kempińska-Podhorecka, Ewa Wunsch, Tomasz Jarowicz, Joanna Raszeja-Wyszomirska, Beata Loniewska, Mariusz Kaczmarczyk, Małgorzata Milkiewicz, Piotr Milkiewicz

“…Primary biliary cirrhosis (PBC) is a chronic cholestatic liver condition characterized by the immune-mediated damage of the intrahepatic bile ducts. …”
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Role of Plasmapheresis in the Treatment of Severe Pruritus in Pregnant Patients with Primary Biliary Cirrhosis: Case Reports by Alallam Alallam, David Barth, E Jenny Heathcote

“…BACKGROUND: Primary biliary cirrhosis (PBC) may be associated with pruritus and, when present, may be accentuated during pregnancy. …”
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TRAF1 Gene Polymorphism Correlates with the Titre of Gp210 Antibody in Patients with Primary Biliary Cirrhosis by Agnieszka Kempinska-Podhorodecka, Zakera Shums, Michał Wasilewicz, Ewa Wunsch, Malgorzata Milkiewicz, Dimitrios P. Bogdanos, Gary L. Norman, Piotr Milkiewicz

“…Whether TRAF1 polymorphisms confer increased risk for primary biliary cirrhosis (PBC), an autoimmune liver disease which can co-exist with RA, is unknown. …”
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SP140L, an Evolutionarily Recent Member of the SP100 Family, Is an Autoantigen in Primary Biliary Cirrhosis by Mario Saare, Uku Hämarik, Rainis Venta, Marina Panarina, Chiara Zucchelli, Maire Pihlap, Anu Remm, Kai Kisand, Urve Toots, Kaidi Möll, Riina Salupere, Giovanna Musco, Raivo Uibo, Pärt Peterson

“…In conclusion, our results show that SP140L is phylogenetically recent member of SP100 proteins and acts as an autoantigen in primary biliary cirrhosis patients.…”
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Combination Therapy of Ursodeoxycholic Acid and Corticosteroids for Primary Biliary Cirrhosis with Features of Autoimmune Hepatitis: A Meta-Analysis by Yan Zhang, Jie Lu, Weiqi Dai, Fan Wang, Miao Shen, Jing Yang, Rong Zhu, Huawei Zhang, Kan Chen, Ping Cheng, Lei He, Chengfen Wang, Ling Xu, Yingqun Zhou, Chuanyong Guo

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Characterization of Autoantibodies against the E1𝜶 Subunit of Branched-Chain 2-Oxoacid Dehydrogenase in Patients with Primary Biliary Cirrhosis by Tsutomu Mori, Hiromasa Ohira, Masahito Kuroda, Masaki Kato, Yoshiki Yamaguchi, Hideo Kochi

“…Primary biliary cirrhosis (PBC) is characterized by antimitochondrial antibodies (AMAs) that react with the lipoyl-containing E2 subunits of 2-oxoacid dehydrogenase complexes such as BCOADC and PDC. …”
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Noninvasive diagnostic methods of liver fibrosis in patients with primary biliary cirrhosis and primary sclerosing cholangitis: role of indirect serological markers by A. F. Sheptulina, Ye. N. Shirokova, V. T. Ivashkin

“…Considering prognostic value and dynamic nature of liver fibrosis in chronic cholestatic diseases: primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC), severity assessment by liver biopsy and/or noninvasive methods should be obligatory component of the investigation plan during patient follow-up to estimate treatment response. …”
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Nuclear receptors in regulation of bile acids transport and metabolism by A. F. Sheptulina, Ye. N. Shirokova, V. T. Ivashkin

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A Review of the Physiological and Immunological Functions of Biliary Epithelial Cells: Targets for Primary Biliary Cirrhosis, Primary Sclerosing Cholangitis and Drug-induced Ductopenias by Chih-Te Wu, Paul A. Davis, VelImir A. Luketic, M. Eric Gershwin

“…These then suggest a myriad of potential roles for BEC in defense from invading microorganisms as well as the pathogenesis of diverse immunologically driven diseases such as primary biliary cirrhosis (PBC), graft-versus-host disease, and primary sclerosing cholangitis (PSC). …”
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A Case of Rheumatoid Arthritis and Limited Systemic Sclerosis Overlap Successfully Treated with Tocilizumab for Arthritis and Concomitant Generalized Lymphadenopathy and Primary Biliary Cirrhosis by Eiko Saito, Shinji Sato, Shinichi Nogi, Noriko Sasaki, Naofumi Chinen, Kiri Honda, Takayuki Wakabayashi, Chiho Yamada, Naoya Nakamura, Yasuo Suzuki

“…A 57-year-old woman with rheumatoid arthritis (RA) and limited systemic sclerosis (lSSc) was suspected to have lymphadenopathy and primary biliary cirrhosis (PBC). Lymph node biopsy showed reactive follicular lymphadenopathy with intrafollicular plasmacyte infiltration that was interleukin-6 positive by immunohistostaining. …”
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Treatment response rate and life prognosis at autoimmune liver diseases by K. V. Ivashkin, Ye. N. Shirokova, V. T. Ivashkin

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Medical Management of Chronic Cholestatic Liver Diseases by Andrea A Gossard, Keith D Lindor

“…Primary biliary cirrhosis and primary sclerosing cholangitis are reviewed in detail, and management options are identified. …”
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Efficacy of silymarinum at chronic diffuse liver diseases by A. V. Matvieiev, E. I. Konyaeva, N. V. Matvieieva

“…To present modern data of foreign literature on efficacy of preparation of Silybum marianum – silymarinum at patients with alcoholinduced liver disease, non-alcoholic steatohepatosis and primary biliary cirrhosis.Original positions. Analysis of literary data demonstrated, that silymarinum is a safe pharmaceutical and, despite of a plenty of clinical and experimental publications, its efficacy at alcoholic liver disease and primary biliary cirrhosis requires further studying as series of systematic reviews and metaanalyses are subject for discussion due to the absence of uniform methodological approaches, application of drugs with different pharmakokinetics and because of ignoring of evidencebased medicine requirements.Conclusion. …”
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Hepatobiliary Tract and Pancreatic Disorders in Celiac Disease by Hugh J Freeman

“…Some disorders have shared immunological or genetic factors, including chronic hepatitis, primary biliary cirrhosis and sclerosing cholangitis. …”
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The Histone Modification Code in the Pathogenesis of Autoimmune Diseases by Yasuto Araki, Toshihide Mimura

“…In this paper, we discuss the significant roles of histone modifications involved in the pathogenesis of autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, primary biliary cirrhosis, and type 1 diabetes.…”
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Genetic Contribution to the Pathogenesis of Primary Biliary Cholangitis by Satoru Joshita, Takeji Umemura, Eiji Tanaka, Masao Ota

“…Formerly termed primary biliary cirrhosis, primary biliary cholangitis (PBC) is a chronic and progressive cholestatic liver disease characterized by the presence of antimitochondrial antibodies. …”
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Lifetime of patients and prognostic value of manifestations and complications of liver cirrhosis by G. K. Mirodzhov, S. A. Avezov, N. S. Tukhtayeva, A. Bakhtibekov, M. M. Giyasov

“…Alcohol-induced LC and primary biliary cirrhosis are over 10 and 5 times less frequent respectively. …”
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Unexplained Findings of Kayser-Fleischer-Like Rings in a Patient with Cryptogenic Cirrhosis by Mahreema Jawairia, Miral Subhani, Ghulam Siddiqui, Apsara Prasad, Ghulamullah Shahzad, Kaleem Rizvon, Paul Mustacchia

“…Cryptogenic cirrhosis (CC) is defined as cirrhosis occurring in an individual without an identifiable cause of liver disease, such as excessive alcohol consumption, viral hepatitis infection, hemochromatosis, autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, chronic intake of medications that could induce cirrhosis, alpha-1-antitrypsin deficiency, Wilson’s disease, or any other rare cause of cirrhosis according to the clinical context. …”
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