Metabolomic alterations in the plasma of patients with various clinical manifestations of COVID-19 by Qi Xin, Xiao Liang, Jin Yang, Xiaorui Wang, Fang Hu, Meng Jiang, Yijia Liu, Jin Gong, Yiwen Pan, Lijuan Liu, Jiao Xu, Yuxin Cui, Hongyu Qin, Han Bai, Yixin Li, Junpeng Ma, Chengsheng Zhang, Bingyin Shi

“…By examining differential expression, we identified candidate metabolites associated with different SARS-CoV-2 infection presentations. Functional and machine learning analyses were performed to explore the metabolites’ functions and verify their candidacy as biomarkers. …”
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<i>Codonopsis pilosula</i> Polysaccharides Exert Antiviral Effect Through Activating Immune Function in a Macrophage Model of Bovine Viral Diarrhea Virus Infection by Xiaowei Feng, Lei Wang, Jingyan Zhang, Haipeng Feng, Xiaoliang Chen, Junyan Wang, Mingxian Shi, Kang Zhang, Jianxi Li

“…The immunity suppression resulting from BVDV in BoMac cells was restored by CPPs, as was verified by phagocytosis increase, the expression up-regulation of cell surface co-stimulatory molecules (CD40, CD80, and CD86), and antigen-presenting function recovery. Furthermore, the expressions of cytokines including TNF-α, IFN-γ, IL-6, IL-18, IL-1β, Caspase-3, Bim, and Bcl-xL at the mRNA and proteins levels were modulated, and a reduction in the apoptosis rate was observed, which demonstrates that CPPs attenuated inflammation and apoptosis induced by BVDV. …”
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Radiological and clinical prognosis of posterior lumbar intervertebral body cage versus posterior transpedicular screw fixation in patient with isthmic spondylolisthesis by Kawa Muhammed Kareem, Ameer Majeed Kareem, Samih Kakamam Hassan, Salim Mardan Omer

“…The research aimed to distinguish discrepancies in clinical presentation, functional outcomes, and mechanical characteristics by evaluating clinical, radiographic, activity, and pain information. …”
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Explosive tumor growth in a patient with colon cancer is associated with reduced neoantigen levels and decreased interferon-gamma (IFN-γ) signaling by Yaqi Wang, Jiahua Lu, Dandan Huang, Pengju Chen, Jingyi Shi, Jie Cheng, Jingbo Gan, Ruifeng Li, Jingxuan Xu, Zhaoya Gao, Xiaodong Wang, Wensheng Huang, Yanhui Yin, Hebing Chen, Jing Huang, Cheng Li, Jin Gu

“…Additionally, they had deficient antigen presentation functions as characterized by decreased IFN-γ signaling activity. …”
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Human Interleukin-1β Profile and Self-Reported Pain Monitoring Using Clear Aligners with or without Acceleration Techniques: A Case Report and Investigational Study by Selma Pascoal, Aline Gonçalves, Andreia Brandão, Duarte Rocha, Sofia Oliveira, Francisca Monteiro, Óscar Carvalho, Susana Coimbra, Teresa Pinho

“…Here, we report a case of a 46-year-old female patient who presented functional and aesthetic complaints. Intraoral examination revealed a diminished overjet and overbite, rotation of teeth 45 and 24, absence of teeth 25, 35, and 36, buccolingual dislocation of tooth 21, a tendency to a Class III malocclusion, and a 2 mm left deviation of the lower midline. …”
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Prediction of altered 3'- UTR miRNA-binding sites from RNA-Seq data: the swine leukocyte antigen complex (SLA) as a model region. by Marie-Laure Endale Ahanda, Eric R Fritz, Jordi Estellé, Zhi-Liang Hu, Ole Madsen, Martien A M Groenen, Dario Beraldi, Ronan Kapetanovic, David A Hume, Robert R R Rowland, Joan K Lunney, Claire Rogel-Gaillard, James M Reecy, Elisabetta Giuffra

“…Seven of these genes (SLA-1, SLA-6, SLA-DQA, SLA-DQB1, SLA-DOA, SLA-DOB and TAP1) are linked to antigen processing and presentation functions, which is reminiscent of associations with disease traits reported for altered miRNA binding to MHC genes in humans. …”
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The use of Functional Capacity Scale in the Assessment of Patients with Traumatic Brain Injury — Multicenter Studies by Robert Ślusarz, Regina Lorencowicz, Joanna Rosińczuk, Renata Jabłońska, Agnieszka Królikowska, Maciej Śniegocki

“…The main aim of this work was to present Functional Capacity Scale in the assessment of patients after traumatic brain injury. …”
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Mixing and switching of speech codes of Ukrainian emigration (on the example of memoirs and epistolary works by Ulas Samchuk) by Mariia Panhelova

“…The purpose of our scientific studio is to present function the mixing and switching codes on the materials of the memoirs («Planet DP») and the epistolary works of Ukrainian writers-emigrants in Canada, in particular, by Ulas O. …”
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Interaction of bacterial extracellular microvesicles with eukaryotic cells. by D. S. Shlykova, V. M. Pisarev, A. M. Gaponov, A. V. Tutelyan

“…In some cases BMV use mechanisms to evade immune surveillance: anti-inflammatory cytokines secretion, alterations of phagocytosis and chemotaxis of macrophages, increasing the proteolytic cleavage of CD14 on the macrophage surface, alterations of antigen-presenting function of dendritic cells, T-cell proliferation suppression, reducing the pro-inflammatory cytokines secretion, evasion of host-immune cells direct interactions, destruction of neutrophilic traps. …”
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The role of epithelial cells in atopy pathogenesis by A. N. Kazimirsky, J. M. Salmasi, G. V. Poryadin, O. A. Svitich, B. G. Bragvadze, A. A. Alekseeva, L. V. Gankovskaya

“…These cytokines have an immunoregulatory action - their nearby antigen presenting functions format the Th2 type of immune response, promote the production of cytokines (IL-4, IL-9, IL-13) and cause the development of an allergic type of inflammation.Conclusion. …”
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Professional propaedeutic council in the university by N. N. Malyarchuk, G. M. Krinitzyna, E. V. Pashchenko, V. V. Pivnenko

“…The structure of such council, its organisational-network, medical-social and educational-methodological blocks are presented. Functional duties of experts and specialists, united in each of PPC blocks, are defined.Practical significance. …”
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Chronic lung tissue deposition of inhaled polyethylene microplastics may lead to fibrotic lesions by Wonkyun Jung, Mi-Jin Yang, Min-Sung Kang, Jin-Bae Kim, Kyung-Sik Yoon, Taekyung Yu, Cheolho Yoon, Hae Won Yang, Seong-Jin Choi, Eun-Jung Park

“…Taken together, we suggest that chronic pulmonary exposure to PE-MPs may cause immune dysregulation by impairing the antigen-presenting function of alveolar macrophages and that PE-MP-induced chronic inflammation may be linked to fibrotic lesions. …”
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Development of a fully integrated hydrological fate and transport model for plant protection products: incorporating groundwater, tile drainage, and runoff by Michael V. Callaghan, Steven K. Frey, Steven K. Frey, Killian Miller, Hyoun-Tae Hwang, Hyoun-Tae Hwang, Reza Zolfaghari, Klaus Hammel, Steven J. Berg, Steven J. Berg, Edward A. Sudicky, Edward A. Sudicky

“…Separate analysis of individual exposure pathways can result in disparate assumptions being made that represent relative worst-case scenarios for each pathway, rather than an integrated reasonable worst-case scenario for all pathways.MethodsThe interplay between PPP degradation, leaching to groundwater, transport in tile drainage, and runoff is well-suited for simulation using an integrated surface–subsurface hydrologic and chemical fate and transport model. This study presents functionality added to HydroGeoSphere (HGS), a three-dimensional, fully integrated, surface–subsurface hydrologic model. …”
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Limitación funcional y rendimiento académico en universitarios de Popayán, Colombia (Functional limitation and academic performance in university students from Popayan, Colombia)... by Nancy Janneth Molano-Tobar, Dolly Ximena Molano-Tobar, Enmanuel Fernando Portilla Fernández

“…It was found that the population in general did not present functional limitations, but those that do appear are related to academic performance corresponding to cognitive, visual, voice and speech functions, with statistical significance (p=0.000). …”
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Exploring How Older Adults Experience semAPP, a 360° Media–Based Tool for Memory Assessment: Qualitative Study by Francesca Bruni, Valentina Mancuso, Jonathan Panigada, Marco Stramba-Badiale, Pietro Cipresso, Elisa Pedroli

“…Moreover, the results match the idea that usability might be influenced by different factors depending on instrument and personal features, such as presentation, functionality, system performance, interactive behavior, attitudes, skills, and personality. …”
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Itaconate derivative 4-OI inhibits M1 macrophage polarization and restores its impaired function in immune thrombocytopenia through metabolic reprogramming by Qiang Liu, Anli Liu, Shaoqiu Leng, Xiaoyu Zhang, Xiaolin Wang, Zhang Cheng, Shuwen Wang, Jun Peng, Qi Feng, Sihan Zhou, Xiuyuan Hao

“…Macrophage polarization, antigen-presenting functions, and phagocytic capability were measured via flow cytometry and enzyme-linked immunosorbent assay (ELISA). …”
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MONOCYTE SUBSETS IN HEALTHY ADULTS AND SEPSIS PATIENTS by A. A. Kalashnikova, T. M. Voroshilova, L. V. Chinenova, N. I. Davydova, N. M. Kalinina

“…IL-10 suppresses the antigen-presenting function of intermediate cells, namely, expression of HLA-DR molecules, as suggested by inverse correlation between the IL-10 concentration and HLA-DR expression density on CD14+CD16+ cells. …”
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