One size does not fit all: revising traditional paradigms for assessing accuracy of QSAR models used for virtual screening by James Wellnitz, Sankalp Jain, Joshua E. Hochuli, Travis Maxfield, Eugene N. Muratov, Alexander Tropsha, Alexey V. Zakharov

“…For this increasingly common task, we now recommend the use of models with the highest positive predictive value (PPV) built on imbalanced training sets as preferred virtual screening tools. This recommendation stems from practical considerations of how the results of virtual screening are used in experimental laboratories where only a small fraction of virtually screened molecules can be tested using standard well plates. …”
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The Gut Microbiome Regulates the Psychomotor Effects and Context-Dependent Rewarding Responses to Cocaine in Germ-Free and Antibiotic-Treated Animal Models by Andrew D. Winters, Dina M. Francescutti, David J. Kracht, Diptaraj S. Chaudhari, Branislava Zagorac, Mariana Angoa-Perez

“…GF mice also showed reduced cocaine-conditioned place preference (CPP) (<i>p</i> = 0.002), which normalized after conventionalization. …”
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β-Glucosidase VmGlu1 is required for toxin production and pathogenicity of Valsa mali by Xinyue Cui, Dewan Zhang, Liyong Gao, Na Liu, Sen Lian, Weichao Ren, Baohua Li, Caixia Wang

“…In this study, we found that the expression level of the β-glucosidase gene VmGlu1 was induced by 9.42-fold following rutin treatment, and VmGlu1 possessed the capability to degrade both rutin and phloridzin, but under the same conditions, VmGlu1 showed a distinct preference for rutin degradation, with an initial degradation rate 8.66 times higher than that of VmGlu2. …”
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Silicon and Phosphorus Co-doping of Aluminium Nitride Nanotube (SiP-AlNNT) as Sensors for Polycyclic Aromatic Hydrocarbon Fuel Pollutants: A Computational Approach by Musa Runde, Uzairu Muhammad Sada, Friday Odey Izachi, Odey S. Eburu, Anthony M.S. Pembere

“…Comparing the behaviour of the nanotube towards sensing and adsorption of the various PAHs, preference due to tiny differences across the analyses is for anthracene. …”
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Effectively alleviate rheumatoid arthritis via maintaining redox balance, inducing macrophage repolarization and restoring homeostasis of fibroblast-like synoviocytes by metformin-... by Rui Zhang, Xingyu Lin, Rongjie Lin, Zhenbin Chen, Chenfang Miao, Yao Wang, Xiaoqin Deng, Jianlong Lin, Shishui Lin, Shaohuang Weng, Min Chen

“…Mechanistically, MCDs restored the homeostasis of FLSs while reducing the level of synovial inflammation by blocking IL-6/gp130 signaling pathway. Combined with preferable biocompatibility, MCDs offer a prospective treatment approach for RA.…”
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The state of the science of interprofessional collaborative practice: A scoping review of the patient health-related outcomes based literature published between 2010 and 2018. by May Nawal Lutfiyya, Linda Feng Chang, Cynthia McGrath, Clark Dana, Martin S Lipsky

“…<h4>Materials and methods</h4>A modified preferred reporting items for systematic reviews and meta-analyses (PRISMA) approach was followed.…”
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Dynamic distribution and accumulation of polycyclic aromatic hydrocarbons in Pueraria lobata during growth based on field experiment by Qing-xiang Jiang, Zhi-xin Wang, Xiang Zhou, Qiu-Fang Cao, Si-qi Hu, Jiang-nan Luo, Wen-wen Deng, Hui Li

“…The tissues absorption of PAHs were selective with the leaves preferring low-rings and roots for high-rings, due to high-rings PAH being difficult to migrate to the above-ground part through transpiration flow. …”
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Integrated malaria vector control strategies and their effectiveness in sub-Saharan Africa: a systematic review protocol for interventional studies by Diederick E Grobbee, Lihanimpo Djalogue, Marianne van der Sande, Patrice Ngangue, Gountante Kombate, Kamba Andre-Marie Soubeiga

“…This systematic review is designed to assess the effectiveness of integrated vector control versus single vector control interventions on malaria incidence and prevalence to guide decisions on controlling malaria vectors in sub-Saharan Africa.Methods and analyses We will systematically retrieve published and grey literature from electronic databases and clinical trial registries. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines will guide us in applying a systematic approach to screening, reviewing and extracting data. …”
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Integrated Recycling and The Impact of Plastic Waste from Industry and Agriculture on The Environment by Anar Zhumadilova, Saule Zhigitova, Maira Turalina, Kuralay Aitekova

“…A comparative analysis of scenarios with a discussion of their strengths and weaknesses was conducted, existing problems were considered and recommendations for possible solutions were provided. The preference for the RR scenario was reasoned. The results obtained can not only serve as an information source for scientific research, but also help practitioners solve the problem of plastic waste management in an environmentally safe and economical way. …”
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Psychological Safety in Saudi Arabian Healthcare: A Scoping Review by Yumna Ali, Roaya Alqurashi, Ahmed M. Asfahani, Mark Leonard, Catherine Elisa John, Yasuhiro Kotera

“…Methods: The review follows the Arksey and O'Malley (2005) method, using the Preferred Reporting Items for Systematic Reviews. The aim of a scoping review is to detect potential research gaps. …”
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A Scoping Review of Educational and Training Interventions on Parkinson’s Disease for Staff in Care Home Settings by Stacey Finlay, Tara Anderson, Elizabeth Henderson, Christine Brown Wilson, Patrick Stark, Gillian Carter, Matthew Rodger, Mihalis Doumas, Emma O’Shea, Laura Creighton, Stephanie Craig, Sophie Crooks, Arnelle Gillis, Gary Mitchell

“…Methods: A scoping review (ScR) was conducted and guided by the Preferred Reporting Items for Systematic Reviews and Meta-analysis extension for ScR (PRISMA-ScR) checklist. …”
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Contextualizing the challenges of education graduate students in the Philippines: translating needs analysis into strategic solutions by Nilo Jayoma Castulo, Arlyne C. Marasigan, Ma. Laarni D. Buenaventura, Jayson L. de Vera, Evelyn C. Bagaporo, Mark Ponce C. San Juan, Nathaniel S. Dalida

“…Respondents predominantly prefer enhancing their research skills through structured training, seminars, and workshops. …”
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Advancements in photovoltaic efficiency: The role of fluorine-doped CZTS in homojunction solar cells by Milad Yousefizad, Zohreh Golshan Bafghi, Amirmohammad Shahriyari, Andia Javanmardi, Naser Hakimi Raad, Ashraf Ahmadi Shadmehri, Siavosh Samoodi, Negin Manavizadeh, Ali Moafi

“…The DFT calculations indicate that F atoms prefer Cu sites and maintain a direct band gap in CZTS, promoting n-type conductivity. …”
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Rice straw degradation by Pseudomonas aeruginosa AMB-CD-1, isolated from fresh cow dung and its impact on rice plants by Kishan Raj, Anup Singh, Tapas Chowdhury, S Gupta, Ravindra Soni

“…Purpose Rice straw degradation in the soil is slow because of the high percentage of complex carbohydrates. Hence, farmers prefer to burn it in the agricultural field as a quicker alternative to the open burning of rice straw. …”
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Selection of an Effective Hand Sanitizer to Reduce COVID-19 Effects and Extension of TOPSIS Technique Based on Correlation Coefficient under Neutrosophic Hypersoft Set by Abdul Samad, Rana Muhammad Zulqarnain, Emre Sermutlu, Rifaqat Ali, Imran Siddique, Fahd Jarad, Thabet Abdeljawad

“…We also introduced some aggregation operators in the considered environment, which can help us establish a prioritization technique for order preference by similarity to the ideal solution (TOPSIS) based on CC and WCC under NHSS. …”
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Explaining the γγ + X excesses at ≈151.5 GeV via the Drell-Yan production of a Higgs triplet by Saiyad Ashanujjaman, Sumit Banik, Guglielmo Coloretti, Andreas Crivellin, Siddharth P. Maharathy, Bruce Mellado

“…Combining all channels in a likelihood ratio test, we find that a non-zero Br[Δ0→γγ], with a best-fit value of 0.66%, is preferred by ≈3σ for a mass of ≈151.5 GeV. While this mass is consistent with the multi-lepton anomalies, there is also an excess at ≈127 GeV with a significance of 3.6σ. …”
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Multi-generational exposure of Daphnia magna to pharmaceuticals: Effects on colonization, reproduction, and habitat selection behavior by María Pilar González, Ilaria Cecconi, David Salvatierra, María Úbeda-Manzanaro, Gema Parra, Eloísa Ramos-Rodríguez, Cristiano V.M. Araújo

“…In the habitat selection tests, organisms cultivated in clean water preferred the compartment with caffeine, highlighting its attractive effect. …”
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Digital light processing three-dimensional printing with acrylic–titanium composite powders for multiscale porous scaffolds by Guangbin Zhao, Yanlong Wu, Bochen Li, Hang Tian, Bo Li, Xiao Li, Xu Chen, Tao Zhou, Yaning Wang, Yichao Gong, Dingchang Hou, Yaxiong Liu, Xuewen Zong, Bingheng Lu

“…Compared with the raw powder slurries, the modified powder slurries exhibited higher stability and preferable curing characteristics, and the depth sensitivity of the modified powder slurries with 45 vol% solid loading increased by approximately 72%. …”
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Agenesis of Medial Patellofemoral Ligament (MPFL) with Habitual Patellar Dislocation in Adolescent Woman with Cerebral Palsy – A Case Report by Nurul Hidayah, Felix Giovanni Hartono, Bramta Putra Manyakori, Agus Sari Budaya

“…However, in this case, the absence of the medial patellar facet and the medial femoral condyle enhances Lateral release and plication of the medial retinaculum more preferable to fixate the left patella and improve functional limitation. …”
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Diagnostic efficiency of exome-based sequencing in pediatric patients with epilepsy by Huafang Zou, Huafang Zou, Qian Zhang, Jianxiang Liao, Jianxiang Liao, Dongfang Zou, Zhanqi Hu, Bing Li, Li Chen, Jialun Wen, Xia Zhao, Victor Wei Zhang, Dezhi Cao, Dezhi Cao

“…Epileptic syndromes were diagnosed in 66 patients, predominantly West Syndrome, Dravet Syndrome and Genetic Epilepsy with Febrile Seizures plus.ConclusionNGS is an effective method for uncovering the genetic foundations of pediatric epilepsy, with diagnostic yields varying based on the sequencing approach used. The growing preference for WES underscores its utility in complex cases, pointing to a trend towards more tailored diagnostic strategies.…”
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