The colorectal cancer microenvironment: Preclinical progress in identifying targets for cancer therapy by Abdo Meyiah, Faez Iqbal Khan, Dia Aldeen Alfaki, Khaled Murshed, Afsheen Raza, Eyad Elkord

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A comprehensive review of peptic ulcer disease: epidemiology, experimental models, and mechanistic insights by Laliteswar Pratap Singh, Sandip Chatterjee, Sanjeeb Kumar Kar

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A Novel Primary Cell Line Model of Localized Prostate Cancer and Radioresistance—A Role for Nicotinamide N-Methyltransferase by Jessica A. Wright, Stephanie D. White, Gavin Frame, Ana Bosiljkov, Shahbaz Khan, Roni Haas, Qian Yang, Minzhi Sheng, Xiaoyong Huang, Geoff S. Higgins, Ian Mills, Michelle R. Downes, Danny Vesprini, Hans T. Chung, Robert A. Screaton, Hon S. Leong, Paul C. Boutros, Thomas Kislinger, Stanley K. Liu

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Delivery of oligonucleotide‐based therapeutics: challenges and opportunities by Suzan M Hammond, Annemieke Aartsma‐Rus, Sandra Alves, Sven E Borgos, Ronald A M Buijsen, Rob W J Collin, Giuseppina Covello, Michela A Denti, Lourdes R Desviat, Lucía Echevarría, Camilla Foged, Gisela Gaina, Alejandro Garanto, Aurelie T Goyenvalle, Magdalena Guzowska, Irina Holodnuka, David R Jones, Sabine Krause, Taavi Lehto, Marisol Montolio, Willeke Van Roon‐Mom, Virginia Arechavala‐Gomeza

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A companion to the preclinical common data elements for phenotyping seizures and epilepsy in rodent models. A report of the TASK3‐WG1C: Phenotyping working group of the ILAE/AES jo... by Melissa Barker‐Haliski, Julika Pitsch, Aristea S. Galanopoulou, Rüdiger Köhling

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A mouse model of overexpression of human IL-6 by tissue-resident macrophages in the context of LPS-induced inflammation by N. R. Chicherina, E. A. Gorshkova, E. A. Myachev, A. S. Yakovleva, A. M. Litvinova, O. A. Namakanova, R. V. Zvartsev, S. A. Nedospasov, M. S. Drutskaya

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Improved Translational Relevance of In Vitro Fibrosis Models by Integrating IOX2-Mediated Hypoxia-Mimicking Pathways by Manuel A. González Hernández, Jennifer Venhorst, Lars Verschuren, Karin Toet, Martien P. M. Caspers, Martine C. Morrison, Beatrice Coornaert, Gerard J. P. van Westen, Roeland Hanemaaijer

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From molecular promise to preclinical results: HDAC inhibitors in the race for healthy aging drugs by Rebecca L McIntyre, Eileen G Daniels, Marte Molenaars, Riekelt H Houtkooper, Georges E Janssens

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Success and Controversy of Natural Products as Therapeutic Modulators of Wnt Signaling and Its Interplay with Oxidative Stress: Comprehensive Review Across Compound Classes and Exp... by Alexey Koval, Nilufar Z. Mamadalieva, Rano Mamadalieva, Fazliddin Jalilov, Vladimir L. Katanaev

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Research priorities for non-invasive therapies to improve hydrocephalus outcomes by Alexandra Hochstetler, Christine Hehnly, William Dawes, Daniel Harris, Cameron Sadegh, Francesco T. Mangano, Samantha N. Lanjewar, Monica J. Chau

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Unveiling the potential: Patient-derived organoids in cancer research and treatment by Zhan Wang

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Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1 by George Sflomos, Laura Battista, Patrick Aouad, Fabio De Martino, Valentina Scabia, Athina Stravodimou, Ayyakkannu Ayyanan, Assia Ifticene‐Treboux, RLS, Philipp Bucher, Maryse Fiche, Giovanna Ambrosini, Cathrin Brisken

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A Nutritional Supplement Containing Curcumin C3 Complex, Glucosamine, and Chondroitin Alleviates Osteoarthritis in Mice and Canines by Enpei Zheng, Ting Cen, Ye Ma, Ziyuan Weng, Chuanheng Jiang, Luxi Hou, Jun Leng, Changmin Hu

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Establishment of patient-derived 3D in vitro models of sarcomas: literature review and guidelines on behalf of the FORTRESS working group by Lore De Cock, Ieva Palubeckaitė, Francesca Bersani, Tobias Faehling, Sandro Pasquali, Sam Umbaugh, Michael Torsten Meister, Molly R. Danks, Piotr Manasterski, Richard Miallot, Manuela Krumbholz, Siyer Roohani, Dominique Heymann, Florencia Cidre-Aranaz, Agnieszka Wozniak, Patrick Schöffski, Judith V.M.G. Bovée, Alessandra Merlini, Sanne Venneker

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Breakthroughs in diabetic retinopathy diagnosis and treatment using preclinical research models: current progress and future directions by Xi Peng, Yihua Peng, Ling Li, Lian Liu, Guangju Zhou, Yan Cai

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Editorial: Immune studies of SARS-CoV2 and vaccines using preclinical modeling by Cordelia Dunai, Cordelia Dunai, Smita S. Iyer, Smita S. Iyer, William J. Murphy, William J. Murphy

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Applying a life course approach to elucidate the biology of sex differences in frailty: early-life gonadectomy diminishes late-life robustness in male and female dogs in the Except... by David J. Waters, Aimee H. Maras, Rong Fu, Andres E. Carrillo, Emily C. Chiang, Cheri L. Suckow

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Using Postbiotics from Functional Foods for Managing Colorectal Cancer: Mechanisms, Sources, Therapeutic Potential, and Clinical Perspectives by Teresa D’Amore, Cinzia Zolfanelli, Vincenzo Lauciello, Alessio Di Ciancia, Alessio Vagliasindi, Slim Smaoui, Theodoros Varzakas

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In vivo evaluation of decellularized skeletal muscle matrices for skeletal muscle repair: A systematic review by Ina Hennion, Charlot Philips, Chong Jiang, Nele Van De Winkel, Laurens J. Ceulemans, Lieven Thorrez

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Experimental animal models and patient-derived platforms to bridge preclinical discovery and translational therapeutics in pulmonary arterial hypertension by Elizabeth Singh, Malik Bisserier

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