Leukotrienes as Modifiers of Preclinical Atherosclerosis? by Graziano Riccioni, Magnus Bäck

“…Preclinical atherosclerosis represents a crucial period associated with several pathophysiological reactions in the vascular wall. …”
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Preclinical Evidences for an Antimanic Effect of Carvedilol by Greicy Coelho de Souza, Julia Ariana de S. Gomes, Ana Isabelle de Góis Queiroz, Maíra Morais de Araújo, Lígia Menezes Cavalcante, Michel de Jesus Souza Machado, Aline Santos Monte, David Freitas de Lucena, João Quevedo, André Ferrer Carvalho, Danielle Macêdo

“…Taken together these results demonstrate a possible antimanic effect of CVD in this preclinical model.…”
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Preclinical Science Regarding Cannabinoids as Analgesics: An Overview by ME Lynch

“…The present article presents an overview of the preclinical science.…”
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Phenotypic Presentation of Children with Joint Hypermobility: Preclinical Signs by Mateus Marino Lamari, Neuseli Marino Lamari, Michael Peres de Medeiros, Gerardo Maria de Araújo Filho, Adriana Barbosa Santos, Matheus Gomes Giacomini, Vitor Roberto Pugliesi Marques, Eny Maria Goloni-Bertollo, Érika Cristina Pavarino

“…Objectives: Identify preclinical signs of JH, in addition to Beighton Score (BS), through signs that are easily recognized early by pediatricians and family members to avoid possible joint deformities in the future. …”
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Advances in preclinical and clinical studies of oncolytic virus combination therapy by Wenlong Du, Jintong Na, Liping Zhong, Liping Zhong, Pumin Zhang

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Preclinical advance in nanoliposome-mediated photothermal therapy in liver cancer by Lixuan Tang, Xiao Yang, Liwen He, Chaogeng Zhu, Qingshan Chen

“…This article reviews the latest preclinical research progress of nanoliposome-based PTT for liver cancer and its metastasis, discusses the preclinical challenges in this field, and proposes directions for improvement, with the aim of improving the effectiveness of liver cancer treatment.…”
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Preclinical research models for endometrial cancer: development and selection of animal models by Yang Xue, Wei Shi, Bing Lun, Meilin Kan, Mengling Jia, Yuelin Wu, Li Yang, Li Yang

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Preclinical Polymodal Hallucinations for 13 Years before Dementia with Lewy Bodies by Carlo Abbate, Pietro Davide Trimarchi, Silvia Inglese, Niccolò Viti, Alessandra Cantatore, Lisa De Agostini, Federico Pirri, Lorenza Marino, Renzo Bagarolo, Daniela Mari

“…We describe a case of dementia with Lewy bodies (DLB) that presented long-lasting preclinical complex polymodal hallucinations. Background. …”
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The colorectal cancer microenvironment: Preclinical progress in identifying targets for cancer therapy by Abdo Meyiah, Faez Iqbal Khan, Dia Aldeen Alfaki, Khaled Murshed, Afsheen Raza, Eyad Elkord

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Preclinical Studies of Chemotherapy Using Histone Deacetylase Inhibitors in Endometrial Cancer by Noriyuki Takai, Hisashi Narahara

“…In this review, we discuss the biologic and therapeutic effects of HDACIs in treating endometrial cancer, with a special focus on preclinical studies.…”
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Advanced In Vitro Models for Preclinical Drug Safety: Recent Progress and Prospects by Dileep G. Nair, Ralf Weiskirchen

“…In this review, we discuss the significance, current status, and future prospects of advanced platforms, specifically organ-on-a-chip models, in supporting preclinical drug discovery.…”
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Preclinical evaluation of avutometinib and defactinib in high‐grade endometrioid endometrial cancer by Tobias Max Philipp Hartwich, Miranda Mansolf, Cem Demirkiran, Michelle Greenman, Stefania Bellone, Blair McNamara, Shuvro P. Nandi, Ludmil B. Alexandrov, Yang Yang‐Hartwich, Silvia Coma, Jonathan Pachter, Alessandro D. Santin

“…As EAC may harbor mutations in the RAS/MAPK pathways, we evaluated the preclinical in vitro and in vivo efficacy of avutometinib, a RAF/MEK clamp, in combination with the focal adhesion kinase (FAK) inhibitors defactinib or VS‐4718, against multiple primary EAC cell lines and xenografts. …”
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Cognitive Phenotypes, Brain Morphometry and the Detection of Cognitive Decline in Preclinical AD by Mark W. Jacobson, Linda K. McEvoy, Anders Dale, Christine Fennema-Notestine

“…Identifying a preclinical phase of Alzheimer’s Disease (PCAD) that is distinct from cognitive changes in healthy aging continues to be a major research focus. …”
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The application of procyanidins in diabetes and its complications: a review of preclinical studies by Yongchuang Zhang, Mengna Li, Haoyuan Liu, Yongfu Fan, Huan Huan Liu

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Quantitative accuracy of preclinical in ovo PET/MRI: influence of attenuation and quantification methods by Theresa Balber, Katarína Benčurová, Manuela Mayrhofer, Joachim Friske, Martin Haas, Claudia Kuntner, Thomas H. Helbich, Marcus Hacker, Markus Mitterhauser, Ivo Rausch

“…The phantom was placed in a preclinical PET/MRI system and PET acquisitions were performed without, and after subsequently adding the different hardware parts to the setup. …”
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Fumonisin B1 neurotoxicity: Preclinical evidence, biochemical mechanisms and therapeutic strategies by Blessing A. Obafemi, Isaac A. Adedara, Cássia Pereira Delgado, Olabisi T. Obafemi, Michael Aschner, Joao B.T. Rocha

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Activation of KATP channels in pain modulation: a systematic review of preclinical studies by Signe Schønning Beich, Lili Kokoti, Mohammad Al-Mahdi Al-Karagholi, Mohammad Al-Mahdi Al-Karagholi

“…Inclusion criteria were preclinical studies measuring pain in vivo upon activation of the KATP channel by administering a stimulator or positive modulator. …”
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The Relationship between Stress and Preclinical Dental Students’ Performance: A Longitudinal Study by Diva Lugassy, Gil Ben-Izhack, Sara Zissu, Rotem Shitrit Lahav, Ophir Rosner, Nir Uziel, Sarit Naishlos, Asaf Shely

“…The aim of this study was to evaluate the changing levels of stress among dental students during 8 months of a basic manual skills course in the preclinical year and to examine the association between stress and dental performance. …”
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Enhanced Neuroprotective Effects of Coadministration of Tetrandrine with Glutathione in Preclinical Model of Parkinson’s Disease by Xiang-Yun Li, Guang-Hai Mei, Qiang Dong, Yu Zhang, Zhuang-Li Guo, Jing-Jing Su, Yu-Ping Tang, Xue-Hong Jin, Hou-Guang Zhou, Yan-Yan Huang

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Developmental dysfunction in a preclinical model of Kcnq2 developmental and epileptic encephalopathy by Miaomiao Mao, Nikola Jancovski, Yafit Kushner, Lucas Teasdale, Phan Truong, Kun Zhou, Samuel Reid, Linghan Jia, Ye Htet Aung, Melody Li, Christopher A. Reid, Sean Byars, Ingrid Scheffer, Steven Petrou, Snezana Maljevic

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