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N-trans-Feruloyloctopamine Wakes Up BBC3, DDIT3, CDKN1A, and NOXA Signals to Accelerate HCC Cell Apoptosis
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163
Overcoming immunosuppression in cancer: how ketogenic diets boost immune checkpoint blockade
Published 2024-11-01“…Preclinical cancer studies have revealed increased activation of and infiltration by tumor-fighting immune cells, especially CD8+ T cells, but also M1 macrophages and natural killer cells, in response to a KD regimen. …”
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164
Potential Human Models of Infammatory Bowel Disease
Published 1995-01-01“…Current human models can be classified into models depicting risk of disease; preclinical disease; acute inflammation; and miscellaneous IBD. …”
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165
Stimulation of TLR4 by LMW-HA Induces Metastasis in Human Papillary Thyroid Carcinoma through CXCR7
Published 2013-01-01Get full text
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166
Immune Checkpoint Modulators: An Emerging Antiglioma Armamentarium
Published 2016-01-01“…Results from recent preclinical and clinical studies demonstrate how checkpoint inhibition can be utilized to prevent tumor immune evasion and both local and systemic immune suppression. …”
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167
The Pharmacotherapy of Chronic Pain: A Review
Published 2006-01-01“…The past two decades have contributed a large body of preclinical work that has assisted in our understanding of the underlying pathophysiological mechanisms that cause chronic pain. …”
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168
MASH as an emerging cause of hepatocellular carcinoma: current knowledge and future perspectives
Published 2025-02-01“…Numerous preclinical models have been created but not many mimicked anthropometric measures and the course of disease progression shown in the patients. …”
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African animal trypanocide resistance: A systematic review and meta-analysis
Published 2024“…To address resistance, most preclinical studies increased the dosage and the treatment time, and this failed to improve the patient’s prognosis. …”
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170
Molecular Imaging Probes for Diagnosis and Therapy Evaluation of Breast Cancer
Published 2013-01-01“…Molecular imaging has the potential to enhance our understanding of breast cancer biology and effects of drug action during both preclinical and clinical phases of drug development. …”
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171
The Key to Unlocking the Chemotherapeutic Potential of PPARγ Ligands: Having the Right Combination
Published 2012-01-01“…Despite extensive preclinical evidence that peroxisome proliferator-activated receptor (PPAR)γ activation protects against tumourigenesis, results from a few clinical trials using PPARγ ligands as monotherapy show modest success. …”
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Application of Surface Roughness Analysis on Micro–Computed Tomographic Images of Bone Erosion: Examples Using a Rodent Model of Rheumatoid Arthritis
Published 2006-10-01“…Quantifying the bone erosion in preclinical models of rheumatoid arthritis is valuable for the evaluation of drug treatments. …”
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Mesenchymal Stem Cells and Cutaneous Wound Healing: Current Evidence and Future Potential
Published 2015-01-01“…This review examines the body of evidence suggesting that MSC accelerate wound healing in both clinical and preclinical studies and also the possible mechanisms controlling its efficacy. …”
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Spontaneous, naturally occurring cancers in non-human primates as a translational model for cancer immunotherapy
Published 2023-01-01“…The complexity of cancer immunotherapy (CIT) demands reliable preclinical models to successfully translate study findings to the clinics. …”
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Strategies to Enhance Mesenchymal Stem Cell-Based Therapies for Acute Respiratory Distress Syndrome
Published 2019-01-01“…Accordingly, several strategies have been explored to improve MSC retention in the lung and enhance the innate properties of MSCs in preclinical models of ARDS. To provide a comprehensive and updated view, we summarize a large body of experimental evidence for a variety of strategies directed towards strengthening the therapeutic potential of MSCs in ARDS.…”
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Recent Advances, Research Trends, and Clinical Relevance of Hyaluronic Acid Applied to Wound Healing and Regeneration
Published 2025-01-01“…This review reports many of the latest developments of hyaluronan and its derivatives in research, preclinical, and published clinical trials for wound healing. …”
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African animal trypanocide resistance: A systematic review and meta-analysis
Published 2023“…To address resistance, most preclinical studies increased the dosage and the treatment time, and this failed to improve the patient’s prognosis. …”
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179
Comparison Study of Airway Reactivity Outcomes due to a Pharmacologic Challenge Test: Impulse Oscillometry versus Least Mean Squared Analysis Techniques
Published 2013-01-01“…The present study represents a preclinical animal study to determine whether these respiratory function techniques (LMS and IOS) are comparable in detecting changes in respiratory resistance derived from a direct pharmacological challenge.…”
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Epigenetic Drug Interventions in Breast Cancer: A Narrative Review of Current Research and Future Directions
Published 2024-09-01“…In this review, we summarise and present the preclinical and clinical evidence for epigenetic drugs in treating breast cancer. …”
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