A Comparison of Dental Students’ Self-Assessment and Instructors’ Assessment in Competency Examinations in a Preclinical Operative Dentistry Course by Alghilan MA, Munaga S, Aldakhil A

“…This study compared dental students’ self-assessments and instructors’ assessments in competency examinations and evaluated the progress and potential predictors of self-assessment performance, including achievement level and gender, in a Preclinical Operative Dentistry course.Methods: The preclinical operative dentistry assessment and self-assessment records by instructors and students, respectively, were collected retrospectively from intra-semester and final examination assessment rubrics. …”
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Overview of preclinical and phase II clinical studies on Pegmolesatide’s long-term erythropoiesis stimulating effect via EPOR-mediated signal transduction by Xiaoying Ma, Zhen Li, Lu Zhang, Hui Qian, Qinkai Chen, Ye Tao, Yunfan Li, Dandan Wang, Zhizhen Hu, Weili Luo, Ping Li, Hai Yu, Changlin Mei, Xueqing Yu, Yuanfeng Zhou

“…Adverse events were mild and manageable, with no reports of severe anaphylaxis. Discussion Preclinical and clinical evidence signifies that Pegmolesatide is a unique, potent PEGylated EPO-memetic peptide (EMP) with a prolonged PD efficacy and PK half-life and a good safety-tolerability profile. …”
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Correlation Analysis between Nerve Fiber Layer Thickness and Peripapillary Vessel Density and Influencing Factors of Peripapillary Vessel Density in Preclinical Diabetic Retinopathy by Donghui Li, Qichang Wang

“…The duration of diabetes and HbA1c are risk factors for peripapillary vessel density reduction in patients with preclinical DR.…”
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Systematic preclinical evaluation of CD33-directed chimeric antigen receptor T cell immunotherapy for acute myeloid leukemia defines optimized construct design by Haiying Qin, Nirali N Shah, Terry J Fry, Lila Yang, John A Chukinas, Samiksha Tarun, Marie Pouzolles, Christopher D Chien, Lisa M Niswander, Anthony R Welch, Sarah K Tasian, Naomi A Taylor

“…Based on this rigorous preclinical evaluation, our validated clinical grade lintuzumab-CD28/CD3ζ CD33CART immunotherapy is now under evaluation in a first-in-child/first-in-human phase 1 clinical trial for children and adolescents/young adults with relapsed/refractory AML.Trial registration number clinicaltrials.gov; NCT03971799.…”
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Advancing Alzheimer’s disease risk prediction: development and validation of a machine learning-based preclinical screening model in a cross-sectional study by Yanfei Chen, Bing Wang, Yankai Shi, Wenhao Qi, Shihua Cao, Bingsheng Wang, Ruihan Xie, Jiani Yao, Xiajing Lou, Chaoqun Dong, Xiaohong Zhu, Danni He

“…The most influential predictors were educational level, total medication count, age, sbp and BMI.Conclusions The proposed classifier can help guide preclinical screening of AD in the elderly population.…”
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Intracalvariosseous injection: an approach for central nervous system drug delivery through skull bone marrow with a preclinical research in strokeResearch in context by Wenqian Liu, Mo Yang, Nanxing Wang, Xiangrong Liu, Chaoyu Wang, Kaibin Shi, Fu-Dong Shi, Yuesong Pan, Mingjun Zhang, Zhiwei Sun, Yongjun Wang, Yilong Wang

“…Our results assessed the feasibility and safety of ICO injection at the preclinical level and evaluated its efficacy in animal models of stroke. …”
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Utility of 131I-HLX58-Der for the Precision Treatment: Evaluation of a Preclinical Radio-Antibody-Drug-Conjugate Approach in Mouse Models by Liu Y, Wang X, Zhang N, He S, Zhang J, Xu X, Song S

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Preparing healthcare leaders of the digital age with an integrative artificial intelligence curriculum: a pilot study by Soo Hwan Park, Roshini Pinto-Powell, Thomas Thesen, Alexander Lindqwister, Joshua Levy, Rachael Chacko, Devina Gonzalez, Connor Bridges, Adam Schwendt, Travis Byrum, Justin Fong, Shahin Shahsavari, Saeed Hassanpour

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Critical updates on oral insulin drug delivery systems for type 2 diabetes mellitus by Chan Yew Low, Wei Ling Gan, Su Jeat Lai, Rachel Su-May Tam, Jie Fei Tan, Stefanie Dietl, Lay Hong Chuah, Nicolas Voelcker, Athirah Bakhtiar

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The Gingiva from the Tissue Surrounding the Bone to the Tissue Regenerating the Bone: A Systematic Review of the Osteogenic Capacity of Gingival Mesenchymal Stem Cells in Preclinical Studies by Gamilah Al-Qadhi, Iman Aboushady, Niyaz Al-Sharabi

“…The current review aims to systematically assess the osteogenic capacity of gingiva-derived mesenchymal stem cells (GMSCs) in preclinical studies. A comprehensive electronic search of PubMed, Embase, Web of Science, and Scopus databases, as well as a manual search of relevant references, was performed in June 2020 without date or language restrictions. …”
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Differentiating Between Perfluorohexyloctane Ophthalmic Solution and Water-Free Cyclosporine Ophthalmic Solution 0.1% for Dry Eye Disease: A Review of Preclinical and Clinical Characteristics by Laura M. Periman, Darrell E. White, Douglas Katsev

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Insights into the mechanisms of serplulimab: a distinctive anti-PD-1 monoclonal antibody, in combination with a TIGIT or LAG3 inhibitor in preclinical tumor immunotherapy studies by Yizhou Zhang, Ruicheng Wei, Ge Song, Xinyi Yang, Mengli Zhang, Wei Liu, Aiying Xiong, Xuehan Zhang, Qianhao Li, Wan-Jen Yang, Chencheng Han, Rui Liu, Chen Hu, Qingyu Wang, Jun Zhu, Yongqiang Shan

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Characterization of the bispecific VHH antibody tarperprumig (ALXN1820) specific for properdin and designed for low-volume administration by Paul Tamburini, Dennis Vestergaard Pedersen, Denise Devore, Josh Cone, Rekha Patel, Todd Hunter, Fang Sun, Gregers Rom Andersen, Jeffrey Hunter

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Application of a novel extracorporeal membrane oxygenation system in awake Hu sheep under various durations by Shuo Ding, Juan Chen, Yanchao Wu, Huiru Lin, Qiqiang Liang, Gaoqin Teng, Zhenjie Liu, Man Huang

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Liposomal Formulations: A Recent Update by Surendra S. Agrawal, Vrinda Baliga, Vaishali Y. Londhe

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Corrigendum to “Cell surface GRP78-directed CAR-T cells are effective at treating human pancreatic cancer in preclinical models” [Translational Oncology volume 39 (2024) 101803] by Yuncang Yuan, Jiawei Fan, Dandan Liang, Shijie Wang, Xu Luo, Yongjie Zhu, Nan Liu, Tingxiu Xiang, Xudong Zhao

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Pulse Wave Velocity as Marker of Preclinical Arterial Disease: Reference Levels in a Uruguayan Population Considering Wave Detection Algorithms, Path Lengths, Aging, and Blood Pressure by Ignacio Farro, Daniel Bia, Yanina Zócalo, Juan Torrado, Federico Farro, Lucía Florio, Alicia Olascoaga, Walter Alallón, Ricardo Lluberas, Ricardo L. Armentano

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Pre-treatment subjective sleep quality as a predictive biomarker of tDCS effects in preclinical Alzheimer's disease patients: Secondary analysis of a randomised clinical trial. by Hanna Lu, Xi Ni, Sandra Sau Man Chan, Calvin Pak Wing Cheng, Waichi Chan, Linda Chiu Wa Lam

“…More thorough research is necessary to explore an efficient approach to managing comorbidities for preclinical AD patients.…”
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Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics for knee osteoarthritis by Aliosha I. Figueroa-Valdés, Patricia Luz-Crawford, Yeimi Herrera-Luna, Nicolás Georges-Calderón, Cynthia García, Hugo E. Tobar, María Jesús Araya, José Matas, Darío Donoso-Meneses, Catalina de la Fuente, Jimena Cuenca, Eliseo Parra, Fernando Lillo, Cristóbal Varela, María Ignacia Cádiz, Rolando Vernal, Alexander Ortloff, Gino Nardocci, Verónica Castañeda, Catalina Adasme-Vidal, Maximiliano Kunze-Küllmer, Yessia Hidalgo, Francisco Espinoza, Maroun Khoury, Francisca Alcayaga-Miranda

“…This study provides data on using UC-MSC-sEV as local therapy for OA, highlighting their regenerative and anti-inflammatory properties and safety in preclinical and a proof-of-principle clinical application. …”
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Preclinical Efficacy and Proteomic Prediction of Molecular Targets for s-cal14.1b and s-cal14.2b Conotoxins with Antitumor Capacity in Xenografts of Malignant Pleural Mesothelioma by Angélica Luna-Nophal, Fernando Díaz-Castillo, Vanessa Izquierdo-Sánchez, Jesús B. Velázquez-Fernández, Mario Orozco-Morales, Luis Lara-Mejía, Johana Bernáldez-Sarabia, Noemí Sánchez-Campos, Oscar Arrieta, José Díaz-Chávez, Jorge-Ismael Castañeda-Sánchez, Alexei-Fedorovish Licea-Navarro, Saé Muñiz-Hernández

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