Evaluating translational science knowledge gains following an online short course for a general scientific audience by Amanda L. Vogel, Shadab F. Hussain, Jessica M. Faupel-Badger

“…The branch updated its course in preclinical translational science with additional content aligned with the NCATS Translational Science Principles, which characterize effective approaches to advance translation. …”
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Present and future of cancer nano-immunotherapy: opportunities, obstacles and challenges by Man Wang, Fei Yu, Yuan Zhang

“…Owing to gaps between preclinical and clinical studies, nano-immunotherapy faces multiple challenges, including the biosafety of nanomaterials and clinical trial design. …”
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Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor 2 Axis Can Promote Mouse and Human Primary Mast Cell Angiogenic Potential through Upregulation of Vascular Endothelial Grow... by Alena Chumanevich, Piper Wedman, Carole A. Oskeritzian

“…However, the role of S1PR2 ligation in proangiogenic vascular endothelial growth factor- (VEGF-) A and matrix metalloproteinase- (MMP-) 2 release from MC is unknown. Using a preclinical MC-dependent model of acute allergic responses and in vitro stimulated primary mouse bone marrow-derived MC (BMMC) or human primary skin MC, we report that S1P signaling resulted in substantial amount of VEGF-A release. …”
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A review of the Bovis Calculus’s intervention mechanism and clinical application in ischemic stroke by Ke Xu, Bowen Deng, Tongtong Jia, Mihong Ren, Hai Chen, Jing Zhang, Jinlin Guo, Yong Li, Jian Wang

“…Furthermore, as a crude drug, BC appears in many Chinese patent medicine (CPM) preparations for the treatment of IS, and clinical and preclinical studies have proved its safety.ConclusionThe use of BC in the treatment of IS has a long history, proven efficacy, and widespread application. …”
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Procedure Time and Students’ Perception Comparing Full Arch Digital Scans with Conventional Impressions: A Cross-Over Randomized Experimental Trial by Hayam A. Alfallaj, Mohammed A. Alsaloum, Sahr H. Altuwaijri, Omar S. Aldibasi, Lubna T. Alkadi

“…This study compares the procedure duration, students’ preference, and perceived procedure difficulty level after students’ initial preclinical exposure to either digital scanning using CEREC Omnicam intraoral scanners or conventional impressions using vinyl polysiloxane impression material. …”
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Migraine in men by Mira P. Fitzek, Deirdre M. Boucherie, Tessa de Vries, Cleo Handtmann, Haniyeh Fathi, Bianca Raffaelli, Antoinette MaassenVanDenBrink

“…Conclusion Men are underrepresented in clinical migraine research. In contrast, preclinical studies often focus solely in male animals as a result of various misconceptions. …”
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Cannabidiol attenuates lipid metabolism and induces CB1 receptor-mediated ER stress associated apoptosis in ovarian cancer cells by Xuanhe Fu, Zhixiong Yu, Fang Fang, Weiping Zhou, Yuxin Bai, Zhongjia Jiang, Biao Yang, Ye Sun, Xing Tian, Guangyan Liu

“…As the primary ingredient in exogenous cannabinoids, cannabidiol (CBD) has been confirmed to exhibit antitumor activity in preclinical studies. However, it is still unclear whether CBD can disrupt fatty acid metabolism and induce apoptosis in OC cells. …”
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An Efficient Protocol for Deriving Liver Stem Cells from Neonatal Mice: Validating Its Differentiation Potential by Sugapriya Dhanasekaran, Devilakshmi Sithambaram, Kavitha Govarthanan, Bijesh Kumar Biswal, Rama S. Verma

“…Finally, we developed a reproducible, efficient protocol for isolation of LDSCs with functional hepatocytes differentiation potential, which further can be used as in vitro model system for assessing drug toxicity assays in various preclinical trials.…”
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Diagnostics of glaucoma before clinical manifestations by N.E. Fomin, A.V. Kuroyedov

“…Mandryka Military Clinical Hospital, Moscow, Russian Federation</b> </p> <p> <b>²Pirogov Russian National Research Medical University, Moscow, Russian Federation</b> </p> <p> <i>The aim of current diagnostics of primary open-angle glaucoma (POAG) is to detect clinical manifestations of the disease. However, a set of preclinical diagnostic techniques to discover POAG predictors before typical signs occur are more promising. …”
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Post-traumatic arthritis: overview on pathogenic mechanisms and role of inflammation by Roberta Ramonda, Leonardo Punzi, Anna Scanu, Francesca Oliviero, Roberto Luisetto, Paola Galozzi, Marta Favero

“…Currently, chronic PTA cannot be prevented, although a large number of agents have been tested in preclinical studies. Given the relevance of inflammatory reaction, anticytokines therapy, in particular the inhibition of interleukin 1 (IL-1), seems to be the most promising strategy. …”
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Advances in the Development and Application of Human Organoids: Techniques, Applications, and Future Perspectives by Zhangcheng Zhu, Yiwen Cheng, Xia Liu, Wenwen Ding, Jiaming Liu, Zongxin Ling, Lingbin Wu

“…This fidelity to native organ systems positions organoids as a powerful tool for advancing our understanding of human biology and for enhancing preclinical drug testing. Recent advancements have led to the successful development of a variety of organoid types, reflecting a broad range of human organs and tissues. …”
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Sex Modified the Association between Sleep Duration and worse Cognitive Performance in Chinese Hypertensive Population: Insight from the China H-Type Hypertension Registry Study by Xinlei Zhou, Junpei Li, Chao Yu, Wangsheng Fang, Yanyou Xie, Li Wang, Si Shen, Wei Zhou, Lingjuan Zhu, Tao Wang, Xiao Huang, Huihui Bao, Jianglong Tu, Xiaoshu Cheng

“…Cognitive decline could be seen as the sign of preclinical phase of dementia, which was found to be sex differentiated. …”
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Weight trajectories in aging humanized APOE mice with translational validity to human Alzheimer's risk population: A retrospective analysis. by Francesca Vitali, Jean-Paul Wiegand, Lillian Parker-Halstead, Allan Tucker, Roberta Diaz Brinton

“…These data are consistent with the heterogeneity observed in the human population for change in body weight during aging and highlight the importance of longitudinal phenotypic characterization of mouse aging to advance the translational validity of preclinical AD mouse models.…”
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Targeting protein synthesis pathways in MYC-amplified medulloblastoma by Devendra Kumar, Ranjana Kanchan, Nagendra K. Chaturvedi

“…Further, targeting this enhanced protein synthesis pathway with combined inhibition of MYC transcription and mTOR translation by small-molecule inhibitors, demonstrates preclinical synergistic anti-tumor potential against MYC-driven medulloblastoma in vitro and in vivo. …”
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Conditions and factors affecting the accuracy of olfactometric detection by Petra Riedlova, Spiros Tavandzis, Josef Kana, Jaromir Roubec

“…This method has great advantages; the dog can detect a tumour in the human body already in preclinical stages, when the patient has no symptoms yet. …”
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Neurobiological Mechanisms Underlying Psychological Dysfunction After Brain Injuries by Prashin Unadkat, Tania Rebeiz, Erum Ajmal, Vincent De Souza, Angela Xia, Julia Jinu, Keren Powell, Chunyan Li

“…This review integrates clinical and preclinical evidence to provide a comprehensive overview of the neurobiological mechanisms underlying neuropsychological disorders, focusing on the role of key brain regions in emotional regulation across various forms of brain injuries. …”
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Rhus Verniciflua Stokes Inhibits PD-1 Expression and Induces Anticancer Effects by Enhancing T Cell Function by Seoyoung Kim PhD, Young-Kwan Lee PhD, Wang-Jun Lee MD, PhD, Hyoun Jong Moon MD, PhD, Sanghun Lee KMD, PhD

“…Background: Over the last decade, the anticancer effects of Rhus verniciflua Stokes (RVS) have been reported in various preclinical or clinical studies. However, the effects of RVS on immuno-oncology, especially on the functional properties of T cells and their phenotypes, remain unclear. …”
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Targeting HGF/c-MET signaling to regulate the tumor microenvironment: Implications for counteracting tumor immune evasion by Yang Xia, Chunye Huang, Min Zhong, Hongguang Zhong, Ruiwen Ruan, Jianping Xiong, Yangyang Yao, Jing Zhou, Jun Deng

“…Nevertheless, numerous preclinical studies have shown that MET imbalance hinders the effectiveness of anti-PD-1/PD-L1 treatments through various mechanisms. …”
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Administration of FTY720 during Tourniquet-Induced Limb Ischemia Reperfusion Injury Attenuates Systemic Inflammation by Anthony D. Foster, Diego Vicente, Jonathan J. Sexton, Luke Johnston, Nick Clark, Crystal Leonhardt, Eric A. Elster, Thomas A. Davis, Matthew J. Bradley

“…These findings suggest that early intervention with FTY720 may benefit the treatment of IRI of the limb. Further preclinical studies are necessary to characterize the short-term and long-term beneficial effects of FTY720 following tourniquet-induced IRI.…”
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Human reference microbiome profiles of different body habitats in healthy individuals by Sujin Oh, Kyoung Un Park, Kyoung Un Park

“…In saliva and blood, differences in the abundances of Epsilonbacteraeota, Firmicutes, Fusobacteria, and Proteobacteria could be used as reference values (95% CI of logFC: [−3.67, −2.47], [−0.35, 0.49], [−4.59, −3.26], and [−1.20, 0.07], respectively).DiscussionAs the reference microbiome profiles could discern healthy subjects and individuals with PD, a relatively mild disease state, they can be applied as reference values representing the healthy status of the microbiome and for screening of disease states, preferably in preclinical stages.…”
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