Neurotoxicological Effects of Some Mycotoxins on Humans Health and Methods of Neuroprotection by Aleksandra Kuć-Szymanek, Daria Kubik-Machura, Klaudia Kościelecka, Tomasz Męcik-Kronenberg, Lidia Radko

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Natural killer cell engagers for cancer immunotherapy by Shahryar Khoshtinat Nikkhoi, Geng Li, Arash Hatefi, Arash Hatefi

“…This review article critically examines the strategies for engineering bi-, tri-, and multi-specific NKCEs for cancer immunotherapy, providing an in-depth analysis of the latest advancements in NKCE platform technologies currently under development by pharmaceutical and biotech companies and discussing the preclinical and clinical progress of these products. …”
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Gut–brain axis and neuropsychiatric health: recent advances by Ceymi Doenyas, Gerard Clarke, Renáta Cserjési

“…The studies described in this Collection support and expand on the observations from previous preclinical and clinical investigations, while also providing essential novel insights that can drive discovery into previously unexplored avenues of brain-gut-microbiome interactions in health and disease.…”
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Enhancing Mesenchymal Stromal Cell Immunomodulation for Treating Conditions Influenced by the Immune System by Bella S. Guerrouahen, Heba Sidahmed, Asma Al Sulaiti, Moza Al Khulaifi, Chiara Cugno

“…In the present review, we focus on the suppressive effect that MSCs exert on the immune system and highlight the significance of in vitro preconditioning and its use in preclinical studies. We discuss the clinical aspects of using MSCs as an immunomodulatory treatment. …”
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Update on the Treatment of Diabetic Retinopathy by Jennifer L. Wilkinson-Berka, Antonia G. Miller

“…This review examines evidence from preclinical and clinical studies that shows that targeting inhibition of the renin-angiotensin system, vascular endothelial growth factor, corticosteroids, protein kinase C, growth hormone, and advanced glycation end-products are potential treatments for DR.…”
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Feasibility of NaF PET/CT and MRI for Noninvasive In Vivo Quantification of Knee Pathophysiological Bone Metabolism in a Canine Model of Post-traumatic Osteoarthritis by Maria I. Menendez DVM, PhD, Bianca Hettlich DrMedVet, Lai Wei PhD, Michael V. Knopp MD, PhD

“…Moreover, it brings a novel musculoskeletal preclinical imaging methodology that can provide unique insights into PTOA pathophysiology.…”
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Assessment of the Association between In Vivo Corneal Morphogeometrical Changes and Keratoconus Eyes with Severe Visual Limitation by J. S. Velázquez, F. Cavas, J. Alió del Barrio, D. G. Fernández-Pacheco, J. Alió

“…This observational case series study evaluated new objective indices in 50 healthy and 30 KC corneas, following a validated protocol created by our research group, which has been previously used for diagnosis and characterization of KC in asymptomatic (preclinical) and mild visually impaired eyes. Results show a statistically significant reduction of corneal volume and an increase of total corneal area in the severe KC group, being anterior and posterior corneal surfaces minimum thickness points the best correlated parameters, although with no discrimination between groups. …”
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Dual Roles of IL-27 in Cancer Biology and Immunotherapy by Marina Fabbi, Grazia Carbotti, Silvano Ferrini

“…Several pieces of evidence, obtained in preclinical tumor models, indicated that IL-27 has a potent antitumor activity, related not only to the induction of tumor-specific Th1 and cytotoxic T lymphocyte (CTL) responses but also to direct inhibitory effects on tumor cell proliferation, survival, invasiveness, and angiogenic potential. …”
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Assessing Medical Students’ Learning Style Preferences at Kabale University Medical School, Uganda. by Muhaise, Hussein, Businge, Phelix Mbabazi, Ssemaluulu, Paul, Kyomugisha, Patricia

“…Relatively, t-test results showed significant (p < 0.05) differences in learning styles between preclinical and clinical students. However, the t-test results for gender factors for all the learning dimensions were insignificant (p > 0.05). …”
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Targeting of the G9a, DNMT1 and UHRF1 epigenetic complex as an effective strategy against pancreatic ductal adenocarcinoma by Daniel Oyon, Amaya Lopez-Pascual, Borja Castello-Uribe, Iker Uriarte, Giulia Orsi, Sofia Llorente, Jasmin Elurbide, Elena Adan-Villaescusa, Emiliana Valbuena-Goiricelaya, Ainara Irigaray-Miramon, Maria Ujue Latasa, Luz A. Martinez-Perez, Luca Reggiani Bonetti, Felipe Prosper, Mariano Ponz-Sarvise, Silvestre Vicent, Antonio Pineda-Lucena, David Ruiz-Clavijo, Bruno Sangro, Urko Aguirre Larracoechea, Tian V. Tian, Andrea Casadei-Gardini, Irene Amat, Maria Arechederra, Carmen Berasain, Jesus M. Urman, Matias A. Avila, Maite G. Fernandez-Barrena

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Determination of Total Phenolics, Flavonoids, and Antioxidant Activity and GC-MS Analysis of Malaysian Stingless Bee Propolis Water Extracts by Sharifah Nur Amalina Syed Salleh, Nur Ayuni Mohd Hanapiah, Hafandi Ahmad, Wan Lutfi Wan Johari, Nurul Huda Osman, Mohd Razif Mamat

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Mice develop obesity and lose myocardial metabolic flexibility months after exertional heat stroke by Jamal M. Alzahrani, Ashley J. Smuder, Bryce J. Gambino, Cristina Delgado, Michael T. Rua, Ryan N. Montalvo, Finleigh P. Fitton, Deborah A. Morse, Thomas L. Clanton

“…We tested whether a single exposure to acute heat illness, using a preclinical mouse model of exertional heat stroke (EHS), can induce late-emerging health disorders that progress into chronic disease. …”
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Therapeutic potential of Garlic (Allium sativum L.) on new models of asthma immune pathobiology: A review by VR Bataduwaarachchi, DCJ Liyanage, SMN Hansanie, HDSM Perera, LG D'Cruz

“…Aims of the study: This review aims to explore the potential effects of garlic (Allium sativum L.) on the immune pathobiology of new asthma models and to provide guidance and comprehensive reference material for preclinical and clinical studies. Materials and methods: A comprehensive literature review was conducted in PubMed, Medline Scopus, and Google Scholar. …”
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Targeting fucosyltransferase FUT8 as a prospective therapeutic approach for DLBCL by Hao Xu, Qi Li, Yuchen Zhang, Chuan He, Xinyun Zhang, Zhiming Wang, Meifang Zhao, Yali Chai, Wenzhuo Zhuang, Bingzong Li

“…Furthermore, our screening efforts involving clinical and preclinical drugs unveiled a compelling synergistic effect between chidamide and morusinol. …”
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Non-enzymatic protein targeting agents as a promising strategy for cancer treatment by Madison Ambrose, Jeremy Lee, Aleem Syed, Zamal Ahmed, Guang Peng

“…To discover this class of new anticancer drugs, two molecular approaches targeting the non-enzymatic activities of proteins have shown promising experimental, preclinical, and clinical results. In the first approach, selective agents known as PROteolysis-TArgeting Chimeras (PROTACs) employ innate endogenous protein degradation machinery in cells to proteolyze the targeted protein. …”
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Enavatuzumab, a Humanized Anti-TWEAK Receptor Monoclonal Antibody, Exerts Antitumor Activity through Attracting and Activating Innate Immune Effector Cells by Shiming Ye, Melvin I. Fox, Nicole A. Belmar, Mien Sho, Debra T. Chao, Donghee Choi, Yuni Fang, Vivian Zhao, Stephen F. Keller, Gary C. Starling, Patricia A. Culp

“…Conditioned media from enavatuzumab-treated tumor cells contained elevated levels of chemokines, which might be responsible for enavatuzumab-triggered effector cell migration. These preclinical studies demonstrate that enavatuzumab can exert its potent antitumor activity by actively recruiting and activating myeloid effectors to kill tumor cells. …”
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Towards autonomous robotic THz-based in vivo skin sensing: the PicoBot by Anubhav Dogra, Dominic Jones, Arturo Ignacio Hernandez Serrano, Shruti Chakraborty, Jacob Joshua Young, Benjamin George Page, Joseph Hardwicke, Pietro Valdastri, Emma Pickwell-MacPherson

“…The tests conducted validate the preclinical feasibility of the concept along with the robustness and advantages of using the PicoBot, compared to a manual measurement setup.…”
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Leaflet: Operative Steps for Interventional Studies in Neuroscience by Maria Meringolo, Sergio Delle Monache, Giuseppina Martella, Antonella Peppe

“…Notably, neuroscience drug development encounters distinct challenges, including the complex nature of diseases, limitations imposed by the blood–brain barrier, the absence of reliable predictive preclinical models, and regulatory hurdles. Ethical and safety considerations are pivotal due to the potential cognitive and motor effects of CNS-active drugs. …”
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AI‐Powered Multimodal Modeling of Personalized Hemodynamics in Aortic Stenosis by Caglar Ozturk, Daniel H. Pak, Luca Rosalia, Debkalpa Goswami, Mary E. Robakowski, Raymond McKay, Christopher T. Nguyen, James S. Duncan, Ellen T. Roche

“…Abstract Aortic stenosis (AS) is the most common valvular heart disease in developed countries. High‐fidelity preclinical models can improve AS management by enabling therapeutic innovation, early diagnosis, and tailored treatment planning. …”
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CRISPR-Cas9 in basic and translational aspects of cancer therapy by Maryam Samareh Salavatipour, Zahra Poursalehi, Negin Hosseini Rouzbahani, Sohaib Mohammadyar, Mohammad Vasei

“…Results: We have defined the basics of this technology and then mentioned some clinical and preclinical studies using this technology in the treatment of a variety of solid tumors as well as hematologic neoplasms. …”
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