Recent developments in the therapeutics of SARS-CoV-2 infection by Priyanka Nagu, Arun Parashar, Pankaj Sharma, Vineet Mehta

“…This review highlights promising herbal molecules such as quercetin, and curcumin, which have demonstrated antiviral effects in-vitro and in some preclinical studies. While current treatment strategies for SARS primarily rely on supportive care and antiviral medications, the exploration of herbal molecules presents an exciting avenue for potential adjunctive therapies. …”
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Targeting the kynurenine pathway: another therapeutic opportunity in the metabolic crosstalk between cancer and immune cells by Irene Kang, Irene Kang, George Theodoropoulos, Medhi Wangpaichitr, Medhi Wangpaichitr, Medhi Wangpaichitr, Medhi Wangpaichitr

“…Additionally, we delve into the complex cellular interactions in cancer and metabolic dependencies within the tumor microenvironment (TME). Insights from preclinical studies, recent clinical trials, and promising therapeutic combinations will be discussed to elucidate and promote a clear path forward for the direction of KP research into cancer-related outcomes.…”
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Purine-rich element binding protein alpha: a DNA/RNA binding protein with multiple roles in cancers by Shiyi Yu, Chengyang Jiang, Yawen Yang, Fei Cheng, Fangchen Liu, Chang Liu, Xue Gong

“…Although DNA/RNA binding proteins are hardly targeted, novel strategies have been applied to identify compounds targeting PURα and have demonstrated promising anti-tumor efficacy in the preclinical study. The present review summarizes the most recently discovered critical roles of PURα in various cancer types, providing an overview of the biomarker and therapeutic target potential of PURα for patients with cancer.…”
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Biphalin, a Dimeric Enkephalin, Alleviates LPS-Induced Activation in Rat Primary Microglial Cultures in Opioid Receptor-Dependent and Receptor-Independent Manners by Katarzyna Popiolek-Barczyk, Anna Piotrowska, Wioletta Makuch, Joanna Mika

“…We demonstrated that intrathecally injected biphalin, a dimeric enkephalin analog, diminished symptoms of neuropathy in a preclinical model of neuropathic pain in rats (CCI, chronic constriction injury of the sciatic nerve) at day 12 postinjury. …”
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Recent advances in near-infrared photobiomodulation for the intervention of acquired brain injury by Yujing Huang, Yujing Zhang, Chen Yang, Mengze Xu, Zhen Yuan

“…Recently, near-infrared (NIR) photobiomodulation (PBM) has emerged as a promising physical intervention method for ABI, demonstrating that low-level light therapy can modulate cellular metabolic processes, reduce the inflammation and reactive oxygen species of ABI microenvironments, and promote neural repair and regeneration. Preclinical studies using ABI models have been carried out, revealing the potential of PBM in promoting brain injury recovery although its clinical application is still in its early stages. …”
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Sparse Regularization-Based Reconstruction for Bioluminescence Tomography Using a Multilevel Adaptive Finite Element Method by Xiaowei He, Yanbin Hou, Duofang Chen, Yuchuan Jiang, Man Shen, Junting Liu, Qitan Zhang, Jie Tian

“…In most clinical or preclinical practices, fine discretization is needed for recovering sources with acceptable resolution when solving BLT with finite element method (FEM). …”
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Case Report: Button battery ingestion—an underestimated emergency in children by Karin Konzett, Stefanie Gang, Lukas Poyntner, Eberhard Reithmeier, Susanne Dertinger, Burkhard Simma

“…Pathological workup showed necrosis with secondary aortoesophageal fistula due to battery-induced colliquation necrosis caused by caustic soda produced at the minus pole. We conclude, that preclinical risk scores, excellent clinical pathways (e.g., from Children's Hospital of Philadelphia) and detailed approaches from the National Capital Poison Center in the USA and also the European Society of Pediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) offer clear and concise instructions for the management of button battery ingestion, but clinical awareness for vascular complications must be heightened. …”
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Prostate-Specific Membrane Antigen as Target for Neuroimaging of Central Nervous System Tumors by Brittany M. Stopa, James Crowley, Csaba Juhász, Cara M. Rogers, Mark R. Witcher, Jackson W. Kiser

“…A PubMed search was conducted, including preclinical and clinical reports. One hundred and twelve records were identified, and after screening, 56 were included in the final report. …”
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High-Dose Neural Stem/Progenitor Cell Transplantation Increases Engraftment and Neuronal Distribution and Promotes Functional Recovery in Rats after Acutely Severe Spinal Cord Inju... by Taoyang Yuan, Qian Liu, Jie Kang, Hua Gao, Songbai Gui

“…Our data suggest that it is important to consider potential dose-related effects on donor cell survival, neuronal distribution, and locomotor recovery in the development of preclinical NSPC transplantation therapy for severe SCI.…”
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Mesenchymal Stem/Stromal Cell-Mediated Mitochondrial Transfer and the Therapeutic Potential in Treatment of Neurological Diseases by Deqiang Han, Xin Zheng, Xueyao Wang, Tao Jin, Li Cui, Zhiguo Chen

“…In the end, we summarized recent advances in preclinical research and clinical trials for the treatment of stroke and spinal cord injury, through application of MSCs and/or MSC-derived mitochondria.…”
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MitoQ Modulates Lipopolysaccharide-Induced Intestinal Barrier Dysfunction via Regulating Nrf2 Signaling by Shengfeng Zhang, Qingniao Zhou, Youcheng Li, Yunli Zhang, Yinmei Wu

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EFFICACY OF AMNIOTIC MEMBRANE MESENCHYMAL STEM CELL THERAPY FOR BURN WOUNDS: META-ANALYSIS STUDY by Bayu Fasi Bermani, Agus Santoso Budi, Magda Rosalina Hutagalung

“…The Metaanalysis was performed for these preclinical studies to assess the efficacy and possible mechanisms of Amniotic Membrane Mesenchymal Stem Cell (AM- MSC) in treating burn wounds. …”
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Influence of <i>Eimeria</i> spp. and <i>Clostridium perfringens</i> Infection on Growth Performance and Toltrazuril Residues in Chickens by Konrad Pietruk, Jacek Karamon, Piotr Jedziniak, Stanisław Tokarzewski, Małgorzata Olejnik

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IMPASSIVE DICTATING: A Mnemonic Acronym for Systematically Generating Differential Diagnoses by Ho M, Coloma M, Ngo R, Santhakumar J

“…By emphasizing mechanisms of disease rather than clinical experience, IMPASSIVE DICTATING may be particularly useful in preclinical education, other teaching contexts, and complex patient presentations. …”
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Correlation Between Sagittal and Transverse Plane Fetal Nuchal Translucency Measurement by Pananya Jomphansa, Suthasinee Metaneedol, Sinart Prommas, Buppa Smanchat, Kornkarn Bhamarapravatana, Komsun Suwannarurk

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Evaluation of Early Markers of Nephropathy in Patients with Type 2 Diabetes Mellitus by Pierina De Muro, Antonio Junior Lepedda, Gabriele Nieddu, Michela Idini, Hai Quy Tram Nguyen, Omar Lobina, Pietro Fresu, Marilena Formato

“…As patients with T2DM are at increased risk of microvascular and macrovascular complications, the preclinical diagnosis of the state is the key point of the disease management. …”
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Therapeutic ultrasound transducer technology and monitoring techniques: a review with clinical examples by Maxime Lafond, Allison Payne, Cyril Lafon

“…While the clinical indications explored in this review are at different points in the clinical evaluation path, based on the ever expanding research being conducted in preclinical realms, it is clear that additional clinical applications of therapeutic ultrasound that utilize a myriad of bioeffects will continue to grow and improve in the coming years.Conclusions: Therapeutic ultrasound will continue to improve in the next decades as the combination of transducer technology and treatment monitoring techniques will continue to evolve and be translated in clinical settings, leading to more personalized and efficient therapeutic ultrasound mediated therapies.…”
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Association between Self-Reported Bruxism and Sleeping Patterns among Dental Students in Saudi Arabia: A Cross-Sectional Study by Shereen M. Shokry, Eman E. El Wakeel, Nassr Al-Maflehi, Zaheera RasRas, Nida Fataftah, Enam Abdul Kareem

“…This questionnaire was randomly distributed among all college preclinical and postclinical students. Sleep bruxism diagnosis was based on self-reported data. …”
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Reevaluating the Concept of Treating Experimental Tumors with a Mixed Bacterial Vaccine: Coley’s Toxin by C. Maletzki, U. Klier, W. Obst, B. Kreikemeyer, M. Linnebacher

“…Data presented herein prove that the historical approach of using killed bacteria as active immunotherapeutic agents still holds promise, and further careful preclinical analyses may pave the way back into clinical applications.…”
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Metabolic stability and its role in the discovery of new chemical entities by Słoczyńska Karolina, Gunia-Krzyżak Agnieszka, Koczurkiewicz Paulina, Wójcik-Pszczoła Katarzyna, Żelaszczyk Dorota, Popiół Justyna, Pękala Elżbieta

“…In the present paper, issues of compound metabolic stability will be discussed, with special emphasis on its significance, in vitro metabolic stability testing, dilemmas regarding in vitro-in vivo extrapolation of the results and some aspects relating to different preclinical species used in in vitro metabolic stability assessment of compounds.…”
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