Semiautomatic Landmark-Based Two-Dimensional—Three-Dimensional Image Fusion in Living Mice: Correlation of Near-Infrared Fluorescence Imaging of Cy5.5-Labeled Antibodies with Flat-... by Christian Dullin, Marta Zientkowska, Joanna Napp, Jeannine Missbach-Guentner, Hans-Willi Krell, Friedemann Muller, Eckhardt Grabbe, Lutz-F. Tietze, Frauke Alves

“…The combination of fpVCT with NIRF imaging will now allow targeted and effective monitoring of preclinical tumor therapies.…”
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Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application by Mengyuan Wang, Quan Yuan, Liang Xie

“…Recently, clinical trials for MSC-mediated therapies have rapidly developed for immune-related diseases following reports from preclinical studies declaring their therapeutic safety and efficacy. …”
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Dietary Conjugated Linoleic Acid Alters Oxidative Stability and Alleviates Plasma Cholesterol Content in Meat of Broiler Chickens by Suriya Kumari Ramiah, Goh Yong Meng, Mahdi Ebrahimi

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Role of phytochemicals in cardiovascular disease management: Insights into mechanisms, efficacy, and clinical application by Esther Ugo Alum

“…The review analyzes findings from clinical trials, epidemiological studies, and preclinical research to explain how these phytochemicals are effective in preventing and treating cardiovascular diseases. …”
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Functional Role of Adult Hippocampal Neurogenesis as a Therapeutic Strategy for Mental Disorders by Heechul Jun, Syed Mohammed Qasim Hussaini, Michael J. Rigby, Mi-Hyeon Jang

“…In this paper, we discuss three major psychiatric disorders, depression, schizophrenia, and drug addiction, in light of preclinical evidence used in establishing the neurobiological significance of adult neurogenesis. …”
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Neoantigen mRNA vaccines and A2A receptor antagonism: A strategy to enhance T cell immunity by Saber Imani, Parham Jabbarzadeh Kaboli, Ali Babaeizad, Mazaher Maghsoudloo

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A new taxonomy of neuroprotective agents for stroke appropriate for the reperfusion era by Mersedeh Bahr-Hosseini, Jeffrey L. Saver

“…By focusing on broad physiologic targets of action rather than granular molecular mechanisms, this six-fold classification of neuroprotection can inform the design of preclinical studies and human clinical trials, including imaging biomarker endpoint selection and treatment timing. …”
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Dengue fever and herbal medicine in Indonesia: Trends, collaborations, and research impact (1985-2023) by Nur Sabila Berlianda, Stefani Widodo, Putri Damayanti Irma, Pratiwi Wardani Dita, Abidah Safithri, Muhammad Almanfaluthi

“…A keyword co-occurrence analysis identified “Aedes aegypti,” “animal model,” and “plant extract” as central themes in the research, which highlights a strong focus on preclinical studies and the chemical analysis of plant-based treatments.…”
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Detection of Cancer Stem Cells from Patient Samples by Sofia Hakala, Anna Hämäläinen, Sanne Sandelin, Nikolaos Giannareas, Elisa Närvä

“…Additionally, methods recently established in laboratories, preclinical studies, and clinical assays are covered. …”
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FDA-approved kinase inhibitors: a promising therapeutic avenue for traumatic brain injury by Dezhu Gao, Yu Shi, Zhiliang Wang, Weiming Liu

“…Nowadays, kinase inhibitors approved by the Food and Drug Administration (FDA) mainly for cancer treatment have shown potential effects in TBI. Preclinical studies suggest their potential in promoting recovery. …”
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The role of DNA methylation in the disorders of bone metabolism by B. I. Yalaev, A. V. Tyurin, R. Y. Mirgalieva, R. I. Khusainova

“…Finding the risk factors will predict the risk of osteoporosis at the preclinical stage, help define the course and severity of the disease, and develop preventive measures based on them to reduce the risk of fractures. …”
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Cultured Human Airway Epithelial Cells (Calu-3): A Model of Human Respiratory Function, Structure, and Inflammatory Responses by Yan Zhu, Aaron Chidekel, Thomas H. Shaffer

“…The Calu-3 cell preparation is a sensitive and efficient preclinical model to study human respiratory processes and diseases related to oxygen- and ventilator-induced lung injury.…”
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Investigating the Insights of Nursing Students About Clinical Pharmacology Courses by Kiarash Fekri, Fereshteh Araghian Mojarad, Mehrrooz Alishah, Seyed Robabe Babaei, Tahereh Yaghoubi

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CAR T cells for treating autoimmune diseases by Dimitrios Mougiakakos, Ulrike Koehl, Stephan Fricke, Ulrich Blache, Sandy Tretbar

“…We will cover first clinical results of applying anti-CD19 and anti-B cell maturation antigen CAR T cells for B cell elimination in systemic lupus erythematosus, refractory antisynthetase syndrome and myasthenia gravis, respectively. Furthermore, in preclinical models, researchers have also developed chimeric autoantibody receptor T cells that can eliminate individual B cell clones producing specific autoantibodies, and regulatory CAR T cells that do not eliminate autoreactive immune cells but dampen their wrong activation. …”
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Structure-guided identification of mitogen-activated protein kinase-1 inhibitors towards anticancer therapeutics. by Md Nayab Sulaimani, Shazia Ahmed, Farah Anjum, Taj Mohammad, Anas Shamsi, Ravins Dohare, Md Imtaiyaz Hassan

“…The study highlights that these compounds could be explored further in preclinical and clinical investigations to develop anticancer therapeutics.…”
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Herbal medicine and leptospirosis in Southeast Asia: A comprehensive bibliometric analysis (1973-2023) by Shah Putri Ade Dian, Stefani Widodo, Putri Damayanti Irma, Halim Shariff, Abidah Safithri, Muhammad Almanfaluthi

“…The research also emphasizes the role of preclinical studies and the chemical analysis of herbal remedies for leptospirosis. …”
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Tumor-infiltrating regulatory T cell: A promising therapeutic target in tumor microenvironment by Tianning Huang, Fan Li, Yiming Wang, Jian Gu, Ling Lu, Peifang Wei

“…In this review, we summarize novel therapeutic approaches targeting both the metabolic pathways and hallmarks of TI-Tregs in preclinical and clinical studies. Although the phenotypic and functional diversity of TI-Tregs remains unclear, our review provides new insights into TI-Treg-based therapies and facilitates precision medicine for tumor treatment.…”
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Dual Inhibition of Activin/Nodal/TGF-β and BMP Signaling Pathways by SB431542 and Dorsomorphin Induces Neuronal Differentiation of Human Adipose Derived Stem Cells by Vedavathi Madhu, Abhijit S. Dighe, Quanjun Cui, D. Nicole Deal

“…Damage to the nervous system can cause devastating diseases or musculoskeletal dysfunctions and transplantation of progenitor stem cells can be an excellent treatment option in this regard. Preclinical studies demonstrate that untreated stem cells, unlike stem cells activated to differentiate into neuronal lineage, do not survive in the neuronal tissues. …”
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Quantification and prediction of human fetal (-)-Δ9-tetrahydrocannabinol/(±)-11-OH-Δ9-tetrahydrocannabinol exposure during pregnancy to inform fetal cannabis toxicity by Aditya R. Kumar, Lyndsey S. Benson, Erica M. Wymore, Jocelyn E. Phipers, Jennifer C. Dempsey, Lucinda A. Cort, Jashvant D. Unadkat

“…To determine causality, preclinical studies mimicking human fetal cannabinoid exposure must be conducted. …”
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mRNA vaccines in the context of cancer treatment: from concept to application by Qiang Fu, Xiaoming Zhao, Jinxia Hu, Yang Jiao, Yunfei Yan, Xuchen Pan, Xin Wang, Fei Jiao

“…Additionally, we summarize preclinical studies and clinical trials to provide valuable insights into the current status of mRNA vaccines in cancer treatment. …”
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