Stem Cells from Human Exfoliated Deciduous Teeth Attenuate Trigeminal Neuralgia in Rats by Xiaofeng Bai, Xuedi Zhang, Chun Wang, Yao Liu, Xuemei Liu, Yu Fan, Xia Zhang

“…Therefore, these results provide preclinical evidence that supports the use of SHED in the treatment of trigeminal neuralgia and potentially other chronic pain conditions.…”
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Leveraging mRNA technology for antigen based immuno-oncology therapies by Wei Zheng, Michele Ceccarelli, Charalampos S Floudas, Siranush Sarkizova

“…While this review centers on therapeutic mRNA vaccines targeting existing tumors, it does not cover preventative vaccines. Preclinical experimental validations are crucial in cancer vaccine development, but we emphasize the computational approaches that facilitate neoantigen selection and design, highlighting their role in advancing mRNA vaccine development. …”
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Therapeutic Targeting of Fibroblast Growth Factor Receptors in Gastric Cancer by Mikito Inokuchi, Yoshitaka Fujimori, Sho Otsuki, Yuya Sato, Masatoshi Nakagawa, Kazuyuki Kojima

“…This review discusses the clinical relevance of FGFR in GC and examines FGFR as a potential therapeutic target in patients with GC. Preclinical studies in animal models suggest that multitargeted tyrosine kinase inhibitors (TKIs), including FGFR inhibitor, suppress tumor cell proliferation and delay tumor progression. …”
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A phase I study of the CDK4/6 inhibitor ribociclib combined with gemcitabine in patients with advanced solid tumors by Aurora Norman, Mahesh Seetharam, Jacob Allred, Jianping Kong, Mateusz Opyrchal, Wen Wee Ma, Yanyan Lou, Grace K. Dy, Amit Mahipal, S. John Weroha, Andrea E. Wahner Hendrickson, Joel M. Reid, Alex A. Adjei

“…Abstract Background Based on preclinical data showing addition of CDK4/6 inhibitors to gemcitabine was synergistic, ribociclib was evaluated in combination with gemcitabine to determine the maximum tolerated dose (MTD) and dose limiting toxicities (DLT). …”
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Therapeutic benefit of the dual ALK/FAK inhibitor ESK440 in ALK-driven neuroblastoma by Seema Chugh, Jean C. Tien, Jennifer Hon, Carson Kenum, Rahul Mannan, Yunhui Cheng, Chi Chiang Li, Zainab I. Taher, Andrew D. Delekta, Pushpinder Singh Bawa, Ingrid J. Apel, Stephanie J. Miner, Xuhong Cao, Rohit Mehra, Saravana M. Dhanasekaran, Yuanyuan Qiao, Rajen Mody, Arul M. Chinnaiyan

“…In this study, we analyzed the efficacy of a Phase Ia-cleared, orally bioavailable dual ALK and focal adhesion kinase (FAK) inhibitor, ESK440, in multiple preclinical NB models. ESK440 potently inhibited proliferation of NB cell lines, with increased sensitivity in cell lines harboring ALK aberrations. …”
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A current review on animal models of anti-asthmatic drugs screening by Shivam Singh, Sunita Kularia, Shivakshi Shukla, Mithilesh Singh, Manish Kumar, Ashish Kumar Sharma

“…By critically evaluating these models, the review emphasises their importance in directing anti-asthmatic drug development and highlights the urgent need for innovation to bridge the gap between preclinical success and clinical efficacy.…”
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Maternal and Neonatal Complications of Methamphetamine Use during Pregnancy by Suthanud Premchit, Nawabhorn Orungrote, Sinart Prommas, Buppa Smanchat, Kornkarn Bhamarapravatana, Komsun Suwannarurk

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The Potential Use of Mesenchymal Stem Cells and Their Derived Exosomes as Immunomodulatory Agents for COVID-19 Patients by Faisal A. Alzahrani, Islam M. Saadeldin, Abrar Ahmad, Dipak Kumar, Esam I. Azhar, Arif Jamal Siddiqui, Bassem Kurdi, Abdulrahim Sajini, Abdulmajeed F. Alrefaei, Sadaf Jahan

“…However, the use of MSCs or MSCs-Exo for treating COVID-19 should strictly adhere to the appropriate manufacturing practices, quality control measurements, preclinical safety and efficacy data, and the proper ethical regulations. …”
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Museomics and morphological analyses of historical and contemporary peninsular Italian wolf (Canis lupus italicus) samples by Elena Fabbri, Antonia Vecchiotti, Federica Mattucci, Edoardo Velli, Vilde Arntzen Engdal, Nicola Baccetti, Adriano De Faveri, Pavel Hulva, Barbora Černá Bolfíková, Urmas Saarma, Elisabetta Cilli, Romolo Caniglia

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Emerging Strategies in Cartilage Repair and Joint Preservation by Mircea Adrian Focsa, Sorin Florescu, Armand Gogulescu

“…<i>Materials and Methods:</i> This review synthesises findings from recent clinical and preclinical studies published within the last five years, retrieved from the PubMed, Scopus, and Web of Science databases. …”
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Effectiveness of Contrast Agents and Molecular Indicators in Alzheimer's Diagnosis Through PET and SPECT Imaging on Animal Models by Yasaman Abaszadeh, Ramin Ardalani, Athena Dehghan Najm Abadi

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Silymarin: a promising modulator of apoptosis and survival signaling in cancer by Ujjawal Sharma, Praveen Kumar Sahni, Bunty Sharma, Madhu Gupta, Damandeep Kaur, Darin Mansor Mathkor, Shafiul Haque, Sabiha Khatoon, Hardeep Singh Tuli, Astha Mishra, Faraz Ahmad

“…Lastly, a number of preclinical studies that provide a basis for upcoming therapeutic interventions are highlighted in the review, providing encouraging directions for additional research and advancement.…”
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Mechanistic Insights into the Anticancer Potential of Methoxyflavones Analogs: A Review by Mohammad Aidiel, Maisarah Abdul Mutalib, Rajesh Ramasamy, Nik Nasihah Nik Ramli, Shirley Gee Hoon Tang, Siti Hajar Adam

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The Influence of Osteoporosis and Diabetes on Dental Implant Stability: A Pilot Study by Liliana Sachelarie, Ioana Scrobota, Felicia Cioara, Timea Claudia Ghitea, Corina Laura Stefanescu, Liana Todor, Georgiana Ioana Potra Cicalau

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Potential therapeutic effects of apigenin for colorectal adenocarcinoma: A systematic review and meta‐analysis by Koohyar Ahmadzadeh, Shayan Roshdi Dizaji, Fatemeh Ramezani, Farnad Imani, Jebreil Shamseddin, Arash Sarveazad, Mahmoud Yousefifard

“…Methods Medline, Embase, Scopus, and Web of Science databases were searched for articles related to apigenin and its effect on CRC in the preclinical setting. Cell viability, growth inhibition, apoptosis, and cell cycle arrest for in‐vitro, and body weight, tumor size, and mortality in in‐vivo studies were extracted as outcomes. …”
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Maytansinoids in cancer therapy: advancements in antibody–drug conjugates and nanotechnology-enhanced drug delivery systems by Matteo Perra, Ines Castangia, Matteo Aroffu, Federica Fulgheri, Rita Abi-Rached, Maria Letizia Manca, Hernán Cortés, María Luisa Del Prado-Audelo, Carla Nomura-Contreras, Alejandra Romero-Montero, Dietrich Büsselberg, Gerardo Leyva-Gómez, Javad Sharifi-Rad, Daniela Calina

“…This review highlights the anticancer activity of maytansinoids, with a focus on AMCs designed to target cancer cells specifically. Preclinical and clinical studies show that AMCs, including FDA-approved drugs like Kadcyla and Elahere, effectively inhibit tumor growth while reducing systemic toxicity. …”
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The Number of Frames on ECG-Gated 18F-FDG Small Animal PET Has a Significant Impact on LV Systolic and Diastolic Functional Parameters by Christoph Eissler, Rudolf A. Werner, Paula Arias-Loza, Naoko Nose, Xinyu Chen, Martin G. Pomper, Steven P. Rowe, Constantin Lapa, Andreas K. Buck, Takahiro Higuchi

“…This study is aimed at investigating the impact of frame numbers in preclinical electrocardiogram- (ECG-) gated 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) on systolic and diastolic left ventricular (LV) parameters in rats. …”
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STD Training in Canadian Medical Schools by Jo-Anne A Doherty, A Gordon Jessamine

“…DESIGN: A four page questionnaire sought information on preclinical, clinical and residency training in terms of the number of classroom and laboratory hours of instruction, the subspecialty responsible for providing the training, and the clinical ‘hands on’ experience of the teachers: each respondent was also asked to assess the quality and scope of instruction provided at his/her medical school. …”
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Exploring the Molecular Modalities in the Pathogenesis of Diabetic Kidney Disease with a Focus on the Potential Therapeutic Implications by Lyubomir Gaydarski, Kristina Petrova, Ivan Angushev, Stancho Stanchev, Alexandar Iliev, Nikola Stamenov, Vidin Kirkov, Boycho Landzhov

“…The apelinergic system, involving apelin and its receptor (APLNR), influences endothelial function, glucose metabolism, and renal health. Preclinical studies highlight its dual role in renal protection and injury through anti-inflammatory and antioxidant pathways, while other evidence suggests that it may exacerbate DKD through podocyte damage and angiogenesis. …”
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Determining the alignment of assessment items with curriculum goals through document analysis by addressing identified item flaws by Humaira Fayyaz Khan, Shazia Qayyum, Huma Beenish, Rehan Ahmed Khan, Samina Iltaf, Lubna Rani Faysal

“…Pre-hoc reports from mid-stake assessments across five academic years were analyzed, covering both preclinical and clinical years. A total of 2,400 multiple-choice questions (MCQs) were reviewed for the mid-stake exams against the institutional checklist in which flaws were categorized into three types: test wiseness, irrelevant difficulty, and miscellaneous flaws. …”
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