Maintenance of intestinal Th17 cells and reduced microbial translocation in SIV-infected rhesus macaques treated with interleukin (IL)-21. by Suresh Pallikkuth, Luca Micci, Zachary S Ende, Robin I Iriele, Barbara Cervasi, Benton Lawson, Colleen S McGary, Kenneth A Rogers, James G Else, Guido Silvestri, Kirk Easley, Jacob D Estes, Francois Villinger, Savita Pahwa, Mirko Paiardini

“…In conclusion, IL-21-treatment in SIV-infected RMs improved mucosal immune function through enhanced preservation of Th17 cells. Further preclinical studies of IL-21 may be warranted to test its potential use during chronic infection in conjunction with antiretroviral therapy.…”
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Exploring TNFR1: from discovery to targeted therapy development by Yingying Li, Ruiwei Ye, Haorui Dai, Jiayi Lin, Yue Cheng, Yonghong Zhou, Yiming Lu

“…This review emphasizes the emerging field of targeted therapies aimed at selectively modulating TNFR1 activity, identifying promising therapeutic strategies that exploit TNFR1 as a drug target through an evaluation of current clinical trials and preclinical studies. In conclusion, this study contributes novel insights into the biological functions of TNFR1 and presents potential therapeutic strategies for clinical application, thereby having substantial scientific and clinical significance.…”
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Biocompatible Peritoneal Dialysis Fluids: Clinical Outcomes by Yeoungjee Cho, Sunil V. Badve, Carmel M. Hawley, Kathryn Wiggins, David W. Johnson

“…In order to overcome these barriers, a number of more biocompatible PD fluids, with neutral pH, low glucose degradation product content, and bicarbonate buffer have been manufactured over the past two decades. Several preclinical studies have demonstrated their benefit in terms of improvement in host cell defence, peritoneal membrane integrity, and cytokine profile. …”
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The Role of PAM4 in the Management of Pancreatic Cancer: Diagnosis, Radioimmunodetection, and Radioimmunotherapy by Suxia Han, Guihua Jin, Lijuan Wang, Meng Li, Chenchen He, Xijing Guo, Qing Zhu

“…Several different radiolabeled immunodiagnostic and immunotherapeutic agents of PAM4 have been developed and some are being evaluated in preclinical and/or clinical studies. The review will focus on PAM4 and its potential utility for the diagnosis, radioimmunodetection, and radioimmunotherapy of pancreatic cancer.…”
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The First Report of Ruminant Fascioliasis in Sabah, East Malaysia by Naim Che Kamaruddin, Muhammad Ali Imran Razali, Ibitoye Emmanuel Busayo, Noor Hazfalinda Hamzah, Lokman Hakim Idris, Nur Mahiza Md Isa

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Modeling Alzheimer’s Disease with Induced Pluripotent Stem Cells: Current Challenges and Future Concerns by Weiwei Zhang, Bin Jiao, Miaojin Zhou, Tao Zhou, Lu Shen

“…As a result, there is a pressing need for the development of new models providing insights into the pathological mechanisms of AD and for the discovery of ways to treat or delay the onset of the disease. Recent preclinical research suggests that stem cells can be used to model AD. …”
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Astaxanthin as a potential therapeutic agent for knee osteoarthritis: A review of mechanisms and clinical evidence by Sidra Sabir, AHM Mahmudur Rahman, Abdul Haseeb Bhutta

“…This review aims to examine the therapeutic mechanisms of astaxanthin in KOA, alongside clinical evidence supporting its effectiveness through a narrative synthesis of preclinical and clinical studies. Methods: A comprehensive review of the literature was conducted across Web of Science, Pubmed, Scopus and Google Scholar, focusing on studies that explored astaxanthin's antioxidative, anti-inflammatory, and cartilage-protective properties in the context of KOA. …”
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Emerging targeted therapies in oral oncology: Focus on EGFR inhibition by Vishnu Priya Veeraraghavan, Shikhar Daniel, Arun Kumar Dasari, Kaladhar Reddy Aileni, Chaitra patil, Santosh R. Patil

“…Small-molecule tyrosine kinase inhibitors (TKIs) and monoclonal antibodies (mAbs) targeting EGFR have shown promise in preclinical studies and clinical trials. However, challenges, such as the development of resistance mechanisms and treatment-related toxicities, pose obstacles to their clinical utility. …”
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Effect of Covid-19 Vaccine on Women's Fertility Hormones by Haydar Basim Najeb, Abdulameer Jasim Mohammed, Emad Mohammed Rasheed

“…More than 184 nominee vaccines are being tested in preclinical use and 104 in clinical stages of development. …”
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Connecting Cerebral White Matter Lesions and Hypertensive Target Organ Damage by Cristina Sierra, Alfons López-Soto, Antonio Coca

“…Stroke is the second leading cause of death and the number one cause of disability worldwide and over 80% of strokes occur in the elderly. Preclinical hypertensive lesions in most target organs are clearly identified: left ventricular hypertrophy for the heart, microalbuminuria for the kidney, fundus abnormalities for the eye, and intima-media thickness and pulse wave velocity for the vessels. …”
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Coregistration of Ultrasonography and Magnetic Resonance Imaging with a Preliminary Investigation of the Spatial Colocalization of Vascular Endothelial Growth Factor Receptor 2 Exp... by Mary E. Loveless, Jennifer G. Whisenant, Kevin Wilson, Andrej Lyshchik, Tuhin K. Sinha, John C. Gore, Thomas E. Yankeelov

“…We present an ultrasonography (US)-magnetic resonance imaging (MRI) coregistration technique and examine its application in a preliminary multimodal, multiparametric study in a preclinical model of breast cancer. Nine mice were injected with 67NR breast cancer cells and imaged 6 and 9 days later with 4.7 T MRI and high-frequency US. …”
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Pharmacokinetic and Biodistribution Assessment of a Near Infrared-Labeled PSMA-Specific Small Molecule in Tumor-Bearing Mice by Joy L. Kovar, Lael L. Cheung, Melanie A. Simpson, D. Michael Olive

“…Use of near infrared (NIR) technologies to perform image-guided surgery may improve accurate delineation of tumor margins. To facilitate preclinical testing of such outcomes, here we developed and characterized a PSMA-targeted small molecule, YC-27. …”
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Electrostatic properties of human germlines and biodistribution of small biologics by Leticia Maria De Souza Cordeiro, Kelley Christine Atkinson, Argin Aivazian, Patrick Frank Joyce, Fang Jia, Alessandro Mascioni

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Progress in Therapy Development for Amyotrophic Lateral Sclerosis by Kalina Venkova-Hristova, Alexandar Christov, Zarine Kamaluddin, Peter Kobalka, Kenneth Hensley

“…Reasons will be considered for the frequent failure of preclinical successes to translate into positive clinical outcomes. …”
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Meta-Analysis of the Therapeutic Effects of Stem Cell-Derived Extracellular Vesicles in Rodent Models of Hemorrhagic Stroke by Conglin Wang, Bo Yan, Pan Liao, Fanglian Chen, Ping Lei

“…Our findings suggest that SCEVs therapy may improve neurofunctional behavior after hemorrhagic stroke and provide important insights into the design of preclinical trials.…”
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The impact of vitamin D on breast cancer treatment: Literature review by Fedosenko Mariia

“…Methods: The authors analyzed and systematized research data on the predictive effect of vitamin D on the prognosis and course of breast cancer, the manifestation of its "non-classical" effects in preclinical and clinical studies, and assessed the possible practical application of the results obtained at the molecular-cellular level. …”
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AI Methods for Antimicrobial Peptides: Progress and Challenges by Carlos A. Brizuela, Gary Liu, Jonathan M. Stokes, Cesar de laFuente‐Nunez

“…AI approaches have recently revolutionised this field by accelerating the discovery of new peptides with anti‐infective activity, particularly in preclinical mouse models. Initially, classical ML approaches dominated the field, but recently there has been a shift towards deep learning (DL) models. …”
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An HLA-Transgenic Mouse Model of Type 1 Diabetes That Incorporates the Reduced but Not Abolished Thymic Insulin Expression Seen in Patients by Jeffrey Babad, Riyasat Ali, Jennifer Schloss, Teresa P. DiLorenzo

“…This model should find utility as a tool to uncover the mechanisms underlying the association between reduced thymic insulin expression and T1D in humans and aid in preclinical studies to evaluate insulin-targeted immunotherapies for the disease.…”
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Noncoding RNAs Associated with PPARs in Etiology of MAFLD as a Novel Approach for Therapeutics Targets by Fatemeh Kazeminasab, Maryam Baharlooie, Kamran Ghaedi

“…This study revealed a subset of ncRNAs that could help in more clear and guided designation of preclinical and clinical studies to verify the therapeutic application of the revealed ncRNAs by manipulating the PPARs molecular mechanism in MAFLD.…”
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Galectin-3 Inhibitors Suppress Anoikis Resistance and Invasive Capacity in Thyroid Cancer Cells by Jie-Jen Lee, Yi-Chiung Hsu, Ying-Syuan Li, Shih-Ping Cheng

“…Galectin-3 inhibitors are potentially suitable for preclinical evaluation of treatment and/or prevention of metastatic spread in thyroid cancer.…”
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