Individual and sex differences in frontloading behavior and approach- avoidance conflict preference predict addiction-like ethanol seeking in rats by Tanner A. McNamara, Hanyi Weng, Hsin Yu Liao, Rutsuko Ito

“…Abstract Recent research has identified sex-dependent links between risk taking behaviors, approach-avoidance bias and alcohol intake. However, preclinical studies have typically assessed alcohol drinking using a singular dimension of intake (i.e. drinking level), failing to capture the multidimensional pattern of aberrant alcohol-seeking observed in alcohol use disorder. …”
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Monitoring of Biodistribution and Persistence of Conditionally Replicative Adenovirus in a Murine Model of Ovarian Cancer Using Capsid-Incorporated mCherry and Expression of Human... by Igor P. Dmitriev, Elena A. Kashentseva, Kenneth H. Kim, Qiana L. Matthews, Stephanie S. Krieger, Jesse J. Parry, Kim N. Nguyen, Walter J. Akers, Samuel Achilefu, Buck E. Rogers, Ronald D. Alvarez, David T. Curiel

“…In the aggregate, the plasticity of our dual imaging approach should provide the technical basis for monitoring CRAd biodistribution and persistence in preclinical studies while offering potential utility for a range of clinical applications.…”
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Phytonanoparticles as novel drug carriers for enhanced osteogenesis and osseointegration by Nandita Suresh, Nebu George Thomas, Matti Mauramo, Tuomas Waltimo, Timo Sorsa, Sukumaran Anil

“…The review discusses advanced strategies in phyto-nanoparticle design, such as surface functionalization and stimuli-responsive release mechanisms, which enhance their efficacy in bone regeneration applications. Preclinical studies demonstrating improved osteoblast proliferation, differentiation, and mineralization are critically analyzed, along with emerging clinical data. …”
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Oligodendrocyte Injury in Multiple Sclerosis. by Mateo Përgjegji, Klei Bame, Ketrina Ceka, Jera Cenalia , Sibora Bërdica , Teona Bushati

“…Emerging therapeutic strategies, such as targeting metabolic pathways, reducing oxidative stress, and enhancing autophagy, have demonstrated potential in preclinical studies. Furthermore, stem cell therapies are being explored for their ability to regenerate oligodendrocytes and restore myelin integrity. …”
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A Proposed Role for Lymphatic Supermicrosurgery in the Management of Alzheimer's Disease: A Primer for Reconstructive Microsurgeons by Joon Pio Hong, Wei F. Chen, Dung H. Nguyen, Qingping Xie

“…A preview of current research evaluating the feasibility of lymphatic reconstruction as a surgical approach to improving Aβ clearance is provided, with the aim of inspiring others to design robust preclinical and clinical investigations into this intriguing hypothesis.…”
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Long Noncoding RNAs in Digestive System Malignancies: A Novel Class of Cancer Biomarkers and Therapeutic Targets? by Athina Kladi-Skandali, Kleita Michaelidou, Andreas Scorilas, Konstantinos Mavridis

“…Regarding digestive system malignancies, the oncogenic HOTAIR is one of the most widely studied lncRNAs in the preclinical level and has already been identified as a potent prognostic marker for major malignancies of the gastrointestinal tract. …”
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The “Trojan Horse” Approach to Tumor Immunotherapy: Targeting the Tumor Microenvironment by Delia Nelson, Scott Fisher, Bruce Robinson

“…There is compelling preclinical data for local immunotherapy approaches in tumor immunology. …”
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Advances in Illuminating Prostate Cancer with Emerging Phototherapies by Ali Usman

“…Combination strategies incorporating PDT and PTT with conventional modalities, including surgery, chemotherapy and immunotherapy, have demonstrated synergistic effects, leading to better therapy sensitization. Preclinical and clinical studies underline the potential of these multimodal approaches to enhance treatment outcomes, particularly for advanced and castration-resistant prostate cancer. …”
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Synthetic embryology of the human heart by Maria Belen Paredes-Espinosa, Janet L. Paluh

“…Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have already been integrated into transplantable patches and are in preclinical efforts to reverse fibrotic scarring from myocardial infarctions. …”
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The potential of Dayak tribal herbal leaves as an anti-breast cancer agent: In silico approach by Kellik Setiawan Volta, Affan Ali Murtadlo Ahmad, Nur Muhammad Ansori Arif, Dhea Kharisma Viol, Dayu Rahma Turista Dora

“…Further research is recommended to isolate and evaluate the bioactive compounds in preclinical and clinical settings. This work supports the potential of traditional Dayak herbal medicine as a natural therapeutic strategy against breast cancer.…”
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Ethnopharmacology, Biological Evaluation, and Chemical Composition of Ziziphus spina-christi (L.) Desf.: A Review by Mahmoud Dogara Abdulrahman, Ali Muhammad Zakariya, Harmand A. Hama, Saber W. Hamad, Sawsan S. Al-Rawi, Sarwan W. Bradosty, Ahmad H. Ibrahim

“…However, the safety and efficacy of Z. spina have not been wholly assessed in humans, and further well-designed clinical trials are needed to corroborate preclinical findings. The mechanism of action of the leaf extract should be examined. …”
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Complement Inhibition as a Proposed Neuroprotective Strategy following Cardiac Arrest by Brad E. Zacharia, Zachary L. Hickman, Bartosz T. Grobelny, Peter A. DeRosa, Andrew F. Ducruet, E. Sander Connolly

“…Emerging preclinical as well as recent human clinical evidence suggests that activation of the complement cascade plays a critical role in the pathogenesis of GCI/R injury following OHCA. …”
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Immunotherapeutic Potential of Lactobacillus Species as Immune Checkpoint Inhibitors in Cancer Immunotherapy by Renukadevi J, Sam Helinto J, Prena D

“…Although the formulation of probiotic species in advanced drug delivery systems, such as niosomes and liposomes, may prove to be successful, regulatory guidelines need to be followed to support their nontoxic effects in preclinical trials followed by clinical studies. Although the concomitant administration of probiotics with ICIs remains a promising strategy, the underlying mechanisms need to be explored to support their systemic nontoxic effects.…”
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Mesenchymal Stem Cells in Sepsis and Associated Organ Dysfunction: A Promising Future or Blind Alley? by Jan Horák, Lukáš Nalos, Vendula Martínková, Jan Beneš, Milan Štengl, Martin Matějovič

“…This article provides an update of the current knowledge regarding MSC in preclinical models of sepsis and sepsis-induced acute kidney injury. …”
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Photobiomodulation and Its Therapeutic Potential in Sleep Disturbances by Jieun Jung, Tae Kim

“…Current scientific evidence from both preclinical and clinical research suggests that PBM has the potential to influence sleep architecture, duration, and quality through complex interactions with cellular metabolic pathways and neurophysiological mechanisms governing the sleep-wake cycle. …”
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Adenine, a key player in biology and medicinal chemistry by Fillion, Alexandra, Vichier-Guerre, Sophie, Arimondo, Paola Barbara

“…This review aims to introduce the adenine and discuss adenine-based inhibitors, their design and use for different therapeutic targets through examples of drugs and compounds that reached clinical and preclinical trials.…”
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Ultraviolet B irradiation-induced keratinocyte senescence and impaired development of 3D epidermal reconstruct by Wattanapitayakul Suvara K., Chularojmontri Linda, Schäfer-Korting Monika

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Natural products as anticancer agents and enhancing their efficacy by a mechanism-based precision approach by Stephen Safe

“…Dietary phenolics including flavonoids and related compounds are associated with multiple health benefits however most individual dietary compounds and other natural products that show promising anticancer activity in preclinical studies exhibit minimal clinical effectiveness and this is particularly true for cancer. …”
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Association of Subjective Cognitive Concerns With Performance on Mobile App–Based Cognitive Assessment in Cognitively Normal Older Adults: Observational Study by Caroline O Nester, Alyssa N De Vito, Sarah Prieto, Zachary J Kunicki, Jennifer Strenger, Karra D Harrington, Nelson Roque, Martin J Sliwinski, Laura A Rabin, Louisa I Thompson

“…There is growing interest in applying a mobile app–based cognitive assessment to remotely screen for cognitive status in preclinical dementia, but the relationship between SCC and relevant mobile assessment metrics is uncertain. …”
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Gut Microbiota–Tumor Microenvironment Interactions: Mechanisms and Clinical Implications for Immune Checkpoint Inhibitor Efficacy in Cancer by Said SS, Ibrahim WN

“…By integrating insights from recent preclinical and clinical studies, we aim to shed light on the potential of microbiome modulation as an adjunct to cancer immunotherapy and as a diagnostic tool, paving the way for personalized therapeutic approaches that optimize patient outcomes.Keywords: ICIs, immunotherapy, gut microbiota, microbiome, tumor microenvironment…”
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