NGcGM3 Ganglioside: A Privileged Target for Cancer Vaccines by Luis E. Fernandez, Mariano R. Gabri, Marcelo D. Guthmann, Roberto E. Gomez, Silvia Gold, Leonardo Fainboim, Daniel E. Gomez, Daniel F. Alonso

“…The present paper examines the role of NGc-gangliosides in tumor biology as well as the available preclinical and clinical data on these vaccine products. …”
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Mesenchymal stem cells for osteoarthritis: Recent advances in related cell therapy by Jianjing Lin, Jingtao Huang, Zilu Jiao, Mengyuan Nian, Canfeng Li, Yali Dai, Shicheng Jia, Xintao Zhang

“…Mesenchymal stem cells from various tissues are the most studied cell type and have been used in preclinical and clinical studies of OA, because they are more widely available, have a greater capacity for in vitro expansion, and have anti‐inflammatory and immunomodulatory properties compared to autologous chondrocytes. …”
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Exercise Intervention Associated with Cognitive Improvement in Alzheimer’s Disease by Meng Ying Cui, Yang Lin, Ji Yao Sheng, Xuewen Zhang, Ran Ji Cui

“…On the other hand, accumulating evidence suggests that exercise intervention may ameliorate the progression of cognitive impairment in aging ones while the standard strategy is lacking based on different levels of cognitive decline especially in mild cognitive impairment (MCI) and AD. MCI is the preclinical stage of AD in which neurodegeneration may be reversed via neuroplasticity. …”
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Molecular Imaging of the Human Pulmonary Vascular Endothelium Using an Adrenomedullin Receptor Ligand by François Harel, Xavier Levac, Quang T. Nguyen, Myriam Létourneau, Sophie Marcil, Vincent Finnerty, Mariève Cossette, Alain Fournier, Jocelyn Dupuis

“…Labeled with 99m Tc, it allows single-photon emission computed tomographic (SPECT) imaging of lung perfusion. In preclinical studies, PulmoBind scans enabled detection of lung perfusion defects and quantification of microcirculatory occlusion caused by pulmonary hypertension. …”
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Hand grip strength and quality of life among adults aged 50–90 years from South West Poland by Antonina Kaczorowska, Sławomir Kozieł, Zofia Ignasiak

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Quarter-Millimeter-Resolution Molecular Mouse Imaging with U-SPECT by Oleksandra Ivashchenko, Frans van der Have, Jose L. Villena, Harald C. Groen, Ruud M. Ramakers, Harrie H. Weinans, Freek J. Beekman

“…Limited spatial resolution of preclinical positron emission tomography (PET) and single-photon emission computed tomography (SPECT) has slowed down applications of molecular imaging in small animals. …”
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Fractional-Order PI Control of First Order Plants with Guaranteed Time Specifications by F. J. Castillo-Garcia, A. San Millan-Rodriguez, V. Feliu-Batlle, L. Sanchez-Rodriguez

“…Because CSs contain both primitive cells and committed progenitors for the three major cell types present in the heart, that is, cardiomyocytes, endothelial cells, and smooth muscle cells, and because they are derived from percutaneous endomyocardial biopsies, they represent an attractive cell source for cardiac regeneration. In preclinical studies, CS-derived cells (CDCs) delivered to infarcted hearts resulted in improved cardiac function. …”
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Calcium Signaling in the Ventricular Myocardium of the Goto-Kakizaki Type 2 Diabetic Rat by L. Al Kury, M. Smail, M. A. Qureshi, V. Sydorenko, A. Shmygol, M. Oz, J. Singh, F. C. Howarth

“…The association between diabetes mellitus (DM) and high mortality linked to cardiovascular disease (CVD) is a major concern worldwide. Clinical and preclinical studies have demonstrated a variety of diastolic and systolic dysfunctions in patients with type 2 diabetes mellitus (T2DM) with the severity of abnormalities depending on the patients’ age and duration of diabetes. …”
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Pediatric Traumatic Brain Injury and Autism: Elucidating Shared Mechanisms by Rahul Singh, Ryan C. Turner, Linda Nguyen, Kartik Motwani, Michelle Swatek, Brandon P. Lucke-Wold

“…Pediatric traumatic brain injury (TBI) and autism spectrum disorder (ASD) are two serious conditions that affect youth. Recent data, both preclinical and clinical, show that pediatric TBI and ASD share not only similar symptoms but also some of the same biologic mechanisms that cause these symptoms. …”
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Biological Strategies to Enhance Healing of the Avascular Area of the Meniscus by Umile Giuseppe Longo, Stefano Campi, Giovanni Romeo, Filippo Spiezia, Nicola Maffulli, Vincenzo Denaro

“…However, data are too heterogeneous to achieve definitive conclusions on the use of these techniques for routine management of meniscal lesions. Although most preclinical and clinical studies are very promising, they are still at an experimental stage. …”
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Patient-Specific Pluripotent Stem Cells in Neurological Diseases by Serpen Durnaoglu, Sermin Genc, Kursad Genc

“…However, iPSC-based therapeutic strategies need to be thoroughly evaluated in preclinical animal models of neurological diseases before they can be applied in a clinical setting.…”
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Brain Metastases Research 1990–2010: Pattern of Citation and Systematic Review of Highly Cited Articles by Carsten Nieder, Anca L. Grosu, Minesh P. Mehta

“…A large variety of preclinical and clinical topics achieved high numbers of citations. …”
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Phytocannabinoids: a new frontier in Alzheimer’s disease management by Jagadeesh S. Rao

“…Both phytocannabinoids contribute to physiological and pharmacological effects. Multiple preclinical studies conducted on animal models of AD have shown that THC specifically targets and modifies the pathological markers of AD while simultaneously enhancing cognitive function. …”
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Development and application of an LC-MS/MS method for the combined quantification of oxysterols and bile acids by Martin Roumain, Giulio G. Muccioli

“…Finally, the method was successfully applied to the analysis of preclinical and clinical samples, quantifying 12 oxysterols and 14 bile acids in human plasma, 10 oxysterols and 18 bile acids in mouse plasma from the vena cava, and 10 oxysterols and 20 bile acids in mouse plasma from the portal vein within a single chromatographic run.…”
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Responsive afatinib treatment in high-grade salivary gland ductal carcinoma and NSCLC with uncommon EGFR mutations: Treatment outcomes by Sivakamavalli Jeyachandran

“…Afatinib, an irreversible EGFR inhibitor, has emerged as a promising option for high-grade salivary gland ductal carcinoma. Preclinical studies demonstrate its effectiveness in inhibiting tumor growth and inducing apoptosis in EGFR-amplified cell lines. …”
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Current Advance and Future Prospects of Tissue Engineering Approach to Dentin/Pulp Regenerative Therapy by Ting Gong, Boon Chin Heng, Edward Chin Man Lo, Chengfei Zhang

“…This multidisciplinary approach which involves the interplay of three key elements of tissue engineering—stem cells, scaffolds, and signaling molecules—has produced an impressive number of favorable outcomes in preclinical animal studies. Nevertheless, many practical hurdles need to be overcome prior to its application in clinical settings. …”
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Non-professional phagocytosis of senescent cancer cells revealed in a 3D-bioprinted model of an irradiated lung tumour by Parul Yadav, Pritiranjan Mondal, Sibani Jani, Deepak K. Saini, Kaushik Chatterjee

“…As interest in non-animal models grows, these findings underscore the potential of 3D bioprinted platforms to serve as robust alternatives for preclinical research.Created with BioRender.com…”
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Heart-on-a-chip: a revolutionary organ-on-chip platform for cardiovascular disease modeling by Beiqin Liu, Shuyue Wang, Hong Ma, Yulin Deng, Jichen Du, Yimeng Zhao, Yu Chen

“…Abstract Heart-on-a-chip (HoC) devices have emerged as a powerful tool for studying the human heart's intricate functions and dysfunctions in vitro. Traditional preclinical models, such as 2D cell cultures model and animal model, have limitations in accurately predicting human response to cardiovascular diseases and treatments. …”
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Comparative phytochemical and pharmacological analysis of two cultivars of Annona squamosa L. cultivated in Egypt by Safaa Yassin, Samah M. Elsohafy, Amr El-Hawiet, Maged S. Abdel-Kader, Doaa A. Ghareeb, Fikria A. Darwish, Masouda E. Amer

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Chronic Caloric Restriction and Exercise Improve Metabolic Conditions of Dietary-Induced Obese Mice in Autophagy Correlated Manner without Involving AMPK by Mingxia Cui, Han Yu, Jinli Wang, Junjie Gao, Ji Li

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