High-Dose Neural Stem/Progenitor Cell Transplantation Increases Engraftment and Neuronal Distribution and Promotes Functional Recovery in Rats after Acutely Severe Spinal Cord Inju... by Taoyang Yuan, Qian Liu, Jie Kang, Hua Gao, Songbai Gui

“…Our data suggest that it is important to consider potential dose-related effects on donor cell survival, neuronal distribution, and locomotor recovery in the development of preclinical NSPC transplantation therapy for severe SCI.…”
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Mesenchymal Stem/Stromal Cell-Mediated Mitochondrial Transfer and the Therapeutic Potential in Treatment of Neurological Diseases by Deqiang Han, Xin Zheng, Xueyao Wang, Tao Jin, Li Cui, Zhiguo Chen

“…In the end, we summarized recent advances in preclinical research and clinical trials for the treatment of stroke and spinal cord injury, through application of MSCs and/or MSC-derived mitochondria.…”
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MitoQ Modulates Lipopolysaccharide-Induced Intestinal Barrier Dysfunction via Regulating Nrf2 Signaling by Shengfeng Zhang, Qingniao Zhou, Youcheng Li, Yunli Zhang, Yinmei Wu

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Influence of <i>Eimeria</i> spp. and <i>Clostridium perfringens</i> Infection on Growth Performance and Toltrazuril Residues in Chickens by Konrad Pietruk, Jacek Karamon, Piotr Jedziniak, Stanisław Tokarzewski, Małgorzata Olejnik

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IMPASSIVE DICTATING: A Mnemonic Acronym for Systematically Generating Differential Diagnoses by Ho M, Coloma M, Ngo R, Santhakumar J

“…By emphasizing mechanisms of disease rather than clinical experience, IMPASSIVE DICTATING may be particularly useful in preclinical education, other teaching contexts, and complex patient presentations. …”
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Correlation Between Sagittal and Transverse Plane Fetal Nuchal Translucency Measurement by Pananya Jomphansa, Suthasinee Metaneedol, Sinart Prommas, Buppa Smanchat, Kornkarn Bhamarapravatana, Komsun Suwannarurk

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Evaluation of Early Markers of Nephropathy in Patients with Type 2 Diabetes Mellitus by Pierina De Muro, Antonio Junior Lepedda, Gabriele Nieddu, Michela Idini, Hai Quy Tram Nguyen, Omar Lobina, Pietro Fresu, Marilena Formato

“…As patients with T2DM are at increased risk of microvascular and macrovascular complications, the preclinical diagnosis of the state is the key point of the disease management. …”
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Association between Self-Reported Bruxism and Sleeping Patterns among Dental Students in Saudi Arabia: A Cross-Sectional Study by Shereen M. Shokry, Eman E. El Wakeel, Nassr Al-Maflehi, Zaheera RasRas, Nida Fataftah, Enam Abdul Kareem

“…This questionnaire was randomly distributed among all college preclinical and postclinical students. Sleep bruxism diagnosis was based on self-reported data. …”
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Reevaluating the Concept of Treating Experimental Tumors with a Mixed Bacterial Vaccine: Coley’s Toxin by C. Maletzki, U. Klier, W. Obst, B. Kreikemeyer, M. Linnebacher

“…Data presented herein prove that the historical approach of using killed bacteria as active immunotherapeutic agents still holds promise, and further careful preclinical analyses may pave the way back into clinical applications.…”
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Metabolic stability and its role in the discovery of new chemical entities by Słoczyńska Karolina, Gunia-Krzyżak Agnieszka, Koczurkiewicz Paulina, Wójcik-Pszczoła Katarzyna, Żelaszczyk Dorota, Popiół Justyna, Pękala Elżbieta

“…In the present paper, issues of compound metabolic stability will be discussed, with special emphasis on its significance, in vitro metabolic stability testing, dilemmas regarding in vitro-in vivo extrapolation of the results and some aspects relating to different preclinical species used in in vitro metabolic stability assessment of compounds.…”
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Neurotoxicological Effects of Some Mycotoxins on Humans Health and Methods of Neuroprotection by Aleksandra Kuć-Szymanek, Daria Kubik-Machura, Klaudia Kościelecka, Tomasz Męcik-Kronenberg, Lidia Radko

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Natural killer cell engagers for cancer immunotherapy by Shahryar Khoshtinat Nikkhoi, Geng Li, Arash Hatefi, Arash Hatefi

“…This review article critically examines the strategies for engineering bi-, tri-, and multi-specific NKCEs for cancer immunotherapy, providing an in-depth analysis of the latest advancements in NKCE platform technologies currently under development by pharmaceutical and biotech companies and discussing the preclinical and clinical progress of these products. …”
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Gut–brain axis and neuropsychiatric health: recent advances by Ceymi Doenyas, Gerard Clarke, Renáta Cserjési

“…The studies described in this Collection support and expand on the observations from previous preclinical and clinical investigations, while also providing essential novel insights that can drive discovery into previously unexplored avenues of brain-gut-microbiome interactions in health and disease.…”
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Enhancing Mesenchymal Stromal Cell Immunomodulation for Treating Conditions Influenced by the Immune System by Bella S. Guerrouahen, Heba Sidahmed, Asma Al Sulaiti, Moza Al Khulaifi, Chiara Cugno

“…In the present review, we focus on the suppressive effect that MSCs exert on the immune system and highlight the significance of in vitro preconditioning and its use in preclinical studies. We discuss the clinical aspects of using MSCs as an immunomodulatory treatment. …”
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Update on the Treatment of Diabetic Retinopathy by Jennifer L. Wilkinson-Berka, Antonia G. Miller

“…This review examines evidence from preclinical and clinical studies that shows that targeting inhibition of the renin-angiotensin system, vascular endothelial growth factor, corticosteroids, protein kinase C, growth hormone, and advanced glycation end-products are potential treatments for DR.…”
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Assessment of the Association between In Vivo Corneal Morphogeometrical Changes and Keratoconus Eyes with Severe Visual Limitation by J. S. Velázquez, F. Cavas, J. Alió del Barrio, D. G. Fernández-Pacheco, J. Alió

“…This observational case series study evaluated new objective indices in 50 healthy and 30 KC corneas, following a validated protocol created by our research group, which has been previously used for diagnosis and characterization of KC in asymptomatic (preclinical) and mild visually impaired eyes. Results show a statistically significant reduction of corneal volume and an increase of total corneal area in the severe KC group, being anterior and posterior corneal surfaces minimum thickness points the best correlated parameters, although with no discrimination between groups. …”
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Dual Roles of IL-27 in Cancer Biology and Immunotherapy by Marina Fabbi, Grazia Carbotti, Silvano Ferrini

“…Several pieces of evidence, obtained in preclinical tumor models, indicated that IL-27 has a potent antitumor activity, related not only to the induction of tumor-specific Th1 and cytotoxic T lymphocyte (CTL) responses but also to direct inhibitory effects on tumor cell proliferation, survival, invasiveness, and angiogenic potential. …”
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Assessing Medical Students’ Learning Style Preferences at Kabale University Medical School, Uganda. by Muhaise, Hussein, Businge, Phelix Mbabazi, Ssemaluulu, Paul, Kyomugisha, Patricia

“…Relatively, t-test results showed significant (p < 0.05) differences in learning styles between preclinical and clinical students. However, the t-test results for gender factors for all the learning dimensions were insignificant (p > 0.05). …”
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Targeting of the G9a, DNMT1 and UHRF1 epigenetic complex as an effective strategy against pancreatic ductal adenocarcinoma by Daniel Oyon, Amaya Lopez-Pascual, Borja Castello-Uribe, Iker Uriarte, Giulia Orsi, Sofia Llorente, Jasmin Elurbide, Elena Adan-Villaescusa, Emiliana Valbuena-Goiricelaya, Ainara Irigaray-Miramon, Maria Ujue Latasa, Luz A. Martinez-Perez, Luca Reggiani Bonetti, Felipe Prosper, Mariano Ponz-Sarvise, Silvestre Vicent, Antonio Pineda-Lucena, David Ruiz-Clavijo, Bruno Sangro, Urko Aguirre Larracoechea, Tian V. Tian, Andrea Casadei-Gardini, Irene Amat, Maria Arechederra, Carmen Berasain, Jesus M. Urman, Matias A. Avila, Maite G. Fernandez-Barrena

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Determination of Total Phenolics, Flavonoids, and Antioxidant Activity and GC-MS Analysis of Malaysian Stingless Bee Propolis Water Extracts by Sharifah Nur Amalina Syed Salleh, Nur Ayuni Mohd Hanapiah, Hafandi Ahmad, Wan Lutfi Wan Johari, Nurul Huda Osman, Mohd Razif Mamat

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