DNA Vaccination: Using the Patient's Immune System to Overcome Cancer by Georg Eschenburg, Alexander Stermann, Robert Preissner, Hellmuth-Alexander Meyer, Holger N. Lode

“…The main challenge of this concept is to transfer the plethora of convincing preclinical and early clinical results to an effective treatment of patients.…”
Get full text

An Update on the Potential of Mesenchymal Stem Cell Therapy for Cutaneous Diseases by Yanyun Li, Ziyu Ye, Weiqin Yang, Qunzhou Zhang, Jincheng Zeng

“…Numerous clinical and preclinical studies have demonstrated the potential application of MSCs in the treatment of tissue inflammation and immune diseases, including inflammatory skin diseases. …”
Get full text

Advances in Gene Therapy for Neurologic Disorders: An Overview by Pallavi Chand, K. Trideva Sastri, Ashish Singh Chauhan, Souvik Chakraborty, Vikash Jakhmola

“…These viral and non-viral vectors techniques are carefully screened through preclinical and clinical levels and eventually render patients with effective therapies. …”
Get full text

Treatment with the CCR5 antagonist OB-002 reduces lung pathology, but does not prevent disease in a Syrian hamster model of SARS-CoV-2 infection. by Bryce M Warner, Robert Vendramelli, Amrit S Boese, Jonathan Audet, Nikesh Tailor, Courtney Meilleur, Nathan Glowach, Marnie Willman, Thang Truong, Estella Moffat, Kevin Tierney, Beata Kosak, Irfan Dhanidina, Jarret Engstrom, Bozena Korczak, Ian McGowan, Carissa Embury-Hyatt, Darwyn Kobasa

“…Since the emergence of SARS-CoV-2 and the COVID-19 pandemic, a wide range of treatment options have been evaluated in preclinical studies and clinical trials, with several being approved for use in humans. …”
Get full text

Herbal and filariasis in Indonesia: A citation network analysis by Elda Monica Arista, Stefani Widodo, Putri Damayanti Irma, Pratiwi Wardani Dita, Abidah Safithri, Muhammad Almanfaluthi

“…The analysis of keyword co-occurrence reveals that “brugia malayi,” “controlled study,” and “ extract” are central themes, reflecting a strong focus on preclinical research and the extraction procedures of plant-based treatments.…”
Get full text

The Role of NK Cells in Pig-to-Human Xenotransplantation by Gisella Puga Yung, Mårten K. J. Schneider, Jörg D. Seebach

“…Finally, we present the status of phenotypic and functional characterization of nonhuman primate (NHP) NK cells, essential for studying their role in xenograft rejection using preclinical pig-to-NHP models, and summarize key advances and important perspectives for future research.…”
Get full text

Impact of the Aversive Effects of Drugs on Their Use and Abuse by Anthony L. Riley, Hayley N. Manke, Shihui Huang

“…Evidence of such effects comes from both clinical and preclinical populations. In support of this position, the present review describes the aversive effects of drugs (assessed primarily in conditioned taste aversion learning), the fact that they occur concurrently with reward as assessed in combined taste aversion/place preference designs, the role of aversive effects in drug-taking (in balance with their rewarding effects), the dissociation of these affective properties in that they can be affected in different ways by the same manipulations, and the impact of various parametric, experiential, and subject factors on the aversive effects of drugs and the consequent impact of these factors on their use and abuse potential.…”
Get full text

Modulating DDAH/NOS Pathway to Discover Vasoprotective Insulin Sensitizers by Li Lai, Yohannes T. Ghebremariam

“…The concentration of ADMA in plasma and tissue is enzymatically regulated by dimethylarginine dimethylaminohydrolase (DDAH), a widely expressed enzyme in the cardiovascular system. In preclinical studies, overexpression of DDAH has been shown to reduce ADMA levels, improve vascular compliance, and increase insulin sensitivity. …”
Get full text

Critical Aspects of Clinical Trial Design for Novel Cell and Gene Therapies by Zinovia Kefalopoulou, Iciar Aviles-Olmos, Thomas Foltynie

“…Neural cell transplantation and gene therapy have attracted considerable interest as promising therapeutic alternatives for patients with Parkinson's disease (PD). Preclinical and open-label studies have suggested that grafted fetal neural tissue or viral vector gene transfer can achieve considerable biochemical and clinical improvements, whereas subsequent double-blind, placebo-controlled protocols have produced rather more modest and variable results. …”
Get full text

Computational design of multi-epitope vaccine against Hepatitis C Virus infection using immunoinformatics techniques. by Sara Zubair, Fahed Parvaiz, Turki Abualait, Khalid Al-Regaiey, Tasneem Anwar, Mahnoor Zafar, Imdad Kaleem, Shahid Bashir

“…The findings indicate that the designed multi-epitope vaccine have a great potential for preclinical and clinical research, which is an important step in addressing the problems related to HCV infection.…”
Get full text

Comparison of cellular-based therapies following a long-segmental peripheral nerve defect in a rat model. by Emily L Errante, Joseph Yunga Tigre, Ericka A Schaeffer, Meredith C Costello, Andrew J Kloehn, Aiko Puerto, Aisha Khan, Yelena Pressman, Risset Silvera, Francisco J Sanchez, Brian R Noga, W Dalton Dietrich, Allan D Levi, S Shelby Burks

“…Our laboratory has had success using SCs in preclinical and clinical treatment settings. Transplanted cells have several known limitations, which exosomes mitigate. …”
Get full text

A study on Visual, Audio and Tactile Reaction Time Among Medical Students at Kampala International University in Uganda. by Keneth Iceland, Kasozi, Mbiydzneyuy, Ngala Elvis, Namubiru, Sarah, Safiriyu, Abass Alao, Sulaiman, Sheu Oluwadare, Okpanachi, Alfred O., Ninsiima, Herbert Izo

“…Furthermore, significant differences in ART and VRT were observed with sex, although these were absent amongst preclinical and clinical students, showing the importance of sex in RT. …”
Get full text

Targeted Anticancer Immunotoxins and Cytotoxic Agents with Direct Killing Moieties by Koji Kawakami, Oumi Nakajima, Ryuichi Morishita, Ryozo Nagai

“…Several agents using unique technology such as a cleavable adapter or immunoliposomes with antibodies are also in the preclinical stage. This review summarizes the generation, mechanism, and development of these agents. …”
Get full text

Fibroin-Hybrid Systems: Current Advances in Biomedical Applications by Matheus Valentin Maia, Eryvaldo Sócrates Tabosa do Egito, Anne Sapin-Minet, Daniel Bragança Viana, Ashok Kakkar, Daniel Crístian Ferreira Soares

“…A selection of recent preclinical evaluations of these hybrids is included to highlight the significance of this approach.…”
Get full text

On QSPR analysis of pulmonary cancer drugs using python-driven topological modeling by Huiling Qin, Mazhar Hussain, Muhammad Farhan Hanif, Muhammad Kamran Siddiqui, Zahid Hussain, Mohamed Abubakar Fiidow

“…The integration of computational and mathematical chemistry will make it easier to evaluate drugs because it can assure consistent data for preclinical development. The paper also reveals specific indices that are superior to others regarding predictive accuracy, thus giving a basis for refining the models to suit the individual compound. …”
Get full text

Sustained and Efficient Delivery of Antivascular Endothelial Growth Factor by the Adeno-associated Virus for the Treatment of Corneal Neovascularization: An Outlook for Its Clinica... by Mengzhen Xie, Lixiang Wang, Yingping Deng, Ke Ma, Hongbo Yin, Xiaolan Zhang, Xingye Xiang, Jing Tang

“…Among the explored methods, adeno-associated virus-mediated delivery of anti-VEGF to treat corneal neovascularization is the most extensively researched and most promising strategy for clinical translation although currently although, it remains predominantly at the preclinical stage. This review comprehensively examines the necessity, benefits, and risks of applying AAV vectors for anti-VEGF drug delivery in corneal vascularization, including its current progress and challenges in clinical translation.…”
Get full text

Biological Evaluation of Garcinia kola Heckel by Abdulrahman Mahmoud Dogara, Saber W. Hamad, Harmand A. Hama, Sarwan W. Bradosty, Soran Kayfi, Sawsan S. Al-Rawi, Abubakar Abdullahi Lema

“…However, the safety and efficacy of G. kola have not been wholly assessed in humans, and further well-designed clinical trials are needed to corroborate preclinical findings. The mechanism of action of the seed extract should be examined. …”
Get full text

In silico evaluation, characterization, and in vitro anticancer activity of curcumin–nimbin loaded nanoformulation in HCT-116 cell lines by Arumugam Madeswaran, Selvam Tamilazhagan, Sellappan Mohan

“…Further studies are required to evaluate the anticancer effect of curcumin–nimbin loaded nanosupension through clinical and preclinical studies for the progress of potential formulation in the treatment of colorectal cancer.…”
Get full text

Polycystic ovary syndrome (PCOS): progress towards a better understanding and treatment of the syndrome by Mimouni, Nour El Houda, Giacobini, Paolo

“…However, the underlying mechanisms of its transmission remain unknown, thus limiting the development of effective therapeutic strategies.This article highlights how an altered fetal environment (prenatal exposure to high levels of anti-Müllerian hormone) can contribute to the onset of PCOS in adulthood and lead to the transgenerational transmission of neuroendocrine and metabolic traits through alterations in the DNA methylation process.The originality of the translational findings summarized here involves the identification of potential biomarkers for early diagnosis of the syndrome, in addition to the validation of a promising therapeutic avenue in a preclinical model of PCOS, which can improve the management of patients suffering from the syndrome.…”
Get full text

Adult Hippocampal Neurogenesis in Parkinson’s Disease: Impact on Neuronal Survival and Plasticity by Martin Regensburger, Iryna Prots, Beate Winner

“…The pathology of the adult neurogenic niches in human PD patients is still mostly elusive, but different preclinical models have shown profound alterations of adult neurogenesis. …”
Get full text