Best practices for cryopreserving sperm in Nonhuman Primates: a systematic review and meta-analysis by Niloofar Sadeghi, Ndifereke Uboh, Corinna N. Ross, John R. McCarrey, Brian P. Hermann

“…Abstract Nonhuman primates (NHPs) are in increasing demand as models for preclinical research. The availability of a highly efficient cryopreservation protocol for use with NHP sperm has potential to significantly alleviate this demand and contribute to rapid increases in overall number of NHPs available for biomedical research. …”
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Development of a UPLC-MS/MS Method for the Quantification of VS-5584 and Its Application in Pharmacokinetic Studies in Rats by Chunling Zhou, Xiaoxin Li, Aiping He, Tianzhu Liu, Jinmiao Tian, Meihua Jiang, Lina Fang

“…VS-5584 is a small-molecular compound that showed equivalent activity against mTOR and all class I PI3K isoforms and demonstrated preclinical activity in diverse cancer cell lines and xenograft tumor model, and rational combination of VS-5584 and other target therapies achieved promising outcomes in oncology. …”
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Markers of Sleep-Disordered Breathing and Prediabetes in US Adults by Omayma Alshaarawy, Srinivas Teppala, Anoop Shankar

“…Background. Prediabetes is a preclinical stage in the hyperglycemia continuum where subjects are at increased risk of developing diabetes. …”
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The Potential Use of the CRISPR-Cas System for HIV-1 Gene Therapy by Gabriela De Nardi Sanches-da-Silva, Luiza Fonseca Sales Medeiros, Fabio Mitsuo Lima

“…Off-target effects and ethical implications were also discussed to evaluate the safety of the approach and viability of its application in humans, respectively. Although preclinical and clinical tests are still needed, the recent results establish an exciting possibility of applying this technology for prophylaxis and treatment of HIV-1.…”
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Extracellular Cold-Inducible RNA-Binding Protein and Hemorrhagic Shock: Mechanisms and Therapeutics by Naureen Rashid, Zhijian Hu, Asha Jacob, Ping Wang

“…Finally, we suggest that future preclinical studies are required to develop the listed therapeutics for hemorrhagic shock and related conditions. …”
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Mesenchymal Stem Cells as Immunomodulators in a Vascularized Composite Allotransplantation by Yur-Ren Kuo, Chien-Chang Chen, Shigeru Goto, Pao-Yuan Lin, Fu-Chan Wei, Chao-Long Chen

“…Mesenchymal stem cells (MSCs) show promise as an immunomodulatory therapeutic agent and are currently being tested in preclinical and clinical settings as therapies for autoimmune disorders or transplant rejection. …”
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Anti-Inflammatory and Antimicrobial Effects of Herbal Formulation Called Apo-Taat Using Extended-Spectrum ß-Lactamase-Producing Escherichia coli Isolates by Thanakan Kitnithiprapha, Sumalee Panthong, Intouch Sakpakdeejaroen, Sumalee Kondo

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Research progress on the therapeutic roles and mechanisms of hydrogen-rich water in periodontitis by LIU Fushuang, WEI Xiaoxuan, ZHOU Jianpeng, WANG Jun

“…However, most studies on HRW in oral diseases are preclinical <i>in vivo</i> and <i>in vitro</i> studies. …”
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Feasibility and Safety of Continuous and Chronic Bilateral Deep Brain Stimulation of the Medial Forebrain Bundle in the Naïve Sprague-Dawley Rat by Luciano L. Furlanetti, Máté D. Döbrössy, Iñigo A. Aranda, Volker A. Coenen

“…This platform represents a powerful tool for further preclinical investigation of the MFB stimulation in the treatment of depression.…”
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Tumor Metastasis to the Liver, and the Roles of Proteinases and Adhesion Molecules: New Concepts from In Vivo Videomicroscopy by Alan C Groom, Ian C MacDonald, Eric E Schmidt, Vincent L Morris, Ann F Chambers

“…Most preclinical studies of tumour metastasis and effects of molecular interventions have been based on end point assays, and little is known about the fate of cells at sequential steps in the metastatic process. …”
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Xenogenic Implantation of Equine Synovial Fluid-Derived Mesenchymal Stem Cells Leads to Articular Cartilage Regeneration by Mohammed Zayed, Steven Newby, Nabil Misk, Robert Donnell, Madhu Dhar

“…Horses are widely used as large animal preclinical models for cartilage repair studies, and hence, there is an interest in using equine synovial fluid-derived mesenchymal stem cells (SFMSCs) in research and clinical applications. …”
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Identification of potent TMPRSS4 inhibitors through structural modeling and molecular dynamics simulations by Ismail Hdoufane, Mehdi Oubahmane, Youssef Habibi, Christelle Delaite, Mohammed M. Alanazi, Driss Cherqaoui

“…FDA-approved, clinical/preclinical drugs and natural products were docked to the pocket of TMPRSS4. …”
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Polysomnographic Features of Sleep Disturbances and REM Sleep Behavior Disorder in the Unilateral 6-OHDA Lesioned Hemiparkinsonian Rat by Quynh Vo, Timothy P. Gilmour, Kala Venkiteswaran, Jidong Fang, Thyagarajan Subramanian

“…Our findings that the sleep architecture in the HP rat resembles that of PD patients demonstrate the value of this model in studying the pathophysiological basis of PD sleep disturbances and preclinical therapeutics for PD related sleep disorders including RBD.…”
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Interleukin-17: Potential Target for Chronic Wounds by Yasmin Hadian, Michelle D. Bagood, Sara E. Dahle, Apra Sood, R. Rivkah Isseroff

“…Interleukin-17 family signaling is reviewed in the context of tissue repair, and preclinical and clinical studies examining its role in the skin and other organ systems are critically reviewed. …”
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Atmospheric air plasma pre-activation and customizable covalent functionalization of PVDF-membranes of microtiter filter plates by Bálint Árpád Ádám, Sára Spátay, Bálint Jávor, Szabolcs László, Levente Illés, Péter Fürjes, Tünde Tóth, Péter Huszthy, Ádám Golcs

“…These polymeric devices are used worldwide on a daily basis—mainly in the pharmaceutical industry—for parallel syntheses, reaction optimization, various preclinical studies and high-throughput screening methods. …”
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Feasibility of enzalutamide on patients with recurrent non-muscle-invasive bladder cancer with marker tumors: phase I study by Takashi Kawahara, Shuya Kandori, Takahiro Kojima, Bryan J. Mathis, Masanobu Shiga, Hiroyuki Nishiyama

“…Abstract Objective Recent preclinical and retrospective clinical evidence shows that androgen receptor (AR)-mediated signals have significant roles in development of non-muscle invasive bladder cancer (NMIBC). …”
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Recent advances in mesenchymal stem cell therapy for multiple sclerosis: clinical applications and challenges by Kamran Sheikhi, Salah Ghaderi, Hassan Firouzi, Sarvenaz Rahimibarghani, Ehsan Shabani, Hamed Afkhami, Hamed Afkhami, Hamed Afkhami, Aref Yarahmadi

“…This review provides an in-depth analysis of MSC mechanisms of action, including immune system regulation, promotion of remyelination, and neuroregeneration. It examines preclinical studies and clinical trials evaluating the efficacy, safety, and limitations of MSC therapy in various MS phenotypes. …”
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STAT signaling in the pathogenesis and therapy of acute myeloid leukemia and myelodysplastic syndromes by Zoe King, Sudhamsh Reddy Desai, David A. Frank, Aditi Shastri

“…By integrating findings from recent preclinical and clinical studies, this review provides insights into the evolving landscape of STAT-targeted therapies, highlighting the promise of these approaches in enhancing treatment efficacy and improving patient outcomes in high-risk hematologic malignancies.…”
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Recognition of ZnT8, Proinsulin, and Homologous MAP Peptides in Sardinian Children at Risk of T1D Precedes Detection of Classical Islet Antibodies by Magdalena Niegowska, Daniela Paccagnini, Carla Mannu, Clara Targhetta, Marco Songini, Leonardo A. Sechi

“…Recent studies suggest that detection of antibodies against ZnT8 protein in preclinical phase can predict the development of T1D. …”
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Ketogenic diets and Alzheimer’s disease by Klaus W. Lange, Katharina M. Lange, Ewelina Makulska-Gertruda, Yukiko Nakamura, Andreas Reissmann, Shigehiko Kanaya, Joachim Hauser

“…The present review provides a synopsis of preclinical studies and clinical trials assessing the efficacy of ketogenic diets in the treatment of AD. …”
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