Botanicals in human nutrition: focus on bioactive food-derived compounds on gut microbiota in gastrointestinal inflammatory diseases by Emanuele Rinninella, Giordana Galeazzi, Elisa Gianferrari, Sabrina Putzu, Pauline Raoul, Marco Cintoni, Francesca Bugli, Maria Cristina Mele, Maura Di Vito

“…We carry out a research on Pubmed – using MeSH terms – on the role of nutraceuticals such as Punica granatum (pomegranate), Ribes nigrum (blackcurrant), Vaccinium myrtillus (blueberry), Vaccinium macrocarpon (cranberry), Olea europea, Aronia melanocarpa (chokeberry), and inulin. We found preclinical and clinical studies confirming a striking potential role of these nutraceuticals in reducing gut inflammation in such conditions through gut eubiosis restoration. …”
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The Nicotinic Acetylcholine Receptor as a Target for Antidepressant Drug Development by Noah S. Philip, Linda L. Carpenter, Audrey R. Tyrka, Lawrence H. Price

“…These drugs probably exert their effects via antagonism at α4β2 nAChRs, and strong preclinical data support the antidepressant efficacy of both classes when used in conjunction with other primary antidepressants (e.g., monoamine reuptake inhibitors). …”
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The Role of Organelle Stresses in Diabetes Mellitus and Obesity: Implication for Treatment by Yi-Cheng Chang, Siow-Wey Hee, Meng-Lun Hsieh, Yung-Ming Jeng, Lee-Ming Chuang

“…ROS scavengers, chemical chaperones, and autophagy activators have demonstrated promising effects for the treatment of insulin resistance and diabetes in preclinical models. Further results from clinical trials are eagerly awaited.…”
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Gliclazide protects ionizing radiation-induced intestinal injury in mice by inhibiting oxidative stress and caspase-3 by Soroush Arzani, Soghra Farzipour, Fereshteh Talebpour Amiri, Seyed Jalal Hosseinimehr

“…The administration of GLZ resulted in a marked decrease in caspase-3 immunoreactivity in the ileum of irradiated mice. This preclinical study exhibited that GLZ has a radioprotective effect against intestinal injury by inhibiting oxidative stress and apoptosis.…”
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A Comprehensive Review of Ethnomedicinal Uses, Phytochemistry, Pharmacology, and Toxicity of Prunus africana (Hook. F.) Kalkman from Africa by James K. Ndung’u, Joseph M. Nguta, Isaac M. Mapenay, Gervason A. Moriasi

“…This review offers a comprehensive compilation of ethnomedicinal applications, phytochemical composition, pharmacological effects, and toxicity assessments of P. africana, serving as a foundation for future preclinical and clinical investigations. By understanding its traditional uses and chemical constituents, researchers can target specific medical conditions with greater precision, potentially expediting the development of safe and effective pharmaceuticals. …”
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Stem Cells in the Treatment of Neuropathic Pain: Research Progress of Mechanism by Meichen Liu, Kai Li, Yunyun Wang, Guoqing Zhao, Jinlan Jiang

“…Recently, research on the treatment of NP by stem cells is increasing and promising results have been achieved in preclinical research. In this review, we briefly introduce the neuropathic pain, the current treatment strategy, and the development of stem cell therapy, and we collected the experimental and clinical trial articles of many kinds of stem cells in the treatment of neuropathic pain from the past ten years. …”
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Chimerism-Based Experimental Models for Tolerance Induction in Vascularized Composite Allografts: Cleveland Clinic Research Experience by Maria Siemionow, Aleksandra Klimczak

“…The preclinical experimental models of vascularized composite allografts (VCAs) have been rapidly developed for the assessment of immunomodulatory protocols for clinical application. …”
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Immunological Regulation of Fibrosis During Heart Failure: It Takes Two to Tango by Vinay Kumar, Shyam S. Bansal

“…The aims of this review are to (i) briefly summarize the role of key immune cells that regulate wound healing during MI and fibrosis during LV remodeling; (ii) underscore phenotypic diversities in immune cells and their subsets to underscore their role in regulating fibrotic responses, and, last but not the least, (iii) highlight gaps in our understanding that restrict the translation of immuno-modulatory therapies from the preclinical models to heart failure patients.…”
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Orthostatic Hypotension in Patients with Parkinson’s Disease and Atypical Parkinsonism by Seyed-Mohammad Fereshtehnejad, Johan Lökk

“…OH may herald the onset of PD before cardinal motor symptoms and our review emphasises the importance of its timely diagnosis (even as one preclinical marker) and multifactorial treatment, starting with patient education and lifestyle approach. …”
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Detection and Delineation of Oral Cancer With a PARP1-Targeted Optical Imaging Agent by Susanne Kossatz, Wolfgang Weber, Thomas Reiner

“…Our fluorescently labeled small-molecule inhibitor PARPi-FL binds to the DNA repair enzyme poly(ADP-ribose)polymerase 1 (PARP1) and is a potential diagnostic aid for oral cancer delineation. Based on our preclinical work, a clinical phase I/II trial opened in March 2017 to evaluate PARPi-FL as a contrast agent for oral cancer imaging. …”
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In Vivo Experiments with Dental Pulp Stem Cells for Pulp-Dentin Complex Regeneration by Sunil Kim, Su-Jung Shin, Yunjung Song, Euiseong Kim

“…While it is important to perform research on cells, scaffolds, and growth factors, it is also critical to develop animal models for preclinical trials. The development of a reproducible animal model of transplantation is essential for obtaining precise and accurate data in vivo. …”
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Intraoperative Imaging of Positron Emission Tomographic Radiotracers Using Cerenkov Luminescence Emissions by Jason P. Holland, Guillaume Normand, Alessandro Ruggiero, Jason S. Lewis, Jan Grimm

“…Overall, these results strongly support the continued development of CLI as a preclinical and possible clinical tool for use in molecular imaging and surgical procedures for accurately defining tumor margins.…”
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The Molecular Imaging of Natural Killer Cells by Mariya Shapovalova, Sean R. Pyper MD, PhD, Branden S. Moriarity PhD, Aaron M. LeBeau PhD

“…In this review, we will provide an overview of the advances made in imaging NK cells in both preclinical and clinical studies.…”
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Prolonged Ileus in an Infant Presenting with Primary Congenital Hypothyroidism by Caroline Chua, Shilpa Gurnurkar, Yahdira Rodriguez-Prado, Victoria Niklas

“…We believe that the preclinical detection and immediate therapy for CH have lessened the prevalence of this presentation in general practice, and hence practitioners are less likely to be familiar with its natural history and management.…”
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Targeting HER2 in Nuclear Medicine for Imaging and Therapy by Adriana V. F. Massicano PhD, Bernadette V. Marquez-Nostra PhD, Suzanne E. Lapi PhD

“…This review presents the most recent advances in HER2 targeting in nuclear medicine focusing on preclinical and clinical studies.…”
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Mutanome Engineered RNA Immunotherapy: Towards Patient-Centered Tumor Vaccination by Mathias Vormehr, Barbara Schrörs, Sebastian Boegel, Martin Löwer, Özlem Türeci, Ugur Sahin

“…Due to their absence during negative selection of T cells and their lack of expression in healthy tissue, tumor mutations are considered as optimal targets for cancer immunotherapy. Preclinical and early clinical data suggest that synthetic mRNA can serve as potent drug format allowing the cost efficient production of highly efficient vaccines in a timely manner. …”
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CathROB: A Highly Compact and Versatile Remote Catheter Navigation System by Laura Cercenelli, Barbara Bortolani, Emanuela Marcelli

“…There were no adverse events, including absence of cardiac perforation or cardiac damage, indicative of the safety profile of CathROB. Although further preclinical and clinical studies are required, the presented CathROB system seems to be a promising solution for an affordable and easy-to-use remote catheter navigation.…”
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Clinical Trials of Immunogene Therapy for Spontaneous Tumors in Companion Animals by Gerardo Claudio Glikin, Liliana María Elena Finocchiaro

“…The encouraging outcomes obtained in companion animals support their ready application in veterinary clinical oncology and serve as preclinical proof of concept and safety assay for future human gene therapy trials.…”
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Liver Protective Effect of Fenofibrate in NASH/NAFLD Animal Models by Ali Mahmoudi, Seyed Adel Moallem, Thomas P. Johnston, Amirhossein Sahebkar

“…In recent decades, several medications related to other metabolic disorders have been evaluated in preclinical studies and in clinical trials due to the correlation of NAFLD with other metabolic diseases. …”
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Corticostriatal contributions to dysregulated motivated behaviors in stress, depression, and substance use disorders by Benjamin M. Siemsen, Daniela Franco, Mary Kay Lobo

“…Stress-induced depression and substance use disorders (SUDs) both share this common underlying pathology, manifested as deficits in perceived reward in depression, and increased attribution of positive valence to drug-predictive stimuli and dysfunctional cognition in SUDs. Here we review preclinical and clinical data that support dysregulation of motivated and reward-related behaviors as a core phenotype shared between these two disorders. …”
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