FDA-approved kinase inhibitors: a promising therapeutic avenue for traumatic brain injury by Dezhu Gao, Yu Shi, Zhiliang Wang, Weiming Liu

“…Nowadays, kinase inhibitors approved by the Food and Drug Administration (FDA) mainly for cancer treatment have shown potential effects in TBI. Preclinical studies suggest their potential in promoting recovery. …”
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The role of DNA methylation in the disorders of bone metabolism by B. I. Yalaev, A. V. Tyurin, R. Y. Mirgalieva, R. I. Khusainova

“…Finding the risk factors will predict the risk of osteoporosis at the preclinical stage, help define the course and severity of the disease, and develop preventive measures based on them to reduce the risk of fractures. …”
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Cultured Human Airway Epithelial Cells (Calu-3): A Model of Human Respiratory Function, Structure, and Inflammatory Responses by Yan Zhu, Aaron Chidekel, Thomas H. Shaffer

“…The Calu-3 cell preparation is a sensitive and efficient preclinical model to study human respiratory processes and diseases related to oxygen- and ventilator-induced lung injury.…”
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Investigating the Insights of Nursing Students About Clinical Pharmacology Courses by Kiarash Fekri, Fereshteh Araghian Mojarad, Mehrrooz Alishah, Seyed Robabe Babaei, Tahereh Yaghoubi

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CAR T cells for treating autoimmune diseases by Dimitrios Mougiakakos, Ulrike Koehl, Stephan Fricke, Ulrich Blache, Sandy Tretbar

“…We will cover first clinical results of applying anti-CD19 and anti-B cell maturation antigen CAR T cells for B cell elimination in systemic lupus erythematosus, refractory antisynthetase syndrome and myasthenia gravis, respectively. Furthermore, in preclinical models, researchers have also developed chimeric autoantibody receptor T cells that can eliminate individual B cell clones producing specific autoantibodies, and regulatory CAR T cells that do not eliminate autoreactive immune cells but dampen their wrong activation. …”
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Structure-guided identification of mitogen-activated protein kinase-1 inhibitors towards anticancer therapeutics. by Md Nayab Sulaimani, Shazia Ahmed, Farah Anjum, Taj Mohammad, Anas Shamsi, Ravins Dohare, Md Imtaiyaz Hassan

“…The study highlights that these compounds could be explored further in preclinical and clinical investigations to develop anticancer therapeutics.…”
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Herbal medicine and leptospirosis in Southeast Asia: A comprehensive bibliometric analysis (1973-2023) by Shah Putri Ade Dian, Stefani Widodo, Putri Damayanti Irma, Halim Shariff, Abidah Safithri, Muhammad Almanfaluthi

“…The research also emphasizes the role of preclinical studies and the chemical analysis of herbal remedies for leptospirosis. …”
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Dual Inhibition of Activin/Nodal/TGF-β and BMP Signaling Pathways by SB431542 and Dorsomorphin Induces Neuronal Differentiation of Human Adipose Derived Stem Cells by Vedavathi Madhu, Abhijit S. Dighe, Quanjun Cui, D. Nicole Deal

“…Damage to the nervous system can cause devastating diseases or musculoskeletal dysfunctions and transplantation of progenitor stem cells can be an excellent treatment option in this regard. Preclinical studies demonstrate that untreated stem cells, unlike stem cells activated to differentiate into neuronal lineage, do not survive in the neuronal tissues. …”
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Quantification and prediction of human fetal (-)-Δ9-tetrahydrocannabinol/(±)-11-OH-Δ9-tetrahydrocannabinol exposure during pregnancy to inform fetal cannabis toxicity by Aditya R. Kumar, Lyndsey S. Benson, Erica M. Wymore, Jocelyn E. Phipers, Jennifer C. Dempsey, Lucinda A. Cort, Jashvant D. Unadkat

“…To determine causality, preclinical studies mimicking human fetal cannabinoid exposure must be conducted. …”
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Rheological Characterization and Printability of Sodium Alginate–Gelatin Hydrogel for 3D Cultures and Bioprinting by Mohan Kumar Dey, Ram V. Devireddy

“…The development of biocompatible hydrogels for 3D bioprinting is essential for creating functional tissue models and advancing preclinical drug testing. This study investigates the formulation, printability, mechanical properties, and biocompatibility of a novel Alg-Gel hydrogel blend (alginate and gelatin) for use in extrusion-based 3D bioprinting. …”
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Insulin Resistance Predicts Atherogenic Lipoprotein Profile in Nondiabetic Subjects by Flávia De C. Cartolano, Gabriela D. Dias, Maria C. P. de Freitas, Antônio M. Figueiredo Neto, Nágila R. T. Damasceno

“…Atherogenic diabetes is associated with an increased cardiovascular risk and mortality in diabetic individuals; however, the impact of insulin resistance (IR) in lipid metabolism in preclinical stages is generally underreported. For that, we evaluated the capacity of IR to predict an atherogenic lipid subfraction profile. …”
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Gene Editing in Pluripotent Stem Cells and Their Derived Organoids by Hang Zhou, Yun Wang, Li-Ping Liu, Yu-Mei Li, Yun-Wen Zheng

“…The applications, characteristics, and existing challenges are summarized in combination with our lab experiences in this field in an effort to help gene-editing technology better serve humans in a regulated manner. Current preclinical and clinical trials have demonstrated initial safety and efficacy of PSC gene editing; however, for better application in clinical settings, additional investigation is warranted.…”
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Advancements in lung regeneration: from bench to bedside by Danial Khayatan, Peyman Esmaeili Fard Barzegar, Arooj Fatima, Tayyaba Sattar, Ambreen Zahid, Syeda Aiman Batool, Mehreen Jabbar, Maryam Mureed, Fatima Haider, Aymun Javed Butt, Sana Hanif, Alexander Seifalian, Hamid Tebyaniyan

“…By critical analysis of in vitro, preclinical, and clinical studies, this review aims to provide a comprehensive overview of the emerging technology of lung regeneration research, shedding light on promising avenues for future therapeutic interventions.…”
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Human Liver Stem Cells Suppress T-Cell Proliferation, NK Activity, and Dendritic Cell Differentiation by Stefania Bruno, Cristina Grange, Marta Tapparo, Chiara Pasquino, Renato Romagnoli, Ennia Dametto, Antonio Amoroso, Ciro Tetta, Giovanni Camussi

“…Human liver stem cells (HLSCs) are a mesenchymal stromal cell-like population resident in the adult liver. Preclinical studies indicate that HLSCs could be a good candidate for cell therapy. …”
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Determination of Muscone in Rats Plasma following Oral Administration of Artificial Musk: Using of Combined Headspace Gas Chromatography-Mass Spectrometry by Qibiao Wu, Haitao Li, Yujing Leng, Haishan Deng, Haibo Cheng, Weixing Shen

“…This method would be applicable to the analysis of plasma concentrations of muscone in preclinical contexts, where artificial musk is used.…”
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In vivo MRI visualization of growth and morphology in the orthotopic xenotrasplantation U87 glioblastoma mouse SCID model by E. L. Zavjalov, I. A. Razumov, L. A. Gerlinskaya, A. V. Romashchenko

“…The results demonstrate that this SCID model may be used as an in vivo preclinical model to test the efficacy and putative side effects of novel anticancer therapies.…”
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Mushroom β-glucan and polyphenol formulations as natural immunity boosters and balancers: nature of the application by Maja Kozarski, Anita Klaus, Leo van Griensven, Dragica Jakovljevic, Nina Todorovic, Wan Abd Al Qadr Imad Wan-Mohtar, Jovana Vunduk

“…The literature data on their bioavailability, metabolic transformations, preclinical and human clinical research, and safety are discussed. …”
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Targeted therapeutic strategies for Nectin-4 in breast cancer: Recent advances and future prospects by Yufei Wang, Guangliang Li, Hanying Wang, Quan Qi, Xian Wang, Haiqi Lu

“…Notably, Nectin-4 was also investigated as a target for breast cancer in preclinical and clinical settings. Nectin-4-targeted approaches, such as ADCs, oncolytic viruses, photothermal therapy and immunotherapy, have shown promising results in early-phase clinical trials. …”
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The Role of Gut Microbiota in Tumor Immunotherapy by Miao Wu, Jiawei Bai, Chengtai Ma, Jie Wei, Xianjin Du

“…These characteristics may be used as biomarkers to predict the prognosis of immunotherapy and may also be developed as “immune potentiators” to assist immunotherapy. Some clinical and preclinical studies have proved that microbial intervention, including microbial transplantation, can improve the sensitivity of immunotherapy or reduce adverse reactions to a certain extent. …”
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Combination of GLP-1 Receptor Activation and Glucagon Blockage Promotes Pancreatic β-Cell Regeneration In Situ in Type 1 Diabetic Mice by Liangbiao Gu, Dandan Wang, Xiaona Cui, Tianjiao Wei, Kun Yang, Jin Yang, Rui Wei, Tianpei Hong

“…Glucagon receptor (GCGR) monoclonal antibody (mAb), a preclinical agent that blocks glucagon pathway, can promote the recovery of functional β-cell mass in type 1 diabetic mice. …”
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