Modeling Alzheimer’s Disease with Induced Pluripotent Stem Cells: Current Challenges and Future Concerns by Weiwei Zhang, Bin Jiao, Miaojin Zhou, Tao Zhou, Lu Shen

“…As a result, there is a pressing need for the development of new models providing insights into the pathological mechanisms of AD and for the discovery of ways to treat or delay the onset of the disease. Recent preclinical research suggests that stem cells can be used to model AD. …”
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Astaxanthin as a potential therapeutic agent for knee osteoarthritis: A review of mechanisms and clinical evidence by Sidra Sabir, AHM Mahmudur Rahman, Abdul Haseeb Bhutta

“…This review aims to examine the therapeutic mechanisms of astaxanthin in KOA, alongside clinical evidence supporting its effectiveness through a narrative synthesis of preclinical and clinical studies. Methods: A comprehensive review of the literature was conducted across Web of Science, Pubmed, Scopus and Google Scholar, focusing on studies that explored astaxanthin's antioxidative, anti-inflammatory, and cartilage-protective properties in the context of KOA. …”
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Effect of Covid-19 Vaccine on Women's Fertility Hormones by Haydar Basim Najeb, Abdulameer Jasim Mohammed, Emad Mohammed Rasheed

“…More than 184 nominee vaccines are being tested in preclinical use and 104 in clinical stages of development. …”
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Connecting Cerebral White Matter Lesions and Hypertensive Target Organ Damage by Cristina Sierra, Alfons López-Soto, Antonio Coca

“…Stroke is the second leading cause of death and the number one cause of disability worldwide and over 80% of strokes occur in the elderly. Preclinical hypertensive lesions in most target organs are clearly identified: left ventricular hypertrophy for the heart, microalbuminuria for the kidney, fundus abnormalities for the eye, and intima-media thickness and pulse wave velocity for the vessels. …”
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Pharmacokinetic and Biodistribution Assessment of a Near Infrared-Labeled PSMA-Specific Small Molecule in Tumor-Bearing Mice by Joy L. Kovar, Lael L. Cheung, Melanie A. Simpson, D. Michael Olive

“…Use of near infrared (NIR) technologies to perform image-guided surgery may improve accurate delineation of tumor margins. To facilitate preclinical testing of such outcomes, here we developed and characterized a PSMA-targeted small molecule, YC-27. …”
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Electrostatic properties of human germlines and biodistribution of small biologics by Leticia Maria De Souza Cordeiro, Kelley Christine Atkinson, Argin Aivazian, Patrick Frank Joyce, Fang Jia, Alessandro Mascioni

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Progress in Therapy Development for Amyotrophic Lateral Sclerosis by Kalina Venkova-Hristova, Alexandar Christov, Zarine Kamaluddin, Peter Kobalka, Kenneth Hensley

“…Reasons will be considered for the frequent failure of preclinical successes to translate into positive clinical outcomes. …”
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Meta-Analysis of the Therapeutic Effects of Stem Cell-Derived Extracellular Vesicles in Rodent Models of Hemorrhagic Stroke by Conglin Wang, Bo Yan, Pan Liao, Fanglian Chen, Ping Lei

“…Our findings suggest that SCEVs therapy may improve neurofunctional behavior after hemorrhagic stroke and provide important insights into the design of preclinical trials.…”
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AI Methods for Antimicrobial Peptides: Progress and Challenges by Carlos A. Brizuela, Gary Liu, Jonathan M. Stokes, Cesar de laFuente‐Nunez

“…AI approaches have recently revolutionised this field by accelerating the discovery of new peptides with anti‐infective activity, particularly in preclinical mouse models. Initially, classical ML approaches dominated the field, but recently there has been a shift towards deep learning (DL) models. …”
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An HLA-Transgenic Mouse Model of Type 1 Diabetes That Incorporates the Reduced but Not Abolished Thymic Insulin Expression Seen in Patients by Jeffrey Babad, Riyasat Ali, Jennifer Schloss, Teresa P. DiLorenzo

“…This model should find utility as a tool to uncover the mechanisms underlying the association between reduced thymic insulin expression and T1D in humans and aid in preclinical studies to evaluate insulin-targeted immunotherapies for the disease.…”
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Noncoding RNAs Associated with PPARs in Etiology of MAFLD as a Novel Approach for Therapeutics Targets by Fatemeh Kazeminasab, Maryam Baharlooie, Kamran Ghaedi

“…This study revealed a subset of ncRNAs that could help in more clear and guided designation of preclinical and clinical studies to verify the therapeutic application of the revealed ncRNAs by manipulating the PPARs molecular mechanism in MAFLD.…”
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Galectin-3 Inhibitors Suppress Anoikis Resistance and Invasive Capacity in Thyroid Cancer Cells by Jie-Jen Lee, Yi-Chiung Hsu, Ying-Syuan Li, Shih-Ping Cheng

“…Galectin-3 inhibitors are potentially suitable for preclinical evaluation of treatment and/or prevention of metastatic spread in thyroid cancer.…”
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Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application by Mengyuan Wang, Quan Yuan, Liang Xie

“…Recently, clinical trials for MSC-mediated therapies have rapidly developed for immune-related diseases following reports from preclinical studies declaring their therapeutic safety and efficacy. …”
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Dietary Conjugated Linoleic Acid Alters Oxidative Stability and Alleviates Plasma Cholesterol Content in Meat of Broiler Chickens by Suriya Kumari Ramiah, Goh Yong Meng, Mahdi Ebrahimi

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Role of phytochemicals in cardiovascular disease management: Insights into mechanisms, efficacy, and clinical application by Esther Ugo Alum

“…The review analyzes findings from clinical trials, epidemiological studies, and preclinical research to explain how these phytochemicals are effective in preventing and treating cardiovascular diseases. …”
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Functional Role of Adult Hippocampal Neurogenesis as a Therapeutic Strategy for Mental Disorders by Heechul Jun, Syed Mohammed Qasim Hussaini, Michael J. Rigby, Mi-Hyeon Jang

“…In this paper, we discuss three major psychiatric disorders, depression, schizophrenia, and drug addiction, in light of preclinical evidence used in establishing the neurobiological significance of adult neurogenesis. …”
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Neoantigen mRNA vaccines and A2A receptor antagonism: A strategy to enhance T cell immunity by Saber Imani, Parham Jabbarzadeh Kaboli, Ali Babaeizad, Mazaher Maghsoudloo

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A new taxonomy of neuroprotective agents for stroke appropriate for the reperfusion era by Mersedeh Bahr-Hosseini, Jeffrey L. Saver

“…By focusing on broad physiologic targets of action rather than granular molecular mechanisms, this six-fold classification of neuroprotection can inform the design of preclinical studies and human clinical trials, including imaging biomarker endpoint selection and treatment timing. …”
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Dengue fever and herbal medicine in Indonesia: Trends, collaborations, and research impact (1985-2023) by Nur Sabila Berlianda, Stefani Widodo, Putri Damayanti Irma, Pratiwi Wardani Dita, Abidah Safithri, Muhammad Almanfaluthi

“…A keyword co-occurrence analysis identified “Aedes aegypti,” “animal model,” and “plant extract” as central themes in the research, which highlights a strong focus on preclinical studies and the chemical analysis of plant-based treatments.…”
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Detection of Cancer Stem Cells from Patient Samples by Sofia Hakala, Anna Hämäläinen, Sanne Sandelin, Nikolaos Giannareas, Elisa Närvä

“…Additionally, methods recently established in laboratories, preclinical studies, and clinical assays are covered. …”
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