A Bayesian Markov Framework for Modeling Breast Cancer Progression by Tong Wu

“…This study develops a three-state Markov framework to estimate the transition rates between normal, preclinical screen-detectable phase (PCDP), and clinical breast cancer using simulated data. …”
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Thrombospondin-1: Multiple Paths to Inflammation by Zenaida Lopez-Dee, Kenneth Pidcock, Linda S. Gutierrez

“…The effects of TSP-1 have been studied in many preclinical tumor models, and mimetic peptides are being tested in cancer clinical trials. …”
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When molecular biology transforms clinical oncology: the EGFR journey in colorectal cancer by Pietro Paolo Vitiello, Nadia Saoudi González, Alberto Bardelli

“…The discovery of growth factors and their involvement in cancer represents the foundation of precision oncology. The preclinical and clinical development of agents targeting epidermal growth factor receptor (EGFR) in colorectal cancer (CRC) were accompanied by big hype and hopes, though the clinical testing of such agents clashed with intrinsic and acquired resistance, greatly limiting their therapeutic value. …”
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Statins in Asthma: Potential Beneficial Effects and Limitations by Dipanjan Bhattacharjee, Bharti Chogtu, Rahul Magazine

“…However, the initial excellent results from the preclinical and animal studies have not borne the results in clinical trials that the scientific world was hoping for. …”
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Impact of the Number of Administered Systemic Treatment Lines on Local Response to Radiation Therapy for Multiple Myeloma by Andrea Emanuele Guerini, MD, Eneida Mataj, MD, Paolo Borghetti, MD, Luca Triggiani, Ludovica Pegurri, MD, Stefania Nici, Stefano Riga, Alessandra Tucci, MD, Angelo Belotti, MD, Marco Lorenzo Bonù, MD, Giorgio Facheris, MD, Stefano Maria Magrini, Luigi Spiazzi, Michela Buglione

“…Purpose: Multiple myeloma (MM) tends to develop resistance to systemic therapy through multiple mechanisms that might as well induce radioresistance, as suggested by preclinical studies. The aim of the present analysis was to elucidate whether the number of systemic treatment lines received prior to radiation therapy (RT) might confer radioresistance and influence local response. …”
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PFOA, PFOS and PFHxS toxicokinetic considerations for the development of an in vivo approach for assessing PFAS relative bioavailability in soil by Albert L. Juhasz, Farzana Kastury, Ruby Jones, Mahima Seeborun, Tanya Caceres, Carina Herde, Michelle Cavallaro, Sarah Dilmetz, Joshua Hutchings, Yevgeniya Grebneva, Chris Desire, Peter Hoffmann

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Advanced 3D bioprinted liver models with human-induced hepatocytes for personalized toxicity screening by Yue Ma, Runbang He, Bo Deng, Miaomiao Luo, Wenjie Zhang, Lina Mao, Wenxiang Hu, Yilei Mao, Huayu Yang, Pengyu Huang

“…The development of advanced in vitro models for assessing liver toxicity and drug responses is crucial for personalized medicine and preclinical drug development. 3D bioprinting technology provides opportunities to create human liver models that are suitable for conducting high-throughput screening for liver toxicity. …”
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CD200R1 immune checkpoint blockade by the first-in-human anti-CD200R1 antibody 23ME-00610: molecular mechanism and engineering of a surrogate antibody by Cristina Melero, S. Jimmy Budiardjo, Anahita Daruwalla, Lance Larrabee, Oleg Ganichkin, Alexander J. Heiler, Jill Fenaux, Ben Chung, Germaine Fuh, Yao-Ming Huang

“…However, 23ME–00610 does not bind CD200R1 of preclinical species such as cynomolgus monkey MfCD200R1. …”
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Radiation dose and fraction in immunotherapy: one-size regimen does not fit all settings, so how does one choose? by Marka Crittenden, Sandra Demaria, C Norman Coleman, Jonathan Schoenfeld, Arta Monjazeb, Samir Khleif, Seema Gupta, Andrew Sikora, Zachary Morris, Chandan Guha, Stephen Shiao, Silvia Chiara Formenti, Bhadrasain Vikram, Mansoor M Ahmed

“…Similarly, preclinical studies should be designed as much as possible to model the intended clinical setting. …”
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Laser Applications in Metal Orthodontic Bracket Debonding: A Systematic Review by Patryk Woś, Sylwia Kiryk, Tomasz Dyl, Jan Kiryk, Tomasz Horodniczy, Magdalena Szablińska, Magdalena Aleksandra Dubowik, Wojciech Dobrzyński, Marcin Mikulewicz, Jacek Matys, Maciej Dobrzyński

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Cancer Cell Adhesion and Metastasis: Selectins, Integrins, and the Inhibitory Potential of Heparins by Gerd Bendas, Lubor Borsig

“…Clinical evidence indicates that heparin, commonly used for treatment of thromboembolic events in cancer patients, is beneficial for their survival. Preclinical studies confirm that heparin possesses antimetastatic activities that lead to attenuation of metastasis in various animal models. …”
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Bidirectional causality of physical exercise in retinal neuroprotection by Stephen K. Agadagba, Suk-yu Yau, Ying Liang, Kristine Dalton, Benjamin Thompson

“…Finally, we discuss future directions for preclinical and clinical research in exercise and eye health.…”
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Antiviral Activity of Resveratrol against Human and Animal Viruses by Yusuf Abba, Hasliza Hassim, Hazilawati Hamzah, Mohamed Mustapha Noordin

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Bacteria in Cancer Therapy: Renaissance of an Old Concept by Sebastian Felgner, Dino Kocijancic, Michael Frahm, Siegfried Weiss

“…This review summarizes and compares the results of the past 150 years in bacteria mediated tumor therapy from preclinical to clinical studies. Lessons we have learned from the past provide a solid foundation on which to base future efforts. …”
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Contemporary Trends in Pulsed Field Ablation for Cardiac Arrhythmias by Hagai Yavin, Mark Prasad, Jonathan Gordon, Tolga Aksu, Henry D. Huang

“…In this review, we discuss the available preclinical and clinical evidence for PFA for atrial fibrillation, developments for ventricular arrhythmia (VA) ablation, and future perspectives.…”
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Current Perspectives regarding Stem Cell-Based Therapy for Alzheimer’s Disease by Kyeong-Ah Kwak, Seung-Pyo Lee, Jin-Young Yang, Young-Seok Park

“…The results from recent preclinical studies regarding stem cell-based therapies are promising. …”
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Toxicological Review of Anticancer Plants Used in Traditional Medicine in Morocco by Soufiane Drioua, Abha Cherkani-Hassani, Otman El-Guourrami, Mouna Ameggouz, Ahmed Zahidi, Abdelhakim Bouyahaya, Sayyed Ibrahim Shah, Yaser Mohammed Al-Worafi, Long Chiau Ming, Hanane Benzaied, Anass Doukkali

“…Further research, including preclinical and clinical trials, should be conducted to investigate the potential therapeutic benefits of these plants. …”
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Advances in the Use of Stem Cells in Veterinary Medicine: From Basic Research to Clinical Practice by Melissa Medeiros Markoski

“…Knowledge about how adult stem cells modulate the molecular signals to activate cell homing has also been increasingly determined, evidencing the mechanisms which enable cells to repair and regenerate injured tissues. Preclinical studies were designed for many animal models and they have contributed to the translation to the human clinic. …”
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Life-Threatening Hypertriglyceridemia in a Patient on Ruxolitinib and Sirolimus for Chronic Graft-versus-Host Disease by Allison P. Watson, Claudio G. Brunstein, Shernan G. Holtan

“…Ruxolitinib is an oral selective Janus-associated kinase 1 (JAK1) and JAK2 inhibitor that was initially approved by the FDA in 2014 for treatment of myelofibrosis. In preclinical and retrospective clinical studies, use of ruxolitinib was shown to reduce graft-versus-host-disease (GVHD) in allograft recipients with moderate/severe corticosteroid-dependent or refractory chronic GVHD. …”
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CCL24 and Fibrosis: A Narrative Review of Existing Evidence and Mechanisms by Raanan Greenman, Chris J. Weston

“…This review delves into the intricate role of CCL24 in fibrotic diseases, highlighting its impact on fibrotic, immune, and vascular pathways. We focus on the preclinical and clinical evidence supporting the therapeutic potential of blocking CCL24 in diseases that involve excessive inflammation and fibrosis.…”
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