Mesenchymal Stem Cells and Tissue Bioengineering Applications in Sheep as Ideal Model by Talita D’Paula Tavares Pereira Muniz, Mariana Correa Rossi, Vânia Maria de Vasconcelos Machado, Ana Liz Garcia Alves

“…This review aimed to describe recent MSC approaches, including those associated with biomaterials, from experimental, clinical, and preclinical studies with sheep models.…”
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Generating unseen diseases patient data using ontology enhanced generative adversarial networks by Chang Sun, Michel Dumontier

“…This innovative approach addresses the scarcity of data for rare diseases, offering valuable applications in data augmentation, hypothesis generation, and preclinical validation of clinical models.…”
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The Use of Adipose-Derived Stem Cells in Selected Skin Diseases (Vitiligo, Alopecia, and Nonhealing Wounds) by Agnieszka Owczarczyk-Saczonek, Anna Wociór, Waldemar Placek, Wojciech Maksymowicz, Joanna Wojtkiewicz

“…The promising results derived from the use of adipose-derived stem cells (ADSCs) in many diseases are a subject of observation in preclinical studies. ADSCs seem to be the ideal cell population for the use in regenerative medicine due to their easy isolation, nonimmunogenic properties, multipotential nature, possibilities for differentiation into various cell lines, and potential for angiogenesis. …”
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Reversing NK cell exhaustion: a novel strategy combining immune checkpoint blockade with drug sensitivity enhancement in the treatment of hepatocellular carcinoma by Yuxiang Huang, Hengjian Liao, Jiefu Luo, Huaning Wei, Anling Li, Yujie Lu, Bangde Xiang

“…TIM-3 and LAG-3), have shown potential to reverse NK cell exhaustion in preclinical studies. This article explores the promise of these innovative strategies in HCC immunotherapy, providing new therapeutic directions for optimizing NK cell function and improving drug sensitivity.…”
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The Impact of the Myeloid Response to Radiation Therapy by Michael J. Gough, Kristina Young, Marka Crittenden

“…Radiation therapy is showing potential as a partner for immunotherapies in preclinical cancer models and early clinical studies. …”
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Colorectal Polyposis and Immune-Based Therapies by Pearl Jacobson-Brown, Manuela G Neuman

“…A broad spectrum of new treatments, including innovative molecular therapies such as gene therapy and treatment with cytokines, is under experimental and preclinical investigation. Nonsteroidal anti-inflammatory drugs and selective cyclooxygenase-2 inhibitors have traditionally been used as inflammation-reducing agents in cases of colon adenoma. …”
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Corneal Stem Cells as a Source of Regenerative Cell-Based Therapy by Jasmin S. Nurković, Radiša Vojinović, Zana Dolićanin

“…Until now, various approaches and methods for isolation of LESCs and CSSCs and their successful transplantation have been described and tested in several preclinical studies and clinical trials. This review describes in detail phenotypic characteristics of LESCs and CSSCs and discusses their therapeutic potential in corneal regeneration. …”
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Umbilical Cord as Prospective Source for Mesenchymal Stem Cell-Based Therapy by Irina Arutyunyan, Andrey Elchaninov, Andrey Makarov, Timur Fatkhudinov

“…The paper presents current evidence on the properties of human umbilical cord-derived mesenchymal stem cells, including origin, proliferative potential, plasticity, stability of karyotype and phenotype, transcriptome, secretome, and immunomodulatory activity. A review of preclinical studies and clinical trials using this cell type is performed. …”
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Within-session habituation and salivary cortisol during exposure treatment in obsessive-compulsive disorder – A link and an influence of DHEA? by Michael Kellner, Alexander Yassouridis, Christoph Muhtz, Klaus Wiedemann

“…Background: Glucocorticoids increase fear extinction in preclinical and human studies. Endogenous cortisol might influence who will benefit from exposure therapy in anxiety-spectrum disorders. …”
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Commentary to F-GP1, a Novel PET Tracer Designed for High-Sensitivity, Low-Background Detection of Thrombi: Imaging Activated Platelets in Clots—Are We Getting There? by Andrew W. Stephens MD, PhD, Norman Koglin PhD, Ludger M. Dinkelborg PhD

“…This commentary describes the current status of GPIIb/IIIa-based PET imaging approaches with a focus on the recently published preclinical data of the small-molecule PET tracer 18 F-GP1. …”
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Receptor Tyrosine Kinases and Inhibitors in Lung Cancer by Evan Pisick, Simha Jagadeesh, Ravi Salgia

“…The inhibitors against the specific RTKs are in various preclinical and clinical trials, and this will be detailed.…”
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Potential Neuroprotective Effect of the Endocannabinoid System on Parkinson’s Disease by María Fernanda Urmeneta-Ortíz, Aldo Rafael Tejeda-Martínez, Orfil González-Reynoso, Mario Eduardo Flores-Soto

“…This review provides a comprehensive summary of current clinical and preclinical evidence concerning ECS alterations in PD, along with potential pharmacological targets that may exert the protection of dopaminergic neurons.…”
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Granulocyte Colony-Stimulating Factor and Its Potential Application for Skeletal Muscle Repair and Regeneration by Craig R. Wright, Alister C. Ward, Aaron P. Russell

“…This has been supported by preclinical studies and clinical trials investigating G-CSF as a potential therapeutic agent in relevant disease states. …”
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Comprehensive Guide to Randomized Controlled Trials in Radiology: Everything You Need to Know by Shreya Shukla, Abhishek Mahajan

“…RCTs are vital in radiology for evaluating new imaging technologies, contrast agents, and therapeutic procedures, despite challenges in translating preclinical findings to clinical practice. This guide discusses the history, principles, methodologies, and applications of RCTs in radiology, highlighting their role in advancing the field and supporting evidence-based practice.…”
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Teaching an old dog new tricks: re-engineering IL-2 for immuno-oncology applications by Mario Sznol, Naiyer Rizvi

“…Interleukin-2 has become a prominent focus of preclinical and clinical investigation, because of its known clinical activity, the important role of this cytokine in immune biology, and the ability to engineer variant proteins with potentially improved antitumor immunomodulatory activity and reduced toxicity. …”
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Update on glasdegib in acute myeloid leukemia – broadening horizons of Hedgehog pathway inhibitors by Fersing Cyril, Mathias Fanny

“…The current paper proposes an extensive, up-to-date review of the preclinical and clinical development of glasdegib. Elements of its routine clinical use and the landscape of ongoing clinical trials are also stated.…”
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Inflammatory Mechanisms of Organ Crosstalk during Ischemic Acute Kidney Injury by Laura E. White, Heitham T. Hassoun

“…Kidney ischemia-reperfusion injury (IRI) incites a proinflammatory cascade and releases cellular and soluble mediators with systemic implications for remote organ injury. Evidence from preclinical models cites mechanisms of organ crosstalk during ischemic AKI including the expression of cellular adhesion molecules, lymphocyte trafficking, release of proinflammatory cytokines and chemokines, and modification of the host innate and adaptive immune response systems. …”
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Clinical and genetic characteristics and medical approach in attenuated form of familial adenomatosis of the colon by A. M. Kuzminov, A. V. Karpukhin, I. Yu. Sachkov, Yu. Yu. Chubarov, T. A. Savel’yeva

“…At attenuated form mutation in АРС gene occurred within 450 and 510 codons and on the edges of this gene that allows both to reveal disease at preclinical stage, and to identify the attenuated variant. …”
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X-Ray Phase-Contrast Imaging with Three 2D Gratings by Ming Jiang, Christopher Lee Wyatt, Ge Wang

“…X-ray imaging is of paramount importance for clinical and preclinical imaging but it is fundamentally restricted by the attenuation-based contrast mechanism, which has remained essentially the same since Roentgen's discovery a century ago. …”
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Expanding the therapeutic horizon in acute myeloid leukemia: The role of phosphoinositide-3-kinase-γ inhibition by Soumyajit Das, Mahendra Pratap Singh, Nishant Rai, Sanjit Sah

“…This study investigates the role of phosphoinositide-3-kinase-γ (PI3Kγ) in AML and explores the therapeutic potential of the PI3Kγ inhibitor, eganelisib, in preclinical models. Using genome-wide CRISPR interference screening, we identified PI3Kγ as a critical survival pathway in certain AML subsets. …”
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